Axon Initial Segment
"Axon Initial Segment" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
First segment of axon that connects distal axon segments to the neuronal CELL BODY at the axon hillock region. The axon initial segment is not protected by the MYELIN SHEATH and has properties critical for axonal growth. The axon initial segment and the axon hillock form an axonal trigger zone.
| Descriptor ID |
D000071040
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| MeSH Number(s) |
A08.675.542.145.250 A11.284.180.075.125 A11.671.137.170 A11.671.501.145.250
|
| Concept/Terms |
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Below are MeSH descriptors whose meaning is more general than "Axon Initial Segment".
Below are MeSH descriptors whose meaning is more specific than "Axon Initial Segment".
This graph shows the total number of publications written about "Axon Initial Segment" by people in this website by year, and whether "Axon Initial Segment" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
|---|
| 2022 | 2 | 0 | 2 |
| 2024 | 1 | 0 | 1 |
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Below are the most recent publications written about "Axon Initial Segment" by people in Profiles.
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Eichel K. Endocytosis in the axon initial segment: Roles in neuronal polarity and plasticity. Curr Opin Neurobiol. 2025 Feb; 90:102949.
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Eichel K, Uenaka T, Belapurkar V, Lu R, Cheng S, Pak JS, Taylor CA, S?dhof TC, Malenka R, Wernig M, ?zkan E, Perrais D, Shen K. Endocytosis in the axon initial segment maintains neuronal polarity. Nature. 2022 09; 609(7925):128-135.
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Eichel K, Shen K. The function of the axon initial segment in neuronal polarity. Dev Biol. 2022 09; 489:47-54.