Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Jonathan Irish

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
ORCID ORCID Icon0000-0001-9428-8866 Additional info

    Collapse Biography 
    Collapse education and training
    Stanford University, Palo Alto, CAPhD04/2004Cancer Biology
    University of Michigan, Ann Arbor, MIBS, Chem.05/1998Chemistry
    University of Michigan, Ann Arbor, MIBS05/1998Biology, Honors
    University of Michigan, Ann Arbor, MIBS05/1998Biochemistry

    Collapse Overview 
    Collapse overview
    The Irish lab studies how signaling governs cell identity in healthy human tissue and in diseases, including brain tumors, blood cancers, and immune disorders. Dr. Irish is an expert in the identification and functional characterization of human cells. Research in the Irish lab emphasizes integrated creation and use of bench and computational techniques. The Irish lab leads the CytoLab data science team at CU Anschutz and is based in Pediatrics-Neurology. Dr. Irish previously trained at Stanford for PhD and postdoc (2004-2011) and directed a research group and shared resource at Vanderbilt University (2012-2024).

    Irish Lab Website:
    https://www.irishlab.org/

    Jonathan Irish on Google Scholar:
    https://scholar.google.com/citations?user=-IJndUMAAAAJ

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Seyedi P, Aleman D, Baxter NN, Bell CM, Bodur M, Calzavara A, Campbell R, Carter M, de Jager P, Emerson SD, Irish J, Martin D, Lee S, Persitz J, Saxe-Braithwaite M, Takata J, Varkul O, Yang S, Zanchetta C, Urbach DR. Effect of single-entry referral models and team-based care on wait times for hip and knee joint replacement in Ontario: a simulation study. CMAJ. 2025 05 19; 197(19):E524-E531. PMID: 40393716.
      View in: PubMed
    2. Seyedi P, Aleman D, Baxter N, Bell C, Bodur M, Calzavara A, Campbell R, Carter M, de Jager P, Emerson S, Gagliardi A, Irish J, Martin D, Lee S, Saxe-Braithwaite M, Takata J, Yang S, Zanchetta C, Urbach D. Referral patterns for common surgical procedures in Ontario: a cross-sectional population-level study. Can J Surg. 2024 Nov-Dec; 67(6):E397-E405. PMID: 39672555.
      View in: PubMed
    3. Grewal K, Calzavara A, McLeod SL, Eskander A, Savage DW, Thompson C, Borgundvaag B, Ovens H, Cheskes S, de Wit K, Irish J, Krzyzanowska MK, Walsh R, Mohindra R, Thiruganasambandamoorthy V, Sutradhar R. Emergency department use before cancer diagnosis in Ontario, Canada: a population-based study. CMAJ. 2024 11 03; 196(37):E1252-E1261. PMID: 39496352.
      View in: PubMed
    4. Syrimi E, Khan N, Murray P, Willcox C, Haigh T, Willcox B, Masand N, Bowen C, Dimakou DB, Zuo J, Barone SM, Irish JM, Kearns P, Taylor GS. Defects in NK cell immunity of pediatric cancer patients revealed by deep immune profiling. iScience. 2024 Sep 20; 27(9):110837. PMID: 39310750.
      View in: PubMed
    5. Campbell RJ, El-Defrawy SR, Bell CM, Urbach DR, Paterson JM, Stukel TA, Gill SS, Irish J, Baxter NN, Wilton AS, Gomez D. Public funding for private for-profit centres and access to cataract surgery by patient socioeconomic status: an Ontario population-based study. CMAJ. 2024 08 25; 196(28):E965-E972. PMID: 39187289.
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    6. Voss K, Bartkowiak T, Sewell AE, Chi C, Landis MD, Schaefer S, Pua HH, Connelly JA, Irish JM, Rathmell JC, Kaviany S. Peripheral T Cell Development and Immunophenotyping of Twins with Heterozygous FOXN1 Mutations. Immunohorizons. 2024 07 01; 8(7):492-499. PMID: 39008056.
      View in: PubMed
    7. Tentori CA, Zhao LP, Tinterri B, Strange KE, Zoldan K, Dimopoulos K, Feng X, Riva E, Lim B, Simoni Y, Murthy V, Hayes MJ, Poloni A, Padron E, Cardoso BA, Cross M, Winter S, Santaolalla A, Patel BA, Groarke EM, Wiseman DH, Jones K, Jamieson L, Manogaran C, Daver N, Gallur L, Ingram W, Ferrell PB, Sockel K, Dulphy N, Chapuis N, Kubasch AS, Olsnes AM, Kulasekararaj A, De Lavellade H, Kern W, Van Hemelrijck M, Bonnet D, Westers TM, Freeman S, Oelschlaegel U, Valcarcel D, Raddi MG, Gr?nb?k K, Fontenay M, Loghavi S, Santini V, Almeida AM, Irish JM, Sallman DA, Young NS, van de Loosdrecht AA, Ad?s L, Della Porta MG, Cargo C, Platzbecker U, Kordasti S. Immune-monitoring of myelodysplastic neoplasms: Recommendations from the i4MDS consortium. Hemasphere. 2024 May; 8(5):e64. PMID: 38756352.
      View in: PubMed
    8. Cross CE, Mayeda C, Medina S, Hayes MJ, Kaviany S, Connelly JA, Rathmell JC, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. Velociraptor: Cross-Platform Quantitative Search Using Hallmark Cell Features. bioRxiv. 2024 May 04. PMID: 38746337.
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    9. Thirman HL, Hayes MJ, Brown LE, Porco JA, Irish JM. Single Cell Profiling Distinguishes Leukemia-Selective Chemotypes. bioRxiv. 2024 May 03. PMID: 38826485.
      View in: PubMed
    10. von Lersner AK, Fernandes F, Ozawa PMM, Jackson M, Masureel M, Ho H, Lima SM, Vagner T, Sung BH, Wehbe M, Franze K, Pua H, Wilson JT, Irish JM, Weaver AM, Di Vizio D, Zijlstra A. Multiparametric Single-Vesicle Flow Cytometry Resolves Extracellular Vesicle Heterogeneity and Reveals Selective Regulation of Biogenesis and Cargo Distribution. ACS Nano. 2024 04 16; 18(15):10464-10484. PMID: 38578701.
      View in: PubMed
    11. Medina S, Brockman AA, Cross CE, Hayes MJ, Mobley BC, Mistry AM, Chotai S, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. IL-8 Instructs Macrophage Identity in Lateral Ventricle Contacting Glioblastoma. bioRxiv. 2024 Mar 30. PMID: 38585888.
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    12. Sahovaler A, Valic MS, Townson JL, Chan HHL, Zheng M, Tzelnick S, Mondello T, Pener-Tessler A, Eu D, El-Sayes A, Ding L, Chen J, Douglas CM, Weersink R, Muhanna N, Zheng G, Irish JC. Nanoparticle-mediated Photodynamic Therapy as a Method to Ablate Oral Cavity Squamous Cell Carcinoma in Preclinical Models. Cancer Res Commun. 2024 03 15; 4(3):796-810. PMID: 38421899.
      View in: PubMed
    13. de Jager P, Aleman D, Baxter N, Bell C, Bodur M, Calzavara A, Campbell R, Carter M, Emerson S, Gagliardi A, Irish J, Martin D, Lee S, Saxe-Braithwaite M, Seyedi P, Takata J, Yang S, Zanchetta C, Urbach D. Social determinants of access to timely elective surgery in Ontario, Canada: a cross-sectional population level study. CMAJ Open. 2023 Nov-Dec; 11(6):E1164-E1180. PMID: 38114259.
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    14. Bri?re R, ?mond M, Benhamed A, Blanchard PG, Drolet S, Habashi R, Golbon B, Shellenberger J, Pasternak J, Merchant S, Shellenberger J, La J, Sawhney M, Brogly S, Cadili L, Horkoff M, Ainslie S, Demetrick J, Chai B, Wiseman K, Hwang H, Alhumoud Z, Salem A, Lau R, Aw K, Nessim C, Gawad N, Alibhai K, Towaij C, Doan D, Ra?che I, Valji R, Turner S, Balmes PN, Hwang H, Hameed SM, Tan JGK, Wijesuriya R, Tan JGK, Hew NLC, Wijesuriya R, Lund M, Hawel J, Gregor J, Leslie K, Lenet T, McIsaac D, Hallet J, Jerath A, Lalu M, Nicholls S, Presseau J, Tinmouth A, Verret M, Wherrett C, Fergusson D, Martel G, Sharma S, McKechnie T, Talwar G, Patel J, Heimann L, Doumouras A, Hong D, Eskicioglu C, Wang C, Guo M, Huang L, Sun S, Davis N, Wang J, Skulsky S, Sikora L, Ra?che I, Son HJ, Gee D, Gomez D, Jung J, Selvam R, Seguin N, Zhang L, Lacaille-Ranger A, Sikora L, McIsaac D, Moloo H, Follett A, Organ M, Pace D, Balvardi S, Kaneva P, Semsar-Kazerooni K, Mueller C, Vassiliou M, Al Mahroos M, Fiore JF, Schwartzman K, Feldman L, Guo M, Karimuddin A, Liu GP, Crump T, Sutherland J, Hickey K, Bonisteel EM, Umali J, Dogar I, Warden G, Boone D, Mathieson A, Hogan M, Pace D, Seguin N, Moloo H, Li Y, Best G, Leong R, Wiseman S, Alaoui AA, Hajjar R, Wassef E, Metellus DS, Dagbert F, Loungnarath R, Ratelle R, Schwenter F, Debroux ?, Wassef R, Gagnon-Konamna M, Pomp A, Richard CS, Sebajang H, Alaoui AA, Hajjar R, Dagbert F, Loungnarath R, Sebajang H, Ratelle R, Schwenter F, Debroux ?, Wassef R, Gagnon-Konamna M, Pomp A, Santos MM, Richard CS, Shi G, Leung R, Lim C, Knowles S, Parmar S, Wang C, Debru E, Mohamed F, Anakin M, Lee Y, Samarasinghe Y, Khamar J, Petrisor B, McKechnie T, Eskicioglu C, Yang I, Mughal HN, Bhugio M, Gok MA, Khan UA, Fernandes AR, Spence R, Porter G, Hoogerboord CM, Neumann K, Pillar M, Guo M, Manhas N, Melck A, Kazi T, McKechnie T, Jessani G, Heimann L, Lee Y, Hong D, Eskicioglu C, McKechnie T, Tessier L, Archer V, Park L, Cohen D, Parpia S, Bhandari M, Dionne J, Eskicioglu C, Bolin S, Afford R, Armstrong M, Karimuddin A, Leung R, Shi G, Lim C, Grant A, Van Koughnett JA, Knowles S, Clement E, Lange C, Roshan A, Karimuddin A, Scott T, Nadeau K, Macmillan J, Wilson J, Deschenes M, Nurullah A, Cahill C, Chen VH, Patterson KM, Wiseman SM, Wen B, Bhudial J, Barton A, Lie J, Park CM, Yang L, Gouskova N, Kim DH, Afford R, Bolin S, Morris-Janzen D, McLellan A, Karimuddin A, Archer V, Cloutier Z, Berg A, McKechnie T, Wiercioch W, Eskicioglu C, Labont? J, Bisson P, B?gin A, Cheng-Oviedo SG, Collin Y, Fernandes AR, Hossain I, Ellsmere J, El-Kefraoui C, Do U, Miller A, Kouyoumdjian A, Cui D, Khorasani E, Landry T, Amar-Zifkin A, Lee L, Feldman L, Fiore J, Au TM, Oppenheimer M, Logsetty S, AlShammari R, AlAbri M, Karimuddin A, Brown C, Raval MJ, Phang PT, Bird S, Baig Z, Abu-Omar N, Gill D, Suresh S, Ginther N, Karpinski M, Ghuman A, Malik PRA, Alibhai K, Zabolotniuk T, Ra?che I, Gawad N, Mashal S, Boulanger N, Watt L, Razek T, Fata P, Grushka J, Wong EG, Hossain I, Landry M, Mackey S, Fairbridge N, Greene A, Borgoankar M, Kim C, DeCarvalho D, Pace D, Wigen R, Walser E, Davidson J, Dorward M, Muszynski L, Dann C, Seemann N, Lam J, Harding K, Lowik AJ, Guinard C, Wiseman S, Ma O, Mocanu V, Lin A, Karmali S, Bigam D, Harding K, Greaves G, Parker B, Nguyen V, Ahmed A, Yee B, Perren J, Norman M, Grey M, Perini R, Jowhari F, Bak A, Drung J, Allen L, Wiseman D, Moffat B, Lee JKH, McGuire C, Ra?che I, Tudorache M, Gawad N, Park LJ, Borges FK, Nenshi R, Jacka M, Heels-Ansdell D, Simunovic M, Bogach J, Serrano PE, Thabane L, Devereaux PJ, Farooq S, Lester E, Kung J, Bradley N, Best G, Ahn S, Zhang L, Prince N, Cheng-Boivin O, Seguin N, Wang H, Quartermain L, Tan S, Shamess J, Simard M, Vigil H, Ra?che I, Hanna M, Moloo H, Azam R, Ko G, Zhu M, Raveendran Y, Lam C, Tang J, Bajwa A, Englesakis M, Reel E, Cleland J, Snell L, Lorello G, Cil T, Ahn HS, Dube C, McIsaac D, Smith D, Leclerc A, Shamess J, Rostom A, Calo N, Thavorn K, Moloo H, Laplante S, Liu L, et al. 2023 Canadian Surgery Forum: Sept. 20-23, 2023. Can J Surg. 2023 Nov-Dec; 66(6 Suppl 1):S54-S136. PMID: 38173057.
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    15. Bewersdorf JP, Shallis RM, Sharon E, Park S, Ramaswamy R, Roe CE, Irish JM, Caldwell A, Wei W, Yacoub A, Madanat YF, Zeidner JF, Altman JK, Odenike O, Yerrabothala S, Kovacsovics T, Podoltsev NA, Halene S, Little RF, Piekarz R, Gore SD, Kim TK, Zeidan AM. A multicenter phase Ib trial of the histone deacetylase inhibitor entinostat in combination with pembrolizumab in patients with myelodysplastic syndromes/neoplasms or acute myeloid leukemia refractory to hypomethylating agents. Ann Hematol. 2024 Jan; 103(1):105-116. PMID: 38036712.
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    16. Norlander AE, Abney M, Cephus JY, Roe CE, Irish JM, Shelburne NJ, Newcomb DC, Hemnes AR, Peebles RS. Reply to Yasuma et?al. Am J Respir Crit Care Med. 2023 12 01; 208(11):1249-1250. PMID: 37774400.
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    17. Norlander AE, Abney M, Cephus JY, Roe CE, Irish JM, Shelburne NJ, Newcomb DC, Hemnes AR, Peebles RS. Prostaglandin I2 Therapy Promotes Regulatory T Cell Generation in Patients with Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2023 09 15; 208(6):737-739. PMID: 37413696.
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    18. Senosain MF, Zou Y, Patel K, Zhao S, Coullomb A, Rowe DJ, Lehman JM, Irish JM, Maldonado F, Kammer MN, Pancaldi V, Lopez CF. Integrated Multi-omics Analysis of Early Lung Adenocarcinoma Links Tumor Biological Features with Predicted Indolence or Aggressiveness. Cancer Res Commun. 2023 07; 3(7):1350-1365. PMID: 37501683.
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    19. Bartkowiak T, Lima SM, Hayes MJ, Mistry AM, Brockman AA, Sinnaeve J, Leelatian N, Roe CE, Mobley BC, Chotai S, Weaver KD, Thompson RC, Chambless LB, Ihrie RA, Irish JM. An immunosuppressed microenvironment distinguishes lateral ventricle-contacting glioblastomas. JCI Insight. 2023 06 22; 8(12). PMID: 37192001.
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    20. Fu R, Sutradhar R, Li Q, Hanna TP, Chan KKW, Irish JC, Coburn N, Hallet J, Dare A, Singh S, Parmar A, Earle CC, Lapointe-Shaw L, Krzyzanowska MK, Finelli A, Louie AV, Look Hong NJ, Witterick IJ, Mahar A, Urbach DR, McIsaac DI, Enepekides D, Eskander A. Association between the COVID-19 pandemic and first cancer treatment modality: a population-based cohort study. CMAJ Open. 2023 May-Jun; 11(3):E426-E433. PMID: 37160325.
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    21. Geben LC, Brockman AA, Chalkley MBL, Sweet SR, Gallagher JE, Scheuing AL, Simerly RB, Ess KC, Irish JM, Ihrie RA. Dephosphorylation of 4EBP1/2 Induces Prenatal Neural Stem Cell Quiescence. bioRxiv. 2023 Feb 15. PMID: 36824760.
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    22. Brockman AA, Khurana R, Bartkowiak T, Thomas PL, Sivagnanam S, Betts CB, Coussens LM, Lovly CM, Irish JM, Ihrie RA. Alignment, segmentation and neighborhood analysis in cyclic immunohistochemistry data using CASSATT. Cytometry B Clin Cytom. 2023 09; 104(5):344-355. PMID: 36748312.
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    23. Alexander MR, Dale BL, Smart CD, Elijovich F, Wogsland CE, Lima SM, Irish JM, Madhur MS. Immune Profiling Reveals Decreases in Circulating Regulatory and Exhausted T?Cells in Human Hypertension. JACC Basic Transl Sci. 2023 Mar; 8(3):319-336. PMID: 37034287.
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    24. Noel CW, Hueniken K, Forner D, Liu G, Eng L, Hosni A, Hahn E, Irish JC, Gilbert R, Yao CMKL, Monteiro E, O'Sullivan B, Waldron J, Huang SH, Goldstein DP, de Almeida JR. Association of Household Income at Diagnosis With Financial Toxicity, Health Utility, and Survival in Patients With Head and Neck Cancer. JAMA Otolaryngol Head Neck Surg. 2023 01 01; 149(1):63-70. PMID: 36416855.
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    25. Medina S, Ihrie RA, Irish JM. Learning cell identity in immunology, neuroscience, and cancer. Semin Immunopathol. 2023 01; 45(1):3-16. PMID: 36534139.
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    26. Huse K, Bai B, Hilden VI, Bollum LK, V?tsveen TK, Munthe LA, Smeland EB, Irish JM, W?lchli S, Myklebust JH. Mechanism of CD79A and CD79B Support for IgM+ B Cell Fitness through B Cell Receptor Surface Expression. J Immunol. 2022 11 15; 209(10):2042-2053. PMID: 36426942.
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    27. Balsamo JA, Penton KE, Zhao Z, Hayes MJ, Lima SM, Irish JM, Bachmann BO. An immunogenic cell injury module for the single-cell multiplexed activity metabolomics platform to identify promising anti-cancer natural products. J Biol Chem. 2022 09; 298(9):102300. PMID: 35931117.
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    28. Kaviany S, Bartkowiak T, Dulek DE, Khan YW, Hayes MJ, Schaefer SG, Ye X, Dahunsi DO, Connelly JA, Irish JM, Rathmell JC. Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1. Immunohorizons. 2022 07 15; 6(7):447-464. PMID: 35840326.
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    29. Kramer KJ, Wilfong EM, Voss K, Barone SM, Shiakolas AR, Raju N, Roe CE, Suryadevara N, Walker LM, Wall SC, Paulo A, Schaefer S, Dahunsi D, Westlake CS, Crowe JE, Carnahan RH, Rathmell JC, Bonami RH, Georgiev IS, Irish JM. Single-cell profiling of the antigen-specific response to BNT162b2 SARS-CoV-2 RNA vaccine. Nat Commun. 2022 06 16; 13(1):3466. PMID: 35710908.
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    30. Blasco MA, Noel CW, Truong T, Huang SH, Goldstein DP, Irish JC, Gilbert R, Hosni A, Hope A, O'Sullivan B, Waldron J, Perez-Ordonez B, Weinreb I, Smith SM, Bartlett E, Yu E, de Almeida JR. Radiologic-pathologic correlation of major versus minor extranodal extension in oral cavity cancer. Head Neck. 2022 06; 44(6):1422-1429. PMID: 35315548.
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    31. Parmar A, Eskander A, Sander B, Naimark D, Irish JC, Chan KKW. Impact of cancer surgery slowdowns on patient survival during the COVID-19 pandemic: a microsimulation modelling study. CMAJ. 2022 03 21; 194(11):E408-E414. PMID: 35314440.
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    32. Wilfong EM, Bartkowiak T, Vowell KN, Westlake CS, Irish JM, Kendall PL, Crofford LJ, Bonami RH. High-Dimensional Analysis Reveals Distinct Endotypes in Patients With Idiopathic Inflammatory Myopathies. Front Immunol. 2022; 13:756018. PMID: 35371068.
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    33. Dahm V, Chan HHL, Daly MJ, Lui JT, Lin VY, Irish J, Chen JM, Le TN. The Feasibility of Eustachian Tube Dilation With a Standard Endovascular Balloon: A Comparative Cadaver Study. Otol Neurotol. 2022 02 01; 43(2):256-262. PMID: 34739430.
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    34. Meghraoui-Kheddar A, Chousterman BG, Guillou N, Barone SM, Granjeaud S, Vallet H, Corneau A, Guessous K, de Roquetaillade C, Boissonnas A, Irish JM, Combadi?re C. Two New Neutrophil Subsets Define a Discriminating Sepsis Signature. Am J Respir Crit Care Med. 2022 01 01; 205(1):46-59. PMID: 34731593.
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    35. Yeh AC, Varelias A, Reddy A, Barone SM, Olver SD, Chilson K, Onstad LE, Ensbey KS, Henden AS, Samson L, Jaeger CA, Bi T, Dahlman KB, Kim TK, Zhang P, Degli-Esposti MA, Newell EW, Jagasia MH, Irish JM, Lee SJ, Hill GR. CMV exposure drives long-term CD57+ CD4 memory T-cell inflation following allogeneic stem cell transplant. Blood. 2021 12 30; 138(26):2874-2885. PMID: 34115118.
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    36. Le Gallou S, Lhomme F, Irish JM, Mingam A, Pangault C, Monvoisin C, Ferrant J, Azzaoui I, Rossille D, Bouabdallah K, Damaj G, Cartron G, Godmer P, Le Gouill S, Casasnovas RO, Molina TJ, Houot R, Lamy T, Tarte K, Fest T, Roussel M. Nonclassical Monocytes Are Prone to Migrate Into Tumor in Diffuse Large B-Cell Lymphoma. Front Immunol. 2021; 12:755623. PMID: 34975843.
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    37. Taboni S, Ferrari M, Daly MJ, Chan HHL, Eu D, Gualtieri T, Jethwa AR, Sahovaler A, Sewell A, Hasan W, Berania I, Qiu J, de Almeida J, Nicolai P, Gilbert RW, Irish JC. Navigation-Guided Transnasal Endoscopic Delineation of the Posterior Margin for Maxillary Sinus Cancers: A Preclinical Study. Front Oncol. 2021; 11:747227. PMID: 34858824.
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    38. Sahovaler A, Chan HHL, Gualtieri T, Daly M, Ferrari M, Vannelli C, Eu D, Manojlovic-Kolarski M, Orzell S, Taboni S, de Almeida JR, Goldstein DP, Deganello A, Nicolai P, Gilbert RW, Irish JC. Augmented Reality and Intraoperative Navigation in Sinonasal Malignancies: A Preclinical Study. Front Oncol. 2021; 11:723509. PMID: 34790568.
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    39. Barone SM, Paul AG, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy. Elife. 2021 08 05; 10. PMID: 34350827.
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    40. Ramsey HE, Stengel K, Pino JC, Johnston G, Childress M, Gorska AE, Arrate PM, Fuller L, Villaume M, Fischer MA, Ferrell PB, Roe CE, Zou J, Lubbock ALR, Stubbs M, Zinkel S, Irish JM, Lopez CF, Hiebert S, Savona MR. Selective Inhibition of JAK1 Primes STAT5-Driven Human Leukemia Cells for ATRA-Induced Differentiation. Target Oncol. 2021 09; 16(5):663-674. PMID: 34324169.
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    41. Senosain MF, Zou Y, Novitskaya T, Vasiukov G, Balar AB, Rowe DJ, Doxie DB, Lehman JM, Eisenberg R, Maldonado F, Zijlstra A, Novitskiy SV, Irish JM, Massion PP. HLA-DR cancer cells expression correlates with T cell infiltration and is enriched in lung adenocarcinoma with indolent behavior. Sci Rep. 2021 Jul 13; 11(1):14424. PMID: 34257356.
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    42. Reisman BJ, Barone SM, Bachmann BO, Irish JM. DebarcodeR increases fluorescent cell barcoding capacity and accuracy. Cytometry A. 2021 09; 99(9):946-953. PMID: 33960644.
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    43. Noel CW, Sutradhar R, Zhao H, Delibasic V, Forner D, Irish JC, Kim J, Husain Z, Mahar A, Karam I, Enepekides DJ, Chan KKW, Singh S, Hallet J, Coburn NG, Eskander A. Reply to K. Yokoyama et al. J Clin Oncol. 2021 07 20; 39(21):2417-2419. PMID: 33950700.
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    44. Sahovaler A, Ziai H, Cardemil F, Huang SH, Su J, Goldstein DP, Gilbert R, Hosni A, Hope A, Waldron J, Spreafico A, Monteiro E, Witterick I, Irish J, Gullane P, Xu W, O'Sullivan B, de Almeida JR. Importance of Margins, Radiotherapy, and Systemic Therapy in Mucosal Melanoma of the Head and Neck. Laryngoscope. 2021 10; 131(10):2269-2276. PMID: 33856051.
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    45. Levine LS, Hiam-Galvez KJ, Marquez DM, Tenvooren I, Madden MZ, Contreras DC, Dahunsi DO, Irish JM, Oluwole OO, Rathmell JC, Spitzer MH. Single-cell analysis by mass cytometry reveals metabolic states of early-activated CD8+ T?cells during the primary immune response. Immunity. 2021 04 13; 54(4):829-844.e5. PMID: 33705706.
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    46. Eskander A, Li Q, Hallet J, Coburn N, Hanna TP, Irish J, Sutradhar R. Access to Cancer Surgery in a Universal Health Care System During the COVID-19 Pandemic. JAMA Netw Open. 2021 03 01; 4(3):e211104. PMID: 33704472.
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    47. Healey DCC, Cephus JY, Barone SM, Chowdhury NU, Dahunsi DO, Madden MZ, Ye X, Yu X, Olszewski K, Young K, Gerriets VA, Siska PJ, Dworski R, Hemler J, Locasale JW, Poyurovsky MV, Peebles RS, Irish JM, Newcomb DC, Rathmell JC. Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. J Immunol. 2021 03 15; 206(6):1127-1139. PMID: 33558372.
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    48. Ferrant J, Lhomme F, Le Gallou S, Irish JM, Roussel M. Circulating Myeloid Regulatory Cells: Promising Biomarkers in B-Cell Lymphomas. Front Immunol. 2020; 11:623993. PMID: 33603754.
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    49. Wang J, Vahid S, Eberg M, Milroy S, Milkovich J, Wright FC, Hunter A, Kalladeen R, Zanchetta C, Wijeysundera HC, Irish J. CMAJ. 2021 01 11; 193(2):E63-E73. PMID: 33431552.
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    50. Muhanna N, Eu D, Chan HH, Daly M, Fricke IB, Douglas CM, Townson JL, Zheng J, Allen C, Jaffray DA, Irish JC. Assessment of a liposomal CT/optical contrast agent for image-guided head and neck surgery. Nanomedicine. 2021 02; 32:102327. PMID: 33220507.
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    51. Barone SM, Paul AGA, Muehling LM, Lannigan JA, Kwok WW, Turner RB, Woodfolk JA, Irish JM. Unsupervised machine learning reveals key immune cell subsets in COVID-19, rhinovirus infection, and cancer therapy. bioRxiv. 2020 Nov 04. PMID: 32766581.
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    132. Knox JJ, Siu LL, Chen E, Dimitroulakos J, Kamel-Reid S, Moore MJ, Chin S, Irish J, LaFramboise S, Oza AM. A Phase I trial of prolonged administration of lovastatin in patients with recurrent or metastatic squamous cell carcinoma of the head and neck or of the cervix. Eur J Cancer. 2005 Mar; 41(4):523-30. PMID: 15737556.
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    133. M?kitie AA, Reis PP, Zhang T, Chin SF, Gullane P, Siu LL, Kamel-Reid S, Irish J. Epstein-Barr virus DNA measured in nasopharyngeal brushings in patients with nasopharyngeal carcinoma: pilot study. J Otolaryngol. 2004 Oct; 33(5):299-303. PMID: 15931814.
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    134. Irish JM, Hovland R, Krutzik PO, Perez OD, Bruserud ?, Gjertsen BT, Nolan GP. Single cell profiling of potentiated phospho-protein networks in cancer cells. Cell. 2004 Jul 23; 118(2):217-28. PMID: 15260991.
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    135. Krutzik PO, Irish JM, Nolan GP, Perez OD. Analysis of protein phosphorylation and cellular signaling events by flow cytometry: techniques and clinical applications. Clin Immunol. 2004 Mar; 110(3):206-21. PMID: 15047199.
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    136. M?kitie AA, MacMillan C, Ho J, Shi W, Lee A, O'Sullivan B, Payne D, Pintilie M, Cummings B, Waldron J, Warde P, Irish J, Brown D, Gilbert R, Gullane P, Liu FF, Kamel-Reid S. Loss of p16 expression has prognostic significance in human nasopharyngeal carcinoma. Clin Cancer Res. 2003 Jun; 9(6):2177-84. PMID: 12796384.
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    137. Groome PA, Schulze K, Boysen M, Hall SF, Mackillop WJ, O'Sullivan B, Irish JC, Warde PR, Schneider KM, Mackenzie RG, Hodson DI, Hammond JA, Gulavita SP, Eapen LJ, Dixon PF, Bissett RJ. A comparison of published head and neck stage groupings in laryngeal cancer using data from two countries. J Clin Epidemiol. 2002 Jun; 55(6):533-44. PMID: 12063095.
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    138. Khoo ML, Freeman JL, Witterick IJ, Irish JC, Rotstein LE, Gullane PJ, Asa SL. Underexpression of p27/Kip in thyroid papillary microcarcinomas with gross metastatic disease. Arch Otolaryngol Head Neck Surg. 2002 Mar; 128(3):253-7. PMID: 11886339.
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    139. Lueg EA, Irish JC, Katz MR, Brown DH, Gullane PJ. A patient- and observer-rated analysis of the impact of lateral rhinotomy on facial aesthetics. Arch Facial Plast Surg. 2001 Oct-Dec; 3(4):241-4. PMID: 11710857.
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    140. Wang Y, Irish J, MacMillan C, Brown D, Xuan Y, Boyington C, Gullane P, Kamel-Reid S. High frequency of microsatellite instability in young patients with head-and-neck squamous-cell carcinoma: lack of involvement of the mismatch repair genes hMLH1 AND hMSH2. Int J Cancer. 2001 Aug 01; 93(3):353-60. PMID: 11433399.
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    141. Curran AJ, Gullane PJ, Irish J, Macmillan C, Freeman J, Kamel-Reid S. Telomerase activity is upregulated in laryngeal squamous cell carcinoma. Laryngoscope. 2000 Mar; 110(3 Pt 1):391-6. PMID: 10718425.
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    142. Irish JC, Bernstein A. Oncogenes in head and neck cancer. Laryngoscope. 1993 Jan; 103(1 Pt 1):42-52. PMID: 8421418.
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