 Nicorandil
"Nicorandil" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A derivative of the NIACINAMIDE that is structurally combined with an organic nitrate. It is a potassium-channel opener that causes vasodilatation of arterioles and large coronary arteries. Its nitrate-like properties produce venous vasodilation through stimulation of guanylate cyclase.
| Descriptor ID |
D020108
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| MeSH Number(s) |
D02.583.575 D03.066.515.530.498 D03.383.725.547.530.498
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| Concept/Terms |
Nicorandil- Nicorandil
- 2-Nicotinamidoethyl Nitrate
- 2 Nicotinamidoethyl Nitrate
- Nitrate, 2-Nicotinamidoethyl
- 2-Nicotinamidethyl Nitrate
- 2 Nicotinamidethyl Nitrate
- Nitrate, 2-Nicotinamidethyl
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Below are MeSH descriptors whose meaning is more general than "Nicorandil".
Below are MeSH descriptors whose meaning is more specific than "Nicorandil".
This graph shows the total number of publications written about "Nicorandil" by people in this website by year, and whether "Nicorandil" was a major or minor topic of these publications.
To see the data from this visualization as text, click here.
| Year | Major Topic | Minor Topic | Total |
|---|
| 2012 | 1 | 0 | 1 | | 2020 | 0 | 1 | 1 | | 2021 | 0 | 2 | 2 |
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Below are the most recent publications written about "Nicorandil" by people in Profiles.
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Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Direct and indirect activation of the adenosine triphosphate-sensitive potassium channel to induce spinal cord ischemic metabolic tolerance. J Thorac Cardiovasc Surg. 2023 03; 165(3):e90-e99.
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Ikeno Y, Ghincea CV, Roda GF, Cheng L, Aftab M, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Reece TB. Optimizing Nicorandil for Spinal Cord Protection in a Murine Model of Complex Aortic Intervention. Semin Thorac Cardiovasc Surg. 2022; 34(1):28-38.
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Ikeno Y, Ghincea CV, Roda GF, Cheng L, Meng X, Weyant MJ, Cleveland JC, Fullerton DA, Aftab M, Reece TB. Reactive Oxygen Species Mediate Nicorandil-induced Metabolic Tolerance to Spinal Cord Injury. Ann Thorac Surg. 2021 07; 112(1):38-44.
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Shiraishi T, Tamura Y, Taniguchi K, Higaki M, Ueda S, Shima T, Nagura M, Nakagawa T, Johnson RJ, Uchida S. Combination of ACE inhibitor with nicorandil provides further protection in chronic kidney disease. Am J Physiol Renal Physiol. 2014 Dec 15; 307(12):F1313-22.
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Tamura Y, Tanabe K, Kitagawa W, Uchida S, Schreiner GF, Johnson RJ, Nakagawa T. Nicorandil, a K(atp) channel opener, alleviates chronic renal injury by targeting podocytes and macrophages. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F339-49.
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Tanabe K, Lanaspa MA, Kitagawa W, Rivard CJ, Miyazaki M, Klawitter J, Schreiner GF, Saleem MA, Mathieson PW, Makino H, Johnson RJ, Nakagawa T. Nicorandil as a novel therapy for advanced diabetic nephropathy in the eNOS-deficient mouse. Am J Physiol Renal Physiol. 2012 May 01; 302(9):F1151-60.
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