Dystonin
"Dystonin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A plakin characterized by repeat sequences homologous to SPECTRIN and PLECTIN and C-terminal EF HAND MOTIFS. It functions as an integrator of INTERMEDIATE FILAMENTS, ACTIN and MICROTUBULES in cytoskeleton networks. It is required for anchoring intermediate filaments to the actin cytoskeleton in neural and muscle cells as well as anchoring KERATIN-containing intermediate filaments to HEMIDESMOSOMES in EPITHELIAL CELLS.
| Descriptor ID |
D000071821
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| MeSH Number(s) |
D12.776.220.790.625
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| Concept/Terms |
Dystonin- Dystonin
- Bullous Pemphigoid Antigen 1
- 230-240 kDa Bullous Pemphigoid Antigen
- 230 240 kDa Bullous Pemphigoid Antigen
- Hemidesmosomal Plaque Protein
- 230 kDa Bullous Pemphigoid Antigen
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Below are MeSH descriptors whose meaning is more general than "Dystonin".
Below are MeSH descriptors whose meaning is more specific than "Dystonin".
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Below are the most recent publications written about "Dystonin" by people in Profiles.
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Borradori L, Koch PJ, Niessen CM, Erkeland S, van Leusden MR, Sonnenberg A. The localization of bullous pemphigoid antigen 180 (BP180) in hemidesmosomes is mediated by its cytoplasmic domain and seems to be regulated by the beta4 integrin subunit. J Cell Biol. 1997 Mar 24; 136(6):1333-47.
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Stanley JR, Tanaka T, Mueller S, Klaus-Kovtun V, Roop D. Isolation of complementary DNA for bullous pemphigoid antigen by use of patients' autoantibodies. J Clin Invest. 1988 Dec; 82(6):1864-70.