 Genes, erbB-2
"Genes, erbB-2" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
The erbB-2 gene is a proto-oncogene that codes for the erbB-2 receptor (RECEPTOR, ERBB-2), a protein with structural features similar to the epidermal growth factor receptor. Its name originates from the viral oncogene homolog (v-erbB) which is a truncated form of the chicken erbB gene found in the avian erythroblastosis virus. Overexpression and amplification of the gene is associated with a significant number of adenocarcinomas. The human c-erbB-2 gene is located at 17q21.2.
| Descriptor ID |
D018734
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| MeSH Number(s) |
G05.360.340.024.340.375.500.791.295.305
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| Concept/Terms |
Genes, erbB-2- Genes, erbB-2
- c-erbB-2 Genes
- c erbB 2 Genes
- c-erbB-2 Gene
- Genes, erbb2
- Gene, erbb2
- erbb2 Gene
- erbb2 Genes
- Genes, HER-2
- HER-2 Gene
- HER-2 Genes
- Genes, neu
- neu Gene
- neu Genes
- Genes, HER2
- Gene, HER2
- HER2 Gene
- HER2 Genes
- erbB-2 Genes
- erbB 2 Genes
- erbB-2 Gene
- c-erbB-2 Proto-Oncogenes
- c erbB 2 Proto Oncogenes
- c-erbB-2 Proto-Oncogene
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Below are MeSH descriptors whose meaning is more general than "Genes, erbB-2".
Below are MeSH descriptors whose meaning is more specific than "Genes, erbB-2".
This graph shows the total number of publications written about "Genes, erbB-2" by people in this website by year, and whether "Genes, erbB-2" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 1995 | 1 | 0 | 1 | | 1996 | 1 | 0 | 1 | | 2000 | 2 | 1 | 3 | | 2001 | 0 | 1 | 1 | | 2002 | 0 | 1 | 1 | | 2003 | 5 | 0 | 5 | | 2004 | 1 | 0 | 1 | | 2005 | 1 | 1 | 2 | | 2007 | 0 | 1 | 1 | | 2008 | 0 | 1 | 1 | | 2009 | 0 | 1 | 1 | | 2011 | 0 | 1 | 1 | | 2013 | 2 | 1 | 3 | | 2015 | 1 | 1 | 2 | | 2017 | 1 | 0 | 1 |
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Below are the most recent publications written about "Genes, erbB-2" by people in Profiles.
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Pillai RN, Behera M, Berry LD, Rossi MR, Kris MG, Johnson BE, Bunn PA, Ramalingam SS, Khuri FR. HER2 mutations in lung adenocarcinomas: A report from the Lung Cancer Mutation Consortium. Cancer. 2017 Nov 01; 123(21):4099-4105.
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Li BT, Ross DS, Aisner DL, Chaft JE, Hsu M, Kako SL, Kris MG, Varella-Garcia M, Arcila ME. HER2 Amplification and HER2 Mutation Are Distinct Molecular Targets in Lung Cancers. J Thorac Oncol. 2016 Mar; 11(3):414-9.
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Sholl LM, Aisner DL, Varella-Garcia M, Berry LD, Dias-Santagata D, Wistuba II, Chen H, Fujimoto J, Kugler K, Franklin WA, Iafrate AJ, Ladanyi M, Kris MG, Johnson BE, Bunn PA, Minna JD, Kwiatkowski DJ. Multi-institutional Oncogenic Driver Mutation Analysis in Lung Adenocarcinoma: The Lung Cancer Mutation Consortium Experience. J Thorac Oncol. 2015 May; 10(5):768-777.
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Zhu P, Davis M, Blackwelder AJ, Bachman N, Liu B, Edgerton S, Williams LL, Thor AD, Yang X. Metformin selectively targets tumor-initiating cells in ErbB2-overexpressing breast cancer models. Cancer Prev Res (Phila). 2014 Feb; 7(2):199-210.
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Hanker AB, Pfefferle AD, Balko JM, Kuba MG, Young CD, S?nchez V, Sutton CR, Cheng H, Perou CM, Zhao JJ, Cook RS, Arteaga CL. Mutant PIK3CA accelerates HER2-driven transgenic mammary tumors and induces resistance to combinations of anti-HER2 therapies. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14372-7.
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Slattery ML, John EM, Stern MC, Herrick J, Lundgreen A, Giuliano AR, Hines L, Baumgartner KB, Torres-Mejia G, Wolff RK. Associations with growth factor genes (FGF1, FGF2, PDGFB, FGFR2, NRG2, EGF, ERBB2) with breast cancer risk and survival: the Breast Cancer Health Disparities Study. Breast Cancer Res Treat. 2013 Aug; 140(3):587-601.
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Fini MA, Monks J, Farabaugh SM, Wright RM. Contribution of xanthine oxidoreductase to mammary epithelial and breast cancer cell differentiation in part modulates inhibitor of differentiation-1. Mol Cancer Res. 2011 Sep; 9(9):1242-54.
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Varella-Garcia M, Mitsudomi T, Yatabe Y, Kosaka T, Nakajima E, Xavier AC, Skokan M, Zeng C, Franklin WA, Bunn PA, Hirsch FR. EGFR and HER2 genomic gain in recurrent non-small cell lung cancer after surgery: impact on outcome to treatment with gefitinib and association with EGFR and KRAS mutations in a Japanese cohort. J Thorac Oncol. 2009 Mar; 4(3):318-25.
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Bhattacharyya S, Wang S, Reinecke D, Kiser W, Kruger RA, DeGrado TR. Synthesis and evaluation of near-infrared (NIR) dye-herceptin conjugates as photoacoustic computed tomography (PCT) probes for HER2 expression in breast cancer. Bioconjug Chem. 2008 Jun; 19(6):1186-93.
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Rahman M, Davis SR, Pumphrey JG, Bao J, Nau MM, Meltzer PS, Lipkowitz S. TRAIL induces apoptosis in triple-negative breast cancer cells with a mesenchymal phenotype. Breast Cancer Res Treat. 2009 Jan; 113(2):217-30.
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