Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Contact Us
If you have any questions or feedback please contact us.

Connection

Robert Freedman to Receptors, Nicotinic

This is a "connection" page, showing publications Robert Freedman has written about Receptors, Nicotinic.

 
Connection Strength
 
 
 
3.414
 
  1. Olincy A, Freedman R. Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb Exp Pharmacol. 2012; (213):211-32.
    View in: PubMed
    Score: 0.295
  2. Tregellas JR, Tanabe J, Rojas DC, Shatti S, Olincy A, Johnson L, Martin LF, Soti F, Kem WR, Leonard S, Freedman R. Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biol Psychiatry. 2011 Jan 01; 69(1):7-11.
    View in: PubMed
    Score: 0.269
  3. Martin LF, Kem WR, Freedman R. Alpha-7 nicotinic receptor agonists: potential new candidates for the treatment of schizophrenia. Psychopharmacology (Berl). 2004 Jun; 174(1):54-64.
    View in: PubMed
    Score: 0.171
  4. Adams CE, Broide RS, Chen Y, Winzer-Serhan UH, Henderson TA, Leslie FM, Freedman R. Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation. Brain Res Dev Brain Res. 2002 Dec 15; 139(2):175-87.
    View in: PubMed
    Score: 0.158
  5. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, Drebing C, Berger R, Venn D, Sirota P, Zerbe G, Olincy A, Ross RG, Adler LE, Freedman R. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 2002 Dec; 59(12):1085-96.
    View in: PubMed
    Score: 0.157
  6. Simosky JK, Stevens KE, Adler LE, Freedman R. Clozapine improves deficient inhibitory auditory processing in DBA/2 mice, via a nicotinic cholinergic mechanism. Psychopharmacology (Berl). 2003 Feb; 165(4):386-96.
    View in: PubMed
    Score: 0.157
  7. Simosky JK, Stevens KE, Freedman R. Nicotinic agonists and psychosis. Curr Drug Targets CNS Neurol Disord. 2002 Apr; 1(2):149-62.
    View in: PubMed
    Score: 0.150
  8. Adams CE, Stitzel JA, Collins AC, Freedman R. Alpha7-nicotinic receptor expression and the anatomical organization of hippocampal interneurons. Brain Res. 2001 Dec 20; 922(2):180-90.
    View in: PubMed
    Score: 0.147
  9. Adler LE, Olincy A, Cawthra E, Hoffer M, Nagamoto HT, Amass L, Freedman R. Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism. Neuropsychopharmacology. 2001 Jun; 24(6):671-9.
    View in: PubMed
    Score: 0.142
  10. Freedman R, Leonard S, Gault JM, Hopkins J, Cloninger CR, Kaufmann CA, Tsuang MT, Farone SV, Malaspina D, Svrakic DM, Sanders A, Gejman P. Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am J Med Genet. 2001 Jan 08; 105(1):20-2.
    View in: PubMed
    Score: 0.138
  11. Freedman R, Adams CE, Leonard S. The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia. J Chem Neuroanat. 2000 Dec; 20(3-4):299-306.
    View in: PubMed
    Score: 0.137
  12. Adams CE, Stevens KE, Kem WR, Freedman R. Inhibition of nitric oxide synthase prevents alpha 7 nicotinic receptor-mediated restoration of inhibitory auditory gating in rat hippocampus. Brain Res. 2000 Sep 22; 877(2):235-44.
    View in: PubMed
    Score: 0.135
  13. Leonard S, Breese C, Adams C, Benhammou K, Gault J, Stevens K, Lee M, Adler L, Olincy A, Ross R, Freedman R. Smoking and schizophrenia: abnormal nicotinic receptor expression. Eur J Pharmacol. 2000 Mar 30; 393(1-3):237-42.
    View in: PubMed
    Score: 0.131
  14. Stevens KE, Kem WR, Freedman R. Selective alpha 7 nicotinic receptor stimulation normalizes chronic cocaine-induced loss of hippocampal sensory inhibition in C3H mice. Biol Psychiatry. 1999 Nov 15; 46(10):1443-50.
    View in: PubMed
    Score: 0.127
  15. Adler LE, Olincy A, Waldo M, Harris JG, Griffith J, Stevens K, Flach K, Nagamoto H, Bickford P, Leonard S, Freedman R. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull. 1998; 24(2):189-202.
    View in: PubMed
    Score: 0.112
  16. Freedman R, Coon H, Myles-Worsley M, Orr-Urtreger A, Olincy A, Davis A, Polymeropoulos M, Holik J, Hopkins J, Hoff M, Rosenthal J, Waldo MC, Reimherr F, Wender P, Yaw J, Young DA, Breese CR, Adams C, Patterson D, Adler LE, Kruglyak L, Leonard S, Byerley W. Linkage of a neurophysiological deficit in schizophrenia to a chromosome 15 locus. Proc Natl Acad Sci U S A. 1997 Jan 21; 94(2):587-92.
    View in: PubMed
    Score: 0.105
  17. Leonard S, Adams C, Breese CR, Adler LE, Bickford P, Byerley W, Coon H, Griffith JM, Miller C, Myles-Worsley M, Nagamoto HT, Rollins Y, Stevens KE, Waldo M, Freedman R. Nicotinic receptor function in schizophrenia. Schizophr Bull. 1996; 22(3):431-45.
    View in: PubMed
    Score: 0.097
  18. Freedman R, Adler LE, Bickford P, Byerley W, Coon H, Cullum CM, Griffith JM, Harris JG, Leonard S, Miller C, et al. Schizophrenia and nicotinic receptors. Harv Rev Psychiatry. 1994 Nov-Dec; 2(4):179-92.
    View in: PubMed
    Score: 0.090
  19. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S, Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar; 170(3):290-8.
    View in: PubMed
    Score: 0.080
  20. Freedman R, Goldowitz D. Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Prog Neurobiol. 2010 Feb 09; 90(2):263-75.
    View in: PubMed
    Score: 0.063
  21. Sinkus ML, Lee MJ, Gault J, Logel J, Short M, Freedman R, Christian SL, Lyon J, Leonard S. A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. Brain Res. 2009 Sep 29; 1291:1-11.
    View in: PubMed
    Score: 0.062
  22. Stephens SH, Logel J, Barton A, Franks A, Schultz J, Short M, Dickenson J, James B, Fingerlin TE, Wagner B, Hodgkinson C, Graw S, Ross RG, Freedman R, Leonard S. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schizophr Res. 2009 Apr; 109(1-3):102-12.
    View in: PubMed
    Score: 0.060
  23. Freedman R, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, Allensworth D, Guzman-Bonilla A, Clement B, Ball MP, Kutnick J, Pender V, Martin LF, Stevens KE, Wagner BD, Zerbe GO, Soti F, Kem WR. Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am J Psychiatry. 2008 Aug; 165(8):1040-7.
    View in: PubMed
    Score: 0.057
  24. Gault J, Hopkins J, Berger R, Drebing C, Logel J, Walton C, Short M, Vianzon R, Olincy A, Ross RG, Adler LE, Freedman R, Leonard S. Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15; 123B(1):39-49.
    View in: PubMed
    Score: 0.042
  25. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S. The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep. 2003 Jun; 5(2):155-61.
    View in: PubMed
    Score: 0.041
  26. Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, Leonard S. Input dysfunction, schizotypy, and genetic models of schizophrenia. Schizophr Res. 2002 Mar 01; 54(1-2):25-32.
    View in: PubMed
    Score: 0.037
  27. Leonard S, Adler LE, Benhammou K, Berger R, Breese CR, Drebing C, Gault J, Lee MJ, Logel J, Olincy A, Ross RG, Stevens K, Sullivan B, Vianzon R, Virnich DE, Waldo M, Walton K, Freedman R. Smoking and mental illness. Pharmacol Biochem Behav. 2001 Dec; 70(4):561-70.
    View in: PubMed
    Score: 0.037
  28. Simosky JK, Stevens KE, Kem WR, Freedman R. Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biol Psychiatry. 2001 Oct 01; 50(7):493-500.
    View in: PubMed
    Score: 0.036
  29. Waldo MC, Adler LE, Leonard S, Olincy A, Ross RG, Harris JG, Freedman R. Familial transmission of risk factors in the first-degree relatives of schizophrenic people. Biol Psychiatry. 2000 Feb 01; 47(3):231-9.
    View in: PubMed
    Score: 0.032
  30. Gault J, Robinson M, Berger R, Drebing C, Logel J, Hopkins J, Moore T, Jacobs S, Meriwether J, Choi MJ, Kim EJ, Walton K, Buiting K, Davis A, Breese C, Freedman R, Leonard S. Genomic organization and partial duplication of the human alpha7 neuronal nicotinic acetylcholine receptor gene (CHRNA7). Genomics. 1998 Sep 01; 52(2):173-85.
    View in: PubMed
    Score: 0.029
  31. Adams CE, Freedman R. Nicotinic antagonist alpha-bungarotoxin binding to rat hippocampal neurons containing nitric oxide synthase. Brain Res. 1997 Nov 21; 776(1-2):111-6.
    View in: PubMed
    Score: 0.028
  32. Breese CR, Adams C, Logel J, Drebing C, Rollins Y, Barnhart M, Sullivan B, Demasters BK, Freedman R, Leonard S. Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol. 1997 Oct 27; 387(3):385-98.
    View in: PubMed
    Score: 0.028
  33. Stevens KE, Freedman R, Collins AC, Hall M, Leonard S, Marks MJ, Rose GM. Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains. Neuropsychopharmacology. 1996 Aug; 15(2):152-62.
    View in: PubMed
    Score: 0.025
  34. Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE. Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry. 2010 May; 51(5):535-49.
    View in: PubMed
    Score: 0.016
  35. Adler LE, Freedman R, Ross RG, Olincy A, Waldo MC. Elementary phenotypes in the neurobiological and genetic study of schizophrenia. Biol Psychiatry. 1999 Jul 01; 46(1):8-18.
    View in: PubMed
    Score: 0.008
  36. Frazier CJ, Rollins YD, Breese CR, Leonard S, Freedman R, Dunwiddie TV. Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. J Neurosci. 1998 Feb 15; 18(4):1187-95.
    View in: PubMed
    Score: 0.007
  37. de la Garza R, McGuire TJ, Freedman R, Hoffer BJ. The electrophysiological effects of nicotine in the rat cerebellum: evidence for direct postsynaptic actions. Neurosci Lett. 1987 Oct 05; 80(3):303-8.
    View in: PubMed
    Score: 0.003
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

Copyright © 2026 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)