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Paul Buehler

TitleAffiliate
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017; 12(2):e0171219. PMID: 28152051.
      View in: PubMed
    2. Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. Am J Respir Crit Care Med. 2016 May 15; 193(10):1111-22. PMID: 26694989; PMCID: PMC4872667 [Available on 05/15/17].
    3. Rentsendorj O, Zhang X, Williams MC, Buehler PW, D'Agnillo F. Transcriptional Suppression of Renal Antioxidant Enzyme Systems in Guinea Pigs Exposed to Polymerized Cell-Free Hemoglobin. Toxics. 2016; 4(1). PMID: 27471729.
      View in: PubMed
    4. Jia Y, Wood F, Buehler PW, Alayash AI. Haptoglobin preferentially binds ß but not a subunits cross-linked hemoglobin tetramers with minimal effects on ligand and redox reactions. PLoS One. 2013; 8(3):e59841. PMID: 23555800; PMCID: PMC3612097.
    5. Schaer DJ, Buehler PW, Alayash AI, Belcher JD, Vercellotti GM. Hemolysis and free hemoglobin revisited: exploring hemoglobin and hemin scavengers as a novel class of therapeutic proteins. Blood. 2013 Feb 21; 121(8):1276-84. PMID: 23264591; PMCID: PMC3578950.
    6. Cooper CE, Schaer DJ, Buehler PW, Wilson MT, Reeder BJ, Silkstone G, Svistunenko DA, Bulow L, Alayash AI. Haptoglobin binding stabilizes hemoglobin ferryl iron and the globin radical on tyrosine ß145. Antioxid Redox Signal. 2013 Jun 10; 18(17):2264-73. PMID: 22702311; PMCID: PMC3638561.
    7. Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L312-26. PMID: 22728465; PMCID: PMC3423829.
    8. Baek JH, D'Agnillo F, Vallelian F, Pereira CP, Williams MC, Jia Y, Schaer DJ, Buehler PW. Hemoglobin-driven pathophysiology is an in vivo consequence of the red blood cell storage lesion that can be attenuated in guinea pigs by haptoglobin therapy. J Clin Invest. 2012 Apr; 122(4):1444-58. PMID: 22446185; PMCID: PMC3314461.
    9. Baek JH, Zhou Y, Harris DR, Schaer DJ, Palmer AF, Buehler PW. Down selection of polymerized bovine hemoglobins for use as oxygen releasing therapeutics in a guinea pig model. Toxicol Sci. 2012 Jun; 127(2):567-81. PMID: 22416071; PMCID: PMC3355313.
    10. Manalo DJ, Baek JH, Buehler PW, Struble E, Abraham B, Alayash AI. Inactivation of prolyl hydroxylase domain (PHD) protein by epigallocatechin (EGCG) stabilizes hypoxia-inducible factor (HIF-1a) and induces hepcidin (Hamp) in rat kidney. Biochem Biophys Res Commun. 2011 Dec 16; 416(3-4):421-6. PMID: 22138393.
      View in: PubMed
    11. Zhou Y, Jia Y, Buehler PW, Chen G, Cabrales P, Palmer AF. Synthesis, biophysical properties, and oxygenation potential of variable molecular weight glutaraldehyde-polymerized bovine hemoglobins with low and high oxygen affinity. Biotechnol Prog. 2011 Jul; 27(4):1172-84. PMID: 21584950.
      View in: PubMed
    12. Baek JH, Reiter CE, Manalo DJ, Buehler PW, Hider RC, Alayash AI. Induction of hypoxia inducible factor (HIF-1a) in rat kidneys by iron chelation with the hydroxypyridinone, CP94. Biochim Biophys Acta. 2011 Apr-Jun; 1809(4-6):262-8. PMID: 21558026.
      View in: PubMed
    13. Buehler PW, Karnaukhova E, Gelderman MP, Alayash AI. Blood aging, safety, and transfusion: capturing the "radical" menace. Antioxid Redox Signal. 2011 May 01; 14(9):1713-28. PMID: 20954814.
      View in: PubMed
    14. Buehler PW, D'Agnillo F, Schaer DJ. Hemoglobin-based oxygen carriers: From mechanisms of toxicity and clearance to rational drug design. Trends Mol Med. 2010 Oct; 16(10):447-57. PMID: 20708968.
      View in: PubMed
    15. Elmer J, Buehler PW, Jia Y, Wood F, Harris DR, Alayash AI, Palmer AF. Functional comparison of hemoglobin purified by different methods and their biophysical implications. Biotechnol Bioeng. 2010 May 01; 106(1):76-85. PMID: 20073089.
      View in: PubMed
    16. Buehler PW, Zhou Y, Cabrales P, Jia Y, Sun G, Harris DR, Tsai AG, Intaglietta M, Palmer AF. Synthesis, biophysical properties and pharmacokinetics of ultrahigh molecular weight tense and relaxed state polymerized bovine hemoglobins. Biomaterials. 2010 May; 31(13):3723-35. PMID: 20149433; PMCID: PMC2837140.
    17. Butt OI, Buehler PW, D'Agnillo F. Differential induction of renal heme oxygenase and ferritin in ascorbate and nonascorbate producing species transfused with modified cell-free hemoglobin. Antioxid Redox Signal. 2010 Feb; 12(2):199-208. PMID: 19659432.
      View in: PubMed
    18. Boretti FS, Buehler PW, D'Agnillo F, Kluge K, Glaus T, Butt OI, Jia Y, Goede J, Pereira CP, Maggiorini M, Schoedon G, Alayash AI, Schaer DJ. Sequestration of extracellular hemoglobin within a haptoglobin complex decreases its hypertensive and oxidative effects in dogs and guinea pigs. J Clin Invest. 2009 Aug; 119(8):2271-80. PMID: 19620788; PMCID: PMC2719941.
    19. Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW. Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):200-9. PMID: 19395680; PMCID: PMC2822981.
    20. Buehler PW, Abraham B, Vallelian F, Linnemayr C, Pereira CP, Cipollo JF, Jia Y, Mikolajczyk M, Boretti FS, Schoedon G, Alayash AI, Schaer DJ. Haptoglobin preserves the CD163 hemoglobin scavenger pathway by shielding hemoglobin from peroxidative modification. Blood. 2009 Mar 12; 113(11):2578-86. PMID: 19131549.
      View in: PubMed
    21. Manalo DJ, Buehler PW, Baek JH, Butt O, D'agnillo F, Alayash AI. Acellular haemoglobin attenuates hypoxia-inducible factor-1alpha (HIF-1alpha) and its target genes in haemodiluted rats. Biochem J. 2008 Sep 15; 414(3):461-9. PMID: 18498252.
      View in: PubMed
    22. Buehler PW, Vallelian F, Mikolajczyk MG, Schoedon G, Schweizer T, Alayash AI, Schaer DJ. Structural stabilization in tetrameric or polymeric hemoglobin determines its interaction with endogenous antioxidant scavenger pathways. Antioxid Redox Signal. 2008 Aug; 10(8):1449-62. PMID: 18522492.
      View in: PubMed
    23. Vallelian F, Pimenova T, Pereira CP, Abraham B, Mikolajczyk MG, Schoedon G, Zenobi R, Alayash AI, Buehler PW, Schaer DJ. The reaction of hydrogen peroxide with hemoglobin induces extensive alpha-globin crosslinking and impairs the interaction of hemoglobin with endogenous scavenger pathways. Free Radic Biol Med. 2008 Oct 15; 45(8):1150-8. PMID: 18708138.
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    24. Cooper CE, Silaghi-Dumitrescu R, Rukengwa M, Alayash AI, Buehler PW. Peroxidase activity of hemoglobin towards ascorbate and urate: a synergistic protective strategy against toxicity of Hemoglobin-Based Oxygen Carriers (HBOC). Biochim Biophys Acta. 2008 Oct; 1784(10):1415-20. PMID: 18457681.
      View in: PubMed
    25. Buehler PW, Alayash AI. All hemoglobin-based oxygen carriers are not created equally. Biochim Biophys Acta. 2008 Oct; 1784(10):1378-81. PMID: 18206989.
      View in: PubMed
    26. Buehler PW, D'Agnillo F, Hoffman V, Alayash AI. Effects of endogenous ascorbate on oxidation, oxygenation, and toxicokinetics of cell-free modified hemoglobin after exchange transfusion in rat and guinea pig. J Pharmacol Exp Ther. 2007 Oct; 323(1):49-60. PMID: 17622572.
      View in: PubMed
    27. Schaer DJ, Alayash AI, Buehler PW. Gating the radical hemoglobin to macrophages: the anti-inflammatory role of CD163, a scavenger receptor. Antioxid Redox Signal. 2007 Jul; 9(7):991-9. PMID: 17508920.
      View in: PubMed
    28. Alayash AI, D'Agnillo F, Buehler PW. First-generation blood substitutes: what have we learned? Biochemical and physiological perspectives. Expert Opin Biol Ther. 2007 May; 7(5):665-75. PMID: 17477804.
      View in: PubMed
    29. Jia Y, Buehler PW, Boykins RA, Venable RM, Alayash AI. Structural basis of peroxide-mediated changes in human hemoglobin: a novel oxidative pathway. J Biol Chem. 2007 Feb 16; 282(7):4894-907. PMID: 17178725.
      View in: PubMed
    30. Dunne J, Caron A, Menu P, Alayash AI, Buehler PW, Wilson MT, Silaghi-Dumitrescu R, Faivre B, Cooper CE. Ascorbate removes key precursors to oxidative damage by cell-free haemoglobin in vitro and in vivo. Biochem J. 2006 Nov 01; 399(3):513-24. PMID: 16848758; PMCID: PMC1615907.
    31. Buehler PW, Boykins RA, Norris S, Alayash AI. Chemical characterization of diaspirin cross-linked hemoglobin polymerized with poly(ethylene glycol). Anal Chem. 2006 Jul 01; 78(13):4634-41. PMID: 16808476.
      View in: PubMed
    32. Buehler PW, Alayash AI. Redox biology of blood revisited: the role of red blood cells in maintaining circulatory reductive capacity. Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1755-60. PMID: 16356136.
      View in: PubMed
    33. Haney CR, Buehler PW, Gulati A. Synthesis and characterization of a novel DTPA polymerized hemoglobin based oxygen carrier. Biochim Biophys Acta. 2005 Oct 10; 1725(3):358-69. PMID: 16102904.
      View in: PubMed
    34. Schaer DJ, Schaer CA, Buehler PW, Boykins RA, Schoedon G, Alayash AI, Schaffner A. CD163 is the macrophage scavenger receptor for native and chemically modified hemoglobins in the absence of haptoglobin. Blood. 2006 Jan 01; 107(1):373-80. PMID: 16189277.
      View in: PubMed
    35. Buehler PW, Boykins RA, Jia Y, Norris S, Freedberg DI, Alayash AI. Structural and functional characterization of glutaraldehyde-polymerized bovine hemoglobin and its isolated fractions. Anal Chem. 2005 Jun 01; 77(11):3466-78. PMID: 15924377.
      View in: PubMed
    36. Boykins RA, Buehler PW, Jia Y, Venable R, Alayash AI. O-raffinose crosslinked hemoglobin lacks site-specific chemistry in the central cavity: structural and functional consequences of beta93Cys modification. Proteins. 2005 Jun 01; 59(4):840-55. PMID: 15822103.
      View in: PubMed
    37. Buehler PW, Alayash AI. Oxygen sensing in the circulation: "cross talk" between red blood cells and the vasculature. Antioxid Redox Signal. 2004 Dec; 6(6):1000-10. PMID: 15548897.
      View in: PubMed
    38. Buehler PW, Alayash AI. Toxicities of hemoglobin solutions: in search of in-vitro and in-vivo model systems. Transfusion. 2004 Oct; 44(10):1516-30. PMID: 15383027.
      View in: PubMed
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