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Connection

Thomas Cech to Tetrahymena

This is a "connection" page, showing publications Thomas Cech has written about Tetrahymena.

 
Connection Strength
 
 
 
7.911
 
  1. Guo F, Gooding AR, Cech TR. Comparison of crystal structure interactions and thermodynamics for stabilizing mutations in the Tetrahymena ribozyme. RNA. 2006 Mar; 12(3):387-95.
    View in: PubMed
    Score: 0.244
  2. Guo F, Gooding AR, Cech TR. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol Cell. 2004 Nov 05; 16(3):351-62.
    View in: PubMed
    Score: 0.224
  3. Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 2004 Aug-Oct; 24(4-5):362-85.
    View in: PubMed
    Score: 0.220
  4. Cech TR. Beginning to understand the end of the chromosome. Cell. 2004 Jan 23; 116(2):273-9.
    View in: PubMed
    Score: 0.213
  5. Bryan TM, Goodrich KJ, Cech TR. Tetrahymena telomerase is active as a monomer. Mol Biol Cell. 2003 Dec; 14(12):4794-804.
    View in: PubMed
    Score: 0.207
  6. Guo F, Cech TR. Evolution of Tetrahymena ribozyme mutants with increased structural stability. Nat Struct Biol. 2002 Nov; 9(11):855-61.
    View in: PubMed
    Score: 0.195
  7. Silverman SK, Cech TR. An early transition state for folding of the P4-P6 RNA domain. RNA. 2001 Feb; 7(2):161-6.
    View in: PubMed
    Score: 0.173
  8. Hagen M, Cech TR. Self-splicing of the Tetrahymena intron from mRNA in mammalian cells. EMBO J. 1999 Nov 15; 18(22):6491-500.
    View in: PubMed
    Score: 0.159
  9. Shoffner GM, Wang R, Podell E, Cech TR, Guo F. In Crystallo Selection to Establish New?RNA?Crystal?Contacts. Structure. 2018 09 04; 26(9):1275-1283.e3.
    View in: PubMed
    Score: 0.144
  10. Golden BL, Podell ER, Gooding AR, Cech TR. Crystals by design: a strategy for crystallization of a ribozyme derived from the Tetrahymena group I intron. J Mol Biol. 1997 Aug 01; 270(5):711-23.
    View in: PubMed
    Score: 0.136
  11. Downs WD, Cech TR. Kinetic pathway for folding of the Tetrahymena ribozyme revealed by three UV-inducible crosslinks. RNA. 1996 Jul; 2(7):718-32.
    View in: PubMed
    Score: 0.126
  12. Strobel SA, Cech TR. Exocyclic amine of the conserved G.U pair at the cleavage site of the Tetrahymena ribozyme contributes to 5'-splice site selection and transition state stabilization. Biochemistry. 1996 Jan 30; 35(4):1201-11.
    View in: PubMed
    Score: 0.122
  13. Doudna JA, Cech TR. Self-assembly of a group I intron active site from its component tertiary structural domains. RNA. 1995 Mar; 1(1):36-45.
    View in: PubMed
    Score: 0.115
  14. Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 1994 Nov 22; 33(46):13856-63.
    View in: PubMed
    Score: 0.113
  15. Murphy FL, Wang YH, Griffith JD, Cech TR. Coaxially stacked RNA helices in the catalytic center of the Tetrahymena ribozyme. Science. 1994 Sep 16; 265(5179):1709-12.
    View in: PubMed
    Score: 0.111
  16. Laggerbauer B, Murphy FL, Cech TR. Two major tertiary folding transitions of the Tetrahymena catalytic RNA. EMBO J. 1994 Jun 01; 13(11):2669-76.
    View in: PubMed
    Score: 0.109
  17. Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 1993 Jan 07; 361(6407):85-8.
    View in: PubMed
    Score: 0.099
  18. Piccirilli JA, McConnell TS, Zaug AJ, Noller HF, Cech TR. Aminoacyl esterase activity of the Tetrahymena ribozyme. Science. 1992 Jun 05; 256(5062):1420-4.
    View in: PubMed
    Score: 0.095
  19. Wang JF, Cech TR. Tertiary structure around the guanosine-binding site of the Tetrahymena ribozyme. Science. 1992 Apr 24; 256(5056):526-9.
    View in: PubMed
    Score: 0.094
  20. Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. 1986. Biotechnology. 1992; 24:57-62.
    View in: PubMed
    Score: 0.092
  21. Young B, Herschlag D, Cech TR. Mutations in a nonconserved sequence of the Tetrahymena ribozyme increase activity and specificity. Cell. 1991 Nov 29; 67(5):1007-19.
    View in: PubMed
    Score: 0.092
  22. Grosshans CA, Cech TR. A hammerhead ribozyme allows synthesis of a new form of the Tetrahymena ribozyme homogeneous in length with a 3' end blocked for transesterification. Nucleic Acids Res. 1991 Jul 25; 19(14):3875-80.
    View in: PubMed
    Score: 0.089
  23. Woodson SA, Cech TR. Alternative secondary structures in the 5' exon affect both forward and reverse self-splicing of the Tetrahymena intervening sequence RNA. Biochemistry. 1991 Feb 26; 30(8):2042-50.
    View in: PubMed
    Score: 0.087
  24. Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 1. Kinetic description of the reaction of an RNA substrate complementary to the active site. Biochemistry. 1990 Nov 06; 29(44):10159-71.
    View in: PubMed
    Score: 0.085
  25. Herschlag D, Cech TR. Catalysis of RNA cleavage by the Tetrahymena thermophila ribozyme. 2. Kinetic description of the reaction of an RNA substrate that forms a mismatch at the active site. Biochemistry. 1990 Nov 06; 29(44):10172-80.
    View in: PubMed
    Score: 0.085
  26. Pyle AM, McSwiggen JA, Cech TR. Direct measurement of oligonucleotide substrate binding to wild-type and mutant ribozymes from Tetrahymena. Proc Natl Acad Sci U S A. 1990 Nov; 87(21):8187-91.
    View in: PubMed
    Score: 0.085
  27. Downs WD, Cech TR. An ultraviolet-inducible adenosine-adenosine cross-link reflects the catalytic structure of the Tetrahymena ribozyme. Biochemistry. 1990 Jun 12; 29(23):5605-13.
    View in: PubMed
    Score: 0.083
  28. Cech TR. Nobel lecture. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 1990 Jun; 10(3):239-61.
    View in: PubMed
    Score: 0.083
  29. Herschlag D, Cech TR. DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature. 1990 Mar 29; 344(6265):405-9.
    View in: PubMed
    Score: 0.082
  30. Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4914-8.
    View in: PubMed
    Score: 0.081
  31. Latham JA, Zaug AJ, Cech TR. Self-splicing and enzymatic cleavage of RNA by a group I intervening sequence. Methods Enzymol. 1990; 181:558-69.
    View in: PubMed
    Score: 0.080
  32. Murphy FL, Cech TR. Alteration of substrate specificity for the endoribonucleolytic cleavage of RNA by the Tetrahymena ribozyme. Proc Natl Acad Sci U S A. 1989 Dec; 86(23):9218-22.
    View in: PubMed
    Score: 0.080
  33. Flor PJ, Flanegan JB, Cech TR. A conserved base pair within helix P4 of the Tetrahymena ribozyme helps to form the tertiary structure required for self-splicing. EMBO J. 1989 Nov; 8(11):3391-9.
    View in: PubMed
    Score: 0.079
  34. Yarus M, Levine J, Morin GB, Cech TR. A Tetrahymena intron nucleotide connected to the GTP/arginine site. Nucleic Acids Res. 1989 Sep 12; 17(17):6969-81.
    View in: PubMed
    Score: 0.079
  35. Barfod ET, Cech TR. The conserved U.G pair in the 5' splice site duplex of a group I intron is required in the first but not the second step of self-splicing. Mol Cell Biol. 1989 Sep; 9(9):3657-66.
    View in: PubMed
    Score: 0.078
  36. Grosshans CA, Cech TR. Metal ion requirements for sequence-specific endoribonuclease activity of the Tetrahymena ribozyme. Biochemistry. 1989 Aug 22; 28(17):6888-94.
    View in: PubMed
    Score: 0.078
  37. Latham JA, Cech TR. Defining the inside and outside of a catalytic RNA molecule. Science. 1989 Jul 21; 245(4915):276-82.
    View in: PubMed
    Score: 0.078
  38. McSwiggen JA, Cech TR. Stereochemistry of RNA cleavage by the Tetrahymena ribozyme and evidence that the chemical step is not rate-limiting. Science. 1989 May 12; 244(4905):679-83.
    View in: PubMed
    Score: 0.077
  39. Zaug AJ, Grosshans CA, Cech TR. Sequence-specific endoribonuclease activity of the Tetrahymena ribozyme: enhanced cleavage of certain oligonucleotide substrates that form mismatched ribozyme-substrate complexes. Biochemistry. 1988 Dec 13; 27(25):8924-31.
    View in: PubMed
    Score: 0.075
  40. Price JV, Cech TR. Determinants of the 3' splice site for self-splicing of the Tetrahymena pre-rRNA. Genes Dev. 1988 Nov; 2(11):1439-47.
    View in: PubMed
    Score: 0.074
  41. Morin GB, Cech TR. Telomeric repeats of Tetrahymena malaccensis mitochondrial DNA: a multimodal distribution that fluctuates erratically during growth. Mol Cell Biol. 1988 Oct; 8(10):4450-8.
    View in: PubMed
    Score: 0.074
  42. Barfod ET, Cech TR. Deletion of nonconserved helices near the 3' end of the rRNA intron of Tetrahymena thermophila alters self-splicing but not core catalytic activity. Genes Dev. 1988 Jun; 2(6):652-63.
    View in: PubMed
    Score: 0.072
  43. Been MD, Cech TR. RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. Science. 1988 Mar 18; 239(4846):1412-6.
    View in: PubMed
    Score: 0.071
  44. Morin GB, Cech TR. Mitochondrial telomeres: surprising diversity of repeated telomeric DNA sequences among six species of Tetrahymena. Cell. 1988 Feb 12; 52(3):367-74.
    View in: PubMed
    Score: 0.070
  45. Morin GB, Cech TR. Phylogenetic relationships and altered genome structures among Tetrahymena mitochondrial DNAs. Nucleic Acids Res. 1988 Jan 11; 16(1):327-46.
    View in: PubMed
    Score: 0.070
  46. Zaug AJ, Cech TR. Self-splicing RNA and an RNA enzyme in Tetrahymena. J Protozool. 1987 Nov; 34(4):416-7.
    View in: PubMed
    Score: 0.069
  47. Been MD, Cech TR. Selection of circularization sites in a group I IVS RNA requires multiple alignments of an internal template-like sequence. Cell. 1987 Sep 11; 50(6):951-61.
    View in: PubMed
    Score: 0.068
  48. Price JV, Engberg J, Cech TR. 5' exon requirement for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA and identification of a cryptic 5' splice site in the 3' exon. J Mol Biol. 1987 Jul 05; 196(1):49-60.
    View in: PubMed
    Score: 0.067
  49. Tanner NK, Cech TR. Guanosine binding required for cyclization of the self-splicing intervening sequence ribonucleic acid from Tetrahymena thermophila. Biochemistry. 1987 Jun 16; 26(12):3330-40.
    View in: PubMed
    Score: 0.067
  50. Been MD, Barfod ET, Burke JM, Price JV, Tanner NK, Zaug AJ, Cech TR. Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. Cold Spring Harb Symp Quant Biol. 1987; 52:147-57.
    View in: PubMed
    Score: 0.065
  51. Zaug AJ, Been MD, Cech TR. The Tetrahymena ribozyme acts like an RNA restriction endonuclease. Nature. 1986 Dec 4-10; 324(6096):429-33.
    View in: PubMed
    Score: 0.065
  52. Morin GB, Cech TR. The telomeres of the linear mitochondrial DNA of Tetrahymena thermophila consist of 53 bp tandem repeats. Cell. 1986 Sep 12; 46(6):873-83.
    View in: PubMed
    Score: 0.064
  53. Zaug AJ, Cech TR. The Tetrahymena intervening sequence ribonucleic acid enzyme is a phosphotransferase and an acid phosphatase. Biochemistry. 1986 Aug 12; 25(16):4478-82.
    View in: PubMed
    Score: 0.063
  54. Bass BL, Cech TR. Ribozyme inhibitors: deoxyguanosine and dideoxyguanosine are competitive inhibitors of self-splicing of the Tetrahymena ribosomal ribonucleic acid precursor. Biochemistry. 1986 Aug 12; 25(16):4473-7.
    View in: PubMed
    Score: 0.063
  55. Inoue T, Sullivan FX, Cech TR. New reactions of the ribosomal RNA precursor of Tetrahymena and the mechanism of self-splicing. J Mol Biol. 1986 May 05; 189(1):143-65.
    View in: PubMed
    Score: 0.062
  56. Burke JM, Irvine KD, Kaneko KJ, Kerker BJ, Oettgen AB, Tierney WM, Williamson CL, Zaug AJ, Cech TR. Role of conserved sequence elements 9L and 2 in self-splicing of the Tetrahymena ribosomal RNA precursor. Cell. 1986 Apr 25; 45(2):167-76.
    View in: PubMed
    Score: 0.062
  57. Zaug AJ, Cech TR. The intervening sequence RNA of Tetrahymena is an enzyme. Science. 1986 Jan 31; 231(4737):470-5.
    View in: PubMed
    Score: 0.061
  58. Inoue T, Sullivan FX, Cech TR. Intermolecular exon ligation of the rRNA precursor of Tetrahymena: oligonucleotides can function as 5' exons. Cell. 1985 Dec; 43(2 Pt 1):431-7.
    View in: PubMed
    Score: 0.060
  59. Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by intercalating dyes. Nucleic Acids Res. 1985 Nov 11; 13(21):7741-58.
    View in: PubMed
    Score: 0.060
  60. Tanner NK, Cech TR. Self-catalyzed cyclization of the intervening sequence RNA of Tetrahymena: inhibition by methidiumpropyl.EDTA and localization of the major dye binding sites. Nucleic Acids Res. 1985 Nov 11; 13(21):7759-79.
    View in: PubMed
    Score: 0.060
  61. Zaug AJ, Kent JR, Cech TR. Reactions of the intervening sequence of the Tetrahymena ribosomal ribonucleic acid precursor: pH dependence of cyclization and site-specific hydrolysis. Biochemistry. 1985 Oct 22; 24(22):6211-8.
    View in: PubMed
    Score: 0.060
  62. Sullivan FX, Cech TR. Reversibility of cyclization of the Tetrahymena rRNA intervening sequence: implication for the mechanism of splice site choice. Cell. 1985 Sep; 42(2):639-48.
    View in: PubMed
    Score: 0.059
  63. Price JV, Cech TR. Coupling of Tetrahymena ribosomal RNA splicing to beta-galactosidase expression in Escherichia coli. Science. 1985 May 10; 228(4700):719-22.
    View in: PubMed
    Score: 0.058
  64. Price JV, Kieft GL, Kent JR, Sievers EL, Cech TR. Sequence requirements for self-splicing of the Tetrahymena thermophila pre-ribosomal RNA. Nucleic Acids Res. 1985 Mar 25; 13(6):1871-89.
    View in: PubMed
    Score: 0.058
  65. Cech TR. Self-splicing RNA: implications for evolution. Int Rev Cytol. 1985; 93:3-22.
    View in: PubMed
    Score: 0.057
  66. Palen TE, Cech TR. Chromatin structure at the replication origins and transcription-initiation regions of the ribosomal RNA genes of Tetrahymena. Cell. 1984 Apr; 36(4):933-42.
    View in: PubMed
    Score: 0.054
  67. Bass BL, Cech TR. Specific interaction between the self-splicing RNA of Tetrahymena and its guanosine substrate: implications for biological catalysis by RNA. Nature. 1984 Apr 26-May 2; 308(5962):820-6.
    View in: PubMed
    Score: 0.054
  68. Cech TR, Tanner NK, Tinoco I, Weir BR, Zuker M, Perlman PS. Secondary structure of the Tetrahymena ribosomal RNA intervening sequence: structural homology with fungal mitochondrial intervening sequences. Proc Natl Acad Sci U S A. 1983 Jul; 80(13):3903-7.
    View in: PubMed
    Score: 0.051
  69. Aigner S, Postberg J, Lipps HJ, Cech TR. The Euplotes La motif protein p43 has properties of a telomerase-specific subunit. Biochemistry. 2003 May 20; 42(19):5736-47.
    View in: PubMed
    Score: 0.051
  70. Brehm SL, Cech TR. Fate of an intervening sequence ribonucleic acid: excision and cyclization of the Tetrahymena ribosomal ribonucleic acid intervening sequence in vivo. Biochemistry. 1983 May 10; 22(10):2390-7.
    View in: PubMed
    Score: 0.051
  71. Palen TE, Cech TR. Transcribed and non-transcribed regions of Tetrahymena ribosomal gene chromatin have different accessibilities to micrococcal nuclease. Nucleic Acids Res. 1983 Apr 11; 11(7):2077-91.
    View in: PubMed
    Score: 0.050
  72. Gottschling DE, Palen TE, Cech TR. Different nucleosome spacing in transcribed and non-transcribed regions of the ribosomal RNA gene in Tetrahymena thermophila. Nucleic Acids Res. 1983 Apr 11; 11(7):2093-109.
    View in: PubMed
    Score: 0.050
  73. Kruger K, Grabowski PJ, Zaug AJ, Sands J, Gottschling DE, Cech TR. Self-splicing RNA: autoexcision and autocyclization of the ribosomal RNA intervening sequence of Tetrahymena. Cell. 1982 Nov; 31(1):147-57.
    View in: PubMed
    Score: 0.049
  74. Zaug AJ, Cech TR. The intervening sequence excised from the ribosomal RNA precursor of Tetrahymena contains a 5-terminal guanosine residue not encoded by the DNA. Nucleic Acids Res. 1982 May 11; 10(9):2823-38.
    View in: PubMed
    Score: 0.047
  75. Cech TR, Brehm SL. Replication of the extrachromosomal ribosomal RNA genes of Tetrahymena thermophilia. Nucleic Acids Res. 1981 Jul 24; 9(14):3531-43.
    View in: PubMed
    Score: 0.045
  76. Juneau K, Podell E, Harrington DJ, Cech TR. Structural basis of the enhanced stability of a mutant ribozyme domain and a detailed view of RNA--solvent interactions. Structure. 2001 Mar 07; 9(3):221-31.
    View in: PubMed
    Score: 0.044
  77. Silverman SK, Deras ML, Woodson SA, Scaringe SA, Cech TR. Multiple folding pathways for the P4-P6 RNA domain. Biochemistry. 2000 Oct 10; 39(40):12465-75.
    View in: PubMed
    Score: 0.042
  78. Cech TR, Karrer KM. Chromatin structure of the ribosomal RNA genes of Tetrahymena thermophila as analyzed by trimethylpsoralen crosslinking in vivo. J Mol Biol. 1980 Feb 05; 136(4):395-416.
    View in: PubMed
    Score: 0.040
  79. Zaug AJ, Cech TR. In vitro splicing of the ribosomal RNA precursor in nuclei of Tetrahymena. Cell. 1980 Feb; 19(2):331-8.
    View in: PubMed
    Score: 0.040
  80. Silverman SK, Zheng M, Wu M, Tinoco I, Cech TR. Quantifying the energetic interplay of RNA tertiary and secondary structure interactions. RNA. 1999 Dec; 5(12):1665-74.
    View in: PubMed
    Score: 0.040
  81. Silverman SK, Cech TR. RNA tertiary folding monitored by fluorescence of covalently attached pyrene. Biochemistry. 1999 Oct 26; 38(43):14224-37.
    View in: PubMed
    Score: 0.040
  82. Cech TR, Rio DC. Localization of transcribed regions on extrachromosomal ribosomal RNA genes of Tetrahymena thermophila by R-loop mapping. Proc Natl Acad Sci U S A. 1979 Oct; 76(10):5051-5.
    View in: PubMed
    Score: 0.039
  83. Silverman SK, Cech TR. Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry. 1999 Jul 06; 38(27):8691-702.
    View in: PubMed
    Score: 0.039
  84. Szewczak AA, Podell ER, Bevilacqua PC, Cech TR. Thermodynamic stability of the P4-P6 domain RNA tertiary structure measured by temperature gradient gel electrophoresis. Biochemistry. 1998 Aug 11; 37(32):11162-70.
    View in: PubMed
    Score: 0.036
  85. Tanner MA, Anderson EM, Gutell RR, Cech TR. Mutagenesis and comparative sequence analysis of a base triple joining the two domains of group I ribozymes. RNA. 1997 Sep; 3(9):1037-51.
    View in: PubMed
    Score: 0.034
  86. Tanner MA, Cech TR. Joining the two domains of a group I ribozyme to form the catalytic core. Science. 1997 Feb 07; 275(5301):847-9.
    View in: PubMed
    Score: 0.033
  87. Golden BL, Gooding AR, Podell ER, Cech TR. X-ray crystallography of large RNAs: heavy-atom derivatives by RNA engineering. RNA. 1996 Dec; 2(12):1295-305.
    View in: PubMed
    Score: 0.032
  88. Kuo LY, Cech TR. Conserved thermochemistry of guanosine nucleophile binding for structurally distinct group I ribozymes. Nucleic Acids Res. 1996 Oct 01; 24(19):3722-7.
    View in: PubMed
    Score: 0.032
  89. Nakamura TM, Wang YH, Zaug AJ, Griffith JD, Cech TR. Relative orientation of RNA helices in a group 1 ribozyme determined by helix extension electron microscopy. EMBO J. 1995 Oct 02; 14(19):4849-59.
    View in: PubMed
    Score: 0.030
  90. Campbell TB, Cech TR. Identification of ribozymes within a ribozyme library that efficiently cleave a long substrate RNA. RNA. 1995 Aug; 1(6):598-609.
    View in: PubMed
    Score: 0.030
  91. Strobel SA, Cech TR. Minor groove recognition of the conserved G.U pair at the Tetrahymena ribozyme reaction site. Science. 1995 Feb 03; 267(5198):675-9.
    View in: PubMed
    Score: 0.029
  92. Zaug AJ, D?vila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu). Biochemistry. 1994 Dec 13; 33(49):14935-47.
    View in: PubMed
    Score: 0.028
  93. Cech TR, Damberger SH, Gutell RR. Representation of the secondary and tertiary structure of group I introns. Nat Struct Biol. 1994 May; 1(5):273-80.
    View in: PubMed
    Score: 0.027
  94. Strobel SA, Cech TR. Translocation of an RNA duplex on a ribozyme. Nat Struct Biol. 1994 Jan; 1(1):13-7.
    View in: PubMed
    Score: 0.026
  95. Cech TR. The efficiency and versatility of catalytic RNA: implications for an RNA world. Gene. 1993 Dec 15; 135(1-2):33-6.
    View in: PubMed
    Score: 0.026
  96. Cech TR. Catalytic RNA: structure and mechanism. Biochem Soc Trans. 1993 May; 21(2):229-34.
    View in: PubMed
    Score: 0.025
  97. Wang JF, Downs WD, Cech TR. Movement of the guide sequence during RNA catalysis by a group I ribozyme. Science. 1993 Apr 23; 260(5107):504-8.
    View in: PubMed
    Score: 0.025
  98. D?vila-Aponte JA, Huss VA, Sogin ML, Cech TR. A self-splicing group I intron in the nuclear pre-rRNA of the green alga, Ankistrodesmus stipitatus. Nucleic Acids Res. 1991 Aug 25; 19(16):4429-36.
    View in: PubMed
    Score: 0.022
  99. Herschlag D, Piccirilli JA, Cech TR. Ribozyme-catalyzed and nonenzymatic reactions of phosphate diesters: rate effects upon substitution of sulfur for a nonbridging phosphoryl oxygen atom. Biochemistry. 1991 May 21; 30(20):4844-54.
    View in: PubMed
    Score: 0.022
  100. Pyle AM, Cech TR. Ribozyme recognition of RNA by tertiary interactions with specific ribose 2'-OH groups. Nature. 1991 Apr 18; 350(6319):628-31.
    View in: PubMed
    Score: 0.022
  101. Celander DW, Cech TR. Visualizing the higher order folding of a catalytic RNA molecule. Science. 1991 Jan 25; 251(4992):401-7.
    View in: PubMed
    Score: 0.022
  102. Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990; 59:543-68.
    View in: PubMed
    Score: 0.020
  103. Young B, Cech TR. Specificity for 3',5'-linked substrates in RNA-catalyzed RNA polymerization. J Mol Evol. 1989 Dec; 29(6):480-5.
    View in: PubMed
    Score: 0.020
  104. Williamson JR, Raghuraman MK, Cech TR. Monovalent cation-induced structure of telomeric DNA: the G-quartet model. Cell. 1989 Dec 01; 59(5):871-80.
    View in: PubMed
    Score: 0.020
  105. Cech TR. RNA chemistry. Ribozyme self-replication? Nature. 1989 Jun 15; 339(6225):507-8.
    View in: PubMed
    Score: 0.019
  106. Woodson SA, Cech TR. Reverse self-splicing of the tetrahymena group I intron: implication for the directionality of splicing and for intron transposition. Cell. 1989 Apr 21; 57(2):335-45.
    View in: PubMed
    Score: 0.019
  107. Cech TR. RNA as an enzyme. Biochem Int. 1989 Jan; 18(1):7-14.
    View in: PubMed
    Score: 0.019
  108. Cech TR. G-strings at chromosome ends. Nature. 1988 Apr 28; 332(6167):777-8.
    View in: PubMed
    Score: 0.018
  109. Kim SH, Cech TR. Three-dimensional model of the active site of the self-splicing rRNA precursor of Tetrahymena. Proc Natl Acad Sci U S A. 1987 Dec; 84(24):8788-92.
    View in: PubMed
    Score: 0.017
  110. Cech TR. The chemistry of self-splicing RNA and RNA enzymes. Science. 1987 Jun 19; 236(4808):1532-9.
    View in: PubMed
    Score: 0.017
  111. Cech TR. RNA as an enzyme. Sci Am. 1986 Nov; 255(5):64-75.
    View in: PubMed
    Score: 0.016
  112. Been MD, Cech TR. One binding site determines sequence specificity of Tetrahymena pre-rRNA self-splicing, trans-splicing, and RNA enzyme activity. Cell. 1986 Oct 24; 47(2):207-16.
    View in: PubMed
    Score: 0.016
  113. Garriga G, Lambowitz AM, Inoue T, Cech TR. Mechanism of recognition of the 5' splice site in self-splicing group I introns. Nature. 1986 Jul 3-9; 322(6074):86-9.
    View in: PubMed
    Score: 0.016
  114. Cech TR. A model for the RNA-catalyzed replication of RNA. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4360-3.
    View in: PubMed
    Score: 0.016
  115. Cech TR, Bass BL. Biological catalysis by RNA. Annu Rev Biochem. 1986; 55:599-629.
    View in: PubMed
    Score: 0.015
  116. Been MD, Cech TR. Sites of circularization of the Tetrahymena rRNA IVS are determined by sequence and influenced by position and secondary structure. Nucleic Acids Res. 1985 Dec 09; 13(23):8389-408.
    View in: PubMed
    Score: 0.015
  117. Zaug AJ, Cech TR. Oligomerization of intervening sequence RNA molecules in the absence of proteins. Science. 1985 Sep 13; 229(4718):1060-4.
    View in: PubMed
    Score: 0.015
  118. Inoue T, Cech TR. Secondary structure of the circular form of the Tetrahymena rRNA intervening sequence: a technique for RNA structure analysis using chemical probes and reverse transcriptase. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):648-52.
    View in: PubMed
    Score: 0.014
  119. Zaug AJ, Kent JR, Cech TR. A labile phosphodiester bond at the ligation junction in a circular intervening sequence RNA. Science. 1984 May 11; 224(4649):574-8.
    View in: PubMed
    Score: 0.014
  120. Cech TR. RNA splicing: three themes with variations. Cell. 1983 Oct; 34(3):713-6.
    View in: PubMed
    Score: 0.013
  121. Zaug AJ, Grabowski PJ, Cech TR. Autocatalytic cyclization of an excised intervening sequence RNA is a cleavage-ligation reaction. Nature. 1983 Feb 17-23; 301(5901):578-83.
    View in: PubMed
    Score: 0.012
  122. Grabowski PJ, Zaug AJ, Cech TR. The intervening sequence of the ribosomal RNA precursor is converted to a circular RNA in isolated nuclei of Tetrahymena. Cell. 1981 Feb; 23(2):467-76.
    View in: PubMed
    Score: 0.011
  123. Cech TR, Pardue ML. Electron microscopy of DNA crosslinked with trimethylpsoralen: test of the secondary structure of eukaryotic inverted repeat sequences. Proc Natl Acad Sci U S A. 1976 Aug; 73(8):2644-8.
    View in: PubMed
    Score: 0.008
  124. Burke JM, Belfort M, Cech TR, Davies RW, Schweyen RJ, Shub DA, Szostak JW, Tabak HF. Structural conventions for group I introns. Nucleic Acids Res. 1987 Sep 25; 15(18):7217-21.
    View in: PubMed
    Score: 0.004
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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