 Alu Elements
"Alu Elements" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The Alu sequence family (named for the restriction endonuclease cleavage enzyme Alu I) is the most highly repeated interspersed repeat element in humans (over a million copies). It is derived from the 7SL RNA component of the SIGNAL RECOGNITION PARTICLE and contains an RNA polymerase III promoter. Transposition of this element into coding and regulatory regions of genes is responsible for many heritable diseases.
| Descriptor ID |
D020087
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| MeSH Number(s) |
G02.111.570.080.708.330.800.800.050 G05.360.080.708.330.800.800.050 G05.360.340.024.425.800.800.050
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| Concept/Terms |
Alu Elements- Alu Elements
- Alu Element
- Element, Alu
- Elements, Alu
- Alu Family
- Alu Families
- Families, Alu
- Family, Alu
- Alu Repetitive Sequences
- Alu Repetitive Sequence
- Repetitive Sequence, Alu
- Repetitive Sequences, Alu
- Sequence, Alu Repetitive
- Sequences, Alu Repetitive
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Below are MeSH descriptors whose meaning is more general than "Alu Elements".
Below are MeSH descriptors whose meaning is more specific than "Alu Elements".
This graph shows the total number of publications written about "Alu Elements" by people in this website by year, and whether "Alu Elements" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1998 | 0 | 1 | 1 | | 2000 | 2 | 1 | 3 | | 2007 | 1 | 0 | 1 | | 2008 | 1 | 1 | 2 | | 2009 | 1 | 0 | 1 | | 2010 | 0 | 2 | 2 | | 2011 | 2 | 0 | 2 | | 2012 | 3 | 0 | 3 | | 2013 | 1 | 0 | 1 | | 2014 | 1 | 0 | 1 | | 2016 | 2 | 0 | 2 | | 2021 | 1 | 0 | 1 |
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Below are the most recent publications written about "Alu Elements" by people in Profiles.
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Nichols PJ, Bevers S, Henen M, Kieft JS, Vicens Q, V?geli B. Recognition of non-CpG repeats in Alu and ribosomal RNAs by the Z-RNA binding domain of ADAR1 induces A-Z junctions. Nat Commun. 2021 02 04; 12(1):793.
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Meyer TJ, Held U, Nevonen KA, Klawitter S, Pirzer T, Carbone L, Schumann GG. The Flow of the Gibbon LAVA Element Is Facilitated by the LINE-1 Retrotransposition Machinery. Genome Biol Evol. 2016 10 30; 8(10):3209-3225.
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Lin L, Jiang P, Park JW, Wang J, Lu ZX, Lam MP, Ping P, Xing Y. The contribution of Alu exons to the human proteome. Genome Biol. 2016 Jan 28; 17:15.
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Cardiello JF, Kugel JF, Goodrich JA. A new twist on cell growth control. Cell Cycle. 2014; 13(22):3474-5.
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Perng W, Villamor E, Shroff MR, Nettleton JA, Pilsner JR, Liu Y, Diez-Roux AV. Dietary intake, plasma homocysteine, and repetitive element DNA methylation in the Multi-Ethnic Study of Atherosclerosis (MESA). Nutr Metab Cardiovasc Dis. 2014 Jun; 24(6):614-22.
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McLain AT, Meyer TJ, Faulk C, Herke SW, Oldenburg JM, Bourgeois MG, Abshire CF, Roos C, Batzer MA. An alu-based phylogeny of lemurs (infraorder: Lemuriformes). PLoS One. 2012; 7(8):e44035.
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Meyer TJ, McLain AT, Oldenburg JM, Faulk C, Bourgeois MG, Conlin EM, Mootnick AR, de Jong PJ, Roos C, Carbone L, Batzer MA. An Alu-based phylogeny of gibbons (hylobatidae). Mol Biol Evol. 2012 Nov; 29(11):3441-50.
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Tarallo V, Hirano Y, Gelfand BD, Dridi S, Kerur N, Kim Y, Cho WG, Kaneko H, Fowler BJ, Bogdanovich S, Albuquerque RJ, Hauswirth WW, Chiodo VA, Kugel JF, Goodrich JA, Ponicsan SL, Chaudhuri G, Murphy MP, Dunaief JL, Ambati BK, Ogura Y, Yoo JW, Lee DK, Provost P, Hinton DR, N??ez G, Baffi JZ, Kleinman ME, Ambati J. DICER1 loss and Alu RNA induce age-related macular degeneration via the NLRP3 inflammasome and MyD88. Cell. 2012 May 11; 149(4):847-59.
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de Koning AP, Gu W, Castoe TA, Batzer MA, Pollock DD. Repetitive elements may comprise over two-thirds of the human genome. PLoS Genet. 2011 Dec; 7(12):e1002384.
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Kaneko H, Dridi S, Tarallo V, Gelfand BD, Fowler BJ, Cho WG, Kleinman ME, Ponicsan SL, Hauswirth WW, Chiodo VA, Karik? K, Yoo JW, Lee DK, Hadziahmetovic M, Song Y, Misra S, Chaudhuri G, Buaas FW, Braun RE, Hinton DR, Zhang Q, Grossniklaus HE, Provis JM, Madigan MC, Milam AH, Justice NL, Albuquerque RJ, Blandford AD, Bogdanovich S, Hirano Y, Witta J, Fuchs E, Littman DR, Ambati BK, Rudin CM, Chong MM, Provost P, Kugel JF, Goodrich JA, Dunaief JL, Baffi JZ, Ambati J. DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. Nature. 2011 Mar 17; 471(7338):325-30.
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