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Connection

Michael Mitchell to Nanoparticles

This is a "connection" page, showing publications Michael Mitchell has written about Nanoparticles.

 
Connection Strength
  
 
 
36.473
  
  1. Zeng Y, Xu J, Wang J, Xue L, Liu J, Geisler HC, Ma X, Melamed JR, Shi Q, Padilla MS, Luo Z, Zhu J, Thatte AS, Figueroa-Espada CG, Ang MJY, Murray AM, Yamagata HM, Kim D, Metzloff AE, Weissman D, Mitchell MJ. mRNA lipid nanoparticle cancer vaccine platform delivering multiple STING activators for enhanced antitumor activity. Proc Natl Acad Sci U S A. 2026 Jul 14; 123(28):e2525718123.
    View in: PubMed
    Score: 0.620
  2. Kim D, Moon SJ, Han EL, Feng E, Murray AM, Wang J, Liu W, Kong G, June CH, Mitchell MJ. HITE: HIV Inspired Lipid Nanoparticle Platform for CAR T Cell Engineering. Nano Lett. 2026 May 06; 26(17):5668-5679.
    View in: PubMed
    Score: 0.611
  3. Yamagata HM, Padilla MS, Hamilton AG, Swingle KL, Thatte AS, Ricciardi AS, Agrawal A, Fitzgerald E, Poirier AJ, Geisler HC, Joseph RA, Chalom OZ, Du S, Li JJ, Kim D, Whitaker RC, Figueroa-Espada CG, Han EL, Murray AM, Alameh MG, Weissman D, Mitchell MJ. Liver-Detargeted Aromatic Bioreducible mRNA Lipid Nanoparticles Confer Lymph Node Tropism and Robust Antigen-Specific Immunity. J Am Chem Soc. 2026 04 08; 148(13):14137-14150.
    View in: PubMed
    Score: 0.608
  4. Shi Q, Gong N, Wang J, Palanki R, Zheng Q, Alameh MG, Dwivedi G, Davis B, Melamed J, Luo Z, Xu J, Figueroa-Espada CG, Xue L, Zeng Y, Han X, Kim D, Chen Q, Yamagata H, Geisler HC, El-Mayta R, Yoon IC, Weissman D, Mitchell MJ. Prodrug-tethered lipid nanoparticles for synergistic messenger RNA cancer immunotherapy. Nat Nanotechnol. 2026 Mar; 21(3):430-442.
    View in: PubMed
    Score: 0.607
  5. Hamilton AG, Thatte AS, Xu J, Luo Z, Safford HC, Swingle KL, Muscat-Rivera J, Kegel M, Han X, Joseph RA, Murray AM, Geisler HC, Whitaker RC, Xue L, Spektor R, Melamed JR, Weissman D, Mitchell MJ. High-Throughput In Vivo Screening Using Barcoded mRNA Identifies Lipid Nanoparticles With Extrahepatic Tropism for In Situ Immunoengineering. Adv Mater. 2026 Mar; 38(13):e14370.
    View in: PubMed
    Score: 0.602
  6. Han EL, Kim D, Murray AM, Mrksich K, Hamilton AG, Tang S, Yoo S, Zhu AT, Tong ER, Palanki R, Hall ML, Bedingfield SK, Mitchell MJ. High-Throughput In Vivo Screening Identifies Structural Factors Driving mRNA Lipid Nanoparticle Delivery to the Brain. ACS Nano. 2026 Feb 03; 20(4):3807-3820.
    View in: PubMed
    Score: 0.601
  7. Ang MJY, Metzloff AE, Thatte AS, Mitchell MJ. Lipid nanoparticles for engineering next generation CAR T cell immunotherapy. Nanoscale Horiz. 2026 Jan 05; 11(1):22-36.
    View in: PubMed
    Score: 0.599
  8. Nachod BE, Thatte AS, Palanki R, Mitchell MJ. Nanoparticle-Based Tolerogenic Vaccines: Next-Generation Strategies for Autoimmune and Allergic Disease Therapies. Angew Chem Int Ed Engl. 2026 02 02; 65(6):e24097.
    View in: PubMed
    Score: 0.598
  9. Wang J, Huang X, Shi Q, Swingle KL, Hamilton AG, Gong N, Mitchell MJ. Drug-loaded bispecific T cell nanoengager overcomes T cell exhaustion for potent cancer immunotherapy. Proc Natl Acad Sci U S A. 2025 Nov 11; 122(45):e2409564122.
    View in: PubMed
    Score: 0.592
  10. Yoo S, Han EL, Murray AM, Kim D, Bang EK, Mitchell MJ. High-Throughput Formulation Using Fast mRNA Lipid Nanoparticle Assembly via Simple Thermomixing (HTF-FLASH). Nano Lett. 2025 10 08; 25(40):14695-14703.
    View in: PubMed
    Score: 0.588
  11. Joseph RA, Haley RM, Padilla MS, Ricciardi AS, Yamagata HM, Mitchell MJ. Cas9 Protein Outperforms mRNA in Lipid Nanoparticle-Mediated CFTR Repair. Nano Lett. 2025 10 01; 25(39):14348-14355.
    View in: PubMed
    Score: 0.587
  12. Swingle KL, Hamilton AG, Han X, Liao KC, Safford HC, Thatte AS, Geisler HC, Xu J, Saw TY, Wan Y, Mitchell MJ. Circular RNA lipid nanoparticle vaccine against SARS-CoV-2. Proc Natl Acad Sci U S A. 2025 Sep 23; 122(38):e2505718122.
    View in: PubMed
    Score: 0.587
  13. Murray AM, Swingle KL, Mitchell MJ. Engineering Nanoparticles for Gynecologic Cancer Therapy. ACS Nano. 2025 Sep 02; 19(34):30758-30785.
    View in: PubMed
    Score: 0.584
  14. Haley RM, Padilla MS, El-Mayta RD, Joseph RA, Weber JA, Figueroa-Espada CG, Mukalel AJ, Ricciardi AS, Palanki R, Geisler HC, Jester MT, Davidson BL, Mitchell MJ. Lipid Nanoparticles for In Vivo Lung Delivery of CRISPR-Cas9 Ribonucleoproteins Allow Gene Editing of Clinical Targets. ACS Nano. 2025 04 15; 19(14):13790-13804.
    View in: PubMed
    Score: 0.569
  15. Tang S, Han EL, Mitchell MJ. Peptide-functionalized nanoparticles for brain-targeted therapeutics. Drug Deliv Transl Res. 2026 Mar; 16(3):741-760.
    View in: PubMed
    Score: 0.568
  16. Safford HC, Shuler CF, Geisler HC, Thatte AS, Swingle KL, Han EL, Murray AM, Hamilton AG, Yamagata HM, Mitchell MJ. Probing the Role of Lipid Nanoparticle Elasticity on mRNA Delivery to the Placenta. Nano Lett. 2025 03 26; 25(12):4800-4808.
    View in: PubMed
    Score: 0.566
  17. Han EL, Tang S, Kim D, Murray AM, Swingle KL, Hamilton AG, Mrksich K, Padilla MS, Palanki R, Li JJ, Mitchell MJ. Peptide-Functionalized Lipid Nanoparticles for Targeted Systemic mRNA Delivery to the Brain. Nano Lett. 2025 01 15; 25(2):800-810.
    View in: PubMed
    Score: 0.557
  18. Swingle KL, Hamilton AG, Safford HC, Geisler HC, Thatte AS, Palanki R, Murray AM, Han EL, Mukalel AJ, Han X, Joseph RA, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Placenta-tropic VEGF mRNA lipid nanoparticles ameliorate murine pre-eclampsia. Nature. 2025 01; 637(8045):412-421.
    View in: PubMed
    Score: 0.556
  19. Han X, Alameh MG, Xu Y, Palanki R, El-Mayta R, Dwivedi G, Swingle KL, Xu J, Gong N, Xue L, Shi Q, Yoon IC, Warzecha CC, Wilson JM, Weissman D, Mitchell MJ. Optimization of the activity and biodegradability of ionizable lipids for mRNA delivery via directed chemical evolution. Nat Biomed Eng. 2024 Nov; 8(11):1412-1424.
    View in: PubMed
    Score: 0.554
  20. Xue L, Zhao G, Gong N, Han X, Shepherd SJ, Xiong X, Xiao Z, Palanki R, Xu J, Swingle KL, Warzecha CC, El-Mayta R, Chowdhary V, Yoon IC, Xu J, Cui J, Shi Y, Alameh MG, Wang K, Wang L, Pochan DJ, Weissman D, Vaughan AE, Wilson JM, Mitchell MJ. Combinatorial design of siloxane-incorporated lipid nanoparticles augments intracellular processing for tissue-specific mRNA therapeutic delivery. Nat Nanotechnol. 2025 Jan; 20(1):132-143.
    View in: PubMed
    Score: 0.549
  21. Kim EH, Teerdhala SV, Padilla MS, Joseph RA, Li JJ, Haley RM, Mitchell MJ. Lipid nanoparticle-mediated RNA delivery for immune cell modulation. Eur J Immunol. 2024 12; 54(12):e2451008.
    View in: PubMed
    Score: 0.547
  22. Mrksich K, Padilla MS, Mitchell MJ. Breaking the final barrier: Evolution of cationic and ionizable lipid structure in lipid nanoparticles to escape the endosome. Adv Drug Deliv Rev. 2024 11; 214:115446.
    View in: PubMed
    Score: 0.547
  23. Gong N, Zhong W, Alameh MG, Han X, Xue L, El-Mayta R, Zhao G, Vaughan AE, Qin Z, Xu F, Hamilton AG, Kim D, Xu J, Kim J, Teng X, Li J, Liang XJ, Weissman D, Guo W, Mitchell MJ. Tumour-derived small extracellular vesicles act as a barrier to therapeutic nanoparticle delivery. Nat Mater. 2024 Dec; 23(12):1736-1747.
    View in: PubMed
    Score: 0.546
  24. Swingle KL, Hamilton AG, Mitchell MJ. Flow cytometric analysis of the murine placenta to evaluate nanoparticle platforms during pregnancy. Placenta. 2025 06 13; 166:132-138.
    View in: PubMed
    Score: 0.544
  25. Palanki R, Han EL, Murray AM, Maganti R, Tang S, Swingle KL, Kim D, Yamagata H, Safford HC, Mrksich K, Peranteau WH, Mitchell MJ. Optimized microfluidic formulation and organic excipients for improved lipid nanoparticle mediated genome editing. Lab Chip. 2024 08 06; 24(16):3790-3801.
    View in: PubMed
    Score: 0.543
  26. Hamilton AG, Swingle KL, Thatte AS, Mukalel AJ, Safford HC, Billingsley MM, El-Mayta RD, Han X, Nachod BE, Joseph RA, Metzloff AE, Mitchell MJ. High-Throughput In Vivo Screening Identifies Differential Influences on mRNA Lipid Nanoparticle Immune Cell Delivery by Administration Route. ACS Nano. 2024 06 25; 18(25):16151-16165.
    View in: PubMed
    Score: 0.537
  27. Geisler HC, Ghalsasi AA, Safford HC, Swingle KL, Thatte AS, Mukalel AJ, Gong N, Hamilton AG, Han EL, Nachod BE, Padilla MS, Mitchell MJ. EGFR-targeted ionizable lipid nanoparticles enhance in vivo mRNA delivery to the placenta. J Control Release. 2024 07; 371:455-469.
    View in: PubMed
    Score: 0.537
  28. Atsavapranee E, Haley RM, Billingsley MM, Chan A, Ruan B, Figueroa-Espada CG, Gong N, Mukalel AJ, Bryan PN, Mitchell MJ. Ionizable lipid nanoparticles for RAS protease delivery to inhibit cancer cell proliferation. J Control Release. 2024 06; 370:614-625.
    View in: PubMed
    Score: 0.535
  29. Metzloff AE, Padilla MS, Gong N, Billingsley MM, Han X, Merolle M, Mai D, Figueroa-Espada CG, Thatte AS, Haley RM, Mukalel AJ, Hamilton AG, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Antigen Presenting Cell Mimetic Lipid Nanoparticles for Rapid mRNA CAR T Cell Cancer Immunotherapy. Adv Mater. 2024 06; 36(26):e2313226.
    View in: PubMed
    Score: 0.528
  30. Mrksich K, Padilla MS, Joseph RA, Han EL, Kim D, Palanki R, Xu J, Mitchell MJ. Influence of ionizable lipid tail length on lipid nanoparticle delivery of mRNA of varying length. J Biomed Mater Res A. 2024 09; 112(9):1494-1505.
    View in: PubMed
    Score: 0.528
  31. Xue L, Hamilton AG, Zhao G, Xiao Z, El-Mayta R, Han X, Gong N, Xiong X, Xu J, Figueroa-Espada CG, Shepherd SJ, Mukalel AJ, Alameh MG, Cui J, Wang K, Vaughan AE, Weissman D, Mitchell MJ. High-throughput barcoding of nanoparticles identifies cationic, degradable lipid-like materials for mRNA delivery to the lungs in female preclinical models. Nat Commun. 2024 Feb 29; 15(1):1884.
    View in: PubMed
    Score: 0.527
  32. Han X, Xu J, Xu Y, Alameh MG, Xue L, Gong N, El-Mayta R, Palanki R, Warzecha CC, Zhao G, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ. In situ combinatorial synthesis of degradable branched lipidoids for systemic delivery of mRNA therapeutics and gene editors. Nat Commun. 2024 02 26; 15(1):1762.
    View in: PubMed
    Score: 0.527
  33. Han EL, Padilla MS, Palanki R, Kim D, Mrksich K, Li JJ, Tang S, Yoon IC, Mitchell MJ. Predictive High-Throughput Platform for Dual Screening of mRNA Lipid Nanoparticle Blood-Brain Barrier Transfection and Crossing. Nano Lett. 2024 02 07; 24(5):1477-1486.
    View in: PubMed
    Score: 0.523
  34. Patel SK, Billingsley MM, Mukalel AJ, Thatte AS, Hamilton AG, Gong N, El-Mayta R, Safford HC, Merolle M, Mitchell MJ. Bile acid-containing lipid nanoparticles enhance extrahepatic mRNA delivery. Theranostics. 2024; 14(1):1-16.
    View in: PubMed
    Score: 0.521
  35. Billingsley MM, Gong N, Mukalel AJ, Thatte AS, El-Mayta R, Patel SK, Metzloff AE, Swingle KL, Han X, Xue L, Hamilton AG, Safford HC, Alameh MG, Papp TE, Parhiz H, Weissman D, Mitchell MJ. In Vivo mRNA CAR T Cell Engineering via Targeted Ionizable Lipid Nanoparticles with Extrahepatic Tropism. Small. 2024 03; 20(11):e2304378.
    View in: PubMed
    Score: 0.519
  36. Hamilton AG, Swingle KL, Joseph RA, Mai D, Gong N, Billingsley MM, Alameh MG, Weissman D, Sheppard NC, June CH, Mitchell MJ. Ionizable Lipid Nanoparticles with Integrated Immune Checkpoint Inhibition for mRNA CAR T Cell Engineering. Adv Healthc Mater. 2023 12; 12(30):e2301515.
    View in: PubMed
    Score: 0.509
  37. Shepherd SJ, Han X, Mukalel AJ, El-Mayta R, Thatte AS, Wu J, Padilla MS, Alameh MG, Srikumar N, Lee D, Weissman D, Issadore D, Mitchell MJ. Throughput-scalable manufacturing of SARS-CoV-2 mRNA lipid nanoparticle vaccines. Proc Natl Acad Sci U S A. 2023 08 15; 120(33):e2303567120.
    View in: PubMed
    Score: 0.507
  38. Safford HC, Swingle KL, Geisler HC, Hamilton AG, Thatte AS, Ghalsasi AA, Billingsley MM, Alameh MG, Weissman D, Mitchell MJ. Orthogonal Design of Experiments for Engineering of Lipid Nanoparticles for mRNA Delivery to the Placenta. Small. 2024 10; 20(41):e2303568.
    View in: PubMed
    Score: 0.506
  39. Han X, Alameh MG, Butowska K, Knox JJ, Lundgreen K, Ghattas M, Gong N, Xue L, Xu Y, Lavertu M, Bates P, Xu J, Nie G, Zhong Y, Weissman D, Mitchell MJ. Adjuvant lipidoid-substituted lipid nanoparticles augment the immunogenicity of SARS-CoV-2 mRNA vaccines. Nat Nanotechnol. 2023 09; 18(9):1105-1114.
    View in: PubMed
    Score: 0.503
  40. Gong N, Mitchell MJ. Rerouting nanoparticles to bone marrow via neutrophil hitchhiking. Nat Nanotechnol. 2023 06; 18(6):548-549.
    View in: PubMed
    Score: 0.500
  41. Haley RM, Chan A, Billingsley MM, Gong N, Padilla MS, Kim EH, Wang H, Yin D, Wangensteen KJ, Tsourkas A, Mitchell MJ. Lipid Nanoparticle Delivery of Small Proteins for Potent In Vivo RAS Inhibition. ACS Appl Mater Interfaces. 2023 May 10; 15(18):21877-21892.
    View in: PubMed
    Score: 0.497
  42. Hamilton AG, Swingle KL, Mitchell MJ. Biotechnology: Overcoming biological barriers to nucleic acid delivery using lipid nanoparticles. PLoS Biol. 2023 04; 21(4):e3002105.
    View in: PubMed
    Score: 0.497
  43. Swingle KL, Safford HC, Geisler HC, Hamilton AG, Thatte AS, Billingsley MM, Joseph RA, Mrksich K, Padilla MS, Ghalsasi AA, Alameh MG, Weissman D, Mitchell MJ. Ionizable Lipid Nanoparticles for In Vivo mRNA Delivery to the Placenta during Pregnancy. J Am Chem Soc. 2023 03 01; 145(8):4691-4706.
    View in: PubMed
    Score: 0.490
  44. El-Mayta R, Padilla MS, Billingsley MM, Han X, Mitchell MJ. Testing the In Vitro and In Vivo Efficiency of mRNA-Lipid Nanoparticles Formulated by Microfluidic Mixing. J Vis Exp. 2023 01 20; (191).
    View in: PubMed
    Score: 0.488
  45. Han X, Gong N, Xue L, Billingsley MM, El-Mayta R, Shepherd SJ, Alameh MG, Weissman D, Mitchell MJ. Ligand-tethered lipid nanoparticles for targeted RNA delivery to treat liver fibrosis. Nat Commun. 2023 01 17; 14(1):75.
    View in: PubMed
    Score: 0.488
  46. Xue L, Gong N, Shepherd SJ, Xiong X, Liao X, Han X, Zhao G, Song C, Huang X, Zhang H, Padilla MS, Qin J, Shi Y, Alameh MG, Pochan DJ, Wang K, Long F, Weissman D, Mitchell MJ. Rational Design of Bisphosphonate Lipid-like Materials for mRNA Delivery to the Bone Microenvironment. J Am Chem Soc. 2022 06 08; 144(22):9926-9937.
    View in: PubMed
    Score: 0.466
  47. Patel SK, Billingsley MM, Frazee C, Han X, Swingle KL, Qin J, Alameh MG, Wang K, Weissman D, Mitchell MJ. Hydroxycholesterol substitution in ionizable lipid nanoparticles for mRNA delivery to T cells. J Control Release. 2022 07; 347:521-532.
    View in: PubMed
    Score: 0.466
  48. Zhang H, Han X, Alameh MG, Shepherd SJ, Padilla MS, Xue L, Butowska K, Weissman D, Mitchell MJ. Rational design of anti-inflammatory lipid nanoparticles for mRNA delivery. J Biomed Mater Res A. 2022 05; 110(5):1101-1108.
    View in: PubMed
    Score: 0.456
  49. Swingle KL, Billingsley MM, Bose SK, White B, Palanki R, Dave A, Patel SK, Gong N, Hamilton AG, Alameh MG, Weissman D, Peranteau WH, Mitchell MJ. Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery. J Control Release. 2022 01; 341:616-633.
    View in: PubMed
    Score: 0.449
  50. Billingsley MM, Hamilton AG, Mai D, Patel SK, Swingle KL, Sheppard NC, June CH, Mitchell MJ. Orthogonal Design of Experiments for Optimization of Lipid Nanoparticles for mRNA Engineering of CAR T Cells. Nano Lett. 2022 01 12; 22(1):533-542.
    View in: PubMed
    Score: 0.447
  51. Shepherd SJ, Warzecha CC, Yadavali S, El-Mayta R, Alameh MG, Wang L, Weissman D, Wilson JM, Issadore D, Mitchell MJ. Scalable mRNA and siRNA Lipid Nanoparticle Production Using a Parallelized Microfluidic Device. Nano Lett. 2021 07 14; 21(13):5671-5680.
    View in: PubMed
    Score: 0.438
  52. Shepherd SJ, Issadore D, Mitchell MJ. Microfluidic formulation of nanoparticles for biomedical applications. Biomaterials. 2021 07; 274:120826.
    View in: PubMed
    Score: 0.433
  53. Swingle KL, Hamilton AG, Mitchell MJ. Lipid Nanoparticle-Mediated Delivery of mRNA Therapeutics and Vaccines. Trends Mol Med. 2021 06; 27(6):616-617.
    View in: PubMed
    Score: 0.431
  54. Riley RS, Kashyap MV, Billingsley MM, White B, Alameh MG, Bose SK, Zoltick PW, Li H, Zhang R, Cheng AY, Weissman D, Peranteau WH, Mitchell MJ. Ionizable lipid nanoparticles for in utero mRNA delivery. Sci Adv. 2021 01; 7(3).
    View in: PubMed
    Score: 0.424
  55. Zhang R, El-Mayta R, Murdoch TJ, Warzecha CC, Billingsley MM, Shepherd SJ, Gong N, Wang L, Wilson JM, Lee D, Mitchell MJ. Helper lipid structure influences protein adsorption and delivery of lipid nanoparticles to spleen and liver. Biomater Sci. 2021 Feb 21; 9(4):1449-1463.
    View in: PubMed
    Score: 0.424
  56. Mitchell MJ, Billingsley MM, Haley RM, Wechsler ME, Peppas NA, Langer R. Engineering precision nanoparticles for drug delivery. Nat Rev Drug Discov. 2021 02; 20(2):101-124.
    View in: PubMed
    Score: 0.421
  57. Billingsley MM, Singh N, Ravikumar P, Zhang R, June CH, Mitchell MJ. Ionizable Lipid Nanoparticle-Mediated mRNA Delivery for Human CAR T Cell Engineering. Nano Lett. 2020 03 11; 20(3):1578-1589.
    View in: PubMed
    Score: 0.398
  58. Guimaraes PPG, Zhang R, Spektor R, Tan M, Chung A, Billingsley MM, El-Mayta R, Riley RS, Wang L, Wilson JM, Mitchell MJ. Ionizable lipid nanoparticles encapsulating barcoded mRNA for accelerated in vivo delivery screening. J Control Release. 2019 12 28; 316:404-417.
    View in: PubMed
    Score: 0.390
  59. Mukalel AJ, Riley RS, Zhang R, Mitchell MJ. Nanoparticles for nucleic acid delivery: Applications in cancer immunotherapy. Cancer Lett. 2019 08 28; 458:102-112.
    View in: PubMed
    Score: 0.378
  60. Riley RS, June CH, Langer R, Mitchell MJ. Delivery technologies for cancer immunotherapy. Nat Rev Drug Discov. 2019 03; 18(3):175-196.
    View in: PubMed
    Score: 0.373
  61. Guimarães PPG, Gaglione S, Sewastianik T, Carrasco RD, Langer R, Mitchell MJ. Nanoparticles for Immune Cytokine TRAIL-Based Cancer Therapy. ACS Nano. 2018 02 27; 12(2):912-931.
    View in: PubMed
    Score: 0.346
  62. Mitchell MJ, King MR. Leukocytes as carriers for targeted cancer drug delivery. Expert Opin Drug Deliv. 2015 Mar; 12(3):375-92.
    View in: PubMed
    Score: 0.274
  63. Borhan B, Murray AM, Saei AA, Ghaffari B, Jackson JE, Mohammed N, Mitchell MJ, Vali H, Whitehead KA, Mahmoudi M. Influence of protein aggregates, extracellular vesicles, and lipoprotein fusion on ionizable lipid nanoparticles protein corona analysis. Nat Commun. 2026 06 12; 17(1).
    View in: PubMed
    Score: 0.154
  64. Han X, Xu Y, Ricciardi AS, Xu J, Xiang Y, Palanki R, Chowdhary V, Xue L, Gong N, Alameh MG, Peranteau WH, Wilson JM, Reker D, Weissman D, Mitchell MJ. Plug-and-play assembly of biodegradable ionizable lipids for potent mRNA delivery and gene editing in vivo. Proc Natl Acad Sci U S A. 2026 Jun 02; 123(22):e2528144123.
    View in: PubMed
    Score: 0.154
  65. Kim JG, Xu J, Lee D, Song J, Lee S, Hong MH, Zhu J, Zhu A, Patwari K, Shim EH, Shin JE, Park OH, Rho J, Ko KC, Lee EG, Kang OY, Won EJ, Kim BH, Jang JP, Jang JH, Kim DJ, Hwang JH, Mitchell MJ, Cha-Molstad H. Comprehensive Engineering of Ionizable Lipid Nanoparticles and mRNA Elements for Next-Generation Vaccines. ACS Nano. 2026 Mar 03; 20(8):7022-7045.
    View in: PubMed
    Score: 0.151
  66. Martins C, Mitchell MJ, Peer D, Perrie Y, Siegwart DJ, Alonso MJ, Aparicio-Blanco J. The RNA delivery dilemma-lipid versus polymer nanoparticle platforms. Drug Deliv Transl Res. 2026 Jun; 16(6):1667-1684.
    View in: PubMed
    Score: 0.150
  67. Hanna AR, Shepherd SJ, Datto GA, El-Mayta R, Anderson T, Navarro IB, Ricciardi AS, Padilla MS, Srikumar N, Zhang S, Yamagata HM, Meng NY, Buser JR, Alameh MG, Mitchell MJ, Issadore DA. Automated and Parallelized Microfluidic Generation of Large and Precisely Defined Lipid Nanoparticle Libraries. ACS Nano. 2026 01 13; 20(1):772-789.
    View in: PubMed
    Score: 0.149
  68. O'Brien EM, Tylek T, Geisler HC, Mukalel AJ, Whitaker RC, Sung S, Binder-Markey BI, Weissman D, Mitchell MJ, Spiller KL. Macrophage cell therapy enabled by interleukin-4 mRNA-loaded lipid nanoparticles to sustain a pro-reparative phenotype in inflammatory injuries. Biomaterials. 2026 May; 328:123869.
    View in: PubMed
    Score: 0.149
  69. Safford HC, Palanki R, Ang M, Mitchell MJ. Emerging Nucleic Acid Cargos for Next-Generation RNA Vaccines and Therapeutics. Bioconjug Chem. 2025 11 19; 36(11):2317-2323.
    View in: PubMed
    Score: 0.148
  70. Henrich IC, Billingsley MM, Jain K, Mondal S, Quick LN, Young R, Nguyen N, Oliveira AM, Blobel GA, Mitchell MJ, Chou MM. Ubiquitin-Specific Protease 6 mRNA Lipid Nanoparticles Ignite Antitumor Immunity and Suppress Tumorigenesis in Ewing Sarcoma. Mol Cancer Ther. 2025 Nov 03; 24(11):1802-1814.
    View in: PubMed
    Score: 0.148
  71. Gong N, Kim D, Alameh MG, El-Mayta R, Han EL, Dwivedi G, Palanki R, Shi Q, Han X, Xue L, Xu J, Meng Z, Luo T, Figueroa-Espada CG, Weissman D, Li J, Mitchell MJ. Mannich reaction-based combinatorial libraries identify antioxidant ionizable lipids for mRNA delivery with reduced immunogenicity. Nat Biomed Eng. 2025 Dec; 9(12):2181-2195.
    View in: PubMed
    Score: 0.145
  72. Vadovics M, Zhao W, Daley EF, Lam K, Daly O, Rashid K, Lee HR, Schreiner P, Lundgreen KA, Gaudette BT, Shuvaev VV, Arguiri E, Muramatsu H, Sárközy A, Mdluli T, Xu J, Han X, De Luna N, Castaño D, Bettini E, Ábrahám E, Lipinszki Z, Carlucci G, Bansode AH, Nguyen K, Le TM, Luu T, Muzykantov VR, Bates P, Allman D, Mitchell MJ, Locci M, Radu CG, Heyes J, Pardi N. Tailoring the adjuvanticity of lipid nanoparticles by PEG lipid ratio and phospholipid modifications. Nat Nanotechnol. 2025 Sep; 20(9):1312-1322.
    View in: PubMed
    Score: 0.144
  73. Wu F, Li N, Xiao Y, Palanki R, Yamagata H, Mitchell MJ, Han X. Lipid Nanoparticles for Delivery of CRISPR Gene Editing Components. Small Methods. 2026 Jan; 10(2):e2401632.
    View in: PubMed
    Score: 0.144
  74. Shin JE, Won EJ, Xu J, Lee JC, Bang JK, Mitchell MJ, Cha-Molstad H. Transition Temperature-Guided Design of Lipid Nanoparticles for Effective mRNA Delivery. ACS Appl Mater Interfaces. 2025 May 14; 17(19):28012-28024.
    View in: PubMed
    Score: 0.143
  75. Padilla MS, Mrksich K, Wang Y, Haley RM, Li JJ, Han EL, El-Mayta R, Kim EH, Dias S, Gong N, Teerdhala SV, Han X, Chowdhary V, Xue L, Siddiqui Z, Yamagata HM, Kim D, Yoon IC, Wilson JM, Radhakrishnan R, Mitchell MJ. Branched endosomal disruptor (BEND) lipids mediate delivery of mRNA and CRISPR-Cas9 ribonucleoprotein complex for hepatic gene editing and T cell engineering. Nat Commun. 2025 Jan 24; 16(1):996.
    View in: PubMed
    Score: 0.140
  76. Xue L, Xiong X, Zhao G, Molina-Arocho W, Palanki R, Xiao Z, Han X, Yoon IC, Figueroa-Espada CG, Xu J, Gong N, Shi Q, Chen Q, Alameh MG, Vaughan AE, Haldar M, Wang K, Weissman D, Mitchell MJ. Multiarm-Assisted Design of Dendron-like Degradable Ionizable Lipids Facilitates Systemic mRNA Delivery to the Spleen. J Am Chem Soc. 2025 01 15; 147(2):1542-1552.
    View in: PubMed
    Score: 0.140
  77. Hwang YH, Shepherd SJ, Kim D, Mukalel AJ, Mitchell MJ, Issadore DA, Lee D. Robust, Scalable Microfluidic Manufacturing of RNA-Lipid Nanoparticles Using Immobilized Antifouling Lubricant Coating. ACS Nano. 2025 01 14; 19(1):1090-1102.
    View in: PubMed
    Score: 0.139
  78. Yoon IC, Xue L, Chen Q, Liu J, Xu J, Siddiqui Z, Kim D, Chen B, Shi Q, Laura Han E, Cherry Ruiz M, Vining KH, Mitchell MJ. Piperazine-Derived Bisphosphonate-Based Ionizable Lipid Nanoparticles Enhance mRNA Delivery to the Bone Microenvironment. Angew Chem Int Ed Engl. 2025 Jan 15; 64(3):e202415389.
    View in: PubMed
    Score: 0.139
  79. Mossburg KJ, Shepherd SJ, Barragan D, O NH, Berkow EK, Maidment PSN, Rosario Berrios DN, Hsu JC, Siedlik MJ, Yadavali S, Mitchell MJ, Issadore D, Cormode DP. Towards the clinical translation of a silver sulfide nanoparticle contrast agent: large scale production with a highly parallelized microfluidic chip. Eur J Nucl Med Mol Imaging. 2025 02; 52(3):1177-1188.
    View in: PubMed
    Score: 0.138
  80. Palanki R, Riley JS, Bose SK, Luks V, Dave A, Kus N, White BM, Ricciardi AS, Swingle KL, Xue L, Sung D, Thatte AS, Safford HC, Chaluvadi VS, Carpenter M, Han EL, Maganti R, Hamilton AG, Mrksich K, Billingsley MB, Zoltick PW, Alameh MG, Weissman D, Mitchell MJ, Peranteau WH. In utero delivery of targeted ionizable lipid nanoparticles facilitates in vivo gene editing of hematopoietic stem cells. Proc Natl Acad Sci U S A. 2024 Aug 06; 121(32):e2400783121.
    View in: PubMed
    Score: 0.136
  81. Han X, Alameh MG, Gong N, Xue L, Ghattas M, Bojja G, Xu J, Zhao G, Warzecha CC, Padilla MS, El-Mayta R, Dwivedi G, Xu Y, Vaughan AE, Wilson JM, Weissman D, Mitchell MJ. Fast and facile synthesis of amidine-incorporated degradable lipids for versatile mRNA delivery in vivo. Nat Chem. 2024 10; 16(10):1687-1697.
    View in: PubMed
    Score: 0.135
  82. Gong N, Alameh MG, El-Mayta R, Xue L, Weissman D, Mitchell MJ. Enhancing in situ cancer vaccines using delivery technologies. Nat Rev Drug Discov. 2024 08; 23(8):607-625.
    View in: PubMed
    Score: 0.135
  83. da Silva WN, Carvalho Costa PA, Scalzo Júnior SRA, Ferreira HAS, Prazeres PHDM, Campos CLV, Rodrigues Alves MT, Alves da Silva NJ, de Castro Santos AL, Guimarães LC, Chen Ferris ME, Thatte A, Hamilton A, Bicalho KA, Lobo AO, Santiago HDC, da Silva Barcelos L, Figueiredo MM, Teixeira MM, Vasconcelos Costa V, Mitchell MJ, Frézard F, Pires Goulart Guimaraes P. Ionizable Lipid Nanoparticle-Mediated TRAIL mRNA Delivery in the Tumor Microenvironment to Inhibit Colon Cancer Progression. Int J Nanomedicine. 2024; 19:2655-2673.
    View in: PubMed
    Score: 0.132
  84. Zhao G, Xue L, Geisler HC, Xu J, Li X, Mitchell MJ, Vaughan AE. Precision treatment of viral pneumonia through macrophage-targeted lipid nanoparticle delivery. Proc Natl Acad Sci U S A. 2024 Feb 13; 121(7):e2314747121.
    View in: PubMed
    Score: 0.131
  85. Thatte AS, Hamilton AG, Nachod BE, Mukalel AJ, Billingsley MM, Palanki R, Swingle KL, Mitchell MJ. mRNA Lipid Nanoparticles for Ex Vivo Engineering of Immunosuppressive T Cells for Autoimmunity Therapies. Nano Lett. 2023 11 22; 23(22):10179-10188.
    View in: PubMed
    Score: 0.129
  86. Prazeres PHDM, Ferreira H, Costa PAC, da Silva W, Alves MT, Padilla M, Thatte A, Santos AK, Lobo AO, Sabino A, Del Puerto HL, Mitchell MJ, Guimaraes PPG. Delivery of Plasmid DNA by Ionizable Lipid Nanoparticles to Induce CAR Expression in T Cells. Int J Nanomedicine. 2023; 18:5891-5904.
    View in: PubMed
    Score: 0.128
  87. Palanki R, Bose SK, Dave A, White BM, Berkowitz C, Luks V, Yaqoob F, Han E, Swingle KL, Menon P, Hodgson E, Biswas A, Billingsley MM, Li L, Yiping F, Carpenter M, Trokhan A, Yeo J, Johana N, Wan TY, Alameh MG, Bennett FC, Storm PB, Jain R, Chan J, Weissman D, Mitchell MJ, Peranteau WH. Ionizable Lipid Nanoparticles for Therapeutic Base Editing of Congenital Brain Disease. ACS Nano. 2023 07 25; 17(14):13594-13610.
    View in: PubMed
    Score: 0.126
  88. Bashiri G, Padilla MS, Swingle KL, Shepherd SJ, Mitchell MJ, Wang K. Nanoparticle protein corona: from structure and function to therapeutic targeting. Lab Chip. 2023 03 14; 23(6):1432-1466.
    View in: PubMed
    Score: 0.123
  89. Chan A, Wang HH, Haley RM, Song C, Gonzalez-Martinez D, Bugaj L, Mitchell MJ, Tsourkas A. Cytosolic Delivery of Small Protein Scaffolds Enables Efficient Inhibition of Ras and Myc. Mol Pharm. 2022 04 04; 19(4):1104-1116.
    View in: PubMed
    Score: 0.115
  90. Parhiz H, Brenner JS, Patel PN, Papp TE, Shahnawaz H, Li Q, Shi R, Zamora ME, Yadegari A, Marcos-Contreras OA, Natesan A, Pardi N, Shuvaev VV, Kiseleva R, Myerson JW, Uhler T, Riley RS, Han X, Mitchell MJ, Lam K, Heyes J, Weissman D, Muzykantov VR. Added to pre-existing inflammation, mRNA-lipid nanoparticles induce inflammation exacerbation (IE). J Control Release. 2022 04; 344:50-61.
    View in: PubMed
    Score: 0.113
  91. Han X, Zhang H, Butowska K, Swingle KL, Alameh MG, Weissman D, Mitchell MJ. An ionizable lipid toolbox for RNA delivery. Nat Commun. 2021 12 13; 12(1):7233.
    View in: PubMed
    Score: 0.113
  92. Zhang D, Atochina-Vasserman EN, Maurya DS, Huang N, Xiao Q, Ona N, Liu M, Shahnawaz H, Ni H, Kim K, Billingsley MM, Pochan DJ, Mitchell MJ, Weissman D, Percec V. One-Component Multifunctional Sequence-Defined Ionizable Amphiphilic Janus Dendrimer Delivery Systems for mRNA. J Am Chem Soc. 2021 08 11; 143(31):12315-12327.
    View in: PubMed
    Score: 0.110
  93. Krohn-Grimberghe M, Mitchell MJ, Schloss MJ, Khan OF, Courties G, Guimaraes PPG, Rohde D, Cremer S, Kowalski PS, Sun Y, Tan M, Webster J, Wang K, Iwamoto Y, Schmidt SP, Wojtkiewicz GR, Nayar R, Frodermann V, Hulsmans M, Chung A, Hoyer FF, Swirski FK, Langer R, Anderson DG, Nahrendorf M. Nanoparticle-encapsulated siRNAs for gene silencing in the haematopoietic stem-cell niche. Nat Biomed Eng. 2020 11; 4(11):1076-1089.
    View in: PubMed
    Score: 0.104
  94. Figueroa-Espada CG, Hofbauer S, Mitchell MJ, Riley RS. Exploiting the placenta for nanoparticle-mediated drug delivery during pregnancy. Adv Drug Deliv Rev. 2020; 160:244-261.
    View in: PubMed
    Score: 0.104
  95. Nasajpour A, Mandla S, Shree S, Mostafavi E, Sharifi R, Khalilpour A, Saghazadeh S, Hassan S, Mitchell MJ, Leijten J, Hou X, Moshaverinia A, Annabi N, Adelung R, Mishra YK, Shin SR, Tamayol A, Khademhosseini A. Nanostructured Fibrous Membranes with Rose Spike-Like Architecture. Nano Lett. 2017 10 11; 17(10):6235-6240.
    View in: PubMed
    Score: 0.084
  96. Mitchell MJ, Webster J, Chung A, Guimarães PP, Khan OF, Langer R. Polymeric mechanical amplifiers of immune cytokine-mediated apoptosis. Nat Commun. 2017 03 20; 8:14179.
    View in: PubMed
    Score: 0.081
  97. Oberli MA, Reichmuth AM, Dorkin JR, Mitchell MJ, Fenton OS, Jaklenec A, Anderson DG, Langer R, Blankschtein D. Lipid Nanoparticle Assisted mRNA Delivery for Potent Cancer Immunotherapy. Nano Lett. 2017 03 08; 17(3):1326-1335.
    View in: PubMed
    Score: 0.080
  98. Xiao Y, Bai M, Ang MJY, Mitchell MJ, Han X. Transient T cell therapies. Adv Pharmacol. 2026; 106:179-212.
    View in: PubMed
    Score: 0.038
  99. Shuvaev VV, Tam YK, Lee BW, Myerson JW, Herbst A, Kiseleva RY, Glassman PM, Parhiz H, Alameh MG, Pardi N, Muramatsu H, Shuvaeva TI, Arguiri E, Marcos-Contreras OA, Hood ED, Brysgel TV, Nong J, Papp TE, Eaton DM, Riley R, Palanki R, Musunuru K, Brenner JS, Mitchell MJ, Ferrari VA, Mui BL, Semple SC, Weppler SA, Atluri P, Margulies KB, Weissman D, Muzykantov VR. Systemic delivery of biotherapeutic RNA to the myocardium transiently modulates cardiac contractility in vivo. Proc Natl Acad Sci U S A. 2025 Jul 22; 122(29):e2409266122.
    View in: PubMed
    Score: 0.036
  100. Chan A, Haley RM, Najar MA, Gonzalez-Martinez D, Bugaj LJ, Burslem GM, Mitchell MJ, Tsourkas A. Lipid-mediated intracellular delivery of recombinant bioPROTACs for the rapid degradation of undruggable proteins. Nat Commun. 2024 Jul 10; 15(1):5808.
    View in: PubMed
    Score: 0.034
  101. Anchordoquy T, Artzi N, Balyasnikova IV, Barenholz Y, La-Beck NM, Brenner JS, Chan WCW, Decuzzi P, Exner AA, Gabizon A, Godin B, Lai SK, Lammers T, Mitchell MJ, Moghimi SM, Muzykantov VR, Peer D, Nguyen J, Popovtzer R, Ricco M, Serkova NJ, Singh R, Schroeder A, Schwendeman AA, Straehla JP, Teesalu T, Tilden S, Simberg D. Mechanisms and Barriers in Nanomedicine: Progress in the Field and Future Directions. ACS Nano. 2024 06 04; 18(22):13983-13999.
    View in: PubMed
    Score: 0.033
  102. Costa PAC, da Silva WN, Moura Prazeres PHD, Ferreira HAS, da Silva NJA, Figueiredo MM, da Silva Oliveira B, Scalzo Júnior SRA, Silva Santos FRD, Fernandes RA, Palanki R, Hamilton AG, Birbrair A, Santos VR, de Miranda AS, Mitchell MJ, Teixeira MM, Costa VV, Guimarães PPG. siRNA lipid nanoparticles for CXCL12 silencing modulate brain immune response during Zika infection. Biomed Pharmacother. 2024 Jan; 170:115981.
    View in: PubMed
    Score: 0.032
  103. Scalzo S, Santos AK, Ferreira HAS, Costa PA, Prazeres PHDM, da Silva NJA, Guimarães LC, E Silva MM, Rodrigues Alves MTR, Viana CTR, Jesus ICG, Rodrigues AP, Birbrair A, Lobo AO, Frezard F, Mitchell MJ, Guatimosim S, Guimaraes PPG. Ionizable Lipid Nanoparticle-Mediated Delivery of Plasmid DNA in Cardiomyocytes. Int J Nanomedicine. 2022; 17:2865-2881.
    View in: PubMed
    Score: 0.029
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