 Receptor, Epidermal Growth Factor
"Receptor, Epidermal Growth Factor" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A cell surface receptor involved in regulation of cell growth and differentiation. It is specific for EPIDERMAL GROWTH FACTOR and EGF-related peptides including TRANSFORMING GROWTH FACTOR ALPHA; AMPHIREGULIN; and HEPARIN-BINDING EGF-LIKE GROWTH FACTOR. The binding of ligand to the receptor causes activation of its intrinsic tyrosine kinase activity and rapid internalization of the receptor-ligand complex into the cell.
| Descriptor ID |
D011958
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| MeSH Number(s) |
D08.811.913.696.620.682.725.400.009.300 D12.776.543.750.630.009.300 D12.776.543.750.750.360.300 D12.776.543.750.750.400.074.300
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| Concept/Terms |
Receptor, Epidermal Growth Factor- Receptor, Epidermal Growth Factor
- Receptor Tyrosine-protein Kinase erbB-1
- Receptor Tyrosine protein Kinase erbB 1
- Transforming Growth Factor alpha Receptor
- Urogastrone Receptor
- TGF-alpha Receptor
- Epidermal Growth Factor Receptor Kinase
- Epidermal Growth Factor Receptor Protein-Tyrosine Kinase
- Epidermal Growth Factor Receptor Protein Tyrosine Kinase
- erbB-1 Proto-Oncogene Protein
- Proto-Oncogene Protein, erbB-1
- erbB 1 Proto Oncogene Protein
- Receptor, EGF
- Receptor, Urogastrone
- Receptor, Transforming-Growth Factor alpha
- Receptor, Transforming Growth Factor alpha
- Receptor, TGF-alpha
- Receptor, TGF alpha
- c-erbB-1 Protein
- c erbB 1 Protein
- Receptor, ErbB-1
- ErbB-1 Receptor
- Receptor, ErbB 1
- Proto-oncogene c-ErbB-1 Protein
- Proto oncogene c ErbB 1 Protein
- c-ErbB-1 Protein, Proto-oncogene
- EGF Receptor
- Epidermal Growth Factor Receptor
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Below are MeSH descriptors whose meaning is more general than "Receptor, Epidermal Growth Factor".
- Chemicals and Drugs [D]
- Enzymes and Coenzymes [D08]
- Enzymes [D08.811]
- Transferases [D08.811.913]
- Phosphotransferases [D08.811.913.696]
- Phosphotransferases (Alcohol Group Acceptor) [D08.811.913.696.620]
- Protein Kinases [D08.811.913.696.620.682]
- Protein-Tyrosine Kinases [D08.811.913.696.620.682.725]
- Receptor Protein-Tyrosine Kinases [D08.811.913.696.620.682.725.400]
- ErbB Receptors [D08.811.913.696.620.682.725.400.009]
- Receptor, Epidermal Growth Factor [D08.811.913.696.620.682.725.400.009.300]
- Amino Acids, Peptides, and Proteins [D12]
- Proteins [D12.776]
- Membrane Proteins [D12.776.543]
- Receptors, Cell Surface [D12.776.543.750]
- Receptor Protein-Tyrosine Kinases [D12.776.543.750.630]
- ErbB Receptors [D12.776.543.750.630.009]
- Receptor, Epidermal Growth Factor [D12.776.543.750.630.009.300]
- Receptors, Peptide [D12.776.543.750.750]
- Receptors, Gastrointestinal Hormone [D12.776.543.750.750.360]
- Receptor, Epidermal Growth Factor [D12.776.543.750.750.360.300]
- Receptors, Growth Factor [D12.776.543.750.750.400]
- ErbB Receptors [D12.776.543.750.750.400.074]
- Receptor, Epidermal Growth Factor [D12.776.543.750.750.400.074.300]
Below are MeSH descriptors whose meaning is more specific than "Receptor, Epidermal Growth Factor".
This graph shows the total number of publications written about "Receptor, Epidermal Growth Factor" by people in this website by year, and whether "Receptor, Epidermal Growth Factor" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2005 | 0 | 1 | 1 | | 2010 | 2 | 0 | 2 |
To return to the timeline, click here.
Below are the most recent publications written about "Receptor, Epidermal Growth Factor" by people in Profiles.
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Bublil EM, Pines G, Patel G, Fruhwirth G, Ng T, Yarden Y. Kinase-mediated quasi-dimers of EGFR. FASEB J. 2010 Dec; 24(12):4744-55.
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Pines G, Köstler WJ, Yarden Y. Oncogenic mutant forms of EGFR: lessons in signal transduction and targets for cancer therapy. FEBS Lett. 2010 Jun 18; 584(12):2699-706.
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Gemmill RM, Zhou M, Costa L, Korch C, Bukowski RM, Drabkin HA. Synergistic growth inhibition by Iressa and Rapamycin is modulated by VHL mutations in renal cell carcinoma. Br J Cancer. 2005 Jun 20; 92(12):2266-77.
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