The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues.
Pate KM, Sherk VD, Carpenter RD, Weaver M, Crapo S, Gally F, Chatham LS, Goldstrohm DA, Crapo JD, Kohrt WM, Bowler RP, Oberley-Deegan RE, Regan EA. The beneficial effects of exercise on cartilage are lost in mice with reduced levels of ECSOD in tissues. J Appl Physiol (1985). 2015 Mar 15; 118(6):760-7.