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Moumita Ghosh

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-6063

    Collapse Research 
    Collapse research activities and funding
    R01HL164555     (VANDIVIER, RICHARD W)Aug 15, 2023 - Jul 31, 2028
    NIH
    Airway Basal Progenitor Dysfunction in the Detection, Progression and Pathogenesis of Early COPD
    Role: Co-Principal Investigator
    R01CA219893     (GHOSH, MOUMITA ;MILLER, YORK E)Sep 1, 2017 - Aug 31, 2023
    NIH
    (PQ1) Progenitor cell malfunction, mutations and changes in microenvironment: A dynamic risk spectrum for cancer evolution
    Role: Principal Investigator
    R01HL129938     (GHOSH, MOUMITA)Sep 16, 2015 - Jun 30, 2020
    NIH
    Exhaustion of Airway Progenitor Cells Indicates Susceptibility to COPD
    Role: Principal Investigator
    K18HL107686     (GHOSH, MOUMITA)Jun 6, 2011 - Nov 30, 2013
    NIH
    A Promitotic Stem Cell Niche: Role For Beta-Catenin and TGFbeta
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Assante A, Lkhagvadorj K, Clambey ET, Danhorn T, Merrick DT, Keith RL, New ML, Degregori J, Miller YE, Ghosh M. Reduced Progenitor Function and Altered Immune Landscape Contribute to Field Cancerization of Lung Adenocarcinoma. Am J Respir Crit Care Med. 2023 Oct 15; 208(8):903-905. PMID: 37639330.
      View in: PubMed
    2. Miller YE, Ghosh M, Merrick DT, Kubala B, Szabo E, Bengtson L, Kocherginsky M, Helenowski IB, Benante K, Schering T, Kim J, Kim H, Ha D, Bergan RC, Khan SA, Keith RL. Phase Ib trial of inhaled iloprost for the prevention of lung cancer with predictive and response biomarker assessment. Front Oncol. 2023; 13:1204726. PMID: 37711198.
      View in: PubMed
    3. Hill W, Lim EL, Weeden CE, Lee C, Augustine M, Chen K, Kuan FC, Marongiu F, Evans EJ, Moore DA, Rodrigues FS, Pich O, Bakker B, Cha H, Myers R, van Maldegem F, Boumelha J, Veeriah S, Rowan A, Naceur-Lombardelli C, Karasaki T, Sivakumar M, De S, Caswell DR, Nagano A, Black JRM, Mart?nez-Ruiz C, Ryu MH, Huff RD, Li S, Fav? MJ, Magness A, Su?rez-Bonnet A, Priestnall SL, L?chtenborg M, Lavelle K, Pethick J, Hardy S, McRonald FE, Lin MH, Troccoli CI, Ghosh M, Miller YE, Merrick DT, Keith RL, Al Bakir M, Bailey C, Hill MS, Saal LH, Chen Y, George AM, Abbosh C, Kanu N, Lee SH, McGranahan N, Berg CD, Sasieni P, Houlston R, Turnbull C, Lam S, Awadalla P, Gr?nroos E, Downward J, Jacks T, Carlsten C, Malanchi I, Hackshaw A, Litchfield K, DeGregori J, Jamal-Hanjani M, Swanton C. Lung adenocarcinoma promotion by air pollutants. Nature. 2023 04; 616(7955):159-167. PMID: 37020004.
      View in: PubMed
    4. Dwyer-Nield LD, McArthur DG, Hudish TM, Hudish LI, Mirita C, Sompel K, Smith AJ, Alavi K, Ghosh M, Merrick DT, Tennis MA, Keith RL. PPARgamma agonism inhibits progression of premalignant lesions in a murine lung squamous cell carcinoma model. Int J Cancer. 2022 Dec 15; 151(12):2195-2205. PMID: 35830207.
      View in: PubMed
    5. Diaz Del Valle F, Zakrajsek JK, Min SJ, Koff PB, Bell HW, Kincaid KA, Frank DN, Ramakrishnan V, Ghosh M, Vandivier RW. Impact of Airline Secondhand Tobacco Smoke Exposure on Respiratory Health and Lung Function Decades After Exposure Cessation. Chest. 2022 09; 162(3):556-568. PMID: 35271841.
      View in: PubMed
    6. Ghosh M, Hill CL, Alsudayri A, Lallier SW, Hayes D, Wijeratne S, Tan ZH, Chiang T, Mahoney JE, Carraro G, Stripp BR, Reynolds SD. Repeated injury promotes tracheobronchial tissue stem cell attrition. Stem Cells Transl Med. 2021 12; 10(12):1696-1713. PMID: 34546001.
      View in: PubMed
    7. Koff PB, Min SJ, Freitag TJ, Diaz DLP, James SS, Voelkel NF, Linderman DJ, Diaz Del Valle F, Zakrajsek JK, Albert RK, Bull TM, Beck A, Stelzner TJ, Ritzwoller DP, Kveton CM, Carwin S, Ghosh M, Keith RL, Westfall JM, Vandivier RW. Impact of Proactive Integrated Care on Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2021 Jan; 8(1). PMID: 33238087.
      View in: PubMed
    8. Summers ME, Richmond BW, Kropski JA, Majka SA, Bastarache JA, Hatzopoulos AK, Bylund J, Ghosh M, Petrache I, Foronjy RF, Geraghty P, Majka SM. Balanced Wnt/Dickkopf-1 signaling by mesenchymal vascular progenitor cells in the microvascular niche maintains distal lung structure and function. Am J Physiol Cell Physiol. 2021 01 01; 320(1):C119-C131. PMID: 33085496.
      View in: PubMed
    9. Leach SM, Finigan J, Vasu VT, Mishra R, Ghosh M, Foster D, Mason R, Kosmider B, Farias Hesson E, Kern JA. The Kinome of Human Alveolar Type II and Basal Cells, and Its Reprogramming in Lung Cancer. Am J Respir Cell Mol Biol. 2019 10; 61(4):481-491. PMID: 30917006.
      View in: PubMed
    10. Ghosh M, Miller YE, Vandivier RW. Reply to Sohal: Airway Basal Cell Reprogramming and Epithelial-Mesenchymal Transition: A Potential Key to Understanding Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 06 15; 197(12):1645-1646. PMID: 29385351.
      View in: PubMed
    11. Ghosh M, Miller YE, Nakachi I, Kwon JB, Bar?n AE, Brantley AE, Merrick DT, Franklin WA, Keith RL, Vandivier RW. Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 04 01; 197(7):885-896. PMID: 29211494.
      View in: PubMed
    12. Vandivier RW, Ghosh M. Understanding the Relevance of the Mouse Cigarette Smoke Model of COPD: Peering through the Smoke. Am J Respir Cell Mol Biol. 2017 07; 57(1):3-4. PMID: 28665224.
      View in: PubMed
    13. Ghosh M, Ahmad S, White CW, Reynolds SD. Transplantation of Airway Epithelial Stem/Progenitor Cells: A Future for Cell-Based Therapy. Am J Respir Cell Mol Biol. 2017 01; 56(1):1-10. PMID: 27632244.
      View in: PubMed
    14. Jayaraja S, Dakhama A, Yun B, Ghosh M, Lee H, Redente EF, Uhlson CL, Murphy RC, Leslie CC. Cytosolic phospholipase A2 contributes to innate immune defense against Candida albicans lung infection. BMC Immunol. 2016 08 08; 17(1):27. PMID: 27501951.
      View in: PubMed
    15. Ghosh M, Dwyer-Nield LD, Kwon JB, Barthel L, Janssen WJ, Merrick DT, Keith RL. Tracheal dysplasia precedes bronchial dysplasia in mouse model of N-nitroso trischloroethylurea induced squamous cell lung cancer. PLoS One. 2015; 10(4):e0122823. PMID: 25860262.
      View in: PubMed
    16. Yun B, Lee H, Ghosh M, Cravatt BF, Hsu KL, Bonventre JV, Ewing H, Gelb MH, Leslie CC. Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation. J Biol Chem. 2014 Jan 17; 289(3):1491-504. PMID: 24297180.
      View in: PubMed
    17. Ghosh M, Smith RW, Runkle CM, Hicks DA, Helm KM, Reynolds SD. Regulation of trachebronchial tissue-specific stem cell pool size. Stem Cells. 2013 Dec; 31(12):2767-78. PMID: 23712882.
      View in: PubMed
    18. Ghosh M, Ahmad S, Jian A, Li B, Smith RW, Helm KM, Seibold MA, Groshong SD, White CW, Reynolds SD. Human tracheobronchial basal cells. Normal versus remodeling/repairing phenotypes in vivo and in vitro. Am J Respir Cell Mol Biol. 2013 Dec; 49(6):1127-34. PMID: 23927678.
      View in: PubMed
    19. Ghosh M, Roy K, Roy S. Immunomodulatory effects of antileishmanial drugs. J Antimicrob Chemother. 2013 Dec; 68(12):2834-8. PMID: 23833177.
      View in: PubMed
    20. Li W, Laskar A, Sultana N, Osman E, Ghosh M, Li Q, Yuan XM. Cell death induced by 7-oxysterols via lysosomal and mitochondrial pathways is p53-dependent. Free Radic Biol Med. 2012 Dec 01; 53(11):2054-61. PMID: 22985798.
      View in: PubMed
    21. Reynolds SD, Brechbuhl HM, Smith MK, Smith RW, Ghosh M. Lung epithelial healing: a modified seed and soil concept. Proc Am Thorac Soc. 2012 May; 9(2):27-37. PMID: 22550238.
      View in: PubMed
    22. Brechbuhl HM, Ghosh M, Smith MK, Smith RW, Li B, Hicks DA, Cole BB, Reynolds PR, Reynolds SD. ?-catenin dosage is a critical determinant of tracheal basal cell fate determination. Am J Pathol. 2011 Jul; 179(1):367-79. PMID: 21703416.
      View in: PubMed
    23. Ghosh M, Brechbuhl HM, Smith RW, Li B, Hicks DA, Titchner T, Runkle CM, Reynolds SD. Context-dependent differentiation of multipotential keratin 14-expressing tracheal basal cells. Am J Respir Cell Mol Biol. 2011 Aug; 45(2):403-10. PMID: 21131447.
      View in: PubMed
    24. Ghosh M, Helm KM, Smith RW, Giordanengo MS, Li B, Shen H, Reynolds SD. A single cell functions as a tissue-specific stem cell and the in vitro niche-forming cell. Am J Respir Cell Mol Biol. 2011 Sep; 45(3):459-69. PMID: 21131442.
      View in: PubMed
    25. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. Am J Physiol Lung Cell Mol Physiol. 2009 Oct; 297(4):L677-86. PMID: 19633071.
      View in: PubMed
    26. Tucker DE, Ghosh M, Ghomashchi F, Loper R, Suram S, John BS, Girotti M, Bollinger JG, Gelb MH, Leslie CC. Role of phosphorylation and basic residues in the catalytic domain of cytosolic phospholipase A2alpha in regulating interfacial kinetics and binding and cellular function. J Biol Chem. 2009 Apr 03; 284(14):9596-611. PMID: 19176526.
      View in: PubMed
    27. McPhillips K, Janssen WJ, Ghosh M, Byrne A, Gardai S, Remigio L, Bratton DL, Kang JL, Henson P. TNF-alpha inhibits macrophage clearance of apoptotic cells via cytosolic phospholipase A2 and oxidant-dependent mechanisms. J Immunol. 2007 Jun 15; 178(12):8117-26. PMID: 17548650.
      View in: PubMed
    28. Ghosh M, Loper R, Ghomashchi F, Tucker DE, Bonventre JV, Gelb MH, Leslie CC. Function, activity, and membrane targeting of cytosolic phospholipase A(2)zeta in mouse lung fibroblasts. J Biol Chem. 2007 Apr 20; 282(16):11676-86. PMID: 17293613.
      View in: PubMed
    29. Ghosh M, Tucker DE, Burchett SA, Leslie CC. Properties of the Group IV phospholipase A2 family. Prog Lipid Res. 2006 Nov; 45(6):487-510. PMID: 16814865.
      View in: PubMed
    30. Ghosh M, Loper R, Gelb MH, Leslie CC. Identification of the expressed form of human cytosolic phospholipase A2beta (cPLA2beta): cPLA2beta3 is a novel variant localized to mitochondria and early endosomes. J Biol Chem. 2006 Jun 16; 281(24):16615-24. PMID: 16617059.
      View in: PubMed
    31. Suram S, Brown GD, Ghosh M, Gordon S, Loper R, Taylor PR, Akira S, Uematsu S, Williams DL, Leslie CC. Regulation of cytosolic phospholipase A2 activation and cyclooxygenase 2 expression in macrophages by the beta-glucan receptor. J Biol Chem. 2006 Mar 03; 281(9):5506-14. PMID: 16407295.
      View in: PubMed
    32. Ahmad S, Ahmad A, Ghosh M, Leslie CC, White CW. Extracellular ATP-mediated signaling for survival in hyperoxia-induced oxidative stress. J Biol Chem. 2004 Apr 16; 279(16):16317-25. PMID: 14761947.
      View in: PubMed
    33. Ghosh M, Stewart A, Tucker DE, Bonventre JV, Murphy RC, Leslie CC. Role of cytosolic phospholipase A(2) in prostaglandin E(2) production by lung fibroblasts. Am J Respir Cell Mol Biol. 2004 Jan; 30(1):91-100. PMID: 12842849.
      View in: PubMed
    34. Stewart A, Ghosh M, Spencer DM, Leslie CC. Enzymatic properties of human cytosolic phospholipase A(2)gamma. J Biol Chem. 2002 Aug 16; 277(33):29526-36. PMID: 12039969.
      View in: PubMed
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