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Connection

Theodore Randolph to Protein Conformation

This is a "connection" page, showing publications Theodore Randolph has written about Protein Conformation.

 
Connection Strength
  
 
 
1.754
  
  1. Chisholm CF, Soucie KR, Song JS, Strauch P, Torres RM, Carpenter JF, Ragheb JA, Randolph TW. Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models. J Pharm Sci. 2017 06; 106(6):1519-1527.
    View in: PubMed
    Score: 0.109
  2. Hassett KJ, Meinerz NM, Semmelmann F, Cousins MC, Garcea RL, Randolph TW. Development of a highly thermostable, adjuvanted human papillomavirus vaccine. Eur J Pharm Biopharm. 2015 Aug; 94:220-8.
    View in: PubMed
    Score: 0.097
  3. Fradkin AH, Mozziconacci O, Sch?neich C, Carpenter JF, Randolph TW. UV photodegradation of murine growth hormone: chemical analysis and immunogenicity consequences. Eur J Pharm Biopharm. 2014 Jul; 87(2):395-402.
    View in: PubMed
    Score: 0.090
  4. Britt KA, Schwartz DK, Wurth C, Mahler HC, Carpenter JF, Randolph TW. Excipient effects on humanized monoclonal antibody interactions with silicone oil emulsions. J Pharm Sci. 2012 Dec; 101(12):4419-32.
    View in: PubMed
    Score: 0.080
  5. Cordes AA, Carpenter JF, Randolph TW. Accelerated stability studies of abatacept formulations: comparison of freeze-thawing- and agitation-induced stresses. J Pharm Sci. 2012 Jul; 101(7):2307-15.
    View in: PubMed
    Score: 0.078
  6. Cordes AA, Platt CW, Carpenter JF, Randolph TW. Selective domain stabilization as a strategy to reduce fusion protein aggregation. J Pharm Sci. 2012 Apr; 101(4):1400-9.
    View in: PubMed
    Score: 0.077
  7. Alford JR, Fowler AC, Wuttke DS, Kerwin BA, Latypov RF, Carpenter JF, Randolph TW. Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. J Pharm Sci. 2011 Oct; 100(10):4215-24.
    View in: PubMed
    Score: 0.073
  8. Salinas BA, Sathish HA, Shah AU, Carpenter JF, Randolph TW. Buffer-dependent fragmentation of a humanized full-length monoclonal antibody. J Pharm Sci. 2010 Jul; 99(7):2962-74.
    View in: PubMed
    Score: 0.069
  9. Fast JL, Cordes AA, Carpenter JF, Randolph TW. Physical instability of a therapeutic Fc fusion protein: domain contributions to conformational and colloidal stability. Biochemistry. 2009 Dec 15; 48(49):11724-36.
    View in: PubMed
    Score: 0.066
  10. Fradkin AH, Carpenter JF, Randolph TW. Immunogenicity of aggregates of recombinant human growth hormone in mouse models. J Pharm Sci. 2009 Sep; 98(9):3247-64.
    View in: PubMed
    Score: 0.065
  11. Crisman RL, Randolph TW. Refolding of proteins from inclusion bodies is favored by a diminished hydrophobic effect at elevated pressures. Biotechnol Bioeng. 2009 Feb 01; 102(2):483-92.
    View in: PubMed
    Score: 0.062
  12. Clausi AL, Morin A, Carpenter JF, Randolph TW. Influence of protein conformation and adjuvant aggregation on the effectiveness of aluminum hydroxide adjuvant in a model alkaline phosphatase vaccine. J Pharm Sci. 2009 Jan; 98(1):114-21.
    View in: PubMed
    Score: 0.062
  13. Alford JR, Kendrick BS, Carpenter JF, Randolph TW. High concentration formulations of recombinant human interleukin-1 receptor antagonist: II. Aggregation kinetics. J Pharm Sci. 2008 Aug; 97(8):3005-21.
    View in: PubMed
    Score: 0.060
  14. Seefeldt MB, Kim YS, Tolley KP, Seely J, Carpenter JF, Randolph TW. High-pressure studies of aggregation of recombinant human interleukin-1 receptor antagonist: thermodynamics, kinetics, and application to accelerated formulation studies. Protein Sci. 2005 Sep; 14(9):2258-66.
    View in: PubMed
    Score: 0.049
  15. Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci. 2005 Feb; 94(2):256-74.
    View in: PubMed
    Score: 0.047
  16. Kim YS, Jones LS, Dong A, Kendrick BS, Chang BS, Manning MC, Randolph TW, Carpenter JF. Effects of sucrose on conformational equilibria and fluctuations within the native-state ensemble of proteins. Protein Sci. 2003 Jun; 12(6):1252-61.
    View in: PubMed
    Score: 0.042
  17. Chi EY, Krishnan S, Kendrick BS, Chang BS, Carpenter JF, Randolph TW. Roles of conformational stability and colloidal stability in the aggregation of recombinant human granulocyte colony-stimulating factor. Protein Sci. 2003 May; 12(5):903-13.
    View in: PubMed
    Score: 0.042
  18. St John RJ, Carpenter JF, Randolph TW. High-pressure refolding of disulfide-cross-linked lysozyme aggregates: thermodynamics and optimization. Biotechnol Prog. 2002 May-Jun; 18(3):565-71.
    View in: PubMed
    Score: 0.039
  19. Carpenter JF, Chang BS, Garzon-Rodriguez W, Randolph TW. Rational design of stable lyophilized protein formulations: theory and practice. Pharm Biotechnol. 2002; 13:109-33.
    View in: PubMed
    Score: 0.038
  20. St John RJ, Carpenter JF, Balny C, Randolph TW. High pressure refolding of recombinant human growth hormone from insoluble aggregates. Structural transformations, kinetic barriers, and energetics. J Biol Chem. 2001 Dec 14; 276(50):46856-63.
    View in: PubMed
    Score: 0.038
  21. DePaz RA, Barnett CC, Dale DA, Carpenter JF, Gaertner AL, Randolph TW. The excluding effects of sucrose on a protein chemical degradation pathway: methionine oxidation in subtilisin. Arch Biochem Biophys. 2000 Dec 01; 384(1):123-32.
    View in: PubMed
    Score: 0.035
  22. Jones LS, Cipolla D, Liu J, Shire SJ, Randolph TW. Investigation of protein-surfactant interactions by analytical ultracentrifugation and electron paramagnetic resonance: the use of recombinant human tissue factor as an example. Pharm Res. 1999 Jun; 16(6):808-12.
    View in: PubMed
    Score: 0.032
  23. Heller MC, Carpenter JF, Randolph TW. Conformational stability of lyophilized PEGylated proteins in a phase-separating system. J Pharm Sci. 1999 Jan; 88(1):58-64.
    View in: PubMed
    Score: 0.031
  24. Carpenter JF, Kendrick BS, Chang BS, Manning MC, Randolph TW. Inhibition of stress-induced aggregation of protein therapeutics. Methods Enzymol. 1999; 309:236-55.
    View in: PubMed
    Score: 0.031
  25. Kendrick BS, Cleland JL, Lam X, Nguyen T, Randolph TW, Manning MC, Carpenter JF. Aggregation of recombinant human interferon gamma: kinetics and structural transitions. J Pharm Sci. 1998 Sep; 87(9):1069-76.
    View in: PubMed
    Score: 0.030
  26. Randolph TW. Phase separation of excipients during lyophilization: effects on protein stability. J Pharm Sci. 1997 Nov; 86(11):1198-203.
    View in: PubMed
    Score: 0.029
  27. Zhou C, Qi W, Lewis EN, Randolph TW, Carpenter JF. Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20. J Pharm Sci. 2016 08; 105(8):2302-9.
    View in: PubMed
    Score: 0.026
  28. Mehta SB, Lewus R, Bee JS, Randolph TW, Carpenter JF. Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation. J Pharm Sci. 2015 Apr; 104(4):1282-90.
    View in: PubMed
    Score: 0.024
  29. Mehta SB, Bee JS, Randolph TW, Carpenter JF. Partial unfolding of a monoclonal antibody: role of a single domain in driving protein aggregation. Biochemistry. 2014 May 27; 53(20):3367-77.
    View in: PubMed
    Score: 0.023
  30. Basu P, Blake-Haskins AW, O'Berry KB, Randolph TW, Carpenter JF. Albinterferon a2b adsorption to silicone oil-water interfaces: effects on protein conformation, aggregation, and subvisible particle formation. J Pharm Sci. 2014 Feb; 103(2):427-36.
    View in: PubMed
    Score: 0.022
  31. Liu L, Qi W, Schwartz DK, Randolph TW, Carpenter JF. The effects of excipients on protein aggregation during agitation: an interfacial shear rheology study. J Pharm Sci. 2013 Aug; 102(8):2460-70.
    View in: PubMed
    Score: 0.021
  32. Chou DK, Krishnamurthy R, Manning MC, Randolph TW, Carpenter JF. Effects of solution conditions on methionine oxidation in albinterferon alfa-2b and the role of oxidation in its conformation and aggregation. J Pharm Sci. 2013 Feb; 102(2):660-73.
    View in: PubMed
    Score: 0.020
  33. Chou DK, Krishnamurthy R, Manning MC, Randolph TW, Carpenter JF. Physical stability of albinterferon-a(2b) in aqueous solution: effects of conformational stability and colloidal stability on aggregation. J Pharm Sci. 2012 Aug; 101(8):2702-19.
    View in: PubMed
    Score: 0.020
  34. Cleland JL, Randolph TW. Mechanism of polyethylene glycol interaction with the molten globule folding intermediate of bovine carbonic anhydrase B. J Biol Chem. 1992 Feb 15; 267(5):3147-53.
    View in: PubMed
    Score: 0.019
  35. Bai S, Manning MC, Randolph TW, Carpenter JF. Aggregation of recombinant human botulinum protein antigen serotype C in varying solution conditions: implications of conformational stability for aggregation kinetics. J Pharm Sci. 2011 Mar; 100(3):836-48.
    View in: PubMed
    Score: 0.017
  36. Vessely C, Estey T, Randolph TW, Henderson I, Cooper J, Nayar R, Braun LJ, Carpenter JF. Stability of a trivalent recombinant protein vaccine formulation against botulinum neurotoxin during storage in aqueous solution. J Pharm Sci. 2009 Sep; 98(9):2970-93.
    View in: PubMed
    Score: 0.016
  37. Thirumangalathu R, Krishnan S, Ricci MS, Brems DN, Randolph TW, Carpenter JF. Silicone oil- and agitation-induced aggregation of a monoclonal antibody in aqueous solution. J Pharm Sci. 2009 Sep; 98(9):3167-81.
    View in: PubMed
    Score: 0.016
  38. Clark DS, Skerker PS, Randolph TW, Blanch HW, Prausnitz JM. Conformational analyses of enzymes and substrates in processing environments. Ann N Y Acad Sci. 1988; 542:16-29.
    View in: PubMed
    Score: 0.014
  39. Thirumangalathu R, Krishnan S, Bondarenko P, Speed-Ricci M, Randolph TW, Carpenter JF, Brems DN. Oxidation of methionine residues in recombinant human interleukin-1 receptor antagonist: implications of conformational stability on protein oxidation kinetics. Biochemistry. 2007 May 29; 46(21):6213-24.
    View in: PubMed
    Score: 0.014
  40. Lee SH, Carpenter JF, Chang BS, Randolph TW, Kim YS. Effects of solutes on solubilization and refolding of proteins from inclusion bodies with high hydrostatic pressure. Protein Sci. 2006 Feb; 15(2):304-13.
    View in: PubMed
    Score: 0.013
  41. Chi EY, Krishnan S, Randolph TW, Carpenter JF. Physical stability of proteins in aqueous solution: mechanism and driving forces in nonnative protein aggregation. Pharm Res. 2003 Sep; 20(9):1325-36.
    View in: PubMed
    Score: 0.011
  42. Kendrick BS, Chang BS, Arakawa T, Peterson B, Randolph TW, Manning MC, Carpenter JF. Preferential exclusion of sucrose from recombinant interleukin-1 receptor antagonist: role in restricted conformational mobility and compaction of native state. Proc Natl Acad Sci U S A. 1997 Oct 28; 94(22):11917-22.
    View in: PubMed
    Score: 0.007
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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