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David Abraham Brown

TitleSenior Instructor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dai W, Amoedo ND, Perry J, Le Grand B, Boucard A, Carreno J, Zhao L, Brown DA, Rossignol R, Kloner RA. Effects of OP2113 on Myocardial Infarct Size and No Reflow in a Rat Myocardial Ischemia/Reperfusion Model. Cardiovasc Drugs Ther. 2021 Feb 08. PMID: 33555510.
      View in: PubMed
    2. King DR, Padget RL, Perry J, Hoeker G, Smyth JW, Brown DA, Poelzing S. Elevated perfusate [Na+] increases contractile dysfunction during ischemia and reperfusion. Sci Rep. 2020 10 14; 10(1):17289. PMID: 33057157.
      View in: PubMed
    3. Allen ME, Pennington ER, Perry JB, Dadoo S, Makrecka-Kuka M, Dambrova M, Moukdar F, Patel HD, Han X, Kidd GK, Benson EK, Raisch TB, Poelzing S, Brown DA, Shaikh SR. The cardiolipin-binding peptide elamipretide mitigates fragmentation of cristae networks following cardiac ischemia reperfusion in rats. Commun Biol. 2020 07 17; 3(1):389. PMID: 32680996.
      View in: PubMed
    4. Martinello K, Giacalone E, Migliore M, Brown DA, Shah MM. The subthreshold-active KV7 current regulates neurotransmission by limiting spike-induced Ca2+ influx in hippocampal mossy fiber synaptic terminals. Commun Biol. 2019; 2:145. PMID: 31044170.
      View in: PubMed
    5. Pennington ER, Sullivan EM, Fix A, Dadoo S, Zeczycki TN, DeSantis A, Schlattner U, Coleman RA, Chicco AJ, Brown DA, Shaikh SR. Proteolipid domains form in biomimetic and cardiac mitochondrial vesicles and are regulated by cardiolipin concentration but not monolyso-cardiolipin. J Biol Chem. 2018 10 12; 293(41):15933-15946. PMID: 30158245.
      View in: PubMed
    6. Sullivan EM, Pennington ER, Sparagna GC, Torres MJ, Neufer PD, Harris M, Washington J, Anderson EJ, Zeczycki TN, Brown DA, Shaikh SR. Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome. J Biol Chem. 2018 01 12; 293(2):466-483. PMID: 29162722.
      View in: PubMed
    7. Holland NA, Fraiser CR, Sloan RC, Devlin RB, Brown DA, Wingard CJ. Ultrafine Particulate Matter Increases Cardiac Ischemia/Reperfusion Injury via Mitochondrial Permeability Transition Pore. Cardiovasc Toxicol. 2017 10; 17(4):441-450. PMID: 28194639.
      View in: PubMed
    8. Sullivan EM, Fix A, Crouch MJ, Sparagna GC, Zeczycki TN, Brown DA, Shaikh SR. Murine diet-induced obesity remodels cardiac and liver mitochondrial phospholipid acyl chains with differential effects on respiratory enzyme activity. J Nutr Biochem. 2017 07; 45:94-103. PMID: 28437736.
      View in: PubMed
    9. Dai W, Cheung E, Alleman RJ, Perry JB, Allen ME, Brown DA, Kloner RA. Cardioprotective Effects of Mitochondria-Targeted Peptide SBT-20 in two Different Models of Rat Ischemia/Reperfusion. Cardiovasc Drugs Ther. 2016 Dec; 30(6):559-566. PMID: 27747447.
      View in: PubMed
    10. Alleman RJ, Tsang AM, Ryan TE, Patteson DJ, McClung JM, Spangenburg EE, Shaikh SR, Neufer PD, Brown DA. Exercise-induced protection against reperfusion arrhythmia involves stabilization of mitochondrial energetics. . 2016 05 15; 310(10):H1360-70. PMID: 26945082.
      View in: PubMed
    11. Shi J, Dai W, Hale SL, Brown DA, Wang M, Han X, Kloner RA. Bendavia restores mitochondrial energy metabolism gene expression and suppresses cardiac fibrosis in the border zone of the infarcted heart. Life Sci. 2015 Nov 15; 141:170-8. PMID: 26431885.
      View in: PubMed
    12. Chicco AJ, Brown DA. "Roid-Rage" at the cellular level: abolition of endogenous cardioprotection by anabolic steroids reveals new links between the RAAS and cardiac KATP channels : editorial to: "AT1 and aldosterone receptors blockade prevents the chronic effect of nandrolone on the exercise-induced cardioprotection in perfused rat heart subjected to ischemia and reperfusion" by S.R. Marques-Neto et al. Cardiovasc Drugs Ther. 2014 Apr; 28(2):113-4. PMID: 24578227.
      View in: PubMed
    13. Brown DA, Hale SL, Baines CP, del Rio CL, Hamlin RL, Yueyama Y, Kijtawornrat A, Yeh ST, Frasier CR, Stewart LM, Moukdar F, Shaikh SR, Fisher-Wellman KH, Neufer PD, Kloner RA. Reduction of early reperfusion injury with the mitochondria-targeting peptide bendavia. J Cardiovasc Pharmacol Ther. 2014 Jan; 19(1):121-32. PMID: 24288396.
      View in: PubMed
    14. Frasier CR, Brown DA, Sloan RC, Hayes B, Stewart LM, Patel HD, Lust RM, Rosenbaum MD. Stage of the estrous cycle does not influence myocardial ischemia-reperfusion injury in rats (Rattus norvegicus). Comp Med. 2013 Oct; 63(5):416-21. PMID: 24210018.
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    15. Robbins J, Passmore GM, Abogadie FC, Reilly JM, Brown DA. Effects of KCNQ2 gene truncation on M-type Kv7 potassium currents. PLoS One. 2013; 8(8):e71809. PMID: 23977150.
      View in: PubMed
    16. Brown DA, Sabbah HN, Shaikh SR. Mitochondrial inner membrane lipids and proteins as targets for decreasing cardiac ischemia/reperfusion injury. Pharmacol Ther. 2013 Dec; 140(3):258-66. PMID: 23867906.
      View in: PubMed
    17. Reilly JM, Telezhkin V, Passmore GM, Marsh SJ, Brown DA. Kv7/M-type potassium channels in rat skin keratinocytes. Pflugers Arch. 2013 Sep; 465(9):1371-81. PMID: 23592175.
      View in: PubMed
    18. Tsai VW, Macia L, Johnen H, Kuffner T, Manadhar R, Jørgensen SB, Lee-Ng KK, Zhang HP, Wu L, Marquis CP, Jiang L, Husaini Y, Lin S, Herzog H, Brown DA, Sainsbury A, Breit SN. TGF-b superfamily cytokine MIC-1/GDF15 is a physiological appetite and body weight regulator. PLoS One. 2013; 8(2):e55174. PMID: 23468844.
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    19. Frasier CR, Moukdar F, Patel HD, Sloan RC, Stewart LM, Alleman RJ, La Favor JD, Brown DA. Redox-dependent increases in glutathione reductase and exercise preconditioning: role of NADPH oxidase and mitochondria. Cardiovasc Res. 2013 Apr 01; 98(1):47-55. PMID: 23341578.
      View in: PubMed
    20. Thompson LC, Frasier CR, Sloan RC, Mann EE, Harrison BS, Brown JM, Brown DA, Wingard CJ. Pulmonary instillation of multi-walled carbon nanotubes promotes coronary vasoconstriction and exacerbates injury in isolated hearts. Nanotoxicology. 2014 Feb; 8(1):38-49. PMID: 23102262.
      View in: PubMed
    21. Sloan RC, Moukdar F, Frasier CR, Patel HD, Bostian PA, Lust RM, Brown DA. Mitochondrial permeability transition in the diabetic heart: contributions of thiol redox state and mitochondrial calcium to augmented reperfusion injury. J Mol Cell Cardiol. 2012 May; 52(5):1009-18. PMID: 22406429.
      View in: PubMed
    22. Shah MM, Migliore M, Brown DA. Differential effects of Kv7 (M-) channels on synaptic integration in distinct subcellular compartments of rat hippocampal pyramidal neurons. J Physiol. 2011 Dec 15; 589(Pt 24):6029-38. PMID: 22041186.
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    23. Frasier CR, Sloan RC, Bostian PA, Gonzon MD, Kurowicki J, Lopresto SJ, Anderson EJ, Brown DA. Short-term exercise preserves myocardial glutathione and decreases arrhythmias after thiol oxidation and ischemia in isolated rat hearts. J Appl Physiol (1985). 2011 Dec; 111(6):1751-9. PMID: 21940849.
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    24. Sloan RC, Rosenbaum M, O'Rourke D, Oppelt K, Frasier CR, Waston CA, Allan AG, Brown DA. High doses of ketamine-xylazine anesthesia reduce cardiac ischemia-reperfusion injury in guinea pigs. J Am Assoc Lab Anim Sci. 2011 May; 50(3):349-54. PMID: 21640030.
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    25. Alibiglou L, Brown DA. Relative temporal leading or following position of the contralateral limb generates different aftereffects in muscle phasing following adaptation training post-stroke. Exp Brain Res. 2011 May; 211(1):37-50. PMID: 21523333.
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    26. Frasier CR, Moore RL, Brown DA. Exercise-induced cardiac preconditioning: how exercise protects your achy-breaky heart. J Appl Physiol (1985). 2011 Sep; 111(3):905-15. PMID: 21393468.
      View in: PubMed
    27. Liu T, Brown DA, O'Rourke B. Role of mitochondrial dysfunction in cardiac glycoside toxicity. J Mol Cell Cardiol. 2010 Nov; 49(5):728-36. PMID: 20620145.
      View in: PubMed
    28. Spangenburg EE, Brown DA, Johnson MS, Moore RL. Alterations in peroxisome proliferator-activated receptor mRNA expression in skeletal muscle after acute and repeated bouts of exercise. Mol Cell Biochem. 2009 Dec; 332(1-2):225-31. PMID: 19588229.
      View in: PubMed
    29. Brown DA. Kv7 (KCNQ) potassium channels that are mutated in human diseases. J Physiol. 2008 Apr 01; 586(7):1781-3. PMID: 18381340.
      View in: PubMed
    30. Brown DA, Aon MA, Akar FG, Liu T, Sorarrain N, O'Rourke B. Effects of 4'-chlorodiazepam on cellular excitation-contraction coupling and ischaemia-reperfusion injury in rabbit heart. Cardiovasc Res. 2008 Jul 01; 79(1):141-9. PMID: 18304929.
      View in: PubMed
    31. Brown DA, Johnson MS, Armstrong CJ, Lynch JM, Caruso NM, Ehlers LB, Fleshner M, Spencer RL, Moore RL. Short-term treadmill running in the rat: what kind of stressor is it? J Appl Physiol (1985). 2007 Dec; 103(6):1979-85. PMID: 17916671.
      View in: PubMed
    32. Anderson CD, Heydarkhan-Hagvall S, Schenke-Layland K, Yang JQ, Jordan MC, Kim JK, Brown DA, Zuk PA, Laks H, Roos KP, Maclellan WR, Beygui RE. The role of cytoprotective cytokines in cardiac ischemia/reperfusion injury. J Surg Res. 2008 Aug; 148(2):164-71. PMID: 18067924.
      View in: PubMed
    33. Brown DA, Maclellan WR, Wu BM, Beygui RE. Analysis of pH gradients resulting from mass transport limitations in engineered heart tissue. Ann Biomed Eng. 2007 Nov; 35(11):1885-97. PMID: 17680364.
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    34. Brown DA, Moore RL. Perspectives in innate and acquired cardioprotection: cardioprotection acquired through exercise. J Appl Physiol (1985). 2007 Nov; 103(5):1894-9. PMID: 17556492.
      View in: PubMed
    35. Hughes S, Marsh SJ, Tinker A, Brown DA. PIP(2)-dependent inhibition of M-type (Kv7.2/7.3) potassium channels: direct on-line assessment of PIP(2) depletion by Gq-coupled receptors in single living neurons. Pflugers Arch. 2007 Oct; 455(1):115-24. PMID: 17447081.
      View in: PubMed
    36. Brown DA, Hughes SA, Marsh SJ, Tinker A. Regulation of M(Kv7.2/7.3) channels in neurons by PIP(2) and products of PIP(2) hydrolysis: significance for receptor-mediated inhibition. J Physiol. 2007 Aug 01; 582(Pt 3):917-25. PMID: 17395626.
      View in: PubMed
    37. Watson PA, Reusch JE, McCune SA, Leinwand LA, Luckey SW, Konhilas JP, Brown DA, Chicco AJ, Sparagna GC, Long CS, Moore RL. Restoration of CREB function is linked to completion and stabilization of adaptive cardiac hypertrophy in response to exercise. . 2007 Jul; 293(1):H246-59. PMID: 17337597.
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    38. Spangenburg EE, Brown DA, Johnson MS, Moore RL. Exercise increases SOCS-3 expression in rat skeletal muscle: potential relationship to IL-6 expression. J Physiol. 2006 May 01; 572(Pt 3):839-48. PMID: 16484300.
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    39. Johnson MS, Moore RL, Brown DA. Sex differences in myocardial infarct size are abolished by sarcolemmal KATP channel blockade in rat. . 2006 Jun; 290(6):H2644-47. PMID: 16473955.
      View in: PubMed
    40. Allen TG, Abogadie FC, Brown DA. Simultaneous release of glutamate and acetylcholine from single magnocellular "cholinergic" basal forebrain neurons. J Neurosci. 2006 Feb 01; 26(5):1588-95. PMID: 16452682.
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    41. Brown DA, Chicco AJ, Jew KN, Johnson MS, Lynch JM, Watson PA, Moore RL. Cardioprotection afforded by chronic exercise is mediated by the sarcolemmal, and not the mitochondrial, isoform of the KATP channel in the rat. J Physiol. 2005 Dec 15; 569(Pt 3):913-24. PMID: 16223762.
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    42. Winks JS, Hughes S, Filippov AK, Tatulian L, Abogadie FC, Brown DA, Marsh SJ. Relationship between membrane phosphatidylinositol-4,5-bisphosphate and receptor-mediated inhibition of native neuronal M channels. J Neurosci. 2005 Mar 30; 25(13):3400-13. PMID: 15800195.
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    43. Brown DA, Lynch JM, Armstrong CJ, Caruso NM, Ehlers LB, Johnson MS, Moore RL. Susceptibility of the heart to ischaemia-reperfusion injury and exercise-induced cardioprotection are sex-dependent in the rat. J Physiol. 2005 Apr 15; 564(Pt 2):619-30. PMID: 15718263.
      View in: PubMed
    44. Dzwonczyk R, del Rio C, Brown DA, Michler RE, Wolf RK, Howie MB. Myocardial electrical impedance responds to ischemia and reperfusion in humans. IEEE Trans Biomed Eng. 2004 Dec; 51(12):2206-9. PMID: 15605871.
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    45. Filippov AK, Fernández-Fernández JM, Marsh SJ, Simon J, Barnard EA, Brown DA. Activation and inhibition of neuronal G protein-gated inwardly rectifying K(+) channels by P2Y nucleotide receptors. Mol Pharmacol. 2004 Sep; 66(3):468-77. PMID: 15322238.
      View in: PubMed
    46. Brown DA, Jew KN, Sparagna GC, Musch TI, Moore RL. Exercise training preserves coronary flow and reduces infarct size after ischemia-reperfusion in rat heart. J Appl Physiol (1985). 2003 Dec; 95(6):2510-8. PMID: 12937028.
      View in: PubMed
    47. Passmore GM, Selyanko AA, Mistry M, Al-Qatari M, Marsh SJ, Matthews EA, Dickenson AH, Brown TA, Burbidge SA, Main M, Brown DA. KCNQ/M currents in sensory neurons: significance for pain therapy. J Neurosci. 2003 Aug 06; 23(18):7227-36. PMID: 12904483.
      View in: PubMed
    48. Mace LC, Palmer BM, Brown DA, Jew KN, Lynch JM, Glunt JM, Parsons TA, Cheung JY, Moore RL. Influence of age and run training on cardiac Na+/Ca2+ exchange. J Appl Physiol (1985). 2003 Nov; 95(5):1994-2003. PMID: 12882992.
      View in: PubMed
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