 Connection
Thomas Cech to Catalysis
This is a "connection" page, showing publications Thomas Cech has written about Catalysis.
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Connection Strength |
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1.488 |
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Cech TR. Evolution of biological catalysis: ribozyme to RNP enzyme. Cold Spring Harb Symp Quant Biol. 2009; 74:11-6.
Score: 0.084
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Vicens Q, Cech TR. A natural ribozyme with 3',5' RNA ligase activity. Nat Chem Biol. 2009 Feb; 5(2):97-9.
Score: 0.079
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Vicens Q, Paukstelis PJ, Westhof E, Lambowitz AM, Cech TR. Toward predicting self-splicing and protein-facilitated splicing of group I introns. RNA. 2008 Oct; 14(10):2013-29.
Score: 0.077
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Qiao F, Cech TR. Triple-helix structure in telomerase RNA contributes to catalysis. Nat Struct Mol Biol. 2008 Jun; 15(6):634-40.
Score: 0.076
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Guo F, Gooding AR, Cech TR. Structure of the Tetrahymena ribozyme: base triple sandwich and metal ion at the active site. Mol Cell. 2004 Nov 05; 16(3):351-62.
Score: 0.059
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Cech TR. Self-splicing and enzymatic activity of an intervening sequence RNA from Tetrahymena. Biosci Rep. 2004 Aug-Oct; 24(4-5):362-85.
Score: 0.058
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Doudna JA, Cech TR. The chemical repertoire of natural ribozymes. Nature. 2002 Jul 11; 418(6894):222-8.
Score: 0.050
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Cech TR. Structural biology. The ribosome is a ribozyme. Science. 2000 Aug 11; 289(5481):878-9.
Score: 0.044
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Haering CH, Nakamura TM, Baumann P, Cech TR. Analysis of telomerase catalytic subunit mutants in vivo and in vitro in Schizosaccharomycespombe. Proc Natl Acad Sci U S A. 2000 Jun 06; 97(12):6367-72.
Score: 0.044
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Silverman SK, Cech TR. Energetics and cooperativity of tertiary hydrogen bonds in RNA structure. Biochemistry. 1999 Jul 06; 38(27):8691-702.
Score: 0.041
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Jabri E, Cech TR. In vitro selection of the Naegleria GIR1 ribozyme identifies three base changes that dramatically improve activity. RNA. 1998 Dec; 4(12):1481-92.
Score: 0.039
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Golden BL, Gooding AR, Podell ER, Cech TR. A preorganized active site in the crystal structure of the Tetrahymena ribozyme. Science. 1998 Oct 09; 282(5387):259-64.
Score: 0.039
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Zhang B, Cech TR. Peptidyl-transferase ribozymes: trans reactions, structural characterization and ribosomal RNA-like features. Chem Biol. 1998 Oct; 5(10):539-53.
Score: 0.039
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Bryan TM, Sperger JM, Chapman KB, Cech TR. Telomerase reverse transcriptase genes identified in Tetrahymena thermophila and Oxytricha trifallax. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8479-84.
Score: 0.038
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Jabri E, Aigner S, Cech TR. Kinetic and secondary structure analysis of Naegleria andersoni GIR1, a group I ribozyme whose putative biological function is site-specific hydrolysis. Biochemistry. 1997 Dec 23; 36(51):16345-54.
Score: 0.037
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Zhang B, Cech TR. Peptide bond formation by in vitro selected ribozymes. Nature. 1997 Nov 06; 390(6655):96-100.
Score: 0.036
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Weinstein LB, Jones BC, Cosstick R, Cech TR. A second catalytic metal ion in group I ribozyme. Nature. 1997 Aug 21; 388(6644):805-8.
Score: 0.036
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Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997 Aug 15; 277(5328):955-9.
Score: 0.036
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McConnell TS, Herschlag D, Cech TR. Effects of divalent metal ions on individual steps of the Tetrahymena ribozyme reaction. Biochemistry. 1997 Jul 08; 36(27):8293-303.
Score: 0.036
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Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 1997 Apr 25; 276(5312):561-7.
Score: 0.035
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Campbell TB, Cech TR. Mutations in the Tetrahymena ribozyme internal guide sequence: effects on docking of the P1 helix into the catalytic core and correlation with catalytic activity. Biochemistry. 1996 Sep 03; 35(35):11493-502.
Score: 0.034
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Weeks KM, Cech TR. Assembly of a ribonucleoprotein catalyst by tertiary structure capture. Science. 1996 Jan 19; 271(5247):345-8.
Score: 0.032
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Weeks KM, Cech TR. Protein facilitation of group I intron splicing by assembly of the catalytic core and the 5' splice site domain. Cell. 1995 Jul 28; 82(2):221-30.
Score: 0.031
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Cech T. Group I introns: new molecular mechanisms for mRNA repair. Biotechnology (N Y). 1995 Apr; 13(4):323-6.
Score: 0.030
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Zaug AJ, D?vila-Aponte JA, Cech TR. Catalysis of RNA cleavage by a ribozyme derived from the group I intron of Anabaena pre-tRNA(Leu). Biochemistry. 1994 Dec 13; 33(49):14935-47.
Score: 0.030
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Pyle AM, Moran S, Strobel SA, Chapman T, Turner DH, Cech TR. Replacement of the conserved G.U with a G-C pair at the cleavage site of the Tetrahymena ribozyme decreases binding, reactivity, and fidelity. Biochemistry. 1994 Nov 22; 33(46):13856-63.
Score: 0.030
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Cech TR. RNA. Fishing for fresh catalysts. Nature. 1993 Sep 16; 365(6443):204-5.
Score: 0.027
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Herschlag D, Eckstein F, Cech TR. Contributions of 2'-hydroxyl groups of the RNA substrate to binding and catalysis by the Tetrahymena ribozyme. An energetic picture of an active site composed of RNA. Biochemistry. 1993 Aug 17; 32(32):8299-311.
Score: 0.027
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Wang JF, Downs WD, Cech TR. Movement of the guide sequence during RNA catalysis by a group I ribozyme. Science. 1993 Apr 23; 260(5107):504-8.
Score: 0.027
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Piccirilli JA, Vyle JS, Caruthers MH, Cech TR. Metal ion catalysis in the Tetrahymena ribozyme reaction. Nature. 1993 Jan 07; 361(6407):85-8.
Score: 0.026
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Pyle AM, Murphy FL, Cech TR. RNA substrate binding site in the catalytic core of the Tetrahymena ribozyme. Nature. 1992 Jul 09; 358(6382):123-8.
Score: 0.025
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Herschlag D, Cech TR. DNA cleavage catalysed by the ribozyme from Tetrahymena. Nature. 1990 Mar 29; 344(6265):405-9.
Score: 0.022
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Cech TR. RNA as an enzyme. Biochem Int. 1989 Jan; 18(1):7-14.
Score: 0.020
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Cech TR. Ribozymes and their medical implications. JAMA. 1988 Nov 25; 260(20):3030-4.
Score: 0.020
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Been MD, Cech TR. RNA as an RNA polymerase: net elongation of an RNA primer catalyzed by the Tetrahymena ribozyme. Science. 1988 Mar 18; 239(4846):1412-6.
Score: 0.019
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Been MD, Barfod ET, Burke JM, Price JV, Tanner NK, Zaug AJ, Cech TR. Structures involved in Tetrahymena rRNA self-splicing and RNA enzyme activity. Cold Spring Harb Symp Quant Biol. 1987; 52:147-57.
Score: 0.017
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Cech TR. RNA as an enzyme. Sci Am. 1986 Nov; 255(5):64-75.
Score: 0.017
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Cech TR. A model for the RNA-catalyzed replication of RNA. Proc Natl Acad Sci U S A. 1986 Jun; 83(12):4360-3.
Score: 0.017
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Cech TR, Bass BL. Biological catalysis by RNA. Annu Rev Biochem. 1986; 55:599-629.
Score: 0.016
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Cech TR. Biologic catalysis by RNA. Harvey Lect. 1986-1987; 82:123-44.
Score: 0.016
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Cech TR. Self-splicing RNA: implications for evolution. Int Rev Cytol. 1985; 93:3-22.
Score: 0.015
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Cate JH, Gooding AR, Podell E, Zhou K, Golden BL, Kundrot CE, Cech TR, Doudna JA. Crystal structure of a group I ribozyme domain: principles of RNA packing. Science. 1996 Sep 20; 273(5282):1678-85.
Score: 0.008
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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