 Pentostatin
"Pentostatin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A potent inhibitor of ADENOSINE DEAMINASE. The drug induces APOPTOSIS of LYMPHOCYTES, and is used in the treatment of many lymphoproliferative malignancies, particularly HAIRY CELL LEUKEMIA. It is also synergistic with some other antineoplastic agents and has immunosuppressive activity.
| Descriptor ID |
D015649
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| MeSH Number(s) |
D03.383.742.680.350.200.700 D13.570.230.677 D13.570.685.350.200.700
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| Concept/Terms |
Pentostatin- Pentostatin
- Deoxycoformycin
- Co-Vidarabine
- 2'-Deoxycoformycin
- 2' Deoxycoformycin
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Below are MeSH descriptors whose meaning is more general than "Pentostatin".
Below are MeSH descriptors whose meaning is more specific than "Pentostatin".
This graph shows the total number of publications written about "Pentostatin" by people in this website by year, and whether "Pentostatin" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2003 | 1 | 0 | 1 | | 2005 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2016 | 0 | 1 | 1 |
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Below are the most recent publications written about "Pentostatin" by people in Profiles.
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Milgrom SA, Nieto Y, Pinnix CC, Smith GL, Wogan CF, Rondon G, Medeiros LJ, Kebriaei P, Dabaja BS. Graft-versus-host disease after radiation therapy in patients who have undergone allogeneic stem cell transplantation: two case reports. J Med Case Rep. 2016 Jul 28; 10:209.
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Reynolds C, Di Bella N, Lyons RM, Hyman W, Richards DA, Robbins GJ, Vellek M, Boehm KA, Zhan F, Asmar L. A Phase III trial of fludarabine, cyclophosphamide, and rituximab vs. pentostatin, cyclophosphamide, and rituximab in B-cell chronic lymphocytic leukemia. Invest New Drugs. 2012 Jun; 30(3):1232-40.
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Di Bella N, Reynolds C, Faragher D, Muscato J, Boehm KA, Asmar L. An open-label pilot study of pentostatin, mitoxantrone, and rituximab in patients with previously untreated, Stage III or IV, low-grade non-Hodgkin lymphoma. Cancer. 2005 Mar 01; 103(5):978-84.
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Drapkin R, Di Bella NJ, Faragher DC, Harden E, Matei C, Hyman W, Mirabel M, Boehm KA, Asmar L. Results of a phase II multicenter trial of pentostatin and rituximab in patients with low grade B-cell non-Hodgkin's lymphoma: an effective and minimally toxic regimen. Clin Lymphoma. 2003 Dec; 4(3):169-75.
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