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Connection

Theodore Randolph to Freeze Drying

This is a "connection" page, showing publications Theodore Randolph has written about Freeze Drying.

 
Connection Strength
  
 
 
4.203
  
  1. Snell JR, Kumar NSK, Suryanarayanan R, Randolph TW. Nanobubbles in Reconstituted Lyophilized Formulations: Interaction With Proteins and Mechanism of Formation. J Pharm Sci. 2020 01; 109(1):284-292.
    View in: PubMed
    Score: 0.645
  2. Katayama DS, Carpenter JF, Menard KP, Manning MC, Randolph TW. Mixing properties of lyophilized protein systems: a spectroscopic and calorimetric study. J Pharm Sci. 2009 Sep; 98(9):2954-69.
    View in: PubMed
    Score: 0.330
  3. Clausi AL, Merkley SA, Carpenter JF, Randolph TW. Inhibition of aggregation of aluminum hydroxide adjuvant during freezing and drying. J Pharm Sci. 2008 Jun; 97(6):2049-61.
    View in: PubMed
    Score: 0.302
  4. Carpenter JF, Chang BS, Garzon-Rodriguez W, Randolph TW. Rational design of stable lyophilized protein formulations: theory and practice. Pharm Biotechnol. 2002; 13:109-33.
    View in: PubMed
    Score: 0.194
  5. Preston KB, Wong TAS, To A, Tashiro TE, Lieberman MM, Granados A, Feliciano K, Harrison J, Yalley-Ogunro J, Elyard HA, Donini O, Lehrer AT, Randolph TW. Single-vial filovirus glycoprotein vaccines: Biophysical characteristics and immunogenicity after co-lyophilization with adjuvant. Vaccine. 2021 09 15; 39(39):5650-5657.
    View in: PubMed
    Score: 0.189
  6. Searles JA, Carpenter JF, Randolph TW. The ice nucleation temperature determines the primary drying rate of lyophilization for samples frozen on a temperature-controlled shelf. J Pharm Sci. 2001 Jul; 90(7):860-71.
    View in: PubMed
    Score: 0.187
  7. Searles JA, Carpenter JF, Randolph TW. Annealing to optimize the primary drying rate, reduce freezing-induced drying rate heterogeneity, and determine T(g)' in pharmaceutical lyophilization. J Pharm Sci. 2001 Jul; 90(7):872-87.
    View in: PubMed
    Score: 0.187
  8. Preston KB, Randolph TW. Stability of lyophilized and spray dried vaccine formulations. Adv Drug Deliv Rev. 2021 04; 171:50-61.
    View in: PubMed
    Score: 0.181
  9. Heller MC, Carpenter JF, Randolph TW. Application of a thermodynamic model to the prediction of phase separations in freeze-concentrated formulations for protein lyophilization. Arch Biochem Biophys. 1999 Mar 15; 363(2):191-201.
    View in: PubMed
    Score: 0.160
  10. Chisholm CF, Kang TJ, Dong M, Lewis K, Namekar M, Lehrer AT, Randolph TW. Thermostable Ebola virus vaccine formulations lyophilized in the presence of aluminum hydroxide. Eur J Pharm Biopharm. 2019 Mar; 136:213-220.
    View in: PubMed
    Score: 0.158
  11. Qi W, Orgel S, Francon A, Randolph TW, Carpenter JF. Urea Improves Stability of Inactivated Polio Vaccine Serotype 3 During Lyophilization and Storage in Dried Formulations. J Pharm Sci. 2018 08; 107(8):2070-2078.
    View in: PubMed
    Score: 0.150
  12. Heller MC, Carpenter JF, Randolph TW. Manipulation of lyophilization-induced phase separation: implications for pharmaceutical proteins. Biotechnol Prog. 1997 Sep-Oct; 13(5):590-6.
    View in: PubMed
    Score: 0.143
  13. Hassett KJ, Meinerz NM, Semmelmann F, Cousins MC, Garcea RL, Randolph TW. Development of a highly thermostable, adjuvanted human papillomavirus vaccine. Eur J Pharm Biopharm. 2015 Aug; 94:220-8.
    View in: PubMed
    Score: 0.122
  14. Hassett KJ, Vance DJ, Jain NK, Sahni N, Rabia LA, Cousins MC, Joshi S, Volkin DB, Middaugh CR, Mantis NJ, Carpenter JF, Randolph TW. Glassy-state stabilization of a dominant negative inhibitor anthrax vaccine containing aluminum hydroxide and glycopyranoside lipid A adjuvants. J Pharm Sci. 2015 Feb; 104(2):627-39.
    View in: PubMed
    Score: 0.119
  15. Xu Y, Grobelny P, Von Allmen A, Knudson K, Pikal M, Carpenter JF, Randolph TW. Protein quantity on the air-solid interface determines degradation rates of human growth hormone in lyophilized samples. J Pharm Sci. 2014 May; 103(5):1356-66.
    View in: PubMed
    Score: 0.113
  16. Hassett KJ, Cousins MC, Rabia LA, Chadwick CM, O'Hara JM, Nandi P, Brey RN, Mantis NJ, Carpenter JF, Randolph TW. Stabilization of a recombinant ricin toxin A subunit vaccine through lyophilization. Eur J Pharm Biopharm. 2013 Oct; 85(2):279-86.
    View in: PubMed
    Score: 0.106
  17. Fradkin AH, Carpenter JF, Randolph TW. Immunogenicity of aggregates of recombinant human growth hormone in mouse models. J Pharm Sci. 2009 Sep; 98(9):3247-64.
    View in: PubMed
    Score: 0.082
  18. Clausi A, Cummiskey J, Merkley S, Carpenter JF, Braun LJ, Randolph TW. Influence of particle size and antigen binding on effectiveness of aluminum salt adjuvants in a model lysozyme vaccine. J Pharm Sci. 2008 Dec; 97(12):5252-62.
    View in: PubMed
    Score: 0.078
  19. Roy S, Henderson I, Nayar R, Randolph TW, Carpenter JF. Effect of pH on stability of recombinant botulinum serotype A vaccine in aqueous solution and during storage of freeze-dried formulations. J Pharm Sci. 2008 Dec; 97(12):5132-46.
    View in: PubMed
    Score: 0.078
  20. Chi EY, Weickmann J, Carpenter JF, Manning MC, Randolph TW. Heterogeneous nucleation-controlled particulate formation of recombinant human platelet-activating factor acetylhydrolase in pharmaceutical formulation. J Pharm Sci. 2005 Feb; 94(2):256-74.
    View in: PubMed
    Score: 0.060
  21. Webb SD, Cleland JL, Carpenter JF, Randolph TW. Effects of annealing lyophilized and spray-lyophilized formulations of recombinant human interferon-gamma. J Pharm Sci. 2003 Apr; 92(4):715-29.
    View in: PubMed
    Score: 0.053
  22. Webb SD, Golledge SL, Cleland JL, Carpenter JF, Randolph TW. Surface adsorption of recombinant human interferon-gamma in lyophilized and spray-lyophilized formulations. J Pharm Sci. 2002 Jun; 91(6):1474-87.
    View in: PubMed
    Score: 0.050
  23. Webb SD, Koval CA, Randolph CM, Randolph TW. Electrochemical determination of dissolution rates of lyophilized pharmaceutical formulations. Anal Chem. 2001 Nov 01; 73(21):5296-301.
    View in: PubMed
    Score: 0.048
  24. Jones LS, Randolph TW, Kohnert U, Papadimitriou A, Winter G, Hagmann ML, Manning MC, Carpenter JF. The effects of Tween 20 and sucrose on the stability of anti-L-selectin during lyophilization and reconstitution. J Pharm Sci. 2001 Oct; 90(10):1466-77.
    View in: PubMed
    Score: 0.048
  25. Heller MC, Carpenter JF, Randolph TW. Protein formulation and lyophilization cycle design: prevention of damage due to freeze-concentration induced phase separation. Biotechnol Bioeng. 1999 Apr 20; 63(2):166-74.
    View in: PubMed
    Score: 0.040
  26. Heller MC, Carpenter JF, Randolph TW. Conformational stability of lyophilized PEGylated proteins in a phase-separating system. J Pharm Sci. 1999 Jan; 88(1):58-64.
    View in: PubMed
    Score: 0.039
  27. Carpenter JF, Kendrick BS, Chang BS, Manning MC, Randolph TW. Inhibition of stress-induced aggregation of protein therapeutics. Methods Enzymol. 1999; 309:236-55.
    View in: PubMed
    Score: 0.039
  28. Randolph TW. Phase separation of excipients during lyophilization: effects on protein stability. J Pharm Sci. 1997 Nov; 86(11):1198-203.
    View in: PubMed
    Score: 0.036
  29. Carpenter JF, Pikal MJ, Chang BS, Randolph TW. Rational design of stable lyophilized protein formulations: some practical advice. Pharm Res. 1997 Aug; 14(8):969-75.
    View in: PubMed
    Score: 0.036
  30. Heller MC, Carpenter JF, Randolph TW. Effects of phase separating systems on lyophilized hemoglobin. J Pharm Sci. 1996 Dec; 85(12):1358-62.
    View in: PubMed
    Score: 0.034
  31. Zhou C, Cleland D, Snell J, Qi W, Randolph TW, Carpenter JF. Formation of Stable Nanobubbles on Reconstituting Lyophilized Formulations Containing Trehalose. J Pharm Sci. 2016 07; 105(7):2249-53.
    View in: PubMed
    Score: 0.033
  32. Izutsu K, Yomota C, Okuda H, Kawanishi T, Randolph TW, Carpenter JF. Impact of heat treatment on miscibility of proteins and disaccharides in frozen solutions. Eur J Pharm Biopharm. 2013 Oct; 85(2):177-83.
    View in: PubMed
    Score: 0.027
  33. Payton NM, Wempe MF, Betker JL, Randolph TW, Anchordoquy TJ. Lyophilization of a triply unsaturated phospholipid: effects of trace metal contaminants. Eur J Pharm Biopharm. 2013 Oct; 85(2):306-13.
    View in: PubMed
    Score: 0.026
  34. Katayama DS, Carpenter JF, Manning MC, Randolph TW, Setlow P, Menard KP. Characterization of amorphous solids with weak glass transitions using high ramp rate differential scanning calorimetry. J Pharm Sci. 2008 Feb; 97(2):1013-24.
    View in: PubMed
    Score: 0.018
  35. Roy S, Jung R, Kerwin BA, Randolph TW, Carpenter JF. Effects of benzyl alcohol on aggregation of recombinant human interleukin-1-receptor antagonist in reconstituted lyophilized formulations. J Pharm Sci. 2005 Feb; 94(2):382-96.
    View in: PubMed
    Score: 0.015
  36. Garzon-Rodriguez W, Koval RL, Chongprasert S, Krishnan S, Randolph TW, Warne NW, Carpenter JF. Optimizing storage stability of lyophilized recombinant human interleukin-11 with disaccharide/hydroxyethyl starch mixtures. J Pharm Sci. 2004 Mar; 93(3):684-96.
    View in: PubMed
    Score: 0.014
  37. Anchordoquy TJ, Izutsu KI, Randolph TW, Carpenter JF. Maintenance of quaternary structure in the frozen state stabilizes lactate dehydrogenase during freeze-drying. Arch Biochem Biophys. 2001 Jun 01; 390(1):35-41.
    View in: PubMed
    Score: 0.012
  38. Allison SD, Manning MC, Randolph TW, Middleton K, Davis A, Carpenter JF. Optimization of storage stability of lyophilized actin using combinations of disaccharides and dextran. J Pharm Sci. 2000 Feb; 89(2):199-214.
    View in: PubMed
    Score: 0.011
  39. Allison SD, Chang B, Randolph TW, Carpenter JF. Hydrogen bonding between sugar and protein is responsible for inhibition of dehydration-induced protein unfolding. Arch Biochem Biophys. 1999 May 15; 365(2):289-98.
    View in: PubMed
    Score: 0.010
  40. Kreilgaard L, Frokjaer S, Flink JM, Randolph TW, Carpenter JF. Effects of additives on the stability of Humicola lanuginosa lipase during freeze-drying and storage in the dried solid. J Pharm Sci. 1999 Mar; 88(3):281-90.
    View in: PubMed
    Score: 0.010
  41. Kreilgaard L, Frokjaer S, Flink JM, Randolph TW, Carpenter JF. Effects of additives on the stability of recombinant human factor XIII during freeze-drying and storage in the dried solid. Arch Biochem Biophys. 1998 Dec 01; 360(1):121-34.
    View in: PubMed
    Score: 0.010
  42. Allison SD, Randolph TW, Manning MC, Middleton K, Davis A, Carpenter JF. Effects of drying methods and additives on structure and function of actin: mechanisms of dehydration-induced damage and its inhibition. Arch Biochem Biophys. 1998 Oct 01; 358(1):171-81.
    View in: PubMed
    Score: 0.010
Connection Strength

The connection strength for concepts is the sum of the scores for each matching publication.

Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.

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