 Solid-Phase Synthesis Techniques
"Solid-Phase Synthesis Techniques" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
Techniques used to synthesize chemicals using molecular substrates that are bound to a solid surface. Typically a series of reactions are conducted on the bound substrate that results in either the covalent attachment of specific moieties or the modification of existing function groups. These techniques offer an advantage to those involving solution reactions in that the substrate compound does not have to be isolated and purified between the reaction steps.
| Descriptor ID |
D060327
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| MeSH Number(s) |
E05.197.500 J01.897.836.249.500
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| Concept/Terms |
Solid-Phase Synthesis Techniques- Solid-Phase Synthesis Techniques
- Solid Phase Synthesis Techniques
- Solid-Phase Synthesis Technique
- Synthesis Technique, Solid-Phase
- Synthesis Techniques, Solid-Phase
- Technique, Solid-Phase Synthesis
- Techniques, Solid-Phase Synthesis
- Solid-Phase Synthesis Methods
- Method, Solid-Phase Synthesis
- Methods, Solid-Phase Synthesis
- Solid Phase Synthesis Methods
- Solid-Phase Synthesis Method
- Synthesis Method, Solid-Phase
- Synthesis Methods, Solid-Phase
Solid-Phase Synthesis- Solid-Phase Synthesis
- Solid Phase Synthesis
- Solid-Phase Syntheses
- Syntheses, Solid-Phase
- Synthesis, Solid-Phase
- Synthesis, Solid Phase
Solid-Phase Peptide Synthesis- Solid-Phase Peptide Synthesis
- Peptide Syntheses, Solid-Phase
- Solid Phase Peptide Synthesis
- Solid-Phase Peptide Syntheses
- Syntheses, Solid-Phase Peptide
- Synthesis, Solid-Phase Peptide
- Peptide Synthesis, Solid-Phase
- Peptide Synthesis, Solid Phase
Solid-Phase Nucleotide Synthesis- Solid-Phase Nucleotide Synthesis
- Nucleotide Syntheses, Solid-Phase
- Nucleotide Synthesis, Solid-Phase
- Solid Phase Nucleotide Synthesis
- Solid-Phase Nucleotide Syntheses
- Syntheses, Solid-Phase Nucleotide
- Synthesis, Solid-Phase Nucleotide
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Below are MeSH descriptors whose meaning is more general than "Solid-Phase Synthesis Techniques".
Below are MeSH descriptors whose meaning is more specific than "Solid-Phase Synthesis Techniques".
This graph shows the total number of publications written about "Solid-Phase Synthesis Techniques" by people in this website by year, and whether "Solid-Phase Synthesis Techniques" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2011 | 1 | 1 | 2 | | 2012 | 0 | 1 | 1 | | 2014 | 0 | 2 | 2 | | 2015 | 0 | 1 | 1 | | 2017 | 0 | 1 | 1 | | 2019 | 1 | 0 | 1 | | 2021 | 1 | 0 | 1 | | 2022 | 0 | 1 | 1 | | 2023 | 0 | 1 | 1 |
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Below are the most recent publications written about "Solid-Phase Synthesis Techniques" by people in Profiles.
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Powell WC, Jing R, Walczak MA. Chemical Synthesis of Microtubule-Associated Protein Tau. J Am Chem Soc. 2023 10 04; 145(39):21514-21526.
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Zhu F, Miller E, Powell WC, Johnson K, Beggs A, Evenson GE, Walczak MA. Umpolung AlaB Reagents for the Synthesis of Non-Proteogenic Amino Acids, Peptides and Proteins. Angew Chem Int Ed Engl. 2022 08 01; 61(31):e202207153.
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Romanucci V, Giordano M, Pagano R, Agarwal C, Agarwal R, Zarrelli A, Di Fabio G. Solid-phase synthesis of curcumin mimics and their anticancer activity against human pancreatic, prostate, and colorectal cancer cell lines. Bioorg Med Chem. 2021 07 15; 42:116249.
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Kostov O, Liboska R, P?v O, Nov?k P, Rosenberg I. Solid-Phase Synthesis of Phosphorothioate/Phosphonothioate and Phosphoramidate/Phosphonamidate Oligonucleotides. Molecules. 2019 May 15; 24(10).
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Murata H, Carmali S, Baker SL, Matyjaszewski K, Russell AJ. Solid-phase synthesis of protein-polymers on reversible immobilization supports. Nat Commun. 2018 02 27; 9(1):845.
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Francis AJ, Resendiz MJE. Protocol for the Solid-phase Synthesis of Oligomers of RNA Containing a 2'-O-thiophenylmethyl Modification and Characterization via Circular Dichroism. J Vis Exp. 2017 07 28; (125).
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Juliano SA, Pierce S, deMayo JA, Balunas MJ, Angeles-Boza AM. Exploration of the Innate Immune System of Styela clava: Zn2+ Binding Enhances the Antimicrobial Activity of the Tunicate Peptide Clavanin A. Biochemistry. 2017 03 14; 56(10):1403-1414.
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Monfregola L, Caruthers MH. Solid-Phase Synthesis, Hybridizing Ability, Uptake, and Nuclease Resistant Profiles of Position-Selective Cationic and Hydrophobic Phosphotriester Oligonucleotides. J Org Chem. 2015 Sep 18; 80(18):9147-58.
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Ryan DM, Coggins MK, Concepcion JJ, Ashford DL, Fang Z, Alibabaei L, Ma D, Meyer TJ, Waters ML. Synthesis and electrocatalytic water oxidation by electrode-bound helical peptide chromophore-catalyst assemblies. Inorg Chem. 2014 Aug 04; 53(15):8120-8.
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Collins JM, Porter KA, Singh SK, Vanier GS. High-efficiency solid phase peptide synthesis (HE-SPPS). Org Lett. 2014 Feb 07; 16(3):940-3.
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