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Connection

Theodore Randolph to Protein Aggregates

This is a "connection" page, showing publications Theodore Randolph has written about Protein Aggregates.

 
Connection Strength
  
 
 
5.495
  
  1. Snell JR, Monticello CR, Her C, Ross EL, Frazer-Abel AA, Carpenter JF, Randolph TW. DEHP Nanodroplets Leached From Polyvinyl Chloride IV Bags Promote Aggregation of IVIG and Activate Complement in Human Serum. J Pharm Sci. 2020 01; 109(1):429-442.
    View in: PubMed
    Score: 0.610
  2. Wu H, Randolph TW. Rapid Quantification of Protein Particles in High-Concentration Antibody Formulations. J Pharm Sci. 2019 03; 108(3):1110-1116.
    View in: PubMed
    Score: 0.583
  3. Daniels AL, Randolph TW. Flow Microscopy Imaging Is Sensitive to Characteristics of Subvisible Particles in Peginesatide Formulations Associated With Severe Adverse Reactions. J Pharm Sci. 2018 05; 107(5):1313-1321.
    View in: PubMed
    Score: 0.554
  4. Maddux NR, Daniels AL, Randolph TW. Microflow Imaging Analyses Reflect Mechanisms of Aggregate Formation: Comparing Protein Particle Data Sets Using the Kullback-Leibler Divergence. J Pharm Sci. 2017 05; 106(5):1239-1248.
    View in: PubMed
    Score: 0.517
  5. Snell JR, Zhou C, Carpenter JF, Randolph TW. Particle Formation and Aggregation of a Therapeutic Protein in Nanobubble Suspensions. J Pharm Sci. 2016 10; 105(10):3057-3063.
    View in: PubMed
    Score: 0.499
  6. Mehta SB, Carpenter JF, Randolph TW. Colloidal Instability Fosters Agglomeration of Subvisible Particles Created by Rupture of Gels of a Monoclonal Antibody Formed at Silicone Oil-Water Interfaces. J Pharm Sci. 2016 08; 105(8):2338-48.
    View in: PubMed
    Score: 0.498
  7. Ludwig DB, Webb JN, Fern?ndez C, Carpenter JF, Randolph TW. Quaternary conformational stability: the effect of reversible self-association on the fibrillation of two insulin analogs. Biotechnol Bioeng. 2011 Oct; 108(10):2359-70.
    View in: PubMed
    Score: 0.347
  8. Movafaghi S, Daniels AL, Kelly MD, Witeof AE, Calderon CP, Randolph TW, Goodwin AP. Hydrogel Coatings on Container Surfaces Reduce Protein Aggregation Caused by Mechanical Stress and Cavitation. ACS Appl Bio Mater. 2021 09 20; 4(9):6946-6953.
    View in: PubMed
    Score: 0.177
  9. Witeof AE, Daniels AL, Rea LT, Movafaghi S, Kurtz K, Davis M, Eveland RW, Calderon CP, Randolph TW. Machine Learning and Accelerated Stress Approaches to Differentiate Potential Causes of Aggregation in Polyclonal Antibody Formulations During Shipping. J Pharm Sci. 2021 07; 110(7):2743-2752.
    View in: PubMed
    Score: 0.171
  10. Daniels AL, Calderon CP, Randolph TW. Machine learning and statistical analyses for extracting and characterizing "fingerprints" of antibody aggregation at container interfaces from flow microscopy images. Biotechnol Bioeng. 2020 11; 117(11):3322-3335.
    View in: PubMed
    Score: 0.165
  11. Chisholm CF, Behnke W, Pokhilchuk Y, Frazer-Abel AA, Randolph TW. Subvisible Particles in IVIg Formulations Activate Complement in Human Serum. J Pharm Sci. 2020 01; 109(1):558-565.
    View in: PubMed
    Score: 0.156
  12. Snell JR, Kumar NSK, Suryanarayanan R, Randolph TW. Nanobubbles in Reconstituted Lyophilized Formulations: Interaction With Proteins and Mechanism of Formation. J Pharm Sci. 2020 01; 109(1):284-292.
    View in: PubMed
    Score: 0.151
  13. Gandhi AV, Randolph TW, Carpenter JF. Conjugation of Emtansine Onto Trastuzumab Promotes Aggregation of the Antibody-Drug Conjugate by Reducing Repulsive Electrostatic Interactions and Increasing Hydrophobic Interactions. J Pharm Sci. 2019 06; 108(6):1973-1983.
    View in: PubMed
    Score: 0.149
  14. Pardeshi NN, Zhou C, Randolph TW, Carpenter JF. Protein Nanoparticles Promote Microparticle Formation in Intravenous Immunoglobulin Solutions During Freeze-Thawing and Agitation Stresses. J Pharm Sci. 2018 07; 107(7):1852-1857.
    View in: PubMed
    Score: 0.140
  15. Sorret LL, DeWinter MA, Schwartz DK, Randolph TW. Protein-protein interactions controlling interfacial aggregation of rhIL-1ra are not described by simple colloid models. Protein Sci. 2018 07; 27(7):1191-1204.
    View in: PubMed
    Score: 0.139
  16. Chisholm CF, Soucie KR, Song JS, Strauch P, Torres RM, Carpenter JF, Ragheb JA, Randolph TW. Immunogenicity of Structurally Perturbed Hen Egg Lysozyme Adsorbed to Silicone Oil Microdroplets in Wild-Type and Transgenic Mouse Models. J Pharm Sci. 2017 06; 106(6):1519-1527.
    View in: PubMed
    Score: 0.130
  17. Zhou C, Qi W, Lewis EN, Randolph TW, Carpenter JF. Reduced Subvisible Particle Formation in Lyophilized Intravenous Immunoglobulin Formulations Containing Polysorbate 20. J Pharm Sci. 2016 08; 105(8):2302-9.
    View in: PubMed
    Score: 0.124
  18. Randolph TW, Schiltz E, Sederstrom D, Steinmann D, Mozziconacci O, Sch?neich C, Freund E, Ricci MS, Carpenter JF, Lengsfeld CS. Do not drop: mechanical shock in vials causes cavitation, protein aggregation, and particle formation. J Pharm Sci. 2015 Feb; 104(2):602-11.
    View in: PubMed
    Score: 0.111
  19. Alford JR, Fowler AC, Wuttke DS, Kerwin BA, Latypov RF, Carpenter JF, Randolph TW. Effect of benzyl alcohol on recombinant human interleukin-1 receptor antagonist structure and hydrogen-deuterium exchange. J Pharm Sci. 2011 Oct; 100(10):4215-24.
    View in: PubMed
    Score: 0.087
  20. Calderon CP, Ripple DC, Srinivasan C, Ma Y, Carrier MJ, Randolph TW, O'Connor TF. Testing Precision Limits of Neural Network-Based Quality Control Metrics in High-Throughput Digital Microscopy. Pharm Res. 2022 Feb; 39(2):263-279.
    View in: PubMed
    Score: 0.046
  21. Nejadnik MR, Randolph TW, Volkin DB, Sch?neich C, Carpenter JF, Crommelin DJA, Jiskoot W. Postproduction Handling and Administration of Protein Pharmaceuticals and Potential Instability Issues. J Pharm Sci. 2018 08; 107(8):2013-2019.
    View in: PubMed
    Score: 0.035
  22. Jiskoot W, Kijanka G, Randolph TW, Carpenter JF, Koulov AV, Mahler HC, Joubert MK, Jawa V, Narhi LO. Mouse Models for Assessing Protein Immunogenicity: Lessons and Challenges. J Pharm Sci. 2016 05; 105(5):1567-1575.
    View in: PubMed
    Score: 0.030
  23. Mehta SB, Lewus R, Bee JS, Randolph TW, Carpenter JF. Gelation of a monoclonal antibody at the silicone oil-water interface and subsequent rupture of the interfacial gel results in aggregation and particle formation. J Pharm Sci. 2015 Apr; 104(4):1282-90.
    View in: PubMed
    Score: 0.028
  24. Teska BM, Alarc?n J, Pettis RJ, Randolph TW, Carpenter JF. Effects of phenol and meta-cresol depletion on insulin analog stability at physiological temperature. J Pharm Sci. 2014 Aug; 103(8):2255-67.
    View in: PubMed
    Score: 0.027
  25. Bee JS, Randolph TW, Carpenter JF, Bishop SM, Dimitrova MN. Effects of surfaces and leachables on the stability of biopharmaceuticals. J Pharm Sci. 2011 Oct; 100(10):4158-70.
    View in: PubMed
    Score: 0.022
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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