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Eric W Prince

TitleResearch Scientist
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-NS General Operations
Phone303/556-2461

    Collapse Research 
    Collapse research activities and funding
    F31CA275272     (PRINCE, ERIC W)Jul 3, 2023 - Jul 2, 2026
    NIH
    Human-centered design of clinical AI to support the diagnosis of pediatric suprasellar tumors
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Prince EW, Mirsky DM, Hankinson TC, G?rg C. Impact of AI Decision Support on Clinical Experts' Radiographic Interpretation of Adamantinomatous Craniopharyngioma. AMIA Annu Symp Proc. 2024; 2024:930-939. PMID: 40417524.
      View in: PubMed
    2. Alimova I, Wang D, DeSisto J, Danis E, Lakshmanachetty S, Prince E, Murdock G, Pierce A, Donson A, Balakrishnan I, Serkova N, Lin H, Foreman NK, Dahl N, Venkataraman S, Vibhakar R. SIRT2 regulates the SMARCB1 loss-driven differentiation block in ATRT. Mol Cancer Res. 2025 Feb 17. PMID: 39960392.
      View in: PubMed
    3. Prince EW, Mirsky DM, Hankinson TC, G?rg C. Current state and promise of user-centered design to harness explainable AI in clinical decision-support systems for patients with CNS tumors. Front Radiol. 2024; 4:1433457. PMID: 39872709.
      View in: PubMed
    4. Prince EW, Hankinson TC, G?rg C. A Visual Analytics Framework for Assessing Interactive AI for Clinical Decision Support. Pac Symp Biocomput. 2025; 30:40-53. PMID: 39670360.
      View in: PubMed
    5. Brooks T, Gao D, Dorris K, Boone K, Mirsky DM, Staulcup S, Prince E, Moskalenko M, Ignowski E, Wandrey N, Fakhoury K, Hankinson TC, Milgrom SA. Does pre-irradiation gross tumor volume predict the risk of progression after radiation therapy in pediatric patients with adamantinomatous craniopharyngioma? J Neurosurg Pediatr. 2024 Dec 01; 34(6):642-648. PMID: 39332032.
      View in: PubMed
    6. Apps JR, Gonzalez-Meljem JM, Guiho R, Pickles JC, Prince E, Schwalbe E, Joshi N, Stone TJ, Ogunbiyi O, Chalker J, Bassey A, Otto G, Davies R, Hughes D, Brandner S, Tan E, Lee V, Hayhurst C, Kline C, Castellano S, Hankinson T, Deutschbein T, Jacques TS, Martinez-Barbera JP. Recurrent adamantinomatous craniopharyngiomas show MAPK pathway activation, clonal evolution and rare TP53-loss-mediated malignant progression. Acta Neuropathol Commun. 2024 Aug 10; 12(1):127. PMID: 39127699.
      View in: PubMed
    7. Prince EW, Apps JR, Jeang J, Chee K, Medlin S, Jackson EM, Dudley R, Limbrick D, Naftel R, Johnston J, Feldstein N, Prolo LM, Ginn K, Niazi T, Smith A, Kilburn L, Chern J, Leonard J, Lam S, Hersh DS, Gonzalez-Meljem JM, Amani V, Donson AM, Mitra SS, Bandopadhayay P, Martinez-Barbera JP, Hankinson TC. Unraveling the complexity of the senescence-associated secretory phenotype in adamantinomatous craniopharyngioma using multimodal machine learning analysis. Neuro Oncol. 2024 06 03; 26(6):1109-1123. PMID: 38334125.
      View in: PubMed
    8. Prince EW, Hankinson TC, G?rg C. The Iterative Design Process of an Explainable AI Application for Non-Invasive Diagnosis of CNS Tumors: A User-Centered Approach. IEEE Workshop Vis Anal Healthc. 2023 Oct; 2023:7-13. PMID: 38989292.
      View in: PubMed
    9. Griesinger AM, Riemondy K, Eswaran N, Donson AM, Willard N, Prince EW, Paine SML, Bowes G, Rheaume J, Chapman RJ, Ramage J, Jackson A, Grundy RG, Foreman NK, Ritzmann TA. Multi-omic approach identifies hypoxic tumor-associated myeloid cells that drive immunobiology of high-risk pediatric ependymoma. iScience. 2023 Sep 15; 26(9):107585. PMID: 37694144.
      View in: PubMed
    10. Prince E, Hankinson TC, G?rg C. EASL: A Framework for Designing, Implementing, and Evaluating ML Solutions in Clinical Healthcare Settings. Proc Mach Learn Res. 2023 Aug; 219:612-630. PMID: 38988337.
      View in: PubMed
    11. Prince EW, Ghosh D, G?rg C, Hankinson TC. Uncertainty-Aware Deep Learning Classification of Adamantinomatous Craniopharyngioma from Preoperative MRI. Diagnostics (Basel). 2023 Mar 16; 13(6). PMID: 36980440.
      View in: PubMed
    12. Chopra T, Neuberger I, Prince E, White C, Maloney J, Stence N, Mirsky D. Age-related changes in the completeness of the circle of Willis in children. Childs Nerv Syst. 2022 06; 38(6):1181-1184. PMID: 35394211.
      View in: PubMed
    13. Prince EW, Hoffman LM, Vijmasi T, Dorris K, McWilliams JA, Jordan KR, Mirsky DM, Hankinson TC. Adamantinomatous craniopharyngioma associated with a compromised blood-brain barrier: patient series. J Neurosurg Case Lessons. 2021 May 10; 1(19):CASE2150. PMID: 35854837.
      View in: PubMed
    14. Prince EW, Whelan R, Mirsky DM, Stence N, Staulcup S, Klimo P, Anderson RCE, Niazi TN, Grant G, Souweidane M, Johnston JM, Jackson EM, Limbrick DD, Smith A, Drapeau A, Chern JJ, Kilburn L, Ginn K, Naftel R, Dudley R, Tyler-Kabara E, Jallo G, Handler MH, Jones K, Donson AM, Foreman NK, Hankinson TC. Robust deep learning classification of adamantinomatous craniopharyngioma from limited preoperative radiographic images. Sci Rep. 2020 10 09; 10(1):16885. PMID: 33037266.
      View in: PubMed
    15. Gillen AE, Riemondy KA, Amani V, Griesinger AM, Gilani A, Venkataraman S, Madhavan K, Prince E, Sanford B, Hankinson TC, Handler MH, Vibhakar R, Jones KL, Mitra S, Hesselberth JR, Foreman NK, Donson AM. Single-Cell RNA Sequencing of Childhood Ependymoma Reveals Neoplastic Cell Subpopulations That Impact Molecular Classification and Etiology. Cell Rep. 2020 08 11; 32(6):108023. PMID: 32783945.
      View in: PubMed
    16. Whelan R, Hengartner A, Folzenlogen Z, Prince E, Hankinson TC. Adamantinomatous craniopharyngioma in the molecular age and the potential of targeted therapies: a review. Childs Nerv Syst. 2020 08; 36(8):1635-1642. PMID: 32440897.
      View in: PubMed
    17. Prince E, Whelan R, Donson A, Staulcup S, Hengartner A, Vijmasi T, Agwu C, Lillehei KO, Foreman NK, Johnston JM, Massimi L, Anderson RCE, Souweidane MM, Naftel RP, Limbrick DD, Grant G, Niazi TN, Dudley R, Kilburn L, Jackson EM, Jallo GI, Ginn K, Smith A, Chern JJ, Lee A, Drapeau A, Krieger MD, Handler MH, Hankinson TC. Transcriptional analyses of adult and pediatric adamantinomatous craniopharyngioma reveals similar expression signatures regarding potential therapeutic targets. Acta Neuropathol Commun. 2020 05 13; 8(1):68. PMID: 32404202.
      View in: PubMed
    18. Moreira DC, Venkataraman S, Subramanian A, Desisto J, Balakrishnan I, Prince E, Pierce A, Griesinger A, Green A, Eberhardt CG, Foreman NK, Vibhakar R. Targeting MYC-driven replication stress in medulloblastoma with AZD1775 and gemcitabine. J Neurooncol. 2020 May; 147(3):531-545. PMID: 32180106.
      View in: PubMed
    19. Whelan R, Prince E, Gilani A, Hankinson T. The Inflammatory Milieu of Adamantinomatous Craniopharyngioma and Its Implications for Treatment. J Clin Med. 2020 Feb 14; 9(2). PMID: 32075140.
      View in: PubMed
    20. Hengartner AC, Prince E, Vijmasi T, Hankinson TC. Adamantinomatous craniopharyngioma: moving toward targeted therapies. Neurosurg Focus. 2020 01 01; 48(1):E7. PMID: 31896087.
      View in: PubMed
    21. Pierce AM, Witt DA, Donson AM, Gilani A, Sanford B, Sill M, Van Court B, Oweida A, Prince EW, Steiner J, Danis E, Dorris K, Hankinson T, Handler MH, Jones KL, Karam SD, Serkova NJ, Vibhakar R, Foreman NK, Griesinger AM. Establishment of patient-derived orthotopic xenograft model of 1q+ posterior fossa group A ependymoma. Neuro Oncol. 2019 12 17; 21(12):1540-1551. PMID: 31276586.
      View in: PubMed
    22. Whelan R, Prince E, Mirsky DM, Naftel R, Bhatia A, Pettorini B, Avula S, Staulcup S, Alexander AL, Meier M, Hankinson TC. Interrater reliability of a method to assess hypothalamic involvement in pediatric adamantinomatous craniopharyngioma. J Neurosurg Pediatr. 2020 01 01; 25(1):37-42. PMID: 31604324.
      View in: PubMed
    23. Lake JA, Donson AM, Prince E, Davies KD, Nellan A, Green AL, Mulcahy Levy J, Dorris K, Vibhakar R, Hankinson TC, Foreman NK, Ewalt MD, Kleinschmidt-DeMasters BK, Hoffman LM, Gilani A. Targeted fusion analysis can aid in the classification and treatment of pediatric glioma, ependymoma, and glioneuronal tumors. Pediatr Blood Cancer. 2020 01; 67(1):e28028. PMID: 31595628.
      View in: PubMed
    24. Flannery PC, DeSisto JA, Amani V, Venkataraman S, Lemma RT, Prince EW, Donson A, Moroze EE, Hoffman L, Levy JMM, Foreman N, Vibhakar R, Green AL. Preclinical analysis of MTOR complex 1/2 inhibition in diffuse intrinsic pontine glioma. Oncol Rep. 2018 Feb; 39(2):455-464. PMID: 29207163.
      View in: PubMed
    25. Alimova I, Pierce AM, Harris P, Donson A, Birks DK, Prince E, Balakrishnan I, Foreman NK, Kool M, Hoffman L, Venkataraman S, Vibhakar R. Targeting Polo-like kinase 1 in SMARCB1 deleted atypical teratoid rhabdoid tumor. Oncotarget. 2017 Nov 14; 8(57):97290-97303. PMID: 29228610.
      View in: PubMed
    26. Amani V, Donson AM, Lummus SC, Prince EW, Griesinger AM, Witt DA, Hankinson TC, Handler MH, Dorris K, Vibhakar R, Foreman NK, Hoffman LM. Characterization of 2 Novel Ependymoma Cell Lines With Chromosome 1q Gain Derived From Posterior Fossa Tumors of Childhood. J Neuropathol Exp Neurol. 2017 Jul 01; 76(7):595-604. PMID: 28863455.
      View in: PubMed
    27. Amani V, Prince EW, Alimova I, Balakrishnan I, Birks D, Donson AM, Harris P, Levy JM, Handler M, Foreman NK, Venkataraman S, Vibhakar R. Polo-like Kinase?1 as a potential therapeutic target in Diffuse Intrinsic Pontine Glioma. BMC Cancer. 2016 08 18; 16:647. PMID: 27538997.
      View in: PubMed
    28. Prince EW, Balakrishnan I, Shah M, Mulcahy Levy JM, Griesinger AM, Alimova I, Harris PS, Birks DK, Donson AM, Davidson N, Remke M, Taylor MD, Handler MH, Foreman NK, Venkataraman S, Vibhakar R. Checkpoint kinase 1 expression is an adverse prognostic marker and therapeutic target in MYC-driven medulloblastoma. Oncotarget. 2016 Aug 16; 7(33):53881-53894. PMID: 27449089.
      View in: PubMed
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