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Connection

Douglas Seals to Aging

This is a "connection" page, showing publications Douglas Seals has written about Aging.

 
Connection Strength
  
 
 
22.512
  
  1. Brunt VE, Ikoba AP, Ziemba BP, Ballak DB, Hoischen A, Dinarello CA, Ehringer MA, Seals DR. Circulating interleukin-37 declines with aging in healthy humans: relations to healthspan indicators and IL37 gene SNPs. Geroscience. 2023 02; 45(1):65-84.
    View in: PubMed
    Score: 0.402
  2. Clayton ZS, Hutton DA, Brunt VE, VanDongen NS, Ziemba BP, Casso AG, Greenberg NT, Mercer AN, Rossman MJ, Campisi J, Melov S, Seals DR. Apigenin restores endothelial function by ameliorating oxidative stress, reverses aortic stiffening, and mitigates vascular inflammation with aging. Am J Physiol Heart Circ Physiol. 2021 07 01; 321(1):H185-H196.
    View in: PubMed
    Score: 0.376
  3. Brunt VE, Casso AG, Gioscia-Ryan RA, Sapinsley ZJ, Ziemba BP, Clayton ZS, Bazzoni AE, VanDongen NS, Richey JJ, Hutton DA, Zigler MC, Neilson AP, Davy KP, Seals DR. Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans. Hypertension. 2021 08; 78(2):499-511.
    View in: PubMed
    Score: 0.374
  4. Rossman MJ, Gioscia-Ryan RA, Santos-Parker JR, Ziemba BP, Lubieniecki KL, Johnson LC, Poliektov NE, Bispham NZ, Woodward KA, Nagy EE, Bryan NS, Reisz JA, D'Alessandro A, Chonchol M, Sindler AL, Seals DR. Inorganic Nitrite Supplementation Improves Endothelial Function With Aging: Translational Evidence for Suppression of Mitochondria-Derived Oxidative Stress. Hypertension. 2021 04; 77(4):1212-1222.
    View in: PubMed
    Score: 0.369
  5. Rossman MJ, Gioscia-Ryan RA, Clayton ZS, Murphy MP, Seals DR. Targeting mitochondrial fitness as a strategy for healthy vascular aging. Clin Sci (Lond). 2020 06 26; 134(12):1491-1519.
    View in: PubMed
    Score: 0.352
  6. Brunt VE, Gioscia-Ryan RA, Casso AG, VanDongen NS, Ziemba BP, Sapinsley ZJ, Richey JJ, Zigler MC, Neilson AP, Davy KP, Seals DR. Trimethylamine-N-Oxide Promotes Age-Related Vascular Oxidative Stress and Endothelial Dysfunction in Mice and Healthy Humans. Hypertension. 2020 07; 76(1):101-112.
    View in: PubMed
    Score: 0.351
  7. Seals DR, Nagy EE, Moreau KL. Aerobic exercise training and vascular function with ageing in healthy men and women. J Physiol. 2019 10; 597(19):4901-4914.
    View in: PubMed
    Score: 0.330
  8. Johnson SA, Litwin NS, Seals DR. Age-Related Vascular Dysfunction: What Registered Dietitian Nutritionists Need to Know. J Acad Nutr Diet. 2019 11; 119(11):1785-1796.
    View in: PubMed
    Score: 0.327
  9. Brunt VE, Gioscia-Ryan RA, Richey JJ, Zigler MC, Cuevas LM, Gonzalez A, V?zquez-Baeza Y, Battson ML, Smithson AT, Gilley AD, Ackermann G, Neilson AP, Weir T, Davy KP, Knight R, Seals DR. Suppression of the gut microbiome ameliorates age-related arterial dysfunction and oxidative stress in mice. J Physiol. 2019 05; 597(9):2361-2378.
    View in: PubMed
    Score: 0.321
  10. Santos-Parker JR, Santos-Parker KS, McQueen MB, Martens CR, Seals DR. Habitual aerobic exercise and circulating proteomic patterns in healthy adults: relation to indicators of healthspan. J Appl Physiol (1985). 2018 11 01; 125(5):1646-1659.
    View in: PubMed
    Score: 0.311
  11. Rossman MJ, LaRocca TJ, Martens CR, Seals DR. Healthy lifestyle-based approaches for successful vascular aging. J Appl Physiol (1985). 2018 12 01; 125(6):1888-1900.
    View in: PubMed
    Score: 0.311
  12. Johnson LC, Martens CR, Santos-Parker JR, Bassett CJ, Strahler TR, Cruickshank-Quinn C, Reisdorph N, McQueen MB, Seals DR. Amino acid and lipid associated plasma metabolomic patterns are related to healthspan indicators with ageing. Clin Sci (Lond). 2018 08 31; 132(16):1765-1777.
    View in: PubMed
    Score: 0.310
  13. Seals DR, Alexander LM. Vascular aging. J Appl Physiol (1985). 2018 12 01; 125(6):1841-1842.
    View in: PubMed
    Score: 0.305
  14. Seals DR, Brunt VE, Rossman MJ. Keynote lecture: strategies for optimal cardiovascular aging. Am J Physiol Heart Circ Physiol. 2018 08 01; 315(2):H183-H188.
    View in: PubMed
    Score: 0.302
  15. Nowak KL, Rossman MJ, Chonchol M, Seals DR. Strategies for Achieving Healthy Vascular Aging. Hypertension. 2018 03; 71(3):389-402.
    View in: PubMed
    Score: 0.297
  16. Tanaka H, Dinenno FA, Seals DR. Reductions in central arterial compliance with age are related to sympathetic vasoconstrictor nerve activity in healthy men. Hypertens Res. 2017 May; 40(5):493-495.
    View in: PubMed
    Score: 0.277
  17. Martens CR, Seals DR. Practical alternatives to chronic caloric restriction for optimizing vascular function with ageing. J Physiol. 2016 12 15; 594(24):7177-7195.
    View in: PubMed
    Score: 0.275
  18. Gioscia-Ryan RA, Battson ML, Cuevas LM, Zigler MC, Sindler AL, Seals DR. Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Aging (Albany NY). 2016 11 22; 8(11):2897-2914.
    View in: PubMed
    Score: 0.274
  19. LaRocca TJ, Martens CR, Seals DR. Nutrition and other lifestyle influences on arterial aging. Ageing Res Rev. 2017 Oct; 39:106-119.
    View in: PubMed
    Score: 0.272
  20. Kaplon RE, Hill SD, Bispham NZ, Santos-Parker JR, Nowlan MJ, Snyder LL, Chonchol M, LaRocca TJ, McQueen MB, Seals DR. Oral trehalose supplementation improves resistance artery endothelial function in healthy middle-aged and older adults. Aging (Albany NY). 2016 06; 8(6):1167-83.
    View in: PubMed
    Score: 0.266
  21. de Picciotto NE, Gano LB, Johnson LC, Martens CR, Sindler AL, Mills KF, Imai S, Seals DR. Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice. Aging Cell. 2016 06; 15(3):522-30.
    View in: PubMed
    Score: 0.261
  22. Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling. J Hypertens. 2015 Dec; 33(12):2477-82.
    View in: PubMed
    Score: 0.256
  23. DeVan AE, Johnson LC, Brooks FA, Evans TD, Justice JN, Cruickshank-Quinn C, Reisdorph N, Bryan NS, McQueen MB, Santos-Parker JR, Chonchol MB, Bassett CJ, Sindler AL, Giordano T, Seals DR. Effects of sodium nitrite supplementation on vascular function and related small metabolite signatures in middle-aged and older adults. J Appl Physiol (1985). 2016 Feb 15; 120(4):416-25.
    View in: PubMed
    Score: 0.256
  24. Santos-Parker JR, LaRocca TJ, Seals DR. Aerobic exercise and other healthy lifestyle factors that influence vascular aging. Adv Physiol Educ. 2014 Dec; 38(4):296-307.
    View in: PubMed
    Score: 0.239
  25. Justice JN, Gioscia-Ryan RA, Johnson LC, Battson ML, de Picciotto NE, Beck HJ, Jiang H, Sindler AL, Bryan NS, Enoka RM, Seals DR. Sodium nitrite supplementation improves motor function and skeletal muscle inflammatory profile in old male mice. J Appl Physiol (1985). 2015 Jan 15; 118(2):163-9.
    View in: PubMed
    Score: 0.238
  26. Gano LB, Donato AJ, Pasha HM, Hearon CM, Sindler AL, Seals DR. The SIRT1 activator SRT1720 reverses vascular endothelial dysfunction, excessive superoxide production, and inflammation with aging in mice. Am J Physiol Heart Circ Physiol. 2014 Dec 15; 307(12):H1754-63.
    View in: PubMed
    Score: 0.237
  27. LaRocca TJ, Hearon CM, Henson GD, Seals DR. Mitochondrial quality control and age-associated arterial stiffening. Exp Gerontol. 2014 Oct; 58:78-82.
    View in: PubMed
    Score: 0.233
  28. Seals DR, Kaplon RE, Gioscia-Ryan RA, LaRocca TJ. You're only as old as your arteries: translational strategies for preserving vascular endothelial function with aging. Physiology (Bethesda). 2014 Jul; 29(4):250-64.
    View in: PubMed
    Score: 0.232
  29. Seals DR. Edward F. Adolph Distinguished Lecture: The remarkable anti-aging effects of aerobic exercise on systemic arteries. J Appl Physiol (1985). 2014 Sep 01; 117(5):425-39.
    View in: PubMed
    Score: 0.231
  30. Justice JN, Carter CS, Beck HJ, Gioscia-Ryan RA, McQueen M, Enoka RM, Seals DR. Battery of behavioral tests in mice that models age-associated changes in human motor function. Age (Dordr). 2014 Apr; 36(2):583-92.
    View in: PubMed
    Score: 0.228
  31. Gioscia-Ryan RA, LaRocca TJ, Sindler AL, Zigler MC, Murphy MP, Seals DR. Mitochondria-targeted antioxidant (MitoQ) ameliorates age-related arterial endothelial dysfunction in mice. J Physiol. 2014 Jun 15; 592(12):2549-61.
    View in: PubMed
    Score: 0.228
  32. Sindler AL, Devan AE, Fleenor BS, Seals DR. Inorganic nitrite supplementation for healthy arterial aging. J Appl Physiol (1985). 2014 Mar 01; 116(5):463-77.
    View in: PubMed
    Score: 0.225
  33. Lesniewski LA, Zigler ML, Durrant JR, Nowlan MJ, Folian BJ, Donato AJ, Seals DR. Aging compounds western diet-associated large artery endothelial dysfunction in mice: prevention by voluntary aerobic exercise. Exp Gerontol. 2013 Nov; 48(11):1218-25.
    View in: PubMed
    Score: 0.219
  34. Donato AJ, Walker AE, Magerko KA, Bramwell RC, Black AD, Henson GD, Lawson BR, Lesniewski LA, Seals DR. Life-long caloric restriction reduces oxidative stress and preserves nitric oxide bioavailability and function in arteries of old mice. Aging Cell. 2013 Oct; 12(5):772-83.
    View in: PubMed
    Score: 0.217
  35. LaRocca TJ, Gioscia-Ryan RA, Hearon CM, Seals DR. The autophagy enhancer spermidine reverses arterial aging. Mech Ageing Dev. 2013 Jul-Aug; 134(7-8):314-20.
    View in: PubMed
    Score: 0.214
  36. DeVan AE, Pierce GL, Brooks FA, Seals DR. The dependence of FMD% on baseline diameter: a problem solved by allometric scaling - no problem in this case. Clin Sci (Lond). 2013 Mar 13; 125(1):55-6.
    View in: PubMed
    Score: 0.212
  37. DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond). 2013 Mar; 124(5):325-31.
    View in: PubMed
    Score: 0.212
  38. Fleenor BS, Sindler AL, Marvi NK, Howell KL, Zigler ML, Yoshizawa M, Seals DR. Curcumin ameliorates arterial dysfunction and oxidative stress with aging. Exp Gerontol. 2013 Feb; 48(2):269-76.
    View in: PubMed
    Score: 0.207
  39. Fleenor BS, Sindler AL, Eng JS, Nair DP, Dodson RB, Seals DR. Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products. Exp Gerontol. 2012 Aug; 47(8):588-94.
    View in: PubMed
    Score: 0.200
  40. LaRocca TJ, Henson GD, Thorburn A, Sindler AL, Pierce GL, Seals DR. Translational evidence that impaired autophagy contributes to arterial ageing. J Physiol. 2012 Jul 15; 590(14):3305-16.
    View in: PubMed
    Score: 0.200
  41. Lesniewski LA, Zigler MC, Durrant JR, Donato AJ, Seals DR. Sustained activation of AMPK ameliorates age-associated vascular endothelial dysfunction via a nitric oxide-independent mechanism. Mech Ageing Dev. 2012 May; 133(5):368-71.
    View in: PubMed
    Score: 0.199
  42. DeVan AE, Seals DR. Vascular health in the ageing athlete. Exp Physiol. 2012 Mar; 97(3):305-10.
    View in: PubMed
    Score: 0.196
  43. Pierce GL, Donato AJ, LaRocca TJ, Eskurza I, Silver AE, Seals DR. Habitually exercising older men do not demonstrate age-associated vascular endothelial oxidative stress. Aging Cell. 2011 Dec; 10(6):1032-7.
    View in: PubMed
    Score: 0.193
  44. Kaplon RE, Walker AE, Seals DR. Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women. J Appl Physiol (1985). 2011 Nov; 111(5):1416-21.
    View in: PubMed
    Score: 0.191
  45. Donato AJ, Magerko KA, Lawson BR, Durrant JR, Lesniewski LA, Seals DR. SIRT-1 and vascular endothelial dysfunction with ageing in mice and humans. J Physiol. 2011 Sep 15; 589(Pt 18):4545-54.
    View in: PubMed
    Score: 0.189
  46. Lesniewski LA, Durrant JR, Connell ML, Henson GD, Black AD, Donato AJ, Seals DR. Aerobic exercise reverses arterial inflammation with aging in mice. Am J Physiol Heart Circ Physiol. 2011 Sep; 301(3):H1025-32.
    View in: PubMed
    Score: 0.188
  47. Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011 May; 120(9):357-75.
    View in: PubMed
    Score: 0.187
  48. Sindler AL, Fleenor BS, Calvert JW, Marshall KD, Zigler ML, Lefer DJ, Seals DR. Nitrite supplementation reverses vascular endothelial dysfunction and large elastic artery stiffness with aging. Aging Cell. 2011 Jun; 10(3):429-37.
    View in: PubMed
    Score: 0.186
  49. Lesniewski LA, Durrant JR, Connell ML, Folian BJ, Donato AJ, Seals DR. Salicylate treatment improves age-associated vascular endothelial dysfunction: potential role of nuclear factor kappaB and forkhead Box O phosphorylation. J Gerontol A Biol Sci Med Sci. 2011 Apr; 66(4):409-18.
    View in: PubMed
    Score: 0.184
  50. Fleenor BS, Marshall KD, Durrant JR, Lesniewski LA, Seals DR. Arterial stiffening with ageing is associated with transforming growth factor-?1-related changes in adventitial collagen: reversal by aerobic exercise. J Physiol. 2010 Oct 15; 588(Pt 20):3971-82.
    View in: PubMed
    Score: 0.180
  51. Rippe C, Lesniewski L, Connell M, LaRocca T, Donato A, Seals D. Short-term calorie restriction reverses vascular endothelial dysfunction in old mice by increasing nitric oxide and reducing oxidative stress. Aging Cell. 2010 Jun; 9(3):304-12.
    View in: PubMed
    Score: 0.173
  52. Walker AE, Seibert SM, Donato AJ, Pierce GL, Seals DR. Vascular endothelial function is related to white blood cell count and myeloperoxidase among healthy middle-aged and older adults. Hypertension. 2010 Feb; 55(2):363-9.
    View in: PubMed
    Score: 0.170
  53. Seals DR, Walker AE, Pierce GL, Lesniewski LA. Habitual exercise and vascular ageing. J Physiol. 2009 Dec 01; 587(Pt 23):5541-9.
    View in: PubMed
    Score: 0.166
  54. Donato AJ, Pierce GL, Lesniewski LA, Seals DR. Role of NFkappaB in age-related vascular endothelial dysfunction in humans. Aging (Albany NY). 2009 Aug 10; 1(8):678-80.
    View in: PubMed
    Score: 0.166
  55. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H425-32.
    View in: PubMed
    Score: 0.163
  56. Lesniewski LA, Connell ML, Durrant JR, Folian BJ, Anderson MC, Donato AJ, Seals DR. B6D2F1 Mice are a suitable model of oxidative stress-mediated impaired endothelium-dependent dilation with aging. J Gerontol A Biol Sci Med Sci. 2009 Jan; 64(1):9-20.
    View in: PubMed
    Score: 0.160
  57. Walker AE, Eskurza I, Pierce GL, Gates PE, Seals DR. Modulation of vascular endothelial function by low-density lipoprotein cholesterol with aging: influence of habitual exercise. Am J Hypertens. 2009 Mar; 22(3):250-6.
    View in: PubMed
    Score: 0.159
  58. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008 Dec; 7(6):805-12.
    View in: PubMed
    Score: 0.155
  59. Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol (1985). 2008 Oct; 105(4):1359-63.
    View in: PubMed
    Score: 0.154
  60. Seals DR, Desouza CA, Donato AJ, Tanaka H. Habitual exercise and arterial aging. J Appl Physiol (1985). 2008 Oct; 105(4):1323-32.
    View in: PubMed
    Score: 0.153
  61. Christou DD, Seals DR. Decreased maximal heart rate with aging is related to reduced {beta}-adrenergic responsiveness but is largely explained by a reduction in intrinsic heart rate. J Appl Physiol (1985). 2008 Jul; 105(1):24-9.
    View in: PubMed
    Score: 0.152
  62. Tanaka H, Seals DR. Endurance exercise performance in Masters athletes: age-associated changes and underlying physiological mechanisms. J Physiol. 2008 Jan 01; 586(1):55-63.
    View in: PubMed
    Score: 0.145
  63. Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR. Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res. 2007 Jun 08; 100(11):1659-66.
    View in: PubMed
    Score: 0.141
  64. Moreau KL, Silver AE, Dinenno FA, Seals DR. Habitual aerobic exercise is associated with smaller femoral artery intima-media thickness with age in healthy men and women. Eur J Cardiovasc Prev Rehabil. 2006 Oct; 13(5):805-11.
    View in: PubMed
    Score: 0.136
  65. Gates PE, Seals DR. Decline in large elastic artery compliance with age: a therapeutic target for habitual exercise. Br J Sports Med. 2006 Nov; 40(11):897-9.
    View in: PubMed
    Score: 0.135
  66. Gates PE, Boucher ML, Silver AE, Monahan KD, Seals DR. Impaired flow-mediated dilation with age is not explained by L-arginine bioavailability or endothelial asymmetric dimethylarginine protein expression. J Appl Physiol (1985). 2007 Jan; 102(1):63-71.
    View in: PubMed
    Score: 0.135
  67. Seals DR, Moreau KL, Gates PE, Eskurza I. Modulatory influences on ageing of the vasculature in healthy humans. Exp Gerontol. 2006 May; 41(5):501-7.
    View in: PubMed
    Score: 0.131
  68. Eskurza I, Kahn ZD, Seals DR. Xanthine oxidase does not contribute to impaired peripheral conduit artery endothelium-dependent dilatation with ageing. J Physiol. 2006 Mar 15; 571(Pt 3):661-8.
    View in: PubMed
    Score: 0.130
  69. Eskurza I, Myerburgh LA, Kahn ZD, Seals DR. Tetrahydrobiopterin augments endothelium-dependent dilatation in sedentary but not in habitually exercising older adults. J Physiol. 2005 Nov 01; 568(Pt 3):1057-65.
    View in: PubMed
    Score: 0.126
  70. Seals DR, Dinenno FA. Collateral damage: cardiovascular consequences of chronic sympathetic activation with human aging. Am J Physiol Heart Circ Physiol. 2004 Nov; 287(5):H1895-905.
    View in: PubMed
    Score: 0.119
  71. Bell C, Carson JM, Motte NW, Seals DR. Ascorbic acid does not affect the age-associated reduction in maximal cardiac output and oxygen consumption in healthy adults. J Appl Physiol (1985). 2005 Mar; 98(3):845-9.
    View in: PubMed
    Score: 0.119
  72. Jones PP, Van Pelt RE, Johnson DG, Seals DR. Role of sympathetic neural activation in age- and habitual exercise-related differences in the thermic effect of food. J Clin Endocrinol Metab. 2004 Oct; 89(10):5138-44.
    View in: PubMed
    Score: 0.118
  73. Bell C, Day DS, Jones PP, Christou DD, Petitt DS, Osterberg K, Melby CL, Seals DR. High energy flux mediates the tonically augmented beta-adrenergic support of resting metabolic rate in habitually exercising older adults. J Clin Endocrinol Metab. 2004 Jul; 89(7):3573-8.
    View in: PubMed
    Score: 0.116
  74. Christou DD, Jones PP, Pimentel AE, Seals DR. Increased abdominal-to-peripheral fat distribution contributes to altered autonomic-circulatory control with human aging. Am J Physiol Heart Circ Physiol. 2004 Oct; 287(4):H1530-7.
    View in: PubMed
    Score: 0.116
  75. Eskurza I, Monahan KD, Robinson JA, Seals DR. Ascorbic acid does not affect large elastic artery compliance or central blood pressure in young and older men. Am J Physiol Heart Circ Physiol. 2004 Apr; 286(4):H1528-34.
    View in: PubMed
    Score: 0.114
  76. Monahan KD, Eskurza I, Seals DR. Ascorbic acid increases cardiovagal baroreflex sensitivity in healthy older men. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2113-7.
    View in: PubMed
    Score: 0.113
  77. Seals DR, Bell C. Chronic sympathetic activation: consequence and cause of age-associated obesity? Diabetes. 2004 Feb; 53(2):276-84.
    View in: PubMed
    Score: 0.113
  78. Eskurza I, Monahan KD, Robinson JA, Seals DR. Effect of acute and chronic ascorbic acid on flow-mediated dilatation with sedentary and physically active human ageing. J Physiol. 2004 Apr 01; 556(Pt 1):315-24.
    View in: PubMed
    Score: 0.113
  79. Gates PE, Tanaka H, Graves J, Seals DR. Left ventricular structure and diastolic function with human ageing. Relation to habitual exercise and arterial stiffness. Eur Heart J. 2003 Dec; 24(24):2213-20.
    View in: PubMed
    Score: 0.112
  80. Moreau KL, Clayton ZS, DuBose LE, Rosenberry R, Seals DR. Effects of regular exercise on vascular function with aging: Does sex matter? Am J Physiol Heart Circ Physiol. 2024 01 01; 326(1):H123-H137.
    View in: PubMed
    Score: 0.111
  81. Tanaka H, Seals DR. Invited Review: Dynamic exercise performance in Masters athletes: insight into the effects of primary human aging on physiological functional capacity. J Appl Physiol (1985). 2003 Nov; 95(5):2152-62.
    View in: PubMed
    Score: 0.111
  82. Bell C, Jones PP, Seals DR. Oxidative stress does not modulate metabolic rate or skeletal muscle sympathetic activity with primary aging in adult humans. J Clin Endocrinol Metab. 2003 Oct; 88(10):4950-4.
    View in: PubMed
    Score: 0.110
  83. Clayton ZS, Rossman MJ, Mahoney SA, Venkatasubramanian R, Maurer GS, Hutton DA, VanDongen NS, Greenberg NT, Longtine AG, Ludwig KR, Brunt VE, LaRocca TJ, Campisi J, Melov S, Seals DR. Cellular Senescence Contributes to Large Elastic Artery Stiffening and Endothelial Dysfunction With Aging: Amelioration With Senolytic Treatment. Hypertension. 2023 10; 80(10):2072-2087.
    View in: PubMed
    Score: 0.109
  84. Jones PP, Christou DD, Jordan J, Seals DR. Baroreflex buffering is reduced with age in healthy men. Circulation. 2003 Apr 08; 107(13):1770-4.
    View in: PubMed
    Score: 0.106
  85. Moreau KL, Donato AJ, Tanaka H, Jones PP, Gates PE, Seals DR. Basal leg blood flow in healthy women is related to age and hormone replacement therapy status. J Physiol. 2003 Feb 15; 547(Pt 1):309-16.
    View in: PubMed
    Score: 0.104
  86. Esler M, Lambert G, Kaye D, Rumantir M, Hastings J, Seals DR. Influence of ageing on the sympathetic nervous system and adrenal medulla at rest and during stress. Biogerontology. 2002; 3(1-2):45-9.
    View in: PubMed
    Score: 0.098
  87. Seals DR, Monahan KD, Bell C, Tanaka H, Jones PP. The aging cardiovascular system: changes in autonomic function at rest and in response to exercise. Int J Sport Nutr Exerc Metab. 2001 Dec; 11 Suppl:S189-95.
    View in: PubMed
    Score: 0.097
  88. Jones PP, Shapiro LF, Keisling GA, Jordan J, Shannon JR, Quaife RA, Seals DR. Altered autonomic support of arterial blood pressure with age in healthy men. Circulation. 2001 Nov 13; 104(20):2424-9.
    View in: PubMed
    Score: 0.097
  89. Craighead DH, Freeberg KA, McCarty NP, Seals DR. Time-efficient, high-resistance inspiratory muscle strength training for cardiovascular aging. Exp Gerontol. 2021 10 15; 154:111515.
    View in: PubMed
    Score: 0.095
  90. Tanaka H, Dinenno FA, Monahan KD, DeSouza CA, Seals DR. Carotid artery wall hypertrophy with age is related to local systolic blood pressure in healthy men. Arterioscler Thromb Vasc Biol. 2001 Jan; 21(1):82-7.
    View in: PubMed
    Score: 0.091
  91. Tanaka H, Monahan KD, Seals DR. Age-predicted maximal heart rate revisited. J Am Coll Cardiol. 2001 Jan; 37(1):153-6.
    View in: PubMed
    Score: 0.091
  92. Schiller BC, Casas YG, Tracy BL, DeSouza CA, Seals DR. Age-related declines in knee extensor strength and physical performance in healthy Hispanic and Caucasian women. J Gerontol A Biol Sci Med Sci. 2000 Dec; 55(12):B563-9.
    View in: PubMed
    Score: 0.091
  93. Monahan KD, Dinenno FA, Tanaka H, Clevenger CM, DeSouza CA, Seals DR. Regular aerobic exercise modulates age-associated declines in cardiovagal baroreflex sensitivity in healthy men. J Physiol. 2000 Nov 15; 529 Pt 1:263-71.
    View in: PubMed
    Score: 0.090
  94. Seals DR, Esler MD. Human ageing and the sympathoadrenal system. J Physiol. 2000 Nov 01; 528(Pt 3):407-17.
    View in: PubMed
    Score: 0.090
  95. DeSouza CA, Shapiro LF, Clevenger CM, Dinenno FA, Monahan KD, Tanaka H, Seals DR. Regular aerobic exercise prevents and restores age-related declines in endothelium-dependent vasodilation in healthy men. Circulation. 2000 Sep 19; 102(12):1351-7.
    View in: PubMed
    Score: 0.089
  96. Tanaka H, Dinenno FA, Seals DR. Age-related increase in femoral intima-media thickness in healthy humans. Arterioscler Thromb Vasc Biol. 2000 Sep; 20(9):2172.
    View in: PubMed
    Score: 0.089
  97. Brunt VE, LaRocca TJ, Bazzoni AE, Sapinsley ZJ, Miyamoto-Ditmon J, Gioscia-Ryan RA, Neilson AP, Link CD, Seals DR. The gut microbiome-derived metabolite trimethylamine N-oxide modulates neuroinflammation and cognitive function with aging. Geroscience. 2021 02; 43(1):377-394.
    View in: PubMed
    Score: 0.089
  98. Johnson LC, Parker K, Aguirre BF, Nemkov TG, D'Alessandro A, Johnson SA, Seals DR, Martens CR. The plasma metabolome as a predictor of biological aging in humans. Geroscience. 2019 12; 41(6):895-906.
    View in: PubMed
    Score: 0.084
  99. Seals DR, Stevenson ET, Jones PP, DeSouza CA, Tanaka H. Lack of age-associated elevations in 24-h systolic and pulse pressures in women who exercise regularly. Am J Physiol. 1999 09; 277(3):H947-55.
    View in: PubMed
    Score: 0.083
  100. Tanaka H, Davy KP, Seals DR. Cardiopulmonary baroreflex inhibition of sympathetic nerve activity is preserved with age in healthy humans. J Physiol. 1999 Feb 15; 515 ( Pt 1):249-54.
    View in: PubMed
    Score: 0.080
  101. Davy KP, Tanaka H, Andros EA, Gerber JG, Seals DR. Influence of age on arterial baroreflex inhibition of sympathetic nerve activity in healthy adult humans. Am J Physiol. 1998 11; 275(5):H1768-72.
    View in: PubMed
    Score: 0.078
  102. Tanaka H, Dinenno FA, Hunt BE, Jones PP, DeSouza CA, Seals DR. Hemodynamic sequelae of age-related increases in arterial stiffness in healthy women. Am J Cardiol. 1998 Nov 01; 82(9):1152-5, A10.
    View in: PubMed
    Score: 0.078
  103. Van Pelt RE, Davy KP, Stevenson ET, Wilson TM, Jones PP, Desouza CA, Seals DR. Smaller differences in total and regional adiposity with age in women who regularly perform endurance exercise. Am J Physiol. 1998 10; 275(4):E626-34.
    View in: PubMed
    Score: 0.078
  104. Davy KP, DeSouza CA, Jones PP, Seals DR. Elevated heart rate variability in physically active young and older adult women. Clin Sci (Lond). 1998 Jun; 94(6):579-84.
    View in: PubMed
    Score: 0.076
  105. DeSouza CA, Jones PP, Seals DR. Physical activity status and adverse age-related differences in coagulation and fibrinolytic factors in women. Arterioscler Thromb Vasc Biol. 1998 Mar; 18(3):362-8.
    View in: PubMed
    Score: 0.075
  106. Tanaka H, DeSouza CA, Seals DR. Absence of age-related increase in central arterial stiffness in physically active women. Arterioscler Thromb Vasc Biol. 1998 Jan; 18(1):127-32.
    View in: PubMed
    Score: 0.074
  107. Tanaka H, Desouza CA, Jones PP, Stevenson ET, Davy KP, Seals DR. Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women. J Appl Physiol (1985). 1997 Dec; 83(6):1947-53.
    View in: PubMed
    Score: 0.074
  108. Stevenson ET, DeSouza CA, Jones PP, Van Pelt RE, Seals DR. Physically active women demonstrate less adverse age-related changes in plasma lipids and lipoproteins. Am J Cardiol. 1997 Nov 15; 80(10):1360-4.
    View in: PubMed
    Score: 0.073
  109. Van Pelt RE, Jones PP, Davy KP, Desouza CA, Tanaka H, Davy BM, Seals DR. Regular exercise and the age-related decline in resting metabolic rate in women. J Clin Endocrinol Metab. 1997 Oct; 82(10):3208-12.
    View in: PubMed
    Score: 0.073
  110. Rossman MJ, Kaplon RE, Hill SD, McNamara MN, Santos-Parker JR, Pierce GL, Seals DR, Donato AJ. Endothelial cell senescence with aging in healthy humans: prevention by habitual exercise and relation to vascular endothelial function. Am J Physiol Heart Circ Physiol. 2017 Nov 01; 313(5):H890-H895.
    View in: PubMed
    Score: 0.073
  111. Hunt BE, Davy KP, Jones PP, DeSouza CA, Van Pelt RE, Tanaka H, Seals DR. Systemic hemodynamic determinants of blood pressure in women: age, physical activity, and hormone replacement. Am J Physiol. 1997 Aug; 273(2 Pt 2):H777-85.
    View in: PubMed
    Score: 0.072
  112. Davy KP, Jones PP, Seals DR. Influence of age on the sympathetic neural adjustments to alterations in systemic oxygen levels in humans. Am J Physiol. 1997 Aug; 273(2 Pt 2):R690-5.
    View in: PubMed
    Score: 0.072
  113. Miller BF, Seals DR, Hamilton KL. A viewpoint on considering physiological principles to study stress resistance and resilience with aging. Ageing Res Rev. 2017 Sep; 38:1-5.
    View in: PubMed
    Score: 0.072
  114. Fitzgerald MD, Tanaka H, Tran ZV, Seals DR. Age-related declines in maximal aerobic capacity in regularly exercising vs. sedentary women: a meta-analysis. J Appl Physiol (1985). 1997 Jul; 83(1):160-5.
    View in: PubMed
    Score: 0.072
  115. Jones PP, Davy KP, Alexander S, Seals DR. Age-related increase in muscle sympathetic nerve activity is associated with abdominal adiposity. Am J Physiol. 1997 Jun; 272(6 Pt 1):E976-80.
    View in: PubMed
    Score: 0.071
  116. Jones PP, Davy KP, DeSouza CA, van Pelt RE, Seals DR. Absence of age-related decline in total blood volume in physically active females. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2534-40.
    View in: PubMed
    Score: 0.071
  117. Tanaka H, Seals DR. Age and gender interactions in physiological functional capacity: insight from swimming performance. J Appl Physiol (1985). 1997 Mar; 82(3):846-51.
    View in: PubMed
    Score: 0.070
  118. Santos-Parker JR, Strahler TR, Vorwald VM, Pierce GL, Seals DR. Habitual aerobic exercise does not protect against micro- or macrovascular endothelial dysfunction in healthy estrogen-deficient postmenopausal women. J Appl Physiol (1985). 2017 01 01; 122(1):11-19.
    View in: PubMed
    Score: 0.068
  119. Lesniewski LA, Seals DR, Walker AE, Henson GD, Blimline MW, Trott DW, Bosshardt GC, LaRocca TJ, Lawson BR, Zigler MC, Donato AJ. Dietary rapamycin supplementation reverses age-related vascular dysfunction and oxidative stress, while modulating nutrient-sensing, cell cycle, and senescence pathways. Aging Cell. 2017 Feb; 16(1):17-26.
    View in: PubMed
    Score: 0.068
  120. LaRocca TJ, Justice JN, Seals DR, Martens CR. Adding value to a graduate physiology seminar by focusing on public communication skills. Adv Physiol Educ. 2016 Sep; 40(3):365-9.
    View in: PubMed
    Score: 0.068
  121. Davy KP, Evans SL, Stevenson ET, Seals DR. Adiposity and regional body fat distribution in physically active young and middle-aged women. Int J Obes Relat Metab Disord. 1996 Aug; 20(8):777-83.
    View in: PubMed
    Score: 0.067
  122. Pierce GL, Harris SA, Seals DR, Casey DP, Barlow PB, Stauss HM. Estimated aortic stiffness is independently associated with cardiac baroreflex sensitivity in humans: role of ageing and habitual endurance exercise. J Hum Hypertens. 2016 09; 30(9):513-20.
    View in: PubMed
    Score: 0.065
  123. Taylor JA, Hayano J, Seals DR. Lesser vagal withdrawal during isometric exercise with age. J Appl Physiol (1985). 1995 Sep; 79(3):805-11.
    View in: PubMed
    Score: 0.063
  124. Evans SL, Davy KP, Stevenson ET, Seals DR. Physiological determinants of 10-km performance in highly trained female runners of different ages. J Appl Physiol (1985). 1995 May; 78(5):1931-41.
    View in: PubMed
    Score: 0.062
  125. Justice JN, Cesari M, Seals DR, Shively CA, Carter CS. Comparative Approaches to Understanding the Relation Between Aging and Physical Function. J Gerontol A Biol Sci Med Sci. 2016 10; 71(10):1243-53.
    View in: PubMed
    Score: 0.061
  126. Davy KP, Johnson DG, Seals DR. Cardiovascular, plasma norepinephrine, and thermal adjustments to prolonged exercise in young and older healthy humans. Clin Physiol. 1995 Mar; 15(2):169-81.
    View in: PubMed
    Score: 0.061
  127. Esler M, Kaye D, Thompson J, Jennings G, Cox H, Turner A, Lambert G, Seals D. Effects of aging on epinephrine secretion and regional release of epinephrine from the human heart. J Clin Endocrinol Metab. 1995 Feb; 80(2):435-42.
    View in: PubMed
    Score: 0.061
  128. Esler MD, Thompson JM, Kaye DM, Turner AG, Jennings GL, Cox HS, Lambert GW, Seals DR. Effects of aging on the responsiveness of the human cardiac sympathetic nerves to stressors. Circulation. 1995 Jan 15; 91(2):351-8.
    View in: PubMed
    Score: 0.060
  129. Esler MD, Turner AG, Kaye DM, Thompson JM, Kingwell BA, Morris M, Lambert GW, Jennings GL, Cox HS, Seals DR. Aging effects on human sympathetic neuronal function. Am J Physiol. 1995 Jan; 268(1 Pt 2):R278-85.
    View in: PubMed
    Score: 0.060
  130. Ng AV, Callister R, Johnson DG, Seals DR. Endurance exercise training is associated with elevated basal sympathetic nerve activity in healthy older humans. J Appl Physiol (1985). 1994 Sep; 77(3):1366-74.
    View in: PubMed
    Score: 0.059
  131. Fontana L, Kennedy BK, Longo VD, Seals D, Melov S. Medical research: treat ageing. Nature. 2014 Jul 24; 511(7510):405-7.
    View in: PubMed
    Score: 0.058
  132. Ng AV, Callister R, Johnson DG, Seals DR. Sympathetic neural reactivity to stress does not increase with age in healthy humans. Am J Physiol. 1994 Jul; 267(1 Pt 2):H344-53.
    View in: PubMed
    Score: 0.058
  133. Seals DR, Taylor JA, Ng AV, Esler MD. Exercise and aging: autonomic control of the circulation. Med Sci Sports Exerc. 1994 May; 26(5):568-76.
    View in: PubMed
    Score: 0.057
  134. Davy KP, Seals DR. Total blood volume in healthy young and older men. J Appl Physiol (1985). 1994 May; 76(5):2059-62.
    View in: PubMed
    Score: 0.057
  135. Ng AV, Callister R, Johnson DG, Seals DR. Age and gender influence muscle sympathetic nerve activity at rest in healthy humans. Hypertension. 1993 Apr; 21(4):498-503.
    View in: PubMed
    Score: 0.053
  136. Taylor JA, Hand GA, Johnson DG, Seals DR. Augmented forearm vasoconstriction during dynamic exercise in healthy older men. Circulation. 1992 Dec; 86(6):1789-99.
    View in: PubMed
    Score: 0.052
  137. Taylor JA, Hand GA, Johnson DG, Seals DR. Sympathoadrenal-circulatory regulation of arterial pressure during orthostatic stress in young and older men. Am J Physiol. 1992 Nov; 263(5 Pt 2):R1147-55.
    View in: PubMed
    Score: 0.052
  138. Fleenor BS, Seals DR, Zigler ML, Sindler AL. Superoxide-lowering therapy with TEMPOL reverses arterial dysfunction with aging in mice. Aging Cell. 2012 Apr; 11(2):269-76.
    View in: PubMed
    Score: 0.049
  139. Pierce GL, Eskurza I, Walker AE, Fay TN, Seals DR. Sex-specific effects of habitual aerobic exercise on brachial artery flow-mediated dilation in middle-aged and older adults. Clin Sci (Lond). 2011 Jan; 120(1):13-23.
    View in: PubMed
    Score: 0.046
  140. Edwards AG, Donato AJ, Lesniewski LA, Gioscia RA, Seals DR, Moore RL. Life-long caloric restriction elicits pronounced protection of the aged myocardium: a role for AMPK. Mech Ageing Dev. 2010 Nov-Dec; 131(11-12):739-42.
    View in: PubMed
    Score: 0.045
  141. Kregel KC, Tipton CM, Seals DR. Thermal adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats. J Appl Physiol (1985). 1990 Apr; 68(4):1337-42.
    View in: PubMed
    Score: 0.043
  142. LaRocca TJ, Seals DR, Pierce GL. Leukocyte telomere length is preserved with aging in endurance exercise-trained adults and related to maximal aerobic capacity. Mech Ageing Dev. 2010 Feb; 131(2):165-7.
    View in: PubMed
    Score: 0.043
  143. Durrant JR, Seals DR, Connell ML, Russell MJ, Lawson BR, Folian BJ, Donato AJ, Lesniewski LA. Voluntary wheel running restores endothelial function in conduit arteries of old mice: direct evidence for reduced oxidative stress, increased superoxide dismutase activity and down-regulation of NADPH oxidase. J Physiol. 2009 Jul 01; 587(Pt 13):3271-85.
    View in: PubMed
    Score: 0.041
  144. Pierce GL, Lesniewski LA, Lawson BR, Beske SD, Seals DR. Nuclear factor-{kappa}B activation contributes to vascular endothelial dysfunction via oxidative stress in overweight/obese middle-aged and older humans. Circulation. 2009 Mar 10; 119(9):1284-92.
    View in: PubMed
    Score: 0.040
  145. Hagberg JM, Yerg JE, Seals DR. Pulmonary function in young and older athletes and untrained men. J Appl Physiol (1985). 1988 Jul; 65(1):101-5.
    View in: PubMed
    Score: 0.038
  146. Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol (1985). 2007 Nov; 103(5):1715-21.
    View in: PubMed
    Score: 0.037
  147. Mazzaro L, Almasi SJ, Shandas R, Seals DR, Gates PE. Aortic input impedance increases with age in healthy men and women. Hypertension. 2005 Jun; 45(6):1101-6.
    View in: PubMed
    Score: 0.031
  148. Seals DR, Hagberg JM, Hurley BF, Ehsani AA, Holloszy JO. Endurance training in older men and women. I. Cardiovascular responses to exercise. J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct; 57(4):1024-9.
    View in: PubMed
    Score: 0.030
  149. Seals DR, Hurley BF, Schultz J, Hagberg JM. Endurance training in older men and women II. Blood lactate response to submaximal exercise. J Appl Physiol Respir Environ Exerc Physiol. 1984 Oct; 57(4):1030-3.
    View in: PubMed
    Score: 0.030
  150. Seals DR, Hagberg JM, Allen WK, Hurley BF, Dalsky GP, Ehsani AA, Holloszy JO. Glucose tolerance in young and older athletes and sedentary men. J Appl Physiol Respir Environ Exerc Physiol. 1984 Jun; 56(6):1521-5.
    View in: PubMed
    Score: 0.029
  151. Murray KO, Maurer GS, Gioscia-Ryan RA, Zigler MC, Ludwig KR, D'Alessandro A, Reisz JA, Rossman MJ, Seals DR, Clayton ZS. The plasma metabolome is associated with preservation of physiological function following lifelong aerobic exercise in mice. Geroscience. 2024 06; 46(3):3311-3324.
    View in: PubMed
    Score: 0.028
  152. Freeberg KA, Udovich CC, Martens CR, Seals DR, Craighead DH. Dietary Supplementation With NAD+-Boosting Compounds in Humans: Current Knowledge and Future Directions. J Gerontol A Biol Sci Med Sci. 2023 12 01; 78(12):2435-2448.
    View in: PubMed
    Score: 0.028
  153. Cavalier AN, Clayton ZS, Wahl D, Hutton DA, McEntee CM, Seals DR, LaRocca TJ. Protective effects of apigenin on the brain transcriptome with aging. Mech Ageing Dev. 2024 Feb; 217:111889.
    View in: PubMed
    Score: 0.028
  154. Bhasin S, Seals D, Migaud M, Musi N, Baur JA. Nicotinamide Adenine Dinucleotide in Aging Biology: Potential Applications and Many Unknowns. Endocr Rev. 2023 11 09; 44(6):1047-1073.
    View in: PubMed
    Score: 0.028
  155. Gates PE, Gentile CL, Seals DR, Christou DD. Adiposity contributes to differences in left ventricular structure and diastolic function with age in healthy men. J Clin Endocrinol Metab. 2003 Oct; 88(10):4884-90.
    View in: PubMed
    Score: 0.028
  156. Longtine AG, Venkatasubramanian R, Zigler MC, Lindquist AJ, Mahoney SA, Greenberg NT, VanDongen NS, Ludwig KR, Moreau KL, Seals DR, Clayton ZS. Female C57BL/6N mice are a viable model of aortic aging in women. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H893-H904.
    View in: PubMed
    Score: 0.027
  157. Seals DR. Habitual exercise and the age-associated decline in large artery compliance. Exerc Sport Sci Rev. 2003 Apr; 31(2):68-72.
    View in: PubMed
    Score: 0.027
  158. Moreau KL, Donato AJ, Seals DR, DeSouza CA, Tanaka H. Regular exercise, hormone replacement therapy and the age-related decline in carotid arterial compliance in healthy women. Cardiovasc Res. 2003 Mar; 57(3):861-8.
    View in: PubMed
    Score: 0.026
  159. Pimentel AE, Gentile CL, Tanaka H, Seals DR, Gates PE. Greater rate of decline in maximal aerobic capacity with age in endurance-trained than in sedentary men. J Appl Physiol (1985). 2003 Jun; 94(6):2406-13.
    View in: PubMed
    Score: 0.026
  160. Donato AJ, Tench K, Glueck DH, Seals DR, Eskurza I, Tanaka H. Declines in physiological functional capacity with age: a longitudinal study in peak swimming performance. J Appl Physiol (1985). 2003 Feb; 94(2):764-9.
    View in: PubMed
    Score: 0.026
  161. Casso AG, VanDongen NS, Gioscia-Ryan RA, Clayton ZS, Greenberg NT, Ziemba BP, Hutton DA, Neilson AP, Davy KP, Seals DR, Brunt VE. Initiation of 3,3-dimethyl-1-butanol at midlife prevents endothelial dysfunction and attenuates in vivo aortic stiffening with ageing in mice. J Physiol. 2022 11; 600(21):4633-4651.
    View in: PubMed
    Score: 0.026
  162. Shannon OM, Clifford T, Seals DR, Craighead DH, Rossman MJ. Nitric oxide, aging and aerobic exercise: Sedentary individuals to Master's athletes. Nitric Oxide. 2022 08 01; 125-126:31-39.
    View in: PubMed
    Score: 0.025
  163. Tanaka H, Seals DR, Monahan KD, Clevenger CM, DeSouza CA, Dinenno FA. Regular aerobic exercise and the age-related increase in carotid artery intima-media thickness in healthy men. J Appl Physiol (1985). 2002 Apr; 92(4):1458-64.
    View in: PubMed
    Score: 0.025
  164. Bell C, Seals DR, Monroe MB, Day DS, Shapiro LF, Johnson DG, Jones PP. Tonic sympathetic support of metabolic rate is attenuated with age, sedentary lifestyle, and female sex in healthy adults. J Clin Endocrinol Metab. 2001 Sep; 86(9):4440-4.
    View in: PubMed
    Score: 0.024
  165. Cavalier AN, Clayton ZS, Hutton DA, Wahl D, Lark DS, Reisz JA, Melov S, Campisi J, Seals DR, LaRocca TJ. Accelerated aging of the brain transcriptome by the common chemotherapeutic doxorubicin. Exp Gerontol. 2021 09; 152:111451.
    View in: PubMed
    Score: 0.024
  166. Dinenno FA, Seals DR, DeSouza CA, Tanaka H. Age-related decreases in basal limb blood flow in humans: time course, determinants and habitual exercise effects. J Physiol. 2001 Mar 01; 531(Pt 2):573-9.
    View in: PubMed
    Score: 0.023
  167. Tanaka H, Dinenno FA, Monahan KD, Clevenger CM, DeSouza CA, Seals DR. Aging, habitual exercise, and dynamic arterial compliance. Circulation. 2000 Sep 12; 102(11):1270-5.
    View in: PubMed
    Score: 0.022
  168. Monroe MB, Van Pelt RE, Schiller BC, Seals DR, Jones PP. Relation of leptin and insulin to adiposity-associated elevations in sympathetic activity with age in humans. Int J Obes Relat Metab Disord. 2000 Sep; 24(9):1183-7.
    View in: PubMed
    Score: 0.022
  169. Dinenno FA, Jones PP, Seals DR, Tanaka H. Age-associated arterial wall thickening is related to elevations in sympathetic activity in healthy humans. Am J Physiol Heart Circ Physiol. 2000 Apr; 278(4):H1205-10.
    View in: PubMed
    Score: 0.022
  170. Dinenno FA, Jones PP, Seals DR, Tanaka H. Limb blood flow and vascular conductance are reduced with age in healthy humans: relation to elevations in sympathetic nerve activity and declines in oxygen demand. Circulation. 1999 Jul 13; 100(2):164-70.
    View in: PubMed
    Score: 0.021
  171. Davy KP, Seals DR, Tanaka H. Augmented cardiopulmonary and integrative sympathetic baroreflexes but attenuated peripheral vasoconstriction with age. Hypertension. 1998 Aug; 32(2):298-304.
    View in: PubMed
    Score: 0.019
  172. Taylor JA, Williams TD, Seals DR, Davy KP. Low-frequency arterial pressure fluctuations do not reflect sympathetic outflow: gender and age differences. Am J Physiol. 1998 04; 274(4):H1194-201.
    View in: PubMed
    Score: 0.019
  173. DeSouza CA, Dengel DR, Macko RF, Cox K, Seals DR. Elevated levels of circulating cell adhesion molecules in uncomplicated essential hypertension. Am J Hypertens. 1997 Dec; 10(12 Pt 1):1335-41.
    View in: PubMed
    Score: 0.018
  174. Hunt BE, Davy KP, Seals DR. Reproducibility of a semiautomated acetylene rebreathing technique for measuring cardiac output in humans at rest. Clin Physiol. 1997 Nov; 17(6):599-607.
    View in: PubMed
    Score: 0.018
  175. Pagliassotti MJ, Estrada AL, Hudson WM, Wei Y, Wang D, Seals DR, Zigler ML, LaRocca TJ. Trehalose supplementation reduces hepatic endoplasmic reticulum stress and inflammatory signaling in old mice. J Nutr Biochem. 2017 07; 45:15-23.
    View in: PubMed
    Score: 0.018
  176. Jasperse JL, Seals DR, Callister R. Active forearm blood flow adjustments to handgrip exercise in young and older healthy men. J Physiol. 1994 Jan 15; 474(2):353-60.
    View in: PubMed
    Score: 0.014
  177. Seals DR, Hagberg JM, Spina RJ, Rogers MA, Schechtman KB, Ehsani AA. Enhanced left ventricular performance in endurance trained older men. Circulation. 1994 Jan; 89(1):198-205.
    View in: PubMed
    Score: 0.014
  178. Taylor JA, Hand GA, Johnson DG, Seals DR. Sympathoadrenal-circulatory regulation during sustained isometric exercise in young and older men. Am J Physiol. 1991 Nov; 261(5 Pt 2):R1061-9.
    View in: PubMed
    Score: 0.012
  179. Kregel KC, Johnson DG, Tipton CM, Seals DR. Cardiovascular-sympathetic adjustments to nonexertional heat stress in mature and senescent Fischer 344 rats. J Appl Physiol (1985). 1990 Dec; 69(6):2043-9.
    View in: PubMed
    Score: 0.011
  180. Hagberg JM, Seals DR, Yerg JE, Gavin J, Gingerich R, Premachandra B, Holloszy JO. Metabolic responses to exercise in young and older athletes and sedentary men. J Appl Physiol (1985). 1988 Aug; 65(2):900-8.
    View in: PubMed
    Score: 0.010
  181. Hagberg JM, Allen WK, Seals DR, Hurley BF, Ehsani AA, Holloszy JO. A hemodynamic comparison of young and older endurance athletes during exercise. J Appl Physiol (1985). 1985 Jun; 58(6):2041-6.
    View in: PubMed
    Score: 0.008
  182. Allen WK, Seals DR, Hurley BF, Ehsani AA, Hagberg JM. Lactate threshold and distance-running performance in young and older endurance athletes. J Appl Physiol (1985). 1985 Apr; 58(4):1281-4.
    View in: PubMed
    Score: 0.008
  183. Yerg JE, Seals DR, Hagberg JM, Holloszy JO. Effect of endurance exercise training on ventilatory function in older individuals. J Appl Physiol (1985). 1985 Mar; 58(3):791-4.
    View in: PubMed
    Score: 0.008
  184. Bell C, Monahan KD, Donato AJ, Hunt BE, Seals DR, Beck KC. Use of acetylene breathing to determine cardiac output in young and older adults. Med Sci Sports Exerc. 2003 Jan; 35(1):58-64.
    View in: PubMed
    Score: 0.007
  185. Moreau KL, Donato AJ, Seals DR, Dinenno FA, Blackett SD, Hoetzer GL, Desouza CA, Tanaka H. Arterial intima-media thickness: site-specific associations with HRT and habitual exercise. Am J Physiol Heart Circ Physiol. 2002 Oct; 283(4):H1409-17.
    View in: PubMed
    Score: 0.006
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