Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Last Name
Institution

Iain Konigsberg

TitleResearch Scientist
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-BIOMED Informatics Gen Ops
Phone207/722-6015

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Konigsberg IR, Warburton D. From Smog to Scar: Epigenetic Signatures of Air Pollution in Interstitial Lung Disease. Am J Respir Crit Care Med. 2025 Oct; 211(10):1744-1746. PMID: 40920897.
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    2. Tukpah AC, Rose JA, Moll MR, Konigsberg IR, Vargas LB, Cutting CC, DeMeo D, Lynch DA, Silverman EK, Cho MH, Hatabu H, Putman RK, Hunninghake GM. Race, Environmental Exposures, and Interstitial Lung Abnormalities. Am J Respir Crit Care Med. 2025 Oct; 211(10):1885-1889. PMID: 40788722.
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    3. Selvaraj MS, Li X, Li Z, Van Buren E, Haidermota S, Postupaka D, Hornsby W, Bis JC, Brody JA, Cade BE, Chung RH, Curran JE, Damrauer SM, de Las Fuentes L, de Vries PS, Duggirala R, Freedman BI, Graff M, Guo X, Hidalgo BA, Hou L, Irvin R, Judy R, Kalyani RR, Kelly TN, Konigsberg IR, Kral BG, Kwee LC, Levy D, Li C, Manichaikul AW, Martin LW, Montasser ME, Morrison AC, Naseri T, North KE, O'Connell JR, Palmer ND, Peyser PA, Reiner AP, Shah SH, Smit RAJ, Smith JA, Taylor KD, Tiwari H, Tsai MY, Viali S, Wang Z, Wang Y, Zhao W, Arnett DK, Blangero J, Boerwinkle E, Bowden DW, Carlson JC, Chen YI, Ellinor PT, Fornage M, He J, Heard-Costa N, Kaplan RC, Kardia SLR, Kooperberg C, Kraus WE, Lange LA, Loos RJF, Mitchell BD, Psaty BM, Rader DJ, Redline S, Rich SS, Yanek LR, Gibbs R, Gabriel S, Viaud-Martinez KA, Dutcher SK, Germer S, Kim R, Rotter JI, Lin X, Peloso GM, Natarajan P. Whole genome sequence analysis of low-density lipoprotein cholesterol across 246 K individuals. Genome Biol. 2025 Sep 09; 26(1):273. PMID: 40926209.
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    4. Hysong MR, Manning AK, Green M, Konigsberg IR, Vargas LB, Sharma J, Lange L, Shuey MK, Glover LM, Wojcik GL, Lee S, Raffield LM, Cromer SJ. Quantifying Social Determinants of Health for Disease Prediction: A Multi-Level Approach Using Healthy People 2030 and All of Us Data. medRxiv. 2025 Sep 03. PMID: 40950446.
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    5. Zhang C, Konigsberg IR, He Y, Zhang J, Chikowore T, Feldman WB, Hu X, Ding Y, Pasaniuc B, Chang D, Chen Q, Lasky-Su JA, Hecker J, Tobin MD, Chen J, Kalra S, Pratte KA, Im HK, Wan ES, Manichaikul A, Silverman EK, Bowler RP, Lange LA, Ortega VE, Martin AR, Cho MH, Moll MR. Multi-Trait Polygenic Scores for COPD and COPD Exacerbations Implicate Druggable Proteins. medRxiv. 2025 Aug 26. PMID: 40909810.
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    6. Kwan MMC, Day NB, Konigsberg IR, Thoresen E, Harrell AG, Busch CE, Davidson EJ, Yang IV, Shields CW. Particle Shape Modulates the Function of Adoptive Macrophage Transfers. Adv Healthc Mater. 2025 Aug 07; e01348. PMID: 40776442.
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    7. Kakar A, Litkowski EM, Scadden AW, Anwar MY, Konigsberg IR, Stanislawski MA, DuPre NC, Mitra R, Baumgartner R, Rsffield LM, Lange EM, Lange LA, Taylor KC. A multi-ethnic polygenic risk score for chronic kidney disease is associated with increased risk of hypertension in African American individuals. Res Sq. 2025 Jun 24. PMID: 40678210.
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    8. Vargas LB, Meyer MC, Konigsberg IR, Kakar A, Carry PM, Li Y, Jones AC, Tiwari HK, Srinivasasainagendra V, Armstrong ND, Kenny EE, Pasaniuc B, Irvin MR, Cho MH, Stanislawski MA, Raghavan S, Shortt JA, Lange LA, Lange EM. Ancestry Calibration of Polygenic Risk Scores Improves Risk Stratification and Effect Estimation in African American Adults. medRxiv. 2025 Jun 18. PMID: 40585132.
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    9. Khan AT, Adebamowo C, Fullerton SM, Hirbo J, Konigsberg IR, Kraft P, Martin I, Nelson SC, Ramsay M, Wojcik GL, Adebamowo SN, Conomos MP, Darst BF, Hysong MR, Li Y, Martin AR, Mathias RA, Rich SS, Sakoda LC, Schrider DR, Sharma J, Smith JL, Sun Q, Zhang Y, Gogarten SM. A data model for population descriptors in genomic research. Am J Hum Genet. 2025 Jul 03; 112(7):1504-1514. PMID: 40513563.
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    10. Konigsberg IR, Vargas LB, Pratte KA, Guzman DE, Pottinger TD, Buschur KL, Blackwell TW, Liu Y, Taylor KD, Johnson WC, Durda P, Tracy RP, Manichaikul A, Oelsner EC, Gabriel S, Gupta N, Onengut-Gumuscu S, Smith JD, Aguet F, Ardlie KG, Tahir UA, Gerszten RE, Clish C, Bleecker ER, Meyers DA, Ortega VE, Christenson SA, DeMeo DL, Hobbs BD, Hersh CP, Castaldi PJ, Curtis JL, Barr RG, Rotter JI, Rich SS, Woodruff PG, Silverman EK, Cho MH, Kechris KJ, Bowler RP, Lange EM, Lange LA, Moll MR. Omic Risk Scores are Associated with COPD-related Traits Across Three Cohorts. medRxiv. 2025 Jun 02. PMID: 40502581.
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    11. Harrall KK, Glueck DH, Lange LA, Litkowski EM, Vanderlinden LA, Konigsberg IR, Cree MG, Perng W, Dabelea D. GLP-1R Polymorphisms Modify the Relationship Between Exposure to Gestational Diabetes and Offspring BMI Growth: The EPOCH Study. Diabetes Care. 2025 May 30. PMID: 40443355.
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    12. Ferrier K, Graff M, Konigsberg IR, Stanislawski M, Highland HM, Raffield LM, Carson AP, Boerwinkle E, Norris JM, Gignoux CR, Hendricks AE, Raghavan S, North KE, Allison MA, Budoff MJ, Kasela S, Aguet F, Joseph JJ, Kooperberg C, Rich SS, Rotter JI, Lange EM, Lange LA. Epigenome-wide association study meta-analysis of BMI in African American Adults. medRxiv. 2025 Feb 11. PMID: 39867370.
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    13. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Jiang MZ, DiCorpo D, Gaynor SM, Dey R, Arnett DK, Benjamin EJ, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly TN, Konigsberg I, Kooperberg C, Kral BG, Li C, Li Y, Lin H, Liu CT, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Mitchell BD, Montasser ME, Morrison AC, Naseri T, North KE, Palmer ND, Peyser PA, Psaty BM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari HK, Vasan RS, Viali S, Wang Z, Wessel J, Yanek LR, Yu B, Dupuis J, Meigs JB, Auer PL, Raffield LM, Manning AK, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. A statistical framework for multi-trait rare variant analysis in large-scale whole-genome sequencing studies. Nat Comput Sci. 2025 Feb; 5(2):125-143. PMID: 39920506.
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    14. Dalapati T, Wang L, Jones AG, Cardwell J, Konigsberg IR, Boss? Y, Sin DD, Timens W, Hao K, Yang I, Ko DC. Context-specific eQTLs provide deeper insight into causal genes underlying shared genetic architecture of COVID-19 and idiopathic pulmonary fibrosis. HGG Adv. 2025 Apr 10; 6(2):100410. PMID: 39876559.
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    15. Harrall KK, Glueck DH, Lange LA, Litkowski EM, Vanderlinden LA, Konigsberg IR, Cree MG, Perng W, Dabelea D. GLP-1R gene polymorphisms and metabolic traits during childhood and adolescence: The EPOCH study. J Clin Endocrinol Metab. 2024 Dec 18. PMID: 39693247.
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    16. Waldrop SW, Perng W, Konigsberg IR, Borengasser SJ. The potential utility of cord blood DNA methylation in pediatric clinical practice. Epigenomics. 2024 Nov-Nov; 16(21-22):1365-1372. PMID: 39530586.
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    17. Moll M, Hecker J, Platig J, Zhang J, Ghosh AJ, Pratte KA, Wang RS, Hill D, Konigsberg IR, Chiles JW, Hersh CP, Castaldi PJ, Glass K, Dy JG, Sin DD, Tal-Singer R, Mouded M, Rennard SI, Anderson GP, Kinney GL, Bowler RP, Curtis JL, McDonald ML, Silverman EK, Hobbs BD, Cho MH. Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes in the COPDGene and ECLIPSE cohort studies. EBioMedicine. 2024 Dec; 110:105429. PMID: 39509750.
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    18. Moll M, Pratte KA, Debban CL, Liu C, Belinsky SA, Picchi M, Konigsberg I, Tern C, Rijhwani H, Hobbs BD, Silverman EK, Tesfaigzi Y, Rich SS, Manichaikul A, Rotter JI, Bowler RP, Cho MH. A protein risk score for all-cause and respiratory-specific mortality in non-Hispanic white and African American individuals who smoke. Sci Rep. 2024 09 04; 14(1):20618. PMID: 39232179.
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    19. Konigsberg IR, Vu T, Liu W, Litkowski EM, Pratte KA, Vargas LB, Gilmore N, Abdel-Hafiz M, Manichaikul A, Cho MH, Hersh CP, DeMeo DL, Banaei-Kashani F, Bowler RP, Lange LA, Kechris KJ. Proteomic networks and related genetic variants associated with smoking and chronic obstructive pulmonary disease. BMC Genomics. 2024 Sep 02; 25(1):825. PMID: 39223457.
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    20. Konigsberg IR, Lin NW, Liao SY, Liu C, MacPhail K, Mroz MM, Davidson E, Restrepo CI, Sharma S, Li L, Maier LA, Yang IV. Multi-omic signatures of sarcoidosis and progression in bronchoalveolar lavage cells. Respir Res. 2024 Jul 30; 25(1):289. PMID: 39080656.
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    21. Dalapati T, Wang L, Jones AG, Cardwell J, Konigsberg IR, Boss? Y, Sin DD, Timens W, Hao K, Yang I, Ko DC. Context-specific eQTLs reveal causal genes underlying shared genetic architecture of critically ill COVID-19 and idiopathic pulmonary fibrosis. medRxiv. 2024 Jul 14. PMID: 39040187.
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    22. Moll M, Hecker J, Platig J, Zhang J, Ghosh AJ, Pratte KA, Wang RS, Hill D, Konigsberg IR, Chiles JW, Hersh CP, Castaldi PJ, Glass K, Dy JG, Sin DD, Tal-Singer R, Mouded M, Rennard SI, Anderson GP, Kinney GL, Bowler RP, Curtis JL, McDonald ML, Silverman EK, Hobbs BD, Cho MH. Polygenic and transcriptional risk scores identify chronic obstructive pulmonary disease subtypes. medRxiv. 2024 May 20. PMID: 38826461.
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    23. Liu W, Vu T, Konigsberg I, Pratte K, Zhuang Y, Kechris K. SmCCNet 2.0: A Comprehensive Tool for Multi-omics Network Inference with Shiny Visualization. bioRxiv. 2024 Apr 07. PMID: 38045372.
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    24. Konigsberg IR, Vu T, Liu W, Litkowski EM, Pratte KA, Vargas LB, Gilmore N, Abdel-Hafiz M, Manichaikul AW, Cho MH, Hersh CP, DeMeo DL, Banaei-Kashani F, Bowler RP, Lange LA, Kechris KJ. Proteomic Networks and Related Genetic Variants Associated with Smoking and Chronic Obstructive Pulmonary Disease. medRxiv. 2024 Feb 28. PMID: 38464285.
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    25. Jankowski CM, Konigsberg IR, Wilson MP, Sun J, Brown TT, Julian CG, Erlandson KM. Skeletal muscle DNA methylation: Effects of exercise and HIV. Aging Cell. 2024 01; 23(1):e14025. PMID: 37920126.
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    26. Li X, Chen H, Selvaraj MS, Van Buren E, Zhou H, Wang Y, Sun R, McCaw ZR, Yu Z, Arnett DK, Bis JC, Blangero J, Boerwinkle E, Bowden DW, Brody JA, Cade BE, Carson AP, Carlson JC, Chami N, Chen YI, Curran JE, de Vries PS, Fornage M, Franceschini N, Freedman BI, Gu C, Heard-Costa NL, He J, Hou L, Hung YJ, Irvin MR, Kaplan RC, Kardia SLR, Kelly T, Konigsberg I, Kooperberg C, Kral BG, Li C, Loos RJF, Mahaney MC, Martin LW, Mathias RA, Minster RL, Mitchell BD, Montasser ME, Morrison AC, Palmer ND, Peyser PA, Psaty BM, Raffield LM, Redline S, Reiner AP, Rich SS, Sitlani CM, Smith JA, Taylor KD, Tiwari H, Vasan RS, Wang Z, Yanek LR, Yu B, Rice KM, Rotter JI, Peloso GM, Natarajan P, Li Z, Liu Z, Lin X. A statistical framework for powerful multi-trait rare variant analysis in large-scale whole-genome sequencing studies. bioRxiv. 2023 Nov 02. PMID: 37961350.
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    27. Abulnoor BA, Attia MH, Konigsberg IR, Konigsberg LW. TestDimorph: An R package for analysis of interpopulation sexual dimorphism differences using summary statistics. Am J Biol Anthropol. 2023 11; 182(3):487-498. PMID: 37694912.
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    28. Hill EB, Konigsberg IR, Ir D, Frank DN, Jambal P, Litkowski EM, Lange EM, Lange LA, Ostendorf DM, Scorsone JJ, Wayland L, Bing K, MacLean PS, Melanson EL, Bessesen DH, Catenacci VA, Stanislawski MA, Borengasser SJ. The Microbiome, Epigenome, and Diet in Adults with Obesity during Behavioral Weight Loss. Nutrients. 2023 Aug 16; 15(16). PMID: 37630778.
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    29. Hill AC, Guo C, Litkowski EM, Manichaikul AW, Yu B, Konigsberg IR, Gorbet BA, Lange LA, Pratte KA, Kechris KJ, DeCamp M, Coors M, Ortega VE, Rich SS, Rotter JI, Gerzsten RE, Clish CB, Curtis JL, Hu X, Obeidat ME, Morris M, Loureiro J, Ngo D, O'Neal WK, Meyers DA, Bleecker ER, Hobbs BD, Cho MH, Banaei-Kashani F, Bowler RP. Large scale proteomic studies create novel privacy considerations. Sci Rep. 2023 06 07; 13(1):9254. PMID: 37286633.
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    30. Konigsberg IR, Lin NW, Liao SY, Liu C, MacPhail K, Mroz MM, Davidson E, Restrepo CI, Sharma S, Li L, Maier LA, Yang IV. Multi-Omic Signatures of Sarcoidosis and Progression in Bronchoalveolar Lavage Cells. bioRxiv. 2023 Jan 27. PMID: 36747844.
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    31. Vargas LB, Lange LA, Ferrier K, Aguet F, Ardlie K, Gabriel S, Gupta N, Smith JD, Blackwell TW, Ding J, Durda P, Tracy RP, Liu Y, Taylor KD, Craig Johnson W, Rich SS, Rotter JI, Lange EM, Konigsberg IR. Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis. Int J Obes (Lond). 2023 02; 47(2):109-116. PMID: 36463326.
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    32. Li L, Konigsberg IR, Bhargava M, Liu S, MacPhail K, Mayer A, Davidson EJ, Liao SY, Lei Z, Mroz PM, Fingerlin TE, Yang IV, Maier LA. Multiomic Signatures of Chronic Beryllium Disease Bronchoalveolar Lavage Cells Relate to T-Cell Function and Innate Immunity. Am J Respir Cell Mol Biol. 2022 12; 67(6):632-640. PMID: 35972918.
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    33. Borie R, Cardwell J, Konigsberg IR, Moore CM, Zhang W, Sasse SK, Gally F, Dobrinskikh E, Walts A, Powers J, Brancato J, Rojas M, Wolters PJ, Brown KK, Blackwell TS, Nakanishi T, Richards JB, Gerber AN, Fingerlin TE, Sachs N, Pulit SL, Zappala Z, Schwartz DA, Yang IV. Colocalization of Gene Expression and DNA Methylation with Genetic Risk Variants Supports Functional Roles of MUC5B and DSP in Idiopathic Pulmonary Fibrosis. Am J Respir Crit Care Med. 2022 11 15; 206(10):1259-1270. PMID: 35816432.
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    34. Arnold CG, Konigsberg I, Adams JY, Sharma S, Aggarwal N, Hopkinson A, Vest A, Campbell M, Boorgula M, Yang I, Gignoux C, Barnes KC, Monte AA. Epigenetics may characterize asymptomatic COVID-19 infection. Hum Genomics. 2022 07 27; 16(1):27. PMID: 35897116.
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    35. Konigsberg IR, Yang IV. Differential Methylation of Chronic Obstructive Pulmonary Disease Lung Macrophage Genes Sheds Light on Disease Pathogenesis. Am J Respir Cell Mol Biol. 2022 06; 66(6):589-590. PMID: 35377834.
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    36. Pan J, Li W, Ni J, Wu K, Konigsberg I, Rivera CE, Tincher C, Gregory C, Zhou X, Doak TG, Lee H, Wang Y, Gao X, Lynch M, Long H. Rates of Mutations and Transcript Errors in the Foodborne Pathogen Salmonella enterica subsp. enterica. Mol Biol Evol. 2022 04 10; 39(4). PMID: 35446958.
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    37. Konigsberg IR, Barnes B, Campbell M, Davidson E, Zhen Y, Pallisard O, Boorgula MP, Cox C, Nandy D, Seal S, Crooks K, Sticca E, Harrison GF, Hopkinson A, Vest A, Arnold CG, Kahn MG, Kao DP, Peterson BR, Wicks SJ, Ghosh D, Horvath S, Zhou W, Mathias RA, Norman PJ, Porecha R, Yang IV, Gignoux CR, Monte AA, Taye A, Barnes KC. Host methylation predicts SARS-CoV-2 infection and clinical outcome. Commun Med (Lond). 2021; 1(1):42. PMID: 35072167.
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    38. Konigsberg IR, Barnes B, Campbell M, Davidson E, Zhen Y, Pallisard O, Boorgula MP, Cox C, Nandy D, Seal S, Crooks K, Sticca E, Harrison GF, Hopkinson A, Vest A, Arnold CG, Kahn MG, Kao DP, Peterson BR, Wicks SJ, Ghosh D, Horvath S, Zhou W, Mathias RA, Norman PJ, Porecha R, Yang IV, Gignoux CR, Monte AA, Taye A, Barnes KC. Host methylation predicts SARS-CoV-2 infection and clinical outcome. Commun Med (Lond). 2021 Oct 26; 1(1):42. PMID: 36750622.
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    39. Konigsberg IR, Borie R, Walts AD, Cardwell J, Rojas M, Metzger F, Hauck SM, Fingerlin TE, Yang IV, Schwartz DA. Molecular Signatures of Idiopathic Pulmonary Fibrosis. Am J Respir Cell Mol Biol. 2021 10; 65(4):430-441. PMID: 34038697.
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    40. Konigsberg IR, Maier LA, Yang IV. Epigenetics and sarcoidosis. Eur Respir Rev. 2021 Jun 30; 30(160). PMID: 34168064.
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    41. Liao SY, Atif SM, Mould K, Konigsberg IR, Fu R, Davidson E, Li L, Fontenot AP, Maier LA, Yang IV. Single-cell RNA sequencing identifies macrophage transcriptional heterogeneities in granulomatous diseases. Eur Respir J. 2021 06; 57(6). PMID: 33602861.
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    42. Siebert JC, Stanislawski MA, Zaman A, Ostendorf DM, Konigsberg IR, Jambal P, Ir D, Bing K, Wayland L, Scorsone JJ, Lozupone CA, G?rg C, Frank DN, Bessesen D, MacLean PS, Melanson EL, Catenacci VA, Borengasser SJ. Multiomic Predictors of Short-Term Weight Loss and Clinical Outcomes During a Behavioral-Based Weight Loss Intervention. Obesity (Silver Spring). 2021 05; 29(5):859-869. PMID: 33811477.
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    43. Furusawa H, Cardwell JH, Okamoto T, Walts AD, Konigsberg IR, Kurche JS, Bang TJ, Schwarz MI, Brown KK, Kropski JA, Rojas M, Cool CD, Lee JS, Wolters PJ, Yang IV, Schwartz DA. Chronic Hypersensitivity Pneumonitis, an Interstitial Lung Disease with Distinct Molecular Signatures. Am J Respir Crit Care Med. 2020 11 15; 202(10):1430-1444. PMID: 32602730.
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    44. Konigsberg IR, Yang IV. It's in the (Epi)genetics: Effects of DNA Methylation on Gene Expression in Atopic Asthma? Chest. 2020 11; 158(5):1799-1801. PMID: 33160517.
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    45. Yang IV, Konigsberg I, MacPhail K, Li L, Davidson EJ, Mroz PM, Hamzeh N, Gillespie M, Silveira LJ, Fingerlin TE, Maier LA. DNA Methylation Changes in Lung Immune Cells Are Associated with Granulomatous Lung Disease. Am J Respir Cell Mol Biol. 2019 01; 60(1):96-105. PMID: 30141971.
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