 Connection
Kenneth MacLean to Homocystinuria
This is a "connection" page, showing publications Kenneth MacLean has written about Homocystinuria.
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5.639 |
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Maclean KN, Jiang H, Phinney WN, Mclagan BM, Roede JR, Stabler SP. Derangement of hepatic polyamine, folate, and methionine cycle metabolism in cystathionine beta-synthase-deficient homocystinuria in the presence and absence of treatment: Possible implications for pathogenesis. Mol Genet Metab. 2021 02; 132(2):128-138.
Score: 0.691
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Van Hove JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Harrington MJ, Pyle L, Creadon-Swindell G, Wempe MF, MacLean KN. Biomarkers of oxidative stress, inflammation, and vascular dysfunction in inherited cystathionine ?-synthase deficient homocystinuria and the impact of taurine treatment in a phase 1/2 human clinical trial. J Inherit Metab Dis. 2019 05; 42(3):424-437.
Score: 0.612
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Maclean KN, Jiang H, Phinney WN, Keating AK, Hurt KJ, Stabler SP. Taurine alleviates repression of betaine-homocysteine S-methyltransferase and significantly improves the efficacy of long-term betaine treatment in a mouse model of cystathionine ?-synthase-deficient homocystinuria. FASEB J. 2019 05; 33(5):6339-6353.
Score: 0.605
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Maclean KN, Jiang H, Aivazidis S, Kim E, Shearn CT, Harris PS, Petersen DR, Allen RH, Stabler SP, Roede JR. Taurine treatment prevents derangement of the hepatic ?-glutamyl cycle and methylglyoxal metabolism in a mouse model of classical homocystinuria: regulatory crosstalk between thiol and sulfinic acid metabolism. FASEB J. 2018 03; 32(3):1265-1280.
Score: 0.560
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Jacobs RL, Jiang H, Kennelly JP, Orlicky DJ, Allen RH, Stabler SP, Maclean KN. Cystathionine beta-synthase deficiency alters hepatic phospholipid and choline metabolism: Post-translational repression of phosphatidylethanolamine N-methyltransferase is a consequence rather than a cause of liver injury in homocystinuria. Mol Genet Metab. 2017 04; 120(4):325-336.
Score: 0.529
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Jiang H, Stabler SP, Allen RH, Abman SH, Maclean KN. Altered hepatic sulfur metabolism in cystathionine ?-synthase-deficient homocystinuria: regulatory role of taurine on competing cysteine oxidation pathways. FASEB J. 2014 Sep; 28(9):4044-54.
Score: 0.437
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Maclean KN, Greiner LS, Evans JR, Sood SK, Lhotak S, Markham NE, Stabler SP, Allen RH, Austin RC, Balasubramaniam V, Jiang H. Cystathionine protects against endoplasmic reticulum stress-induced lipid accumulation, tissue injury, and apoptotic cell death. J Biol Chem. 2012 Sep 14; 287(38):31994-2005.
Score: 0.385
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Jiang H, Stabler SP, Allen RH, Maclean KN. Altered expression of apoA-I, apoA-IV and PON-1 activity in CBS deficient homocystinuria in the presence and absence of treatment: possible implications for cardiovascular outcomes. Mol Genet Metab. 2012 Sep; 107(1-2):55-65.
Score: 0.378
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Maclean KN, Jiang H, Greiner LS, Allen RH, Stabler SP. Long-term betaine therapy in a murine model of cystathionine beta-synthase deficient homocystinuria: decreased efficacy over time reveals a significant threshold effect between elevated homocysteine and thrombotic risk. Mol Genet Metab. 2012 Mar; 105(3):395-403.
Score: 0.367
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Keating AK, Freehauf C, Jiang H, Brodsky GL, Stabler SP, Allen RH, Graham DK, Thomas JA, Van Hove JL, Maclean KN. Constitutive induction of pro-inflammatory and chemotactic cytokines in cystathionine beta-synthase deficient homocystinuria. Mol Genet Metab. 2011 Aug; 103(4):330-7.
Score: 0.353
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Maclean KN, Sikora J, Ko?ich V, Jiang H, Greiner LS, Kraus E, Krijt J, Overdier KH, Collard R, Brodsky GL, Meltesen L, Crnic LS, Allen RH, Stabler SP, Elleder M, Rozen R, Patterson D, Kraus JP. A novel transgenic mouse model of CBS-deficient homocystinuria does not incur hepatic steatosis or fibrosis and exhibits a hypercoagulative phenotype that is ameliorated by betaine treatment. Mol Genet Metab. 2010 Oct-Nov; 101(2-3):153-62.
Score: 0.332
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Maclean KN, Sikora J, Ko?ich V, Jiang H, Greiner LS, Kraus E, Krijt J, Crnic LS, Allen RH, Stabler SP, Elleder M, Kraus JP. Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment. Mol Genet Metab. 2010 Oct-Nov; 101(2-3):163-71.
Score: 0.332
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Bar-Or D, Curtis CG, Sullivan A, Rael LT, Thomas GW, Craun M, Bar-Or R, Maclean KN, Kraus JP. Plasma albumin cysteinylation is regulated by cystathionine beta-synthase. Biochem Biophys Res Commun. 2004 Dec 24; 325(4):1449-53.
Score: 0.057
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Connection Strength
The connection strength for concepts is the sum of the scores for each matching publication.
Publication scores are based on many factors, including how long ago they were written and whether the person is a first or senior author.
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