Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
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Stephen M Humphries

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-RAD General Operations

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Humphries SM, Chung A, Swigris JJ, Oh AS, Walsh SLF, Lynch DA, Goldin JG, Kim GHJ. Quantification of Interstitial Lung Diseases, From the AJR Special Series on Quantitative Imaging. AJR Am J Roentgenol. 2025 Dec; 225(6):e2432053. PMID: 39564907.
      View in: PubMed
    2. Kim JS, Pugashetti J, Ma SF, Huang Y, Podolanczuk AJ, Lynch DA, Oh A, Mychaleckyj J, Manichaikul A, Rich S, Chua F, Adams TM, Flaherty KR, Lee JS, Lasky JA, Raghu G, Murray S, Spino C, Martinez FJ, Noth I, Humphries SM, Adegunsoye A, Molyneaux PL, Oldham JM, Newton CA. Associations of interstitial lung disease subtype and CT pattern with lung function and survival. Thorax. 2025 Nov 14; 80(12):927-934. PMID: 40484639.
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    3. Koslow M, Baraghoshi D, Swigris JJ, Brown KK, Fernández Pérez ER, Huie TJ, Keith RC, Mohning MP, Solomon JJ, Yunt ZX, Manco G, Lynch DA, Humphries SM. One-Year Change in Quantitative Computed Tomography Is Associated with Meaningful Outcomes in Fibrotic Lung Disease. Am J Respir Crit Care Med. 2025 Oct; 211(10):1775-1784. PMID: 40824122.
      View in: PubMed
    4. Putman RK, Rose JA, San José Estepar R, Tukpah AC, Cutting CC, Hino T, Hata A, Nishino M, Humphries SM, Lynch DA, Silverman EK, Cho MH, Rosas IO, Washko GR, Hatabu H, San José Estepar R, Hunninghake GM. Visual and Quantitative Interstitial Lung Abnormality Progression in COPDGene. Am J Respir Crit Care Med. 2025 Oct; 211(10):1794-1801. PMID: 40720797.
      View in: PubMed
    5. Wei Kam ML, Humphries SM, Swigris JJ, Solomon JJ. Response. Chest. 2025 Sep; 168(3):e85-e86. PMID: 40935556.
      View in: PubMed
    6. Kwee AKAL, Pompe E, Gallardo Estrella L, Charbonnier JP, Humphries SM, Tiddens HAWM, Crapo JD, Casaburi R, de Jong PA, Lynch DA, Mohamed Hoesein FAA. Effect of High Altitude on Small Pulmonary Vein and Artery Volume in the COPDGene Cohort: Towards Better Understanding of Lung Physiology and Pulmonary Disease. J Pers Med. 2025 Aug 15; 15(8). PMID: 40863440.
      View in: PubMed
    7. Matson SM, Kim GHJ, Humphries SM, Roth MD, Goldin J, Tashkin DP, Leng M, England BR, Lee JS, Volkmann ER. Impact of quantitative radiological features of interstitial lung disease on immunomodulatory treatment response in three autoimmune interstitial lung disease cohorts. Thorax. 2025 07 15; 80(8):540-546. PMID: 40210443.
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    8. Podolanczuk AJ, Hunninghake GM, Wilson KC, Khor YH, Kheir F, Pang B, Adegunsoye A, Cararie G, Corte TJ, Flanagan J, Gudmundsson G, Hariri LP, Hatabu H, Humphries SM, Kaul B, Kim JS, Konigshoff M, Kropski JA, Lee JS, Luo F, Lynch DA, Martinez FJ, Montesi SB, Moodley Y, Oldham JM, Piciucchi S, Putman RK, Richeldi L, Rosas IO, Salisbury ML, Salvatore MM, Selman M, Seo JB, Song JW, Thomson CC, Vivero M, Wain LV, Wijsenbeek M, Schwartz DA, Ryerson CJ. Approach to the Evaluation and Management of Interstitial Lung Abnormalities: An Official American Thoracic Society Clinical Statement. Am J Respir Crit Care Med. 2025 Jul; 211(7):1132-1155. PMID: 40387336.
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    9. Balte PP, Kim JS, Sun Y, Allen N, Angelini E, Arynchyn A, Barr RG, Blaha M, Bowler R, Carr J, Cole SA, Couper D, Demmer RT, Doyle M, Elkind M, San José Estépar R, Garcia-Bedoya O, Garudadri S, Hansel NN, Hermann EA, Hoffman EA, Humphries SM, Hunninghake GM, Kaplan R, Krishnan JA, Laine A, Lee JS, Lynch DA, Make B, Matsushita K, McKleroy W, Min YI, Naik SN, O'Connor G, O'Driscoll O, Oren E, Podolanczuk AJ, Post WS, Pottinger T, Regan E, Rusk A, Salvatore M, Schwartz DA, Smith B, Sotres-Alvarez D, Umans JG, Vasan RS, Washko G, Wenzel S, Woodruff P, Xanthakis V, Ortega VE, Oelsner EC. Associations of Prepandemic Lung Function and Structure with COVID-19 Outcomes: The C4R Study. Am J Respir Crit Care Med. 2025 Jul; 211(7):1196-1210. PMID: 40238945.
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    10. Bhatt SP, Abadi E, Anzueto A, Bodduluri S, Casaburi R, Castaldi PJ, Cho MH, Comellas AP, Conrad DJ, Curtis JL, Dass C, DeMeo DL, Dransfield MT, San José Estépar R, Flenaugh EL, Foreman MG, Fortis S, Gupta A, Han MK, Hanania NA, Hersh CP, Hokanson JE, Humphries SM, Kirby M, Kunisaki KM, Li PZ, Lynch DA, MacIntyre NR, Make BJ, Mannino DM, Martinez FJ, McEvoy CE, Miller BE, Moll M, Nakhmani A, Newell JD, Pratte KA, Regan EA, Reinhardt JM, Rennard SI, Rossiter HB, Strand MJ, Suri R, Wan ES, Wendt CH, Westney GE, Wilson CG, Wise RA, Young KA, Tan WC, Silverman EK, Crapo JD. A Multidimensional Diagnostic Approach for Chronic Obstructive Pulmonary Disease. JAMA. 2025 06 24; 333(24):2164-2175. PMID: 40382791.
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    11. Wilson TM, Bolt M, Stahly A, Lee JS, Bang TJ, Sachs PB, Deane KD, Humphries SM, Solomon JJ, Demoruelle MK. Transforming growth factor-beta is increased in sputum from individuals with rheumatoid arthritis-associated pulmonary fibrosis. Rheumatology (Oxford). 2025 Jun 01; 64(6):3989-3995. PMID: 39693122.
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    12. San José Estépar R, Barr RG, Fain SB, Grenier PA, Hoffman EA, Humphries SM, Kirby M, Obuchowski N, Ryerson CJ, Seo JB, Tal-Singer R, Ash SY, Bankier AA, Crapo J, Han MK, Kellermeyer L, Goldin J, McCollough CH, Newell JD, Miller BE, Nordenmark LH, Remy-Jardin M, Prokop M, Ohno Y, Silverman EK, Strange C, Washko GR, Lynch DA. The Use of Computed Tomography Densitometry for the Assessment of Emphysema in Clinical Trials: A Position Paper from the Fleischner Society. Am J Respir Crit Care Med. 2025 May; 211(5):709-728. PMID: 40126404.
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    13. Baraghoshi D, Strand MJ, Humphries SM, Lynch DA, Kaizer AM, Porras AR. Uncertainty-aware quantitative CT evaluation of emphysema and mortality risk from variable radiation dose images. Eur Radiol. 2025 Oct; 35(10):6115-6126. PMID: 40185924.
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    14. Blumhagen RZ, Humphries SM, Peljto AL, Lynch DA, Cardwell J, Bang TJ, Teague SD, Sigakis C, Walts AD, Puthenvedu D, Wolters PJ, Blackwell TS, Kropski JA, Brown KK, Schwarz MI, Yang IV, Steele MP, Schwartz DA, Lee JS. MUC5B Genotype and Other Common Variants Are Associated with Computational Imaging Features of Usual Interstitial Pneumonia. Ann Am Thorac Soc. 2025 Apr; 22(4):533-540. PMID: 39591102.
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    15. Liu CM, Fischer JL, Zemanick ET, Woods JC, Markarian KK, Fain SB, Froh D, Heltshe SL, Hoffman LR, Humphries SM, Kramer EL, Ode KL, Lewis M, Li DA, Mata J, Milla SS, Niedbalski PJ, Sawatzky BD, Sim MS, Sullivan JS, Trout AT, Goss CH, Taylor-Cousar JL, Beswick DM. The impact of highly effective modulator therapy on sinusitis and dysosmia in young children with cystic fibrosis: a prospective study protocol. ERJ Open Res. 2025 Jan; 11(1). PMID: 39811548.
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    16. Salisbury ML, Markin C, Fadely T, Guttentag AR, Humphries SM, Lynch DA, Kropski JA, Blackwell TS. Progressive Early Interstitial Lung Abnormalities in Persons at Risk for Familial Pulmonary Fibrosis: A Prospective Cohort Study. Am J Respir Crit Care Med. 2024 Dec 15; 210(12):1441-1452. PMID: 39137317.
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    17. Humphries SM, Adegunsoye A, Demoruelle MK, Wei Kam ML, Amigues I, Bang TJ, Teague SD, Lynch DA, Chung JH, Strek ME, Swigris JJ, Solomon JJ. Quantitative CT Scan Analysis in Rheumatoid Arthritis-Related Interstitial Lung Disease. Chest. 2025 May; 167(5):1428-1439. PMID: 39528110.
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    18. Kwee AKAL, Andrinopoulou ER, van der Veer T, Gallardo-Estrella L, Charbonnier JP, Humphries SM, Lynch DA, Tiddens HAWM, de Jong PA, Pompe E. Higher small pulmonary artery and vein volume on computed tomography is associated with mortality in current and former smokers. EBioMedicine. 2024 Oct; 108:105366. PMID: 39353280.
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    19. Massey CJ, Humphries SM, Mace JC, Smith TL, Soler ZM, Ramakrishnan VR. Multi-institutional validation of an AI-based sinus CT analytic platform with olfactory assessments. Int Forum Allergy Rhinol. 2024 Nov; 14(11):1806-1809. PMID: 38995344.
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    20. Chae KJ, Hwang HJ, Duarte Achcar R, Cooley JC, Humphries SM, Kligerman S, Lynch DA. Central Role of CT in Management of Pulmonary Fibrosis. Radiographics. 2024 06; 44(6):e230165. PMID: 38752767.
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    21. Humphries SM, Thieke D, Baraghoshi D, Strand MJ, Swigris JJ, Chae KJ, Hwang HJ, Oh AS, Flaherty KR, Adegunsoye A, Jablonski R, Lee CT, Husain AN, Chung JH, Strek ME, Lynch DA. Deep Learning Classification of Usual Interstitial Pneumonia Predicts Outcomes. Am J Respir Crit Care Med. 2024 05 01; 209(9):1121-1131. PMID: 38207093.
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    22. Miller JE, Oh E, Khatiwada A, Humphries SM, Wilson A, Vladar EK, Lynch DA, Taylor-Cousar JL, Beswick DM. Two-Year Impact of Highly Effective Modulator Therapy on Olfactory Dysfunction. Laryngoscope. 2024 Jun; 134(6):2492-2494. PMID: 38647113.
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    23. Bell AJ, Pal R, Labaki WW, Hoff BA, Wang JM, Murray S, Kazerooni EA, Galban S, Lynch DA, Humphries SM, Martinez FJ, Hatt CR, Han MK, Ram S, Galban CJ. Local heterogeneity of normal lung parenchyma and small airways disease are associated with COPD severity and progression. Respir Res. 2024 Feb 28; 25(1):106. PMID: 38419014.
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    24. Oh AS, Lynch DA, Swigris JJ, Baraghoshi D, Dyer DS, Hale VA, Koelsch TL, Marrocchio C, Parker KN, Teague SD, Flaherty KR, Humphries SM. Deep Learning-based Fibrosis Extent on Computed Tomography Predicts Outcome of Fibrosing Interstitial Lung Disease Independent of Visually Assessed Computed Tomography Pattern. Ann Am Thorac Soc. 2024 Feb; 21(2):218-227. PMID: 37696027.
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    25. DeBoer EM, Weinman JP, Ley-Zaporozhan J, Griese M, Deterding R, Lynch DA, Humphries SM, Jacob J. Imaging of pulmonary fibrosis in children: A review, with proposed diagnostic criteria. Pediatr Pulmonol. 2024 Apr; 59(4):845-854. PMID: 38214442.
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    26. Vegas Sánchez-Ferrero G, Díaz AA, Ash SY, Baraghoshi D, Strand M, Crapo JD, Silverman EK, Humphries SM, Washko GR, Lynch DA, San José Estépar R. Quantification of Emphysema Progression at CT Using Simultaneous Volume, Noise, and Bias Lung Density Correction. Radiology. 2024 01; 310(1):e231632. PMID: 38165244.
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    27. Miller JE, Taylor-Cousar JL, Humphries SM, Khatiwada A, Chen H, Wilson A, Vladar EK, Lynch DA, Li DA, Beswick DM. Chronic rhinosinusitis and olfaction after highly effective modulator therapy: The role of individual sinus inflammation. Int Forum Allergy Rhinol. 2024 May; 14(5):986-989. PMID: 38146638.
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    28. Kim JS, Montesi SB, Adegunsoye A, Humphries SM, Salisbury ML, Hariri LP, Kropski JA, Richeldi L, Wells AU, Walsh S, Jenkins RG, Rosas I, Noth I, Hunninghake GM, Martinez FJ, Podolanczuk AJ. Approach to Clinical Trials for the Prevention of Pulmonary Fibrosis. Ann Am Thorac Soc. 2023 12; 20(12):1683-1693. PMID: 37703509.
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    29. Marrocchio C, Humphries SM, Lynch DA. Chest Computed Tomography Findings in Unilateral Pulmonary Fibrosis Secondary to Chronic Hypoperfusion. J Thorac Imaging. 2024 Sep 01; 39(5):269-274. PMID: 38095281.
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    30. Bell AJ, Pal R, Labaki WW, Hoff BA, Wang JM, Murray S, Kazerooni EA, Galban S, Lynch DA, Humphries SM, Martinez FJ, Hatt CR, Han MK, Ram S, Galban CJ. Quantitative CT of Normal Lung Parenchyma and Small Airways Disease Topologies are Associated With COPD Severity and Progression. medRxiv. 2023 Nov 20. PMID: 37333382.
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    31. Baraghoshi D, Strand M, Humphries SM, San José Estépar R, Vegas Sanchez-Ferrero G, Charbonnier JP, Latisenko R, Silverman EK, Crapo JD, Lynch DA. Erratum for: Quantitative CT Evaluation of Emphysema Progression over 10 Years in the COPDGene Study. Radiology. 2023 Nov; 309(2):e239028. PMID: 38015087.
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    32. Castaldi PJ, Xu Z, Young KA, Hokanson JE, Lynch DA, Humphries SM, Ross JC, Cho MH, Hersh CP, Crapo JD, Strand M, Silverman EK. Heterogeneity and Progression of Chronic Obstructive Pulmonary Disease: Emphysema-Predominant and Non-Emphysema-Predominant Disease. Am J Epidemiol. 2023 10 10; 192(10):1647-1658. PMID: 37160347.
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    33. Beswick DM, Khatiwada A, Miller JE, Humphries SM, Wilson A, Vladar EK, Lynch DA, Taylor-Cousar JL. Impact of highly effective modulator therapy on chronic rhinosinusitis and health status: 2-year follow-up. J Cyst Fibros. 2024 Mar; 23(2):214-218. PMID: 37805356.
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    34. Ash SY, Choi B, Oh A, Lynch DA, Humphries SM. Deep Learning Assessment of Progression of Emphysema and Fibrotic Interstitial Lung Abnormality. Am J Respir Crit Care Med. 2023 09 15; 208(6):666-675. PMID: 37364281.
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    35. Denton CP, Goh NS, Humphries SM, Maher TM, Spiera R, Devaraj A, Ho L, Stock C, Erhardt E, Alves M, Wells AU. Extent of fibrosis and lung function decline in patients with systemic sclerosis and interstitial lung disease: data from the SENSCIS trial. Rheumatology (Oxford). 2023 05 02; 62(5):1870-1876. PMID: 36111858.
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    36. Baraghoshi D, Strand M, Humphries SM, San José Estépar R, Vegas Sanchez-Ferrero G, Charbonnier JP, Latisenko R, Silverman EK, Crapo JD, Lynch DA. Quantitative CT Evaluation of Emphysema Progression over 10 Years in the COPDGene Study. Radiology. 2023 05; 307(4):e222786. PMID: 37039685.
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    37. Fernández Pérez ER, Crooks JL, Lynch DA, Humphries SM, Koelsch TL, Swigris JJ, Solomon JJ, Mohning MP, Groshong SD, Fier K. Pirfenidone in fibrotic hypersensitivity pneumonitis: a double-blind, randomised clinical trial of efficacy and safety. Thorax. 2023 11; 78(11):1097-1104. PMID: 37028940.
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    38. Wilson TM, Solomon JJ, Humphries SM, Swigris JJ, Ahmed F, Wang H, Darrah E, Demoruelle MK. Serum antibodies to peptidylarginine deiminase-4 in rheumatoid arthritis associated-interstitial lung disease are associated with decreased lung fibrosis and improved survival. Am J Med Sci. 2023 06; 365(6):480-487. PMID: 36918112.
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    39. Barnes H, Humphries SM, George PM, Assayag D, Glaspole I, Mackintosh JA, Corte TJ, Glassberg M, Johannson KA, Calandriello L, Felder F, Wells A, Walsh S. Machine learning in radiology: the new frontier in interstitial lung diseases. Lancet Digit Health. 2023 01; 5(1):e41-e50. PMID: 36517410.
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    40. Walsh SLF, Mackintosh JA, Calandriello L, Silva M, Sverzellati N, Larici AR, Humphries SM, Lynch DA, Jo HE, Glaspole I, Grainge C, Goh N, Hopkins PMA, Moodley Y, Reynolds PN, Zappala C, Keir G, Cooper WA, Mahar AM, Ellis S, Wells AU, Corte TJ. Deep Learning-based Outcome Prediction in Progressive Fibrotic Lung Disease Using High-Resolution Computed Tomography. Am J Respir Crit Care Med. 2022 10 01; 206(7):883-891. PMID: 35696341.
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    41. Bhatt SP, Bodduluri S, Nakhmani A, Kim YI, Reinhardt JM, Hoffman EA, Motahari A, Wilson CG, Humphries SM, Regan EA, DeMeo DL. Sex Differences in Airways at Chest CT: Results from the COPDGene Cohort. Radiology. 2022 12; 305(3):699-708. PMID: 35916677.
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    42. Humphries SM, Mackintosh JA, Jo HE, Walsh SLF, Silva M, Calandriello L, Chapman S, Ellis S, Glaspole I, Goh N, Grainge C, Hopkins PMA, Keir GJ, Moodley Y, Reynolds PN, Walters EH, Baraghoshi D, Wells AU, Lynch DA, Corte TJ. Quantitative computed tomography predicts outcomes in idiopathic pulmonary fibrosis. Respirology. 2022 12; 27(12):1045-1053. PMID: 35875881.
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    43. Choi B, Adan N, Doyle TJ, San José Estépar R, Harmouche R, Humphries SM, Moll M, Cho MH, Putman RK, Hunninghake GM, Kalhan R, Liu GY, Diaz AA, Mason SE, Rahaghi FN, Pistenmaa CL, Enzer N, Poynton C, Sánchez-Ferrero GV, Ross JC, Lynch DA, Martinez FJ, Han MK, Bowler RP, Wilson DO, Rosas IO, Washko GR, San José Estépar R, Ash SY. Quantitative Interstitial Abnormality Progression and Outcomes in the Genetic Epidemiology of COPD and Pittsburgh Lung Screening Study Cohorts. Chest. 2023 01; 163(1):164-175. PMID: 35780812.
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    44. Beswick DM, Humphries SM, Miller JE, Balkissoon CD, Khatiwada A, Vladar EK, Ramakrishnan VR, Lynch DA, Taylor-Cousar JL. Objective and patient-based measures of chronic rhinosinusitis in people with cystic fibrosis treated with highly effective modulator therapy. Int Forum Allergy Rhinol. 2022 11; 12(11):1435-1438. PMID: 35595546.
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    45. Oh AS, Baraghoshi D, Lynch DA, Ash SY, Crapo JD, Humphries SM. Emphysema Progression at CT by Deep Learning Predicts Functional Impairment and Mortality: Results from the COPDGene Study. Radiology. 2022 09; 304(3):672-679. PMID: 35579519.
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    46. Zell-Baran LM, Humphries SM, Moore CM, Lynch DA, Charbonnier JP, Oh AS, Rose CS. Quantitative imaging analysis detects subtle airway abnormalities in symptomatic military deployers. BMC Pulm Med. 2022 Apr 27; 22(1):163. PMID: 35477425.
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    47. Matson SM, Deane KD, Peljto AL, Bang TJ, Sachs PB, Walts AD, Collora C, Ye S, Demoruelle MK, Humphries SM, Schwartz DA, Lee JS. Prospective Identification of Subclinical Interstitial Lung Disease in a Rheumatoid Arthritis Cohort Is Associated with the MUC5B Promoter Variant. Am J Respir Crit Care Med. 2022 02 15; 205(4):473-476. PMID: 34874815.
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    48. Beswick DM, Humphries SM, Balkissoon CD, Strand M, E Miller J, Khatiwada A, Vladar EK, Lynch DA, Taylor-Cousar JL. Olfactory dysfunction in people with cystic fibrosis with at least one copy of F508del. Int Forum Allergy Rhinol. 2022 07; 12(7):963-966. PMID: 34908251.
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    49. Beswick DM, Humphries SM, Balkissoon CD, Strand M, Vladar EK, Lynch DA, Taylor-Cousar JL. Impact of Cystic Fibrosis Transmembrane Conductance Regulator Therapy on Chronic Rhinosinusitis and Health Status: Deep Learning CT Analysis and Patient-reported Outcomes. Ann Am Thorac Soc. 2022 01; 19(1):12-19. PMID: 34436985.
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    50. Beswick DM, Humphries SM, Balkissoon CD, Strand M, Vladar EK, Ramakrishnan VR, Taylor-Cousar JL. Olfactory dysfunction in cystic fibrosis: Impact of CFTR modulator therapy. J Cyst Fibros. 2022 03; 21(2):e141-e147. PMID: 34598881.
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    51. Redente EF, Black BP, Backos DS, Bahadur AN, Humphries SM, Lynch DA, Tuder RM, Zemans RL, Riches DWH. Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice. Am J Respir Cell Mol Biol. 2021 06; 64(6):669-676. PMID: 33406369.
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    52. Tejwani V, Fawzy A, Putcha N, Castaldi PJ, Cho MH, Pratte KA, Bhatt SP, Lynch DA, Humphries SM, Kinney GL, D'Alessio FR, Hansel NN. Emphysema Progression and Lung Function Decline Among Angiotensin Converting Enzyme Inhibitors and Angiotensin-Receptor Blockade Users in the COPDGene Cohort. Chest. 2021 10; 160(4):1245-1254. PMID: 34029566.
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    53. Oganesyan A, Hoffner-Heinike A, Barker AJ, Frank BS, Ivy DD, Hunter KS, Mitchell MB, Humphries SM, Fenster BE, Schäfer M. Abnormal pulmonary flow is associated with impaired right ventricular coupling in patients with COPD. Int J Cardiovasc Imaging. 2021 Oct; 37(10):3039-3048. PMID: 34021434.
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    54. DeBoer EM, Liptzin DR, Humphries SM, Lynch DA, Robison K, Galambos C, Dishop MK, Deterding RR, Weinman JP. Ground glass and fibrotic change in children with surfactant protein C dysfunction mutations. Pediatr Pulmonol. 2021 07; 56(7):2223-2231. PMID: 33666361.
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    55. Hatt CR, Oh AS, Obuchowski NA, Charbonnier JP, Lynch DA, Humphries SM. Comparison of CT Lung Density Measurements between Standard Full-Dose and Reduced-Dose Protocols. Radiol Cardiothorac Imaging. 2021 Apr; 3(2):e200503. PMID: 33969308.
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    56. Arriaza LR, Massey CJ, Humphries SM, Beswick DM, Saavedra MT, Ramakrishnan VR. CFTR-related disorder in an adult with refractory chronic rhinosinusitis: A missed diagnosis and novel mutation. Int Forum Allergy Rhinol. 2021 07; 11(7):1135-1137. PMID: 33823074.
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    57. Ash SY, San José Estépar R, Fain SB, Tal-Singer R, Stockley RA, Nordenmark LH, Rennard S, Han MK, Merrill D, Humphries SM, Diaz AA, Mason SE, Rahaghi FN, Pistenmaa CL, Sciurba FC, Vegas-Sánchez-Ferrero G, Lynch DA, Washko GR. Relationship between Emphysema Progression at CT and Mortality in Ever-Smokers: Results from the COPDGene and ECLIPSE Cohorts. Radiology. 2021 04; 299(1):222-231. PMID: 33591891.
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    58. El Kaddouri B, Strand MJ, Baraghoshi D, Humphries SM, Charbonnier JP, van Rikxoort EM, Lynch DA. Fleischner Society Visual Emphysema CT Patterns Help Predict Progression of Emphysema in Current and Former Smokers: Results from the COPDGene Study. Radiology. 2021 02; 298(2):441-449. PMID: 33320065.
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    59. Beswick DM, Humphries SM, Balkissoon CD, Vladar EK, Ramakrishnan VR, Lynch DA, Taylor-Cousar JL. Machine learning evaluates improvement in sinus computed tomography opacification with CFTR modulator therapy. Int Forum Allergy Rhinol. 2021 05; 11(5):953-954. PMID: 33140564.
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    60. Oh AS, Strand M, Pratte K, Regan EA, Humphries S, Crapo JD, Lynch DA. Visual Emphysema at Chest CT in GOLD Stage 0 Cigarette Smokers Predicts Disease Progression: Results from the COPDGene Study. Radiology. 2020 09; 296(3):641-649. PMID: 32633676.
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    61. Humphries SM, Centeno JP, Notary AM, Gerow J, Cicchetti G, Katial RK, Beswick DM, Ramakrishnan VR, Alam R, Lynch DA. Volumetric assessment of paranasal sinus opacification on computed tomography can be automated using a convolutional neural network. Int Forum Allergy Rhinol. 2020 11; 10(11):1218-1225. PMID: 32306522.
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    62. Salisbury ML, Hewlett JC, Ding G, Markin CR, Douglas K, Mason W, Guttentag A, Phillips JA, Cogan JD, Reiss S, Mitchell DB, Wu P, Young LR, Lancaster LH, Loyd JE, Humphries SM, Lynch DA, Kropski JA, Blackwell TS. Development and Progression of Radiologic Abnormalities in Individuals at Risk for Familial Interstitial Lung Disease. Am J Respir Crit Care Med. 2020 05 15; 201(10):1230-1239. PMID: 32011901.
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    63. Kirby M, Hatt C, Obuchowski N, Humphries SM, Sieren J, Lynch DA, Fain SB. Inter- and intra-software reproducibility of computed tomography lung density measurements. Med Phys. 2020 Jul; 47(7):2962-2969. PMID: 32160310.
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    64. Schäfer M, Frank BS, Humphries SM, Hunter KS, Carmody KL, Jacobsen R, Mitchell MB, Jaggers J, Stone ML, Morgan GJ, Barker AJ, Browne LP, Ivy DD, Younoszai A, Di Maria MV. Flow profile characteristics in Fontan circulation are associated with the single ventricle dilation and function: principal component analysis study. Am J Physiol Heart Circ Physiol. 2020 05 01; 318(5):H1032-H1040. PMID: 32167782.
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    65. Walsh SLF, Humphries SM, Wells AU, Brown KK. Imaging research in fibrotic lung disease; applying deep learning to unsolved problems. Lancet Respir Med. 2020 11; 8(11):1144-1153. PMID: 32109428.
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    66. Pompe E, Strand M, van Rikxoort EM, Hoffman EA, Barr RG, Charbonnier JP, Humphries S, Han MK, Hokanson JE, Make BJ, Regan EA, Silverman EK, Crapo JD, Lynch DA. Five-year Progression of Emphysema and Air Trapping at CT in Smokers with and Those without Chronic Obstructive Pulmonary Disease: Results from the COPDGene Study. Radiology. 2020 04; 295(1):218-226. PMID: 32013794.
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    67. Humphries SM, Notary AM, Centeno JP, Strand MJ, Crapo JD, Silverman EK, Lynch DA. Deep Learning Enables Automatic Classification of Emphysema Pattern at CT. Radiology. 2020 02; 294(2):434-444. PMID: 31793851.
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    68. Raghu G, Ley B, Brown KK, Cottin V, Gibson KF, Kaner RJ, Lederer DJ, Noble PW, Song JW, Wells AU, Whelan TP, Lynch DA, Humphries SM, Moreau E, Goodman K, Patterson SD, Smith V, Gong Q, Sundy JS, O'Riordan TG, Martinez FJ. Risk factors for disease progression in idiopathic pulmonary fibrosis. Thorax. 2020 01; 75(1):78-80. PMID: 31611341.
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    69. Mathai SK, Humphries S, Kropski JA, Blackwell TS, Powers J, Walts AD, Markin C, Woodward J, Chung JH, Brown KK, Steele MP, Loyd JE, Schwarz MI, Fingerlin T, Yang IV, Lynch DA, Schwartz DA. MUC5B variant is associated with visually and quantitatively detected preclinical pulmonary fibrosis. Thorax. 2019 12; 74(12):1131-1139. PMID: 31558622.
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    70. Regan EA, Lowe KE, Make BJ, Lynch DA, Kinney GL, Budoff MJ, Mao SS, Dyer D, Curtis JL, Bowler RP, Han MK, Beaty TH, Hokanson JE, Kern E, Humphries S, Curran-Everett D, van Beek EJR, Silverman EK, Crapo JD, Finigan JH. Identifying Smoking-Related Disease on Lung Cancer Screening CT Scans: Increasing the Value. Chronic Obstr Pulm Dis. 2019 Jul 24; 6(3):233-245. PMID: 31342730.
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    71. Wu X, Kim GH, Salisbury ML, Barber D, Bartholmai BJ, Brown KK, Conoscenti CS, De Backer J, Flaherty KR, Gruden JF, Hoffman EA, Humphries SM, Jacob J, Maher TM, Raghu G, Richeldi L, Ross BD, Schlenker-Herceg R, Sverzellati N, Wells AU, Martinez FJ, Lynch DA, Goldin J, Walsh SLF. Computed Tomographic Biomarkers in Idiopathic Pulmonary Fibrosis. The Future of Quantitative Analysis. Am J Respir Crit Care Med. 2019 01 01; 199(1):12-21. PMID: 29986154.
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    72. Humphries SM, Swigris JJ, Brown KK, Strand M, Gong Q, Sundy JS, Raghu G, Schwarz MI, Flaherty KR, Sood R, O'Riordan TG, Lynch DA. Quantitative high-resolution computed tomography fibrosis score: performance characteristics in idiopathic pulmonary fibrosis. Eur Respir J. 2018 09; 52(3). PMID: 30139770.
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    73. Mastej EJ, DeBoer EM, Humphries SM, Cook MC, Hunter KS, Liptzin DR, Weinman JP, Deterding RR. Lung and airway shape in neuroendocrine cell hyperplasia of infancy. Pediatr Radiol. 2018 11; 48(12):1745-1754. PMID: 29955904.
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    74. Lynch DA, Moore CM, Wilson C, Nevrekar D, Jennermann T, Humphries SM, Austin JHM, Grenier PA, Kauczor HU, Han MK, Regan EA, Make BJ, Bowler RP, Beaty TH, Curran-Everett D, Hokanson JE, Curtis JL, Silverman EK, Crapo JD. CT-based Visual Classification of Emphysema: Association with Mortality in the COPDGene Study. Radiology. 2018 09; 288(3):859-866. PMID: 29762095.
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    75. Schäfer M, Humphries S, Stenmark KR, Kheyfets VO, Buckner JK, Hunter KS, Fenster BE. 4D-flow cardiac magnetic resonance-derived vorticity is sensitive marker of left ventricular diastolic dysfunction in patients with mild-to-moderate chronic obstructive pulmonary disease. Eur Heart J Cardiovasc Imaging. 2018 04 01; 19(4):415-424. PMID: 28460004.
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    76. Redente EF, Aguilar MA, Black BP, Edelman BL, Bahadur AN, Humphries SM, Lynch DA, Wollin L, Riches DWH. Nintedanib reduces pulmonary fibrosis in a model of rheumatoid arthritis-associated interstitial lung disease. Am J Physiol Lung Cell Mol Physiol. 2018 06 01; 314(6):L998-L1009. PMID: 29543042.
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    77. Humphries SM, Yagihashi K, Huckleberry J, Rho BH, Schroeder JD, Strand M, Schwarz MI, Flaherty KR, Kazerooni EA, van Beek EJR, Lynch DA. Idiopathic Pulmonary Fibrosis: Data-driven Textural Analysis of Extent of Fibrosis at Baseline and 15-Month Follow-up. Radiology. 2017 10; 285(1):270-278. PMID: 28493789.
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    78. Ginsburg SB, Zhao J, Humphries S, Jou S, Yagihashi K, Lynch DA, Schroeder JD. Texture-based Quantification of Centrilobular Emphysema and Centrilobular Nodularity in Longitudinal CT Scans of Current and Former Smokers. Acad Radiol. 2016 11; 23(11):1349-1358. PMID: 27575837.
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    79. Humphries SM, Hunter KS, Shandas R, Deterding RR, DeBoer EM. Erratum to: Analysis of pediatric airway morphology using statistical shape modeling. Med Biol Eng Comput. 2016 06; 54(6):913. PMID: 26815534.
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    80. Humphries SM, Hunter KS, Shandas R, Deterding RR, DeBoer EM. Analysis of pediatric airway morphology using statistical shape modeling. Med Biol Eng Comput. 2016 Jun; 54(6):899-911. PMID: 26718559.
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    81. Christensen AM, Humphries SM, Goh KY, Swift D. Advanced "tactile" medical imaging for separation surgeries of conjoined twins. Childs Nerv Syst. 2004 Aug; 20(8-9):547-53. PMID: 15278381.
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