Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Vitaly Oleg Kheyfets

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
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    R01HL152250     (KHEYFETS, VITALY)May 1, 2023 - Dec 31, 2026
    NIH
    What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?
    Role: Principal Investigator
    R01HL152250     (KHEYFETS, VITALY)Mar 1, 2023 - Feb 28, 2027
    NIH/NHLBI
    What triggers RV Fiber Re-Orientation in response to RV pressure overload, and what is its Consequence on Inter-Ventricular Decoupling?
    Role Description: Identify transcriptomic signature driving fiber re-orientation during myocardial remodeling and how it impacts pumping function and inter-ventricular coupling
    Role: Principal Investigator
    25B1716     (HEDJAZI)Dec 1, 2022 - Nov 30, 2023
    NIH/NHLBI
    Developing a computational platform for in silico surgical intervention for Fontan surgery.
    Role: Co-Investigator
    SL210006     (LEE)Oct 1, 2022 - Sep 30, 2025
    DOD
    The pathobiological role of dysregulated pulmonary vascular metabolism in systemic sclerosis-associated pulmonary arterial hypertension.
    Role: Consultant
    R56HL152250     (KHEYFETS, VITALY)Sep 15, 2021 - Aug 31, 2022
    NIH
    Cause and effect of transient changes in stress, gene expression, and RV fiber orientation during RV remodeling, and its impact on RV function and inter-ventricular coupling in pulmonary hypertension
    Role: Principal Investigator
    R01HL158868     (SPIEKERKOETTER, EDDA FRAUKE)Jul 25, 2021 - May 31, 2025
    NIH
    Understanding and targeting molecular as well as structural events governing right ventricular adaptation, failure and recovery in pulmonary hypertension using repurposed drugs
    Role: Co-Investigator
    P01HL152961     (STENMARK, KURT R.)Aug 1, 2020 - Jun 30, 2025
    NIH
    Complement Mediated Remodeling in Pulmonary Vascular Disease
    Role: Consultant
    K25HL133481     (KHEYFETS, VITALY)Aug 1, 2017 - Jul 31, 2022
    NIH
    Inter-ventricular decoupling is an overlooked contributor to right ventricular myocardial stress and dysfunction in pediatric pulmonary hypertension
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping sleep's oscillatory events as a biomarker of Alzheimer's disease. Alzheimers Dement. 2024 01; 20(1):301-315. PMID: 37610059.
      View in: PubMed
    2. Hu CJ, Laux A, Gandjeva A, Wang L, Li M, Brown RD, Riddle S, Kheyfets VO, Tuder RM, Zhang H, Stenmark KR. The Effect of Hypoxia-inducible Factor Inhibition on the Phenotype of Fibroblasts in Human and Bovine Pulmonary Hypertension. Am J Respir Cell Mol Biol. 2023 07; 69(1):73-86. PMID: 36944195.
      View in: PubMed
    3. Kheyfets VO, Kumar S, Heerdt PM, Ichimura K, Brown RD, Lucero M, Essafri I, Williams S, Stenmark KR, Spiekerkoetter E. Characterizing the Spatiotemporal Transcriptomic Response of the Right Ventricle to Acute Pressure Overload. Int J Mol Sci. 2023 Jun 05; 24(11). PMID: 37298696.
      View in: PubMed
    4. Ichimura K, Santana EJ, Kuznetsova T, Cauwenberghs N, Sabovcik F, Chun L, Francisco NLC, Kheyfets VO, Salerno M, Zamanian RT, Spiekerkoetter E, Haddad F. Novel left ventricular mechanical index in pulmonary arterial hypertension. Pulm Circ. 2023 Apr; 13(2):e12216. PMID: 37063750.
      View in: PubMed
    5. Brown RD, Hunter KS, Li M, Frid MG, Harral J, Krafsur GM, Holt TN, Williams J, Zhang H, Riddle SR, Edwards MG, Kumar S, Hu CJ, Graham BB, Walker LA, Garry FB, Buttrick PM, Lahm T, Kheyfets VO, Hansen KC, Stenmark KR. Functional and molecular determinants of right ventricular response to severe pulmonary hypertension in a large animal model. Am J Physiol Heart Circ Physiol. 2023 06 01; 324(6):H804-H820. PMID: 36961489.
      View in: PubMed
    6. Pulver RL, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Holtzman DM, Morris JC, Toedebusch CD, Sillau SH, Bettcher BM, Lucey BP, McConnell BV. Mapping Sleep's Oscillatory Events as a Biomarker of Alzheimer's Disease. bioRxiv. 2023 Feb 16. PMID: 36824720.
      View in: PubMed
    7. Kheyfets VO, Sweatt AJ, Gomberg-Maitland M, Ivy DD, Condliffe R, Kiely DG, Lawrie A, Maron BA, Zamanian RT, Stenmark KR. Computational platform for doctor-artificial intelligence cooperation in pulmonary arterial hypertension prognostication: a pilot study. ERJ Open Res. 2023 Jan; 9(1). PMID: 36776484.
      View in: PubMed
    8. Gu S, Goel K, Forbes LM, Kheyfets VO, Yu YA, Tuder RM, Stenmark KR. Tensions in Taxonomies: Current Understanding and Future Directions in the Pathobiologic Basis and Treatment of Group 1 and Group 3 Pulmonary Hypertension. Compr Physiol. 2023 01 30; 13(1):4295-4319. PMID: 36715285.
      View in: PubMed
    9. Javadi E, Laudenschlager S, Kheyfets V, Di Maria M, Stone M, Jamali S, Powell AJ, Moghari MH. Predicting Hemodynamic Performance of Fontan Operation for Glenn Physiology using Computational Fluid Dynamics: Ten Patient-specific Cases. J Clin Images Med Case Rep. 2022 Jun; 3(6). PMID: 36339935.
      View in: PubMed
    10. McConnell BV, Kronberg E, Medenblik LM, Kheyfets VO, Ramos AR, Sillau SH, Pulver RL, Bettcher BM. The Rise and Fall of Slow Wave Tides: Vacillations in Coupled Slow Wave/Spindle Pairing Shift the Composition of Slow Wave Activity in Accordance With Depth of Sleep. Front Neurosci. 2022; 16:915934. PMID: 35812239.
      View in: PubMed
    11. Campbell NV, Mickael C, Kumar S, Zhang H, Campbell IL, Gillen AE, Trentin CO, Diener K, Gao B, Kheyfets VO, Gu S, Kumar R, Phang T, Brown RD, Graham BB, Stenmark KR. Single-cell RNA sequencing and binary hierarchical clustering define lung interstitial macrophage heterogeneity in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2022 07 01; 323(1):L58-L68. PMID: 35608266.
      View in: PubMed
    12. Mickael C, Kheyfets VO, Langou?t-Astri? C, Lee MH, Sanders LA, Trentin CO, Sweatt AJ, Zamanian RT, Bull TM, Stenmark K, Graham BB, Tuder RM. Peripheral Blood Inflammation Profile of Patients with Pulmonary Arterial Hypertension Using the High-Throughput Olink Proteomics Platform. Am J Respir Cell Mol Biol. 2022 05; 66(5):580-581. PMID: 35486078.
      View in: PubMed
    13. Heerdt PM, Singh I, Elassal A, Kheyfets V, Richter MJ, Tello K. Pressure-based estimation of right ventricular ejection fraction. ESC Heart Fail. 2022 04; 9(2):1436-1443. PMID: 35150211.
      View in: PubMed
    14. Walter R, Hunter K, Stenmark K, Kheyfets VO. Hemodynamically Unloading the Distal Pulmonary Circulation in Pulmonary Hypertension: A Modeling Study. J Biomech Eng. 2022 02 01; 144(2). PMID: 34251418.
      View in: PubMed
    15. Dufva MJ, Ivy D, Campbell K, Lam A, Rauff A, Breeman KTN, Douwes JM, Berger RMF, Kheyfets VO, Hunter K. Ventricular-vascular coupling is predictive of adverse clinical outcome in paediatric pulmonary arterial hypertension. Open Heart. 2021 09; 8(2). PMID: 34583983.
      View in: PubMed
    16. Boehm M, Tian X, Ali MK, Mao Y, Ichimura K, Zhao M, Kuramoto K, Dannewitz Prosseda S, Fajardo G, Dufva MJ, Qin X, Kheyfets VO, Bernstein D, Reddy S, Metzger RJ, Zamanian RT, Haddad F, Spiekerkoetter E. Improving Right Ventricular Function by Increasing BMP Signaling with FK506. Am J Respir Cell Mol Biol. 2021 09; 65(3):272-287. PMID: 33938785.
      View in: PubMed
    17. Dufva MJ, Boehm M, Ichimura K, Truong U, Qin X, Tabakh J, Hunter KS, Ivy D, Spiekerkoetter E, Kheyfets VO. Pulmonary arterial banding in mice may be a suitable model for studies on ventricular mechanics in pediatric pulmonary arterial hypertension. J Cardiovasc Magn Reson. 2021 06 03; 23(1):66. PMID: 34078382.
      View in: PubMed
    18. Sch?fer M, Frank BS, Ivy DD, Abman SH, Stenmark KR, Mitchell MB, Browne LP, Barker AJ, Hunter KS, Kheyfets V, Miller-Reed K, Ing R, Morgan GJ, Truong U. Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension. J Am Heart Assoc. 2021 04 20; 10(8):e020548. PMID: 33821682.
      View in: PubMed
    19. Stroh JN, Bennett TD, Kheyfets V, Albers D. Clinical Decision Support for Traumatic Brain Injury: Identifying a Framework for Practical Model-Based Intracranial Pressure Estimation at Multihour Timescales. JMIR Med Inform. 2021 Mar 22; 9(3):e23215. PMID: 33749613.
      View in: PubMed
    20. Boehm M, Tian X, Mao Y, Ichimura K, Dufva MJ, Ali K, Dannewitz Prosseda S, Shi Y, Kuramoto K, Reddy S, Kheyfets VO, Metzger RJ, Spiekerkoetter E. Delineating the molecular and histological events that govern right ventricular recovery using a novel mouse model of pulmonary artery de-banding. Cardiovasc Res. 2020 08 01; 116(10):1700-1709. PMID: 31738411.
      View in: PubMed
    21. Kheyfets VO, Lammers SR, Wagner J, Bartels K, Piccoli J, Smith BJ. PEEP/ FIO2 ARDSNet Scale Grouping of a Single Ventilator for Two Patients: Modeling Tidal Volume Response. Respir Care. 2020 08; 65(8):1094-1103. PMID: 32712582.
      View in: PubMed
    22. Kheyfets VO, Dufva MJ, Boehm M, Tian X, Qin X, Tabakh JE, Truong U, Ivy D, Spiekerkoetter E. The left ventricle undergoes biomechanical and gene expression changes in response to increased right ventricular pressure overload. Physiol Rep. 2020 05; 8(9):e14347. PMID: 32367677.
      View in: PubMed
    23. Kopf KW, Harral JW, Staker EA, Summers ME, Petrache I, Kheyfets V, Irwin DC, Majka SM. Optimization of combined measures of airway physiology and cardiovascular hemodynamics in mice. Pulm Circ. 2020 Jan-Mar; 10(1):2045894020912937. PMID: 32206308.
      View in: PubMed
    24. Heerdt PM, Kheyfets V, Charania S, Elassal A, Singh I. A pressure-based single beat method for estimation of right ventricular ejection fraction: proof of concept. Eur Respir J. 2020 03; 55(3). PMID: 31771999.
      View in: PubMed
    25. Kong F, Kheyfets V, Finol E, Cai XC. Simulation of unsteady blood flows in a patient-specific compliant pulmonary artery with a highly parallel monolithically coupled fluid-structure interaction algorithm. Int J Numer Method Biomed Eng. 2019 07; 35(7):e3208. PMID: 30989794.
      View in: PubMed
    26. Breeman KTN, Dufva M, Ploegstra MJ, Kheyfets V, Willems TP, Wigger J, Hunter KS, Ivy DD, Berger RMF, Truong U. Right ventricular-vascular coupling ratio in pediatric pulmonary arterial hypertension: A comparison between cardiac magnetic resonance and right heart catheterization measurements. Int J Cardiol. 2019 10 15; 293:211-217. PMID: 31109778.
      View in: PubMed
    27. Kheyfets VO, Truong U, Ivy D, Shandas R. Structural and Biomechanical Adaptations of Right Ventricular Remodeling-In Pulmonary Arterial Hypertension-Reduces Left Ventricular Rotation During Contraction: A Computational Study. J Biomech Eng. 2019 May 01; 141(5). PMID: 30714069.
      View in: PubMed
    28. Sch?fer M, Ivy DD, Abman SH, Stenmark K, Browne LP, Barker AJ, Mitchell MB, Morgan GJ, Wilson N, Shah A, Kollengode M, Naresh N, Fonseca B, DiMaria M, Buckner JK, Hunter KS, Kheyfets V, Fenster BE, Truong U. Differences in pulmonary arterial flow hemodynamics between children and adults with pulmonary arterial hypertension as assessed by 4D-flow CMR studies. Am J Physiol Heart Circ Physiol. 2019 05 01; 316(5):H1091-H1104. PMID: 30822118.
      View in: PubMed
    29. Dufva MJ, Truong U, Tiwari P, Ivy DD, Shandas R, Kheyfets VO. Left ventricular torsion rate and the relation to right ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2018 Jul-Sep; 8(3):2045894018791352. PMID: 30003835.
      View in: PubMed
    30. Bordones AD, Leroux M, Kheyfets VO, Wu YA, Chen CY, Finol EA. Computational Fluid Dynamics Modeling of the Human Pulmonary Arteries with Experimental Validation. Ann Biomed Eng. 2018 Sep; 46(9):1309-1324. PMID: 29786774.
      View in: PubMed
    31. Sch?fer M, Humphries S, Stenmark KR, Kheyfets VO, Buckner JK, Hunter KS, Fenster BE. 4D-flow cardiac magnetic resonance-derived vorticity is sensitive marker of left ventricular diastolic dysfunction in patients with mild-to-moderate chronic obstructive pulmonary disease. Eur Heart J Cardiovasc Imaging. 2018 04 01; 19(4):415-424. PMID: 28460004.
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    32. Kong F, Kheyfets V, Finol E, Cai XC. An efficient parallel simulation of unsteady blood flows in patient-specific pulmonary artery. Int J Numer Method Biomed Eng. 2018 04; 34(4):e2952. PMID: 29245182.
      View in: PubMed
    33. Sch?fer M, Barker AJ, Kheyfets V, Stenmark KR, Crapo J, Yeager ME, Truong U, Buckner JK, Fenster BE, Hunter KS. Helicity and Vorticity of Pulmonary Arterial Flow in Patients With Pulmonary Hypertension: Quantitative Analysis of Flow Formations. J Am Heart Assoc. 2017 Dec 20; 6(12). PMID: 29263034.
      View in: PubMed
    34. Sch?fer M, Truong U, Browne LP, Morgan GJ, Ross M, Ing R, Hunter KS, Kheyfets VO, Abman SH, Ivy DD, Wilson N. Measuring Flow Hemodynamic Indices and Oxygen Consumption in Children with Pulmonary Hypertension: A Comparison of Catheterization and Phase-Contrast MRI. Pediatr Cardiol. 2018 Feb; 39(2):268-274. PMID: 29043395.
      View in: PubMed
    35. Sch?fer M, Kheyfets VO, Barker AJ, Stenmark K, Hunter KS, McClatchey PM, Buckner JK, Reece TB, Jazaeri O, Fenster BE. Reduced shear stress and associated aortic deformation in the thoracic aorta of patients with chronic obstructive pulmonary disease. J Vasc Surg. 2018 07; 68(1):246-253. PMID: 28986100.
      View in: PubMed
    36. Kheyfets VO, Sucharov CC, Truong U, Dunning J, Hunter K, Ivy D, Miyamoto S, Shandas R. Circulating miRNAs in Pediatric Pulmonary Hypertension Show Promise as Biomarkers of Vascular Function. Oxid Med Cell Longev. 2017; 2017:4957147. PMID: 28819545.
      View in: PubMed
    37. Sch?fer M, Ivy DD, Barker AJ, Kheyfets V, Shandas R, Abman SH, Hunter KS, Truong U. Characterization of CMR-derived haemodynamic data in children with pulmonary arterial hypertension. Eur Heart J Cardiovasc Imaging. 2017 Apr 01; 18(4):424-431. PMID: 27444679.
      View in: PubMed
    38. Sch?fer M, Ivy DD, Abman SH, Barker AJ, Browne LP, Fonseca B, Kheyfets V, Hunter KS, Truong U. Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency? Circ Cardiovasc Imaging. 2017 02; 10(2). PMID: 28193613.
      View in: PubMed
    39. Kheyfets VO, Dunning J, Truong U, Ivy D, Hunter K, Shandas R. A Zero-Dimensional Model and Protocol for Simulating Patient-Specific Pulmonary Hemodynamics From Limited Clinical Data. J Biomech Eng. 2016 12 01; 138(12). PMID: 27684888.
      View in: PubMed
    40. Kheyfets VO, Schafer M, Podgorski CA, Schroeder JD, Browning J, Hertzberg J, Buckner JK, Hunter KS, Shandas R, Fenster BE. 4D magnetic resonance flow imaging for estimating pulmonary vascular resistance in pulmonary hypertension. J Magn Reson Imaging. 2016 10; 44(4):914-22. PMID: 27173445.
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    41. Sch?fer M, Kheyfets VO, Schroeder JD, Dunning J, Shandas R, Buckner JK, Browning J, Hertzberg J, Hunter KS, Fenster BE. Main pulmonary arterial wall shear stress correlates with invasive hemodynamics and stiffness in pulmonary hypertension. Pulm Circ. 2016 Mar; 6(1):37-45. PMID: 27076906.
      View in: PubMed
    42. Sch?fer M, Browning J, Schroeder JD, Shandas R, Kheyfets VO, Buckner JK, Hunter KS, Hertzberg JR, Fenster BE. Vorticity is a marker of diastolic ventricular interdependency in pulmonary hypertension. Pulm Circ. 2016 Mar; 6(1):46-54. PMID: 27162613.
      View in: PubMed
    43. Kheyfets VO, Dunning J, Truong U, Ivy DD, Hunter KA, Shandas R. Assessment of N-terminal prohormone B-type natriuretic peptide as a measure of vascular and ventricular function in pediatric pulmonary arterial hypertension. Pulm Circ. 2015 Dec; 5(4):658-66. PMID: 26697173.
      View in: PubMed
    44. Truong U, Patel S, Kheyfets V, Dunning J, Fonseca B, Barker AJ, Ivy D, Shandas R, Hunter K. Non-invasive determination by cardiovascular magnetic resonance of right ventricular-vascular coupling in children and adolescents with pulmonary hypertension. J Cardiovasc Magn Reson. 2015 Sep 16; 17:81. PMID: 26376972.
      View in: PubMed
    45. Kheyfets VO, Rios L, Smith T, Schroeder T, Mueller J, Murali S, Lasorda D, Zikos A, Spotti J, Reilly JJ, Finol EA. Patient-specific computational modeling of blood flow in the pulmonary arterial circulation. Comput Methods Programs Biomed. 2015 Jul; 120(2):88-101. PMID: 25975872.
      View in: PubMed
    46. Kheyfets V, Thirugnanasambandam M, Rios L, Evans D, Smith T, Schroeder T, Mueller J, Murali S, Lasorda D, Spotti J, Finol E. The role of wall shear stress in the assessment of right ventricle hydraulic workload. Pulm Circ. 2015 Mar; 5(1):90-100. PMID: 25992274.
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    47. Kheyfets VO, Thornton RC, Kowal M, Finol EA. A protocol for measuring pull-off stress of wound-treatment polymers. J Biomech Eng. 2014 Jul; 136(7). PMID: 24718322.
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    48. Kheyfets VO, Kieweg SL. Gravity-Driven Thin Film Flow of an Ellis Fluid. J Nonnewton Fluid Mech. 2013 Dec 01; 202:88-98. PMID: 25309029.
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    49. Kheyfets VO, O'Dell W, Smith T, Reilly JJ, Finol EA. Considerations for numerical modeling of the pulmonary circulation--a review with a focus on pulmonary hypertension. J Biomech Eng. 2013 Jun; 135(6):61011-15. PMID: 23699723.
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    50. Kheyfets VO, Kieweg SL. Experimental and numerical models of three-dimensional gravity-driven flow of shear-thinning polymer solutions used in vaginal delivery of microbicides. J Biomech Eng. 2013 Jun; 135(6):61009-14. PMID: 23699721.
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    51. Zhang H, Kheyfets VO, Finol EA. Robust infrarenal aortic aneurysm lumen centerline detection for rupture status classification. Med Eng Phys. 2013 Sep; 35(9):1358-67. PMID: 23608300.
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    52. Steinman DA, Hoi Y, Fahy P, Morris L, Walsh MT, Aristokleous N, Anayiotos AS, Papaharilaou Y, Arzani A, Shadden SC, Berg P, Janiga G, Bols J, Segers P, Bressloff NW, Cibis M, Gijsen FH, Cito S, Pallar?s J, Browne LD, Costelloe JA, Lynch AG, Degroote J, Vierendeels J, Fu W, Qiao A, Hodis S, Kallmes DF, Kalsi H, Long Q, Kheyfets VO, Finol EA, Kono K, Malek AM, Lauric A, Menon PG, Pekkan K, Esmaily Moghadam M, Marsden AL, Oshima M, Katagiri K, Peiffer V, Mohamied Y, Sherwin SJ, Schaller J, Goubergrits L, Usera G, Mendina M, Valen-Sendstad K, Habets DF, Xiang J, Meng H, Yu Y, Karniadakis GE, Shaffer N, Loth F. Variability of computational fluid dynamics solutions for pressure and flow in a giant aneurysm: the ASME 2012 Summer Bioengineering Conference CFD Challenge. J Biomech Eng. 2013 Feb; 135(2):021016. PMID: 23445061.
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