 Succinate-Semialdehyde Dehydrogenase
"Succinate-Semialdehyde Dehydrogenase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An enzyme that plays a role in the GLUTAMATE and butanoate metabolism pathways by catalyzing the oxidation of succinate semialdehyde to SUCCINATE using NAD+ as a coenzyme. Deficiency of this enzyme, causes 4-hydroxybutyricaciduria, a rare inborn error in the metabolism of the neurotransmitter 4-aminobutyric acid (GABA).
| Descriptor ID |
D050644
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| MeSH Number(s) |
D08.811.682.657.163.843
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| Concept/Terms |
Succinate-Semialdehyde Dehydrogenase- Succinate-Semialdehyde Dehydrogenase
- Dehydrogenase, Succinate-Semialdehyde
- Succinate Semialdehyde Dehydrogenase
- Dehydrogenase, Succinate Semialdehyde
- Semialdehyde Dehydrogenase, Succinate
- Succinic Semialdehyde Dehydrogenase
- Dehydrogenase, Succinic Semialdehyde
- Semialdehyde Dehydrogenase, Succinic
- NAD(+)-Dependent Succinic Semialdehyde Dehydrogenase
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Below are MeSH descriptors whose meaning is more general than "Succinate-Semialdehyde Dehydrogenase".
Below are MeSH descriptors whose meaning is more specific than "Succinate-Semialdehyde Dehydrogenase".
This graph shows the total number of publications written about "Succinate-Semialdehyde Dehydrogenase" by people in this website by year, and whether "Succinate-Semialdehyde Dehydrogenase" was a major or minor topic of these publications.
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| Year | Major Topic | Minor Topic | Total |
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| 2019 | 0 | 1 | 1 |
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Below are the most recent publications written about "Succinate-Semialdehyde Dehydrogenase" by people in Profiles.
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Jung HY, Kwon HJ, Kim W, Nam SM, Kim JW, Hahn KR, Yoo DY, Yoon YS, Choi SY, Kim DW, Hwang IK. Role of pyridoxine in GABA synthesis and degradation in the hippocampus. Tissue Cell. 2019 Dec; 61:72-78.
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Gibson KM, Goodman SI, Frerman FE, Glasgow AM. Succinic semialdehyde dehydrogenase deficiency associated with combined 4-hydroxybutyric and dicarboxylic acidurias: potential for clinical misdiagnosis based on urinary organic acid profiling. J Pediatr. 1989 Apr; 114(4 Pt 1):607-10.
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