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Connection

Michael Mitchell to Mice

This is a "connection" page, showing publications Michael Mitchell has written about Mice.

 
Connection Strength
  
 
 
3.845
  
  1. Zeng Y, Xu J, Wang J, Xue L, Liu J, Geisler HC, Ma X, Melamed JR, Shi Q, Padilla MS, Luo Z, Zhu J, Thatte AS, Figueroa-Espada CG, Ang MJY, Murray AM, Yamagata HM, Kim D, Metzloff AE, Weissman D, Mitchell MJ. mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity. Proc Natl Acad Sci U S A. 2026 Jul 14; 123(28):e2525718123.
    View in: PubMed
    Score: 0.071
  2. Han X, Xu Y, Ricciardi AS, Xu J, Xiang Y, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Reker D, Weissman D, Mitchell MJ. Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Proc Natl Acad Sci U S A. 2026 Jun 02; 123(22):e2528144123.
    View in: PubMed
    Score: 0.070
  3. Yamagata HM, Padilla MS, Hamilton AG, Swingle KL, Thatte AS, Ricciardi AS, Agrawal A, Fitzgerald E, Poirier AJ, Geisler HC, Joseph RA, Chalom OZ, Du S, Li JJ, Kim D, Whitaker RC, Figueroa-Espada CG, Han EL, Murray AM, Alameh MG, Weissman D, Mitchell MJ. Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity. J Am Chem Soc. 2026 04 08; 148(13):14137-14150.
    View in: PubMed
    Score: 0.069
  4. Shi Q, Gong N, Wang J, Palanki R, Zheng Q, Alameh MG, Dwivedi G, Davis B, Melamed J, Luo Z, Xu J, Figueroa-Espada CG, Xue L, Zeng Y, Han X, Kim D, Chen Q, Yamagata H, Geisler HC, El-Mayta R, Yoon IC, Weissman D, Mitchell MJ. Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy. Nat Nanotechnol. 2026 Mar; 21(3):430-442.
    View in: PubMed
    Score: 0.069
  5. Al Dala Ali M, Longepied G, Lévy N, Metzler-Guillemain C, Mitchell MJ. Nucleoporin NUP210L and BAF-paralogue BAF-L redundantly ensure nuclear integrity and manchette microtubule organisation in mouse spermatids. Hum Mol Genet. 2026 Feb 10; 35(3).
    View in: PubMed
    Score: 0.069
  6. Hamilton AG, Thatte AS, Xu J, Luo Z, Safford HC, Swingle KL, Muscat-Rivera J, Kegel M, Han X, Joseph RA, Murray AM, Geisler HC, Whitaker RC, Xue L, Spektor R, Melamed JR, Weissman D, Mitchell MJ. High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering. Adv Mater. 2026 Mar; 38(13):e14370.
    View in: PubMed
    Score: 0.069
  7. Han EL, Kim D, Murray AM, Mrksich K, Hamilton AG, Tang S, Yoo S, Zhu AT, Tong ER, Palanki R, Hall ML, Bedingfield SK, Mitchell MJ. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS Nano. 2026 Feb 03; 20(4):3807-3820.
    View in: PubMed
    Score: 0.069
  8. Wang J, Huang X, Shi Q, Swingle KL, Hamilton AG, Gong N, Mitchell MJ. Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2409564122.
    View in: PubMed
    Score: 0.068
  9. Yoo S, Han EL, Murray AM, Kim D, Bang EK, Mitchell MJ. High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH). Nano Lett. 2025 10 08; 25(40):14695-14703.
    View in: PubMed
    Score: 0.067
  10. Joseph RA, Haley RM, Padilla MS, Ricciardi AS, Yamagata HM, Mitchell MJ. Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair. Nano Lett. 2025 10 01; 25(39):14348-14355.
    View in: PubMed
    Score: 0.067
  11. Swingle KL, Hamilton AG, Han X, Liao KC, Safford HC, Thatte AS, Geisler HC, Xu J, Saw TY, Wan Y, Mitchell MJ. Circular RNA lipid nanoparticle vaccine against SARS-CoV-2. Proc Natl Acad Sci U S A. 2025 Sep 23; 122(38):e2505718122.
    View in: PubMed
    Score: 0.067
  12. Gong N, Kim D, Alameh MG, El-Mayta R, Han EL, Dwivedi G, Palanki R, Shi Q, Han X, Xue L, Xu J, Meng Z, Luo T, Figueroa-Espada CG, Weissman D, Li J, Mitchell MJ. Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity. Nat Biomed Eng. 2025 Dec; 9(12):2181-2195.
    View in: PubMed
    Score: 0.066
  13. Haley RM, Padilla MS, El-Mayta RD, Joseph RA, Weber JA, Figueroa-Espada CG, Mukalel AJ, Ricciardi AS, Palanki R, Geisler HC, Jester MT, Davidson BL, Mitchell MJ. Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets. ACS Nano. 2025 04 15; 19(14):13790-13804.
    View in: PubMed
    Score: 0.065
  14. Safford HC, Shuler CF, Geisler HC, Thatte AS, Swingle KL, Han EL, Murray AM, Hamilton AG, Yamagata HM, Mitchell MJ. Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta. Nano Lett. 2025 03 26; 25(12):4800-4808.
    View in: PubMed
    Score: 0.065
  15. Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat Commun. 2025 Jan 24; 16(1):996.
    View in: PubMed
    Score: 0.064
  16. Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ. Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen. J Am Chem Soc. 2025 01 15; 147(2):1542-1552.
    View in: PubMed
    Score: 0.064
  17. Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 01 15; 25(2):800-810.
    View in: PubMed
    Score: 0.064
  18. Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Nature. 2025 01; 637(8045):412-421.
    View in: PubMed
    Score: 0.064
  19. Han X, Alameh MG, Xu Y, Palanki R, El-Mayta R, Dwivedi G, Swingle KL, Xu J, Gong N, Xue L, Shi Q, Yoon IC, Warzecha CC, Wilson JM, Weissman D, Mitchell MJ. Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nat Biomed Eng. 2024 Nov; 8(11):1412-1424.
    View in: PubMed
    Score: 0.063
  20. Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nat Nanotechnol. 2025 Jan; 20(1):132-143.
    View in: PubMed
    Score: 0.063
  21. Gong N, Zhong W, Alameh MG, Han X, Xue L, El-Mayta R, Zhao G, Vaughan AE, Qin Z, Xu F, Hamilton AG, Kim D, Xu J, Kim J, Teng X, Li J, Liang XJ, Weissman D, Guo W, Mitchell MJ. Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Nat Mater. 2024 Dec; 23(12):1736-1747.
    View in: PubMed
    Score: 0.062
  22. Palanki R, Yamagata H, Mitchell MJ. OLAH connects fatty acid metabolism to the severity of respiratory viral disease. Cell. 2024 Aug 22; 187(17):4549-4551.
    View in: PubMed
    Score: 0.062
  23. Swingle KL, Hamilton AG, Mitchell MJ. Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy. Placenta. 2025 06 13; 166:132-138.
    View in: PubMed
    Score: 0.062
  24. Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ. Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab Chip. 2024 08 06; 24(16):3790-3801.
    View in: PubMed
    Score: 0.062
  25. Han X, Alameh MG, Gong N, Xue L, Ghattas M, Bojja G, Xu J, Zhao G, Warzecha CC, Padilla MS, El-Mayta R, Dwivedi G, Xu Y, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ. Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nat Chem. 2024 10; 16(10):1687-1697.
    View in: PubMed
    Score: 0.062
  26. Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ. High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. ACS Nano. 2024 06 25; 18(25):16151-16165.
    View in: PubMed
    Score: 0.061
  27. Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ. EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. J Control Release. 2024 07; 371:455-469.
    View in: PubMed
    Score: 0.061
  28. Atsavapranee E, Haley RM, Billingsley MM, Chan A, Ruan B, Figueroa-Espada CG, Gong N, Mukalel AJ, Bryan PN, Mitchell MJ. Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation. J Control Release. 2024 06; 370:614-625.
    View in: PubMed
    Score: 0.061
  29. Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Adv Mater. 2024 06; 36(26):e2313226.
    View in: PubMed
    Score: 0.060
  30. Mrksich K, Padilla MS, Joseph RA, Han EL, Kim D, Palanki R, Xu J, Mitchell MJ. Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. J Biomed Mater Res A. 2024 09; 112(9):1494-1505.
    View in: PubMed
    Score: 0.060
  31. Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ. High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nat Commun. 2024 Feb 29; 15(1):1884.
    View in: PubMed
    Score: 0.060
  32. Han X, Xu J, Xu Y, Alameh MG, Xue L, Gong N, El-Mayta R, Palanki R, Warzecha CC, Zhao G, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ. In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nat Commun. 2024 02 26; 15(1):1762.
    View in: PubMed
    Score: 0.060
  33. Gong N, Han X, Xue L, Billingsley MM, Huang X, El-Mayta R, Qin J, Sheppard NC, June CH, Mitchell MJ. Small-molecule-mediated control of the anti-tumour activity and off-tumour toxicity of a supramolecular bispecific T cell engager. Nat Biomed Eng. 2024 May; 8(5):513-528.
    View in: PubMed
    Score: 0.060
  34. Han EL, Padilla MS, Palanki R, Kim D, Mrksich K, Li JJ, Tang S, Yoon IC, Mitchell MJ. Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano Lett. 2024 02 07; 24(5):1477-1486.
    View in: PubMed
    Score: 0.060
  35. Al Dala Ali M, Longepied G, Nicolet A, Metzler-Guillemain C, Mitchell MJ. Spermatozoa in mice lacking the nucleoporin NUP210L show defects in head shape and motility but not in nuclear compaction or histone replacement. Clin Genet. 2024 04; 105(4):364-375.
    View in: PubMed
    Score: 0.059
  36. Safford HC, Swingle KL, Geisler HC, Hamilton AG, Thatte AS, Ghalsasi AA, Billingsley MM, Alameh MG, Weissman D, Mitchell MJ. Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta. Small. 2024 10; 20(41):e2303568.
    View in: PubMed
    Score: 0.058
  37. Han X, Alameh MG, Butowska K, Knox JJ, Lundgreen K, Ghattas M, Gong N, Xue L, Xu Y, Lavertu M, Bates P, Xu J, Nie G, Zhong Y, Weissman D, Mitchell MJ. Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Nat Nanotechnol. 2023 09; 18(9):1105-1114.
    View in: PubMed
    Score: 0.057
  38. Guimarães PPG, Figueroa-Espada CG, Riley RS, Gong N, Xue L, Sewastianik T, Dennis PS, Loebel C, Chung A, Shepherd SJ, Haley RM, Hamilton AG, El-Mayta R, Wang K, Langer R, Anderson DG, Carrasco RD, Mitchell MJ. In vivo bone marrow microenvironment siRNA delivery using lipid-polymer nanoparticles for multiple myeloma therapy. Proc Natl Acad Sci U S A. 2023 06 20; 120(25):e2215711120.
    View in: PubMed
    Score: 0.057
  39. Haley RM, Chan A, Billingsley MM, Gong N, Padilla MS, Kim EH, Wang H, Yin D, Wangensteen KJ, Tsourkas A, Mitchell MJ. Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition. ACS Appl Mater Interfaces. 2023 May 10; 15(18):21877-21892.
    View in: PubMed
    Score: 0.057
  40. El-Mayta R, Padilla MS, Billingsley MM, Han X, Mitchell MJ. Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing. J Vis Exp. 2023 01 20; (191).
    View in: PubMed
    Score: 0.056
  41. Palanki R, Swingle KL, Mitchell MJ. A (Controlled) Spill of IL2 for Localized Treatment of Mesothelioma. Clin Cancer Res. 2022 12 01; 28(23):5010-5012.
    View in: PubMed
    Score: 0.055
  42. Xue L, Gong N, Shepherd SJ, Xiong X, Liao X, Han X, Zhao G, Song C, Huang X, Zhang H, Padilla MS, Qin J, Shi Y, Alameh MG, Pochan DJ, Wang K, Long F, Weissman D, Mitchell MJ. Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J Am Chem Soc. 2022 06 08; 144(22):9926-9937.
    View in: PubMed
    Score: 0.053
  43. Zhang H, Han X, Alameh MG, Shepherd SJ, Padilla MS, Xue L, Butowska K, Weissman D, Mitchell MJ. Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery. J Biomed Mater Res A. 2022 05; 110(5):1101-1108.
    View in: PubMed
    Score: 0.052
  44. Swingle KL, Billingsley MM, Bose SK, White B, Palanki R, Dave A, Patel SK, Gong N, Hamilton AG, Alameh MG, Weissman D, Peranteau WH, Mitchell MJ. Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. J Control Release. 2022 01; 341:616-633.
    View in: PubMed
    Score: 0.051
  45. Shepherd SJ, Warzecha CC, Yadavali S, El-Mayta R, Alameh MG, Wang L, Weissman D, Wilson JM, Issadore D, Mitchell MJ. Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device. Nano Lett. 2021 07 14; 21(13):5671-5680.
    View in: PubMed
    Score: 0.050
  46. Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH, Mitchell MJ. Ionizable lipid nanoparticles for in utero mRNA delivery. Sci Adv. 2021 01; 7(3).
    View in: PubMed
    Score: 0.048
  47. Affara NA, Mitchell MJ. The role of human and mouse Y chromosome genes in male infertility. J Endocrinol Invest. 2000 Nov; 23(10):630-45.
    View in: PubMed
    Score: 0.048
  48. Guimaraes PPG, Zhang R, Spektor R, Tan M, Chung A, Billingsley MM, El-Mayta R, Riley RS, Wang L, Wilson JM, Mitchell MJ. Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. J Control Release. 2019 12 28; 316:404-417.
    View in: PubMed
    Score: 0.045
  49. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome VII. Mouse chromosome Y. Mamm Genome. 1998; 8 Spec No:S378-81.
    View in: PubMed
    Score: 0.039
  50. Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 03 20; 8:14179.
    View in: PubMed
    Score: 0.037
  51. Mitchell MJ, Metzler-Guillemain C, Toure A, Coutton C, Arnoult C, Ray PF. Single gene defects leading to sperm quantitative anomalies. Clin Genet. 2017 02; 91(2):208-216.
    View in: PubMed
    Score: 0.036
  52. Vernet N, Mahadevaiah SK, Decarpentrie F, Longepied G, de Rooij DG, Burgoyne PS, Mitchell MJ. Mouse Y-Encoded Transcription Factor Zfy2 Is Essential for Sperm Head Remodelling and Sperm Tail Development. PLoS One. 2016; 11(1):e0145398.
    View in: PubMed
    Score: 0.034
  53. Bishop CE, Mitchell MJ. Encyclopedia of the mouse genome V. Mouse Y chromosome. Mamm Genome. 1996; 6 Spec No:S331-3.
    View in: PubMed
    Score: 0.034
  54. Decarpentrie F, Ojarikre OA, Mitchell MJ, Burgoyne PS. Recombination between the mouse Y chromosome short arm and an additional Y short arm-derived chromosomal segment attached distal to the X chromosome PAR. Chromosoma. 2016 Jun; 125(2):177-88.
    View in: PubMed
    Score: 0.034
  55. Mitchell MJ, Lin KS, King MR. Fluid shear stress increases neutrophil activation via platelet-activating factor. Biophys J. 2014 May 20; 106(10):2243-53.
    View in: PubMed
    Score: 0.031
  56. Mitchell MJ, King MR. Unnatural killer cells to prevent bloodborne metastasis: inspiration from biology and engineering. Expert Rev Anticancer Ther. 2014 Jun; 14(6):641-4.
    View in: PubMed
    Score: 0.030
  57. Mitchell MJ, Wayne E, Rana K, Schaffer CB, King MR. TRAIL-coated leukocytes that kill cancer cells in the circulation. Proc Natl Acad Sci U S A. 2014 Jan 21; 111(3):930-5.
    View in: PubMed
    Score: 0.030
  58. Decarpentrie F, Vernet N, Mahadevaiah SK, Longepied G, Streichemberger E, Aknin-Seifer I, Ojarikre OA, Burgoyne PS, Metzler-Guillemain C, Mitchell MJ. Human and mouse ZFY genes produce a conserved testis-specific transcript encoding a zinc finger protein with a short acidic domain and modified transactivation potential. Hum Mol Genet. 2012 Jun 15; 21(12):2631-45.
    View in: PubMed
    Score: 0.026
  59. Torborg SR, Kim JY, Singhal A, Grbovic-Huezo O, Holm M, Wu K, Han X, Ho YJ, Haglund C, Mitchell MJ, Lowe SW, Dow LE, Pitter KL, Sanchez-Rivera FJ, Levchenko A, Tammela T. Disruption of WNT/Notch signaling in pancreatic cancer reveals tumors depend on the intricate equilibrium of malignant cell states. Dev Cell. 2026 May 13; 61(5):1012-1027.e8.
    View in: PubMed
    Score: 0.017
  60. Kim JG, Xu J, Lee D, Song J, Lee S, Hong MH, Zhu J, Zhu A, Patwari K, Shim EH, Shin JE, Park OH, Rho J, Ko KC, Lee EG, Kang OY, Won EJ, Kim BH, Jang JP, Jang JH, Kim DJ, Hwang JH, Mitchell MJ, Cha-Molstad H. Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines. ACS Nano. 2026 Mar 03; 20(8):7022-7045.
    View in: PubMed
    Score: 0.017
  61. O'Brien EM, Tylek T, Geisler HC, Mukalel AJ, Whitaker RC, Sung S, Binder-Markey BI, Weissman D, Mitchell MJ, Spiller KL. Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries. Biomaterials. 2026 May; 328:123869.
    View in: PubMed
    Score: 0.017
  62. Henrich IC, Billingsley MM, Jain K, Mondal S, Quick LN, Young R, Nguyen N, Oliveira AM, Blobel GA, Mitchell MJ, Chou MM. Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma. Mol Cancer Ther. 2025 Nov 03; 24(11):1802-1814.
    View in: PubMed
    Score: 0.017
  63. Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo. Proc Natl Acad Sci U S A. 2025 Jul 22; 122(29):e2409266122.
    View in: PubMed
    Score: 0.017
  64. Vadovics M, Zhao W, Daley EF, Lam K, Daly O, Rashid K, Lee HR, Schreiner P, Lundgreen KA, Gaudette BT, Shuvaev VV, Arguiri E, Muramatsu H, Sárközy A, Mdluli T, Xu J, Han X, De Luna N, Castaño D, Bettini E, Ábrahám E, Lipinszki Z, Carlucci G, Bansode AH, Nguyen K, Le TM, Luu T, Muzykantov VR, Bates P, Allman D, Mitchell MJ, Locci M, Radu CG, Heyes J, Pardi N. Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications. Nat Nanotechnol. 2025 Sep; 20(9):1312-1322.
    View in: PubMed
    Score: 0.016
  65. Shin JE, Won EJ, Xu J, Lee JC, Bang JK, Mitchell MJ, Cha-Molstad H. Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery. ACS Appl Mater Interfaces. 2025 May 14; 17(19):28012-28024.
    View in: PubMed
    Score: 0.016
  66. Mossburg KJ, Shepherd SJ, Barragan D, O NH, Berkow EK, Maidment PSN, Rosario Berrios DN, Hsu JC, Siedlik MJ, Yadavali S, Mitchell MJ, Issadore D, Cormode DP. Towards the clinical translation of a silver sulfide nanoparticle contrast agent: large scale production with a highly parallelized microfluidic chip. Eur J Nucl Med Mol Imaging. 2025 02; 52(3):1177-1188.
    View in: PubMed
    Score: 0.016
  67. Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2400783121.
    View in: PubMed
    Score: 0.015
  68. Chan A, Haley RM, Najar MA, Gonzalez-Martinez D, Bugaj LJ, Burslem GM, Mitchell MJ, Tsourkas A. Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nat Commun. 2024 Jul 10; 15(1):5808.
    View in: PubMed
    Score: 0.015
  69. Zhao G, Gentile ME, Xue L, Cosgriff CV, Weiner AI, Adams-Tzivelekidis S, Wong J, Li X, Kass-Gergi S, Holcomb NP, Basal MC, Stewart KM, Planer JD, Cantu E, Christie JD, Crespo MM, Mitchell MJ, Meyer NJ, Vaughan AE. Vascular endothelial-derived SPARCL1 exacerbates viral pneumonia through pro-inflammatory macrophage activation. Nat Commun. 2024 May 18; 15(1):4235.
    View in: PubMed
    Score: 0.015
  70. da Silva WN, Carvalho Costa PA, Scalzo Júnior SRA, Ferreira HAS, Prazeres PHDM, Campos CLV, Rodrigues Alves MT, Alves da Silva NJ, de Castro Santos AL, Guimarães LC, Chen Ferris ME, Thatte A, Hamilton A, Bicalho KA, Lobo AO, Santiago HDC, da Silva Barcelos L, Figueiredo MM, Teixeira MM, Vasconcelos Costa V, Mitchell MJ, Frézard F, Pires Goulart Guimaraes P. Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression. Int J Nanomedicine. 2024; 19:2655-2673.
    View in: PubMed
    Score: 0.015
  71. Yang F, Akhtar MN, Zhang D, El-Mayta R, Shin J, Dorsey JF, Zhang L, Xu X, Guo W, Bagley SJ, Fuchs SY, Koumenis C, Lathia JD, Mitchell MJ, Gong Y, Fan Y. An immunosuppressive vascular niche drives macrophage polarization and immunotherapy resistance in glioblastoma. Sci Adv. 2024 03; 10(9):eadj4678.
    View in: PubMed
    Score: 0.015
  72. Zhao G, Xue L, Geisler HC, Xu J, Li X, Mitchell MJ, Vaughan AE. Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proc Natl Acad Sci U S A. 2024 Feb 13; 121(7):e2314747121.
    View in: PubMed
    Score: 0.015
  73. Zhao G, Xue L, Weiner AI, Gong N, Adams-Tzivelekidis S, Wong J, Gentile ME, Nottingham AN, Basil MC, Lin SM, Niethamer TK, Diamond JM, Bermudez CA, Cantu E, Han X, Cao Y, Alameh MG, Weissman D, Morrisey EE, Mitchell MJ, Vaughan AE. TGF-ßR2 signaling coordinates pulmonary vascular repair after viral injury in mice and human tissue. Sci Transl Med. 2024 01 31; 16(732):eadg6229.
    View in: PubMed
    Score: 0.015
  74. Delbridge ML, Longepied G, Depetris D, Mattei MG, Disteche CM, Marshall Graves JA, Mitchell MJ. TSPY, the candidate gonadoblastoma gene on the human Y chromosome, has a widely expressed homologue on the X - implications for Y chromosome evolution. Chromosome Res. 2004; 12(4):345-56.
    View in: PubMed
    Score: 0.015
  75. Costa PAC, da Silva WN, Moura Prazeres PHD, Ferreira HAS, da Silva NJA, Figueiredo MM, da Silva Oliveira B, Scalzo Júnior SRA, Silva Santos FRD, Fernandes RA, Palanki R, Hamilton AG, Birbrair A, Santos VR, de Miranda AS, Mitchell MJ, Teixeira MM, Costa VV, Guimarães PPG. siRNA lipid nanoparticles for CXCL12 silencing modulate brain immune response during Zika infection. Biomed Pharmacother. 2024 Jan; 170:115981.
    View in: PubMed
    Score: 0.015
  76. Zhong W, Lu Y, Han X, Yang J, Qin Z, Zhang W, Yu Z, Wu B, Liu S, Xu W, Zheng C, Schuchter LM, Karakousis GC, Mitchell TC, Amaravadi R, Flowers AJ, Gimotty PA, Xiao M, Mills G, Herlyn M, Dong H, Mitchell MJ, Kim J, Xu X, Guo W. Upregulation of exosome secretion from tumor-associated macrophages plays a key role in the suppression of anti-tumor immunity. Cell Rep. 2023 10 31; 42(10):113224.
    View in: PubMed
    Score: 0.015
  77. Palanki R, Bose SK, Dave A, White BM, Berkowitz C, Luks V, Yaqoob F, Han E, Swingle KL, Menon P, Hodgson E, Biswas A, Billingsley MM, Li L, Yiping F, Carpenter M, Trokhan A, Yeo J, Johana N, Wan TY, Alameh MG, Bennett FC, Storm PB, Jain R, Chan J, Weissman D, Mitchell MJ, Peranteau WH. Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease. ACS Nano. 2023 07 25; 17(14):13594-13610.
    View in: PubMed
    Score: 0.014
  78. Nong J, Glassman PM, Myerson JW, Zuluaga-Ramirez V, Rodriguez-Garcia A, Mukalel A, Omo-Lamai S, Walsh LR, Zamora ME, Gong X, Wang Z, Bhamidipati K, Kiseleva RY, Villa CH, Greineder CF, Kasner SE, Weissman D, Mitchell MJ, Muro S, Persidsky Y, Brenner JS, Muzykantov VR, Marcos-Contreras OA. Targeted Nanocarriers Co-Opting Pulmonary Intravascular Leukocytes for Drug Delivery to the Injured Brain. ACS Nano. 2023 07 25; 17(14):13121-13136.
    View in: PubMed
    Score: 0.014
  79. Xu J, Yan N, Wang C, Gao C, Han X, Yang C, Xu J, Wang K, Mitchell MJ, Zhang Y, Nie G. Platelet-Mimicking Nanosponges for Functional Reversal of Antiplatelet Agents. Circ Res. 2023 02 03; 132(3):339-354.
    View in: PubMed
    Score: 0.014
  80. McElreavey K, Mitchell MJ. The sexually transmitted genome. Trends Genet. 2002 Jan; 18(1):13-4.
    View in: PubMed
    Score: 0.013
  81. Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR. Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). J Control Release. 2022 04; 344:50-61.
    View in: PubMed
    Score: 0.013
  82. Zhang D, Atochina-Vasserman EN, Maurya DS, Huang N, Xiao Q, Ona N, Liu M, Shahnawaz H, Ni H, Kim K, Billingsley MM, Pochan DJ, Mitchell MJ, Weissman D, Percec V. One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. J Am Chem Soc. 2021 08 11; 143(31):12315-12327.
    View in: PubMed
    Score: 0.013
  83. Gong N, Zhang Y, Teng X, Wang Y, Huo S, Qing G, Ni Q, Li X, Wang J, Ye X, Zhang T, Chen S, Wang Y, Yu J, Wang PC, Gan Y, Zhang J, Mitchell MJ, Li J, Liang XJ. Proton-driven transformable nanovaccine for cancer immunotherapy. Nat Nanotechnol. 2020 12; 15(12):1053-1064.
    View in: PubMed
    Score: 0.012
  84. Lévy N, Navarro A, Bishop CE, Mitchell MJ. The ubiquitin-activating enzyme E1 homologous genes on the mouse Y chromosome (Ube1y) represent one functional gene and six partial pseudogenes. Mamm Genome. 2000 Feb; 11(2):164-8.
    View in: PubMed
    Score: 0.011
  85. Mitchell MJ. Spermatogenesis and the mouse Y chromosome: specialisation out of decay. Results Probl Cell Differ. 2000; 28:233-70.
    View in: PubMed
    Score: 0.011
  86. Bishop CE, Mitchell MJ. Mouse Y chromosome. Mamm Genome. 1999 Oct; 10(10):962.
    View in: PubMed
    Score: 0.011
  87. Mazeyrat S, Saut N, Mattei MG, Mitchell MJ. RBMY evolved on the Y chromosome from a ubiquitously transcribed X-Y identical gene. Nat Genet. 1999 Jul; 22(3):224-6.
    View in: PubMed
    Score: 0.011
  88. Mazeyrat S, Saut N, Sargent CA, Grimmond S, Longepied G, Ehrmann IE, Ellis PS, Greenfield A, Affara NA, Mitchell MJ. The mouse Y chromosome interval necessary for spermatogonial proliferation is gene dense with syntenic homology to the human AZFa region. Hum Mol Genet. 1998 Oct; 7(11):1713-24.
    View in: PubMed
    Score: 0.010
  89. Mazeyrat S, Mitchell MJ. Rodent Y chromosome TSPY gene is functional in rat and non-functional in mouse. Hum Mol Genet. 1998 Mar; 7(3):557-62.
    View in: PubMed
    Score: 0.010
  90. Kherraf ZE, Christou-Kent M, Karaouzene T, Amiri-Yekta A, Martinez G, Vargas AS, Lambert E, Borel C, Dorphin B, Aknin-Seifer I, Mitchell MJ, Metzler-Guillemain C, Escoffier J, Nef S, Grepillat M, Thierry-Mieg N, Satre V, Bailly M, Boitrelle F, Pernet-Gallay K, Hennebicq S, Fauré J, Bottari SP, Coutton C, Ray PF, Arnoult C. SPINK2 deficiency causes infertility by inducing sperm defects in heterozygotes and azoospermia in homozygotes. EMBO Mol Med. 2017 08; 9(8):1132-1149.
    View in: PubMed
    Score: 0.010
  91. Elkhatib RA, Paci M, Boissier R, Longepied G, Auguste Y, Achard V, Bourgeois P, Levy N, Branger N, Mitchell MJ, Metzler-Guillemain C. LEM-domain proteins are lost during human spermiogenesis but BAF and BAF-L persist. Reproduction. 2017 10; 154(4):387-401.
    View in: PubMed
    Score: 0.009
  92. Levy N, de Boer P, Mattei J, Mitchell MJ. Molecular analysis of an isoYq chromosome in a sterile male mouse. Mamm Genome. 1996 Aug; 7(8):608-9.
    View in: PubMed
    Score: 0.009
  93. Yamauchi Y, Riel JM, Ruthig VA, Ortega EA, Mitchell MJ, Ward MA. Two genes substitute for the mouse Y chromosome for spermatogenesis and reproduction. Science. 2016 Jan 29; 351(6272):514-6.
    View in: PubMed
    Score: 0.009
  94. Scott DM, Ehrmann IE, Ellis PS, Bishop CE, Agulnik AI, Simpson E, Mitchell MJ. Identification of a mouse male-specific transplantation antigen, H-Y. Nature. 1995 Aug 24; 376(6542):695-8.
    View in: PubMed
    Score: 0.008
  95. Elkhatib R, Longepied G, Paci M, Achard V, Grillo JM, Levy N, Mitchell MJ, Metzler-Guillemain C. Nuclear envelope remodelling during human spermiogenesis involves somatic B-type lamins and a spermatid-specific B3 lamin isoform. Mol Hum Reprod. 2015 Mar; 21(3):225-36.
    View in: PubMed
    Score: 0.008
  96. Vernet N, Mahadevaiah SK, Yamauchi Y, Decarpentrie F, Mitchell MJ, Ward MA, Burgoyne PS. Mouse Y-linked Zfy1 and Zfy2 are expressed during the male-specific interphase between meiosis I and meiosis II and promote the 2nd meiotic division. PLoS Genet. 2014 Jun; 10(6):e1004444.
    View in: PubMed
    Score: 0.008
  97. Agulnik AI, Mitchell MJ, Lerner JL, Woods DR, Bishop CE. A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens. Hum Mol Genet. 1994 Jun; 3(6):873-8.
    View in: PubMed
    Score: 0.008
  98. Agulnik AI, Mitchell MJ, Mattei MG, Borsani G, Avner PA, Lerner JL, Bishop CE. A novel X gene with a widely transcribed Y-linked homologue escapes X-inactivation in mouse and human. Hum Mol Genet. 1994 Jun; 3(6):879-84.
    View in: PubMed
    Score: 0.008
  99. McLaren A, Simpson E, Bishop CE, Mitchell MJ, Darling SM. Recombination between the X and Y chromosomes and the Sxr region of the mouse. Genet Res. 1992 Dec; 60(3):175-84.
    View in: PubMed
    Score: 0.007
  100. Mitchell MJ, Woods DR, Wilcox SA, Graves JA, Bishop CE. Marsupial Y chromosome encodes a homologue of the mouse Y-linked candidate spermatogenesis gene Ube1y. Nature. 1992 Oct 08; 359(6395):528-31.
    View in: PubMed
    Score: 0.007
  101. Mitchell MJ, Bishop CE. A structural analysis of the Sxr region of the mouse Y chromosome. Genomics. 1992 Jan; 12(1):26-34.
    View in: PubMed
    Score: 0.006
  102. Mitchell MJ, Woods DR, Tucker PK, Opp JS, Bishop CE. Homology of a candidate spermatogenic gene from the mouse Y chromosome to the ubiquitin-activating enzyme E1. Nature. 1991 Dec 12; 354(6353):483-6.
    View in: PubMed
    Score: 0.006
  103. Vernet N, Mahadevaiah SK, Ojarikre OA, Longepied G, Prosser HM, Bradley A, Mitchell MJ, Burgoyne PS. The Y-encoded gene zfy2 acts to remove cells with unpaired chromosomes at the first meiotic metaphase in male mice. Curr Biol. 2011 May 10; 21(9):787-93.
    View in: PubMed
    Score: 0.006
  104. Mitchell MJ, Laughon BE, Lin S. Biochemical studies on the effect of Clostridium difficile toxin B on actin in vivo and in vitro. Infect Immun. 1987 Jul; 55(7):1610-5.
    View in: PubMed
    Score: 0.005
  105. Turner JM, Mahadevaiah SK, Ellis PJ, Mitchell MJ, Burgoyne PS. Pachytene asynapsis drives meiotic sex chromosome inactivation and leads to substantial postmeiotic repression in spermatids. Dev Cell. 2006 Apr; 10(4):521-9.
    View in: PubMed
    Score: 0.004
  106. Cutler JA, Mitchell MJ, Smith MP, Savidge GF. The identification and classification of 41 novel mutations in the factor VIII gene (F8C). Hum Mutat. 2002 Mar; 19(3):274-8.
    View in: PubMed
    Score: 0.003
  107. Mazeyrat S, Saut N, Grigoriev V, Mahadevaiah SK, Ojarikre OA, Bishop C, Eicher EM, Mitchell MJ, Burgoyne PS. A Y-encoded subunit of the translation initiation factor Eif2 is essential for mouse spermatogenesis. Nat Genet. 2001 Sep; 29(1):49-53.
    View in: PubMed
    Score: 0.003
  108. Scott D, Addey C, Ellis P, James E, Mitchell MJ, Saut N, Jurcevic S, Simpson E. Dendritic cells permit identification of genes encoding MHC class II-restricted epitopes of transplantation antigens. Immunity. 2000 Jun; 12(6):711-20.
    View in: PubMed
    Score: 0.003
  109. Ehrmann IE, Ellis PS, Mazeyrat S, Duthie S, Brockdorff N, Mattei MG, Gavin MA, Affara NA, Brown GM, Simpson E, Mitchell MJ, Scott DM. Characterization of genes encoding translation initiation factor eIF-2gamma in mouse and human: sex chromosome localization, escape from X-inactivation and evolution. Hum Mol Genet. 1998 Oct; 7(11):1725-37.
    View in: PubMed
    Score: 0.003
  110. Laval SH, Blair HJ, Mitchell MJ, Boyd Y. Smcx lies distal to DXHX674 and DXHX679 on the mouse X chromosome. Mamm Genome. 1996 Jul; 7(7):552.
    View in: PubMed
    Score: 0.002
  111. King TR, Christianson GJ, Mitchell MJ, Bishop CE, Scott D, Ehrmann I, Simpson E, Eicher EM, Roopenian DC. Deletion mapping by immunoselection against the H-Y histocompatibility antigen further resolves the Sxra region of the mouse Y chromosome and reveals complexity of the Hya locus. Genomics. 1994 Nov 01; 24(1):159-68.
    View in: PubMed
    Score: 0.002
  112. Kalaria RN, Mitchell MJ, Harik SI. Correlation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity with blood-brain barrier monoamine oxidase activity. Proc Natl Acad Sci U S A. 1987 May; 84(10):3521-5.
    View in: PubMed
    Score: 0.001
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