 Connection
Thomas Cech to Telomere
This is a "connection" page, showing publications Thomas Cech has written about Telomere.
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Connection Strength |
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12.623 |
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Wu G, Taylor E, Youmans DT, Arnoult N, Cech TR. Rapid dynamics allow the low-abundance RTEL1 helicase to promote telomere replication. Nucleic Acids Res. 2025 Feb 27; 53(5).
Score: 0.790
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Johnson K, Seidel JM, Cech TR. Small molecule telomerase inhibitors are also potent inhibitors of telomeric C-strand synthesis. RNA. 2024 08 16; 30(9):1213-1226.
Score: 0.762
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Arnoult N, Cech TR. Telomerase misbehaves after a breakup. Science. 2024 02 16; 383(6684):702-703.
Score: 0.736
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Zaug AJ, Goodrich KJ, Song JJ, Sullivan AE, Cech TR. Reconstitution of a telomeric replicon organized by CST. Nature. 2022 08; 608(7924):819-825.
Score: 0.659
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Lim CJ, Cech TR. Shaping human telomeres: from shelterin and CST complexes to telomeric chromatin organization. Nat Rev Mol Cell Biol. 2021 04; 22(4):283-298.
Score: 0.597
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Lim CJ, Barbour AT, Zaug AJ, Goodrich KJ, McKay AE, Wuttke DS, Cech TR. The structure of human CST reveals a decameric assembly bound to telomeric DNA. Science. 2020 06 05; 368(6495):1081-1085.
Score: 0.569
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Schmidt JC, Zaug AJ, Cech TR. Live Cell Imaging Reveals the Dynamics of Telomerase Recruitment to Telomeres. Cell. 2016 Aug 25; 166(5):1188-1197.e9.
Score: 0.437
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Xi L, Schmidt JC, Zaug AJ, Ascarrunz DR, Cech TR. A novel two-step genome editing strategy with CRISPR-Cas9 provides new insights into telomerase action and TERT gene expression. Genome Biol. 2015 Nov 10; 16:231.
Score: 0.415
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Dalby AB, Hofr C, Cech TR. Contributions of the TEL-patch amino acid cluster on TPP1 to telomeric DNA synthesis by human telomerase. J Mol Biol. 2015 Mar 27; 427(6 Pt B):1291-1303.
Score: 0.393
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Schmidt JC, Dalby AB, Cech TR. Identification of human TERT elements necessary for telomerase recruitment to telomeres. Elife. 2014 Oct 01; 3.
Score: 0.384
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Nandakumar J, Cech TR. Finding the end: recruitment of telomerase to telomeres. Nat Rev Mol Cell Biol. 2013 Feb; 14(2):69-82.
Score: 0.341
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Berman AJ, Cech TR. SnapShot: telomeres and telomerase. Cell. 2012 Nov 21; 151(5):1138-1138.e1.
Score: 0.338
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Nandakumar J, Bell CF, Weidenfeld I, Zaug AJ, Leinwand LA, Cech TR. The TEL patch of telomere protein TPP1 mediates telomerase recruitment and processivity. Nature. 2012 Dec 13; 492(7428):285-9.
Score: 0.336
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Pfingsten JS, Goodrich KJ, Taabazuing C, Ouenzar F, Chartrand P, Cech TR. Mutually exclusive binding of telomerase RNA and DNA by Ku alters telomerase recruitment model. Cell. 2012 Mar 02; 148(5):922-32.
Score: 0.321
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Berman AJ, Akiyama BM, Stone MD, Cech TR. The RNA accordion model for template positioning by telomerase RNA during telomeric DNA synthesis. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1371-5.
Score: 0.315
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Nandakumar J, Cech TR. DNA-induced dimerization of the single-stranded DNA binding telomeric protein Pot1 from Schizosaccharomyces pombe. Nucleic Acids Res. 2012 Jan; 40(1):235-44.
Score: 0.311
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Taylor DJ, Podell ER, Taatjes DJ, Cech TR. Multiple POT1-TPP1 proteins coat and compact long telomeric single-stranded DNA. J Mol Biol. 2011 Jul 01; 410(1):10-7.
Score: 0.304
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Qiao F, Goodrich KJ, Cech TR. Engineering cis-telomerase RNAs that add telomeric repeats to themselves. Proc Natl Acad Sci U S A. 2010 Mar 16; 107(11):4914-8.
Score: 0.280
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Mozdy AD, Podell ER, Cech TR. Multiple yeast genes, including Paf1 complex genes, affect telomere length via telomerase RNA abundance. Mol Cell Biol. 2008 Jun; 28(12):4152-61.
Score: 0.245
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Mozdy AD, Cech TR. Low abundance of telomerase in yeast: implications for telomerase haploinsufficiency. RNA. 2006 Sep; 12(9):1721-37.
Score: 0.218
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Zaug AJ, Podell ER, Cech TR. Human POT1 disrupts telomeric G-quadruplexes allowing telomerase extension in vitro. Proc Natl Acad Sci U S A. 2005 Aug 02; 102(31):10864-9.
Score: 0.203
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Mandell JG, B?hler J, Volpe TA, Martienssen RA, Cech TR. Global expression changes resulting from loss of telomeric DNA in fission yeast. Genome Biol. 2005; 6(1):R1.
Score: 0.195
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Lei M, Podell ER, Cech TR. Structure of human POT1 bound to telomeric single-stranded DNA provides a model for chromosome end-protection. Nat Struct Mol Biol. 2004 Dec; 11(12):1223-9.
Score: 0.194
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Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T. POT1 recruits and regulates CST-Pola/primase at human telomeres. Cell. 2024 Jul 11; 187(14):3638-3651.e18.
Score: 0.188
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Lei M, Podell ER, Baumann P, Cech TR. DNA self-recognition in the structure of Pot1 bound to telomeric single-stranded DNA. Nature. 2003 Nov 13; 426(6963):198-203.
Score: 0.181
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Lei M, Baumann P, Cech TR. Cooperative binding of single-stranded telomeric DNA by the Pot1 protein of Schizosaccharomyces pombe. Biochemistry. 2002 Dec 10; 41(49):14560-8.
Score: 0.169
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Baumann P, Cech TR. Pot1, the putative telomere end-binding protein in fission yeast and humans. Science. 2001 May 11; 292(5519):1171-5.
Score: 0.152
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Baumann P, Cech TR. Protection of telomeres by the Ku protein in fission yeast. Mol Biol Cell. 2000 Oct; 11(10):3265-75.
Score: 0.146
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Rowland TJ, Dumbovic G, Hass EP, Rinn JL, Cech TR. Single-cell imaging reveals unexpected heterogeneity of telomerase reverse transcriptase expression across human cancer cell lines. Proc Natl Acad Sci U S A. 2019 09 10; 116(37):18488-18497.
Score: 0.135
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Bryan TM, Cech TR. Telomerase and the maintenance of chromosome ends. Curr Opin Cell Biol. 1999 Jun; 11(3):318-24.
Score: 0.133
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Nakamura TM, Cooper JP, Cech TR. Two modes of survival of fission yeast without telomerase. Science. 1998 Oct 16; 282(5388):493-6.
Score: 0.127
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Greenwood J, Patel H, Cech TR, Cooper JP. Fission yeast telosomes: non-canonical histone-containing chromatin structures dependent on shelterin and RNA. Nucleic Acids Res. 2018 09 28; 46(17):8865-8875.
Score: 0.127
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Froelich-Ammon SJ, Dickinson BA, Bevilacqua JM, Schultz SC, Cech TR. Modulation of telomerase activity by telomere DNA-binding proteins in Oxytricha. Genes Dev. 1998 May 15; 12(10):1504-14.
Score: 0.123
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Cooper JP, Nimmo ER, Allshire RC, Cech TR. Regulation of telomere length and function by a Myb-domain protein in fission yeast. Nature. 1997 Feb 20; 385(6618):744-7.
Score: 0.113
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Lingner J, Cooper JP, Cech TR. Telomerase and DNA end replication: no longer a lagging strand problem? Science. 1995 Sep 15; 269(5230):1533-4.
Score: 0.103
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Hicke B, Rempel R, Maller J, Swank RA, Hamaguchi JR, Bradbury EM, Prescott DM, Cech TR. Phosphorylation of the Oxytricha telomere protein: possible cell cycle regulation. Nucleic Acids Res. 1995 Jun 11; 23(11):1887-93.
Score: 0.101
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Cech TR. Chromosome end games. Science. 1994 Oct 21; 266(5184):387-8.
Score: 0.096
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Fang G, Cech TR. Characterization of a G-quartet formation reaction promoted by the beta-subunit of the Oxytricha telomere-binding protein. Biochemistry. 1993 Nov 02; 32(43):11646-57.
Score: 0.090
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Fang G, Cech TR. The beta subunit of Oxytricha telomere-binding protein promotes G-quartet formation by telomeric DNA. Cell. 1993 Sep 10; 74(5):875-85.
Score: 0.089
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Ishikawa F, Matunis MJ, Dreyfuss G, Cech TR. Nuclear proteins that bind the pre-mRNA 3' splice site sequence r(UUAG/G) and the human telomeric DNA sequence d(TTAGGG)n. Mol Cell Biol. 1993 Jul; 13(7):4301-10.
Score: 0.088
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Fang G, Cech TR. Oxytricha telomere-binding protein: DNA-dependent dimerization of the alpha and beta subunits. Proc Natl Acad Sci U S A. 1993 Jul 01; 90(13):6056-60.
Score: 0.088
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Gray JT, Celander DW, Price CM, Cech TR. Cloning and expression of genes for the Oxytricha telomere-binding protein: specific subunit interactions in the telomeric complex. Cell. 1991 Nov 15; 67(4):807-14.
Score: 0.079
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Fang GW, Cech TR. Molecular cloning of telomere-binding protein genes from Stylonychia mytilis. Nucleic Acids Res. 1991 Oct 25; 19(20):5515-8.
Score: 0.078
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Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature. 2011 May 22; 474(7351):399-402.
Score: 0.076
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Zappulla DC, Goodrich KJ, Arthur JR, Gurski LA, Denham EM, Stellwagen AE, Cech TR. Ku can contribute to telomere lengthening in yeast at multiple positions in the telomerase RNP. RNA. 2011 Feb; 17(2):298-311.
Score: 0.074
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Nandakumar J, Podell ER, Cech TR. How telomeric protein POT1 avoids RNA to achieve specificity for single-stranded DNA. Proc Natl Acad Sci U S A. 2010 Jan 12; 107(2):651-6.
Score: 0.069
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Jacobs SA, Podell ER, Cech TR. Crystal structure of the essential N-terminal domain of telomerase reverse transcriptase. Nat Struct Mol Biol. 2006 Mar; 13(3):218-25.
Score: 0.053
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Zappulla DC, Goodrich K, Cech TR. A miniature yeast telomerase RNA functions in vivo and reconstitutes activity in vitro. Nat Struct Mol Biol. 2005 Dec; 12(12):1072-7.
Score: 0.052
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Opresko PL, Mason PA, Podell ER, Lei M, Hickson ID, Cech TR, Bohr VA. POT1 stimulates RecQ helicases WRN and BLM to unwind telomeric DNA substrates. J Biol Chem. 2005 Sep 16; 280(37):32069-80.
Score: 0.051
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Lei M, Zaug AJ, Podell ER, Cech TR. Switching human telomerase on and off with hPOT1 protein in vitro. J Biol Chem. 2005 May 27; 280(21):20449-56.
Score: 0.050
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Mandell JG, Goodrich KJ, B?hler J, Cech TR. Expression of a RecQ helicase homolog affects progression through crisis in fission yeast lacking telomerase. J Biol Chem. 2005 Feb 18; 280(7):5249-57.
Score: 0.049
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Cech TR. Beginning to understand the end of the chromosome. Cell. 2004 Jan 23; 116(2):273-9.
Score: 0.046
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Classen S, Lyons D, Cech TR, Schultz SC. Sequence-specific and 3'-end selective single-strand DNA binding by the Oxytricha nova telomere end binding protein alpha subunit. Biochemistry. 2003 Aug 12; 42(31):9269-77.
Score: 0.044
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Colgin LM, Baran K, Baumann P, Cech TR, Reddel RR. Human POT1 facilitates telomere elongation by telomerase. Curr Biol. 2003 May 27; 13(11):942-6.
Score: 0.044
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Seto AG, Zaug AJ, Sobel SG, Wolin SL, Cech TR. Saccharomyces cerevisiae telomerase is an Sm small nuclear ribonucleoprotein particle. Nature. 1999 Sep 09; 401(6749):177-80.
Score: 0.034
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Hammond PW, Cech TR. Euplotes telomerase: evidence for limited base-pairing during primer elongation and dGTP as an effector of translocation. Biochemistry. 1998 Apr 14; 37(15):5162-72.
Score: 0.031
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Lingner J, Cech TR. Telomerase and chromosome end maintenance. Curr Opin Genet Dev. 1998 Apr; 8(2):226-32.
Score: 0.031
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Cech TR, Nakamura TM, Lingner J. Telomerase is a true reverse transcriptase. A review. Biochemistry (Mosc). 1997 Nov; 62(11):1202-5.
Score: 0.030
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Lingner J, Cech TR, Hughes TR, Lundblad V. Three Ever Shorter Telomere (EST) genes are dispensable for in vitro yeast telomerase activity. Proc Natl Acad Sci U S A. 1997 Oct 14; 94(21):11190-5.
Score: 0.030
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Nakamura TM, Morin GB, Chapman KB, Weinrich SL, Andrews WH, Lingner J, Harley CB, Cech TR. Telomerase catalytic subunit homologs from fission yeast and human. Science. 1997 Aug 15; 277(5328):955-9.
Score: 0.029
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Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech TR. Reverse transcriptase motifs in the catalytic subunit of telomerase. Science. 1997 Apr 25; 276(5312):561-7.
Score: 0.029
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Tang M, Li Y, Zhang Y, Chen Y, Huang W, Wang D, Zaug AJ, Liu D, Zhao Y, Cech TR, Ma W, Songyang Z. Disease mutant analysis identifies a new function of DAXX in telomerase regulation and telomere maintenance. J Cell Sci. 2015 Jan 15; 128(2):331-41.
Score: 0.024
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Zappulla DC, Roberts JN, Goodrich KJ, Cech TR, Wuttke DS. Inhibition of yeast telomerase action by the telomeric ssDNA-binding protein, Cdc13p. Nucleic Acids Res. 2009 Feb; 37(2):354-67.
Score: 0.016
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F?rstemann K, Zaug AJ, Cech TR, Lingner J. Yeast telomerase is specialized for C/A-rich RNA templates. Nucleic Acids Res. 2003 Mar 15; 31(6):1646-55.
Score: 0.011
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Willis MC, Hicke BJ, Uhlenbeck OC, Cech TR, Koch TH. Photocrosslinking of 5-iodouracil-substituted RNA and DNA to proteins. Science. 1993 Nov 19; 262(5137):1255-7.
Score: 0.006
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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