 Chlorpromazine
"Chlorpromazine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The prototypical phenothiazine antipsychotic drug. Like the other drugs in this class chlorpromazine's antipsychotic actions are thought to be due to long-term adaptation by the brain to blocking DOPAMINE RECEPTORS. Chlorpromazine has several other actions and therapeutic uses, including as an antiemetic and in the treatment of intractable hiccup.
| Descriptor ID |
D002746
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| MeSH Number(s) |
D02.886.369.198 D03.633.300.741.198
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| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Chlorpromazine".
Below are MeSH descriptors whose meaning is more specific than "Chlorpromazine".
This graph shows the total number of publications written about "Chlorpromazine" by people in this website by year, and whether "Chlorpromazine" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2004 | 0 | 1 | 1 | | 2014 | 1 | 0 | 1 |
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Below are the most recent publications written about "Chlorpromazine" by people in Profiles.
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Huff LS, Prado R, Pederson JF, Dunnick CA, Lucas LM. Chlorpromazine-induced skin pigmentation with corneal and lens opacities. Cutis. 2014 May; 93(5):247-50.
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Riffell JL, Zimmerman C, Khong A, McHardy LM, Roberge M. Effects of chemical manipulation of mitotic arrest and slippage on cancer cell survival and proliferation. Cell Cycle. 2009 Sep 15; 8(18):3025-38.
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Ray RS, Agrawal N, Sharma A, Hans RK. Use of L-929 cell line for phototoxicity assessment. Toxicol In Vitro. 2008 Oct; 22(7):1775-81.
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Law AJ, Hutchinson LJ, Burnet PW, Harrison PJ. Antipsychotics increase microtubule-associated protein 2 mRNA but not spinophilin mRNA in rat hippocampus and cortex. J Neurosci Res. 2004 May 01; 76(3):376-82.
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Relling MV, Mulhern RK, Fairclough D, Baker D, Pui CH. Chlorpromazine with and without lorazepam as antiemetic therapy in children receiving uniform chemotherapy. J Pediatr. 1993 Nov; 123(5):811-6.
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Burkhardt C, Kelly JP, Lim YH, Filley CM, Parker WD. Neuroleptic medications inhibit complex I of the electron transport chain. Ann Neurol. 1993 May; 33(5):512-7.
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Changeux JP, Pinset C, Ribera AB. Effects of chlorpromazine and phencyclidine on mouse C2 acetylcholine receptor kinetics. J Physiol. 1986 Sep; 378:497-513.
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Pokras R, Tabakoff B. On the mechanism by which dopamine inhibits prolactin release in the anterior pituitary. Life Sci. 1982 Dec 06; 31(23):2587-93.
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Gardos G, Cole JO. Maintenance antipsychotic therapy: is the cure worse than the disease? Am J Psychiatry. 1976 Jan; 133(1):32-6.
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Erwin VG, Heston WD, Tabakoff B. Purification and characterization of an NADH-linked aldehyde reductase from bovine brain. J Neurochem. 1972 Oct; 19(10):2269-78.
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