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Edward Lau

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
ORCID ORCID Icon0000-0001-9083-5922 Additional info

    Collapse Biography 
    Collapse education and training
    Stanford University, Palo Alto, CAPostdoc01/2020Cardiovascular
    University of California Los Angeles, Los Angeles, CAPhD12/2014Proteomics/ Bioinformatics
    University of California Berkeley, Berkeley, CABA05/2006Biology

    Collapse Overview 
    Collapse overview
    My lab's research uses genomics, proteomics, and bioinformatics approaches to understand basic cellular processes in human induced pluripotent stem cell (iPSC) models. Two current focuses include applying unbiased methods to understand cellular crosstalk and protein homeostasis under normal and senescent conditions. Website: https://laulab.net

    Collapse Research 
    Collapse research activities and funding
    F32HL139045     (LAU, EDWARD)Jul 28, 2017 - Feb 27, 2020
    NIH
    Identifying Markers of Induced Pluripotent Stem Cell-Derived Cardiomyocyte (iPSC-CM) Maturity
    Role: Principal Investigator

    K99HL144829     (LAU, EDWARD)Jan 15, 2019 - Dec 31, 2020
    NIH
    Proteomics Approach to Identify Cardiokine Signals in Human iPSC Models
    Role: Principal Investigator

    R00HL144829     (LAU, EDWARD)Aug 20, 2020 - Jul 31, 2023
    NIH
    Multi-Omics Approach to Identify Cardiokines in Human iPSC Models
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Woulfe KC, Jeffrey DA, Pires Da Silva J, Wilson CE, Mahaffey JH, Lau E, Slavov D, Hailu F, Karimpour-Fard A, Dockstader K, Bristow MR, Stauffer BL, Miyamoto SD, Sucharov CC. Serum response factor deletion 5 regulates phospholamban phosphorylation and calcium uptake. J Mol Cell Cardiol. 2021 Jun 15; 159:28-37. PMID: 34139234.
      View in: PubMed
    2. Chour T, Tian L, Lau E, Thomas D, Itzhaki I, Malak O, Zhang JZ, Qin X, Wardak M, Liu Y, Chandy M, Black KE, Lam MP, Neofytou E, Wu JC. Method for selective ablation of undifferentiated human pluripotent stem cell populations for cell-based therapies. JCI Insight. 2021 04 08; 6(7). PMID: 33830086.
      View in: PubMed
    3. Han Y, Wood SD, Wright JM, Dostal V, Lau E, Lam MPY. Computation-assisted targeted proteomics of alternative splicing protein isoforms in the human heart. J Mol Cell Cardiol. 2021 05; 154:92-96. PMID: 33549679.
      View in: PubMed
    4. Chandy M, Rhee JW, Ozen MO, Williams DR, Pepic L, Liu C, Zhang H, Malisa J, Lau E, Demirci U, Wu JC. Atlas of Exosomal microRNAs Secreted From Human iPSC-Derived Cardiac Cell Types. Circulation. 2020 Nov 03; 142(18):1794-1796. PMID: 33136510.
      View in: PubMed
    5. Dostal V, Wood SD, Thomas CT, Han Y, Lau E, Lam MPY. Proteomic signatures of acute oxidative stress response to paraquat in the mouse heart. Sci Rep. 2020 10 28; 10(1):18440. PMID: 33116222.
      View in: PubMed
    6. Han Y, Wright JM, Lau E, Lam MPY. Determining Alternative Protein Isoform Expression Using RNA Sequencing and Mass Spectrometry. STAR Protoc. 2020 Dec 18; 1(3):100138. PMID: 33377032.
      View in: PubMed
    7. Zhang JX, Lau E, Paik DT, Zhuge Y, Wu JC. High-throughput Preparation of DNA, RNA, and Protein from Cryopreserved Human iPSCs for Multi-omics Analysis. Curr Protoc Stem Cell Biol. 2020 09; 54(1):e114. PMID: 32584494.
      View in: PubMed
    8. Rhee JW, Yi H, Thomas D, Lam CK, Belbachir N, Tian L, Qin X, Malisa J, Lau E, Paik DT, Kim Y, Choi BS, Sayed N, Sallam K, Liao R, Wu JC. Modeling Secondary Iron Overload Cardiomyopathy with Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Cell Rep. 2020 07 14; 32(2):107886. PMID: 32668256.
      View in: PubMed
    9. Lau E, Han Y, Williams DR, Thomas CT, Shrestha R, Wu JC, Lam MPY. Splice-Junction-Based Mapping of Alternative Isoforms in the Human Proteome. Cell Rep. 2019 12 10; 29(11):3751-3765.e5. PMID: 31825849.
      View in: PubMed
    10. Lee J, Termglinchan V, Diecke S, Itzhaki I, Lam CK, Garg P, Lau E, Greenhaw M, Seeger T, Wu H, Zhang JZ, Chen X, Gil IP, Ameen M, Sallam K, Rhee JW, Churko JM, Chaudhary R, Chour T, Wang PJ, Snyder MP, Chang HY, Karakikes I, Wu JC. Activation of PDGF pathway links LMNA mutation to dilated cardiomyopathy. Nature. 2019 08; 572(7769):335-340. PMID: 31316208.
      View in: PubMed
    11. Seeger T, Shrestha R, Lam CK, Chen C, McKeithan WL, Lau E, Wnorowski A, McMullen G, Greenhaw M, Lee J, Oikonomopoulos A, Lee S, Yang H, Mercola M, Wheeler M, Ashley EA, Yang F, Karakikes I, Wu JC. A Premature Termination Codon Mutation in MYBPC3 Causes Hypertrophic Cardiomyopathy via Chronic Activation of Nonsense-Mediated Decay. Circulation. 2019 02 05; 139(6):799-811. PMID: 30586709.
      View in: PubMed
    12. Lau E, Paik DT, Wu JC. Systems-Wide Approaches in Induced Pluripotent Stem Cell Models. Annu Rev Pathol. 2019 01 24; 14:395-419. PMID: 30379619.
      View in: PubMed
    13. Lau E, Venkatraman V, Thomas CT, Wu JC, Van Eyk JE, Lam MPY. Identifying High-Priority Proteins Across the Human Diseasome Using Semantic Similarity. J Proteome Res. 2018 12 07; 17(12):4267-4278. PMID: 30256117.
      View in: PubMed
    14. Lau E, Wu JC. Omics, Big Data, and Precision Medicine in Cardiovascular Sciences. Circ Res. 2018 04 27; 122(9):1165-1168. PMID: 29700063.
      View in: PubMed
    15. Lee AS, Inayathullah M, Lijkwan MA, Zhao X, Sun W, Park S, Hong WX, Parekh MB, Malkovskiy AV, Lau E, Qin X, Pothineni VR, Sanchez-Freire V, Zhang WY, Kooreman NG, Ebert AD, Chan CKF, Nguyen PK, Rajadas J, Wu JC. Prolonged survival of transplanted stem cells after ischaemic injury via the slow release of pro-survival peptides from a collagen matrix. Nat Biomed Eng. 2018 Feb; 2(2):104-113. PMID: 29721363.
      View in: PubMed
    16. Lau E, Cao Q, Lam MPY, Wang J, Ng DCM, Bleakley BJ, Lee JM, Liem DA, Wang D, Hermjakob H, Ping P. Integrated omics dissection of proteome dynamics during cardiac remodeling. Nat Commun. 2018 01 09; 9(1):120. PMID: 29317621.
      View in: PubMed
    17. Lam MP, Lau E, Ng DC, Wang D, Ping P. Cardiovascular proteomics in the era of big data: experimental and computational advances. Clin Proteomics. 2016; 13:23. PMID: 27980500.
      View in: PubMed
    18. Lau E, Watson KE, Ping P. Connecting the Dots: From Big Data to Healthy Heart. Circulation. 2016 Aug 02; 134(5):362-4. PMID: 27481999.
      View in: PubMed
    19. Gramolini A, Lau E, Liu PP. Identifying Low-Abundance Biomarkers: Aptamer-Based Proteomics Potentially Enables More Sensitive Detection in Cardiovascular Diseases. Circulation. 2016 Jul 26; 134(4):286-9. PMID: 27444931.
      View in: PubMed
    20. Lam MP, Venkatraman V, Xing Y, Lau E, Cao Q, Ng DC, Su AI, Ge J, Van Eyk JE, Ping P. Data-Driven Approach To Determine Popular Proteins for Targeted Proteomics Translation of Six Organ Systems. J Proteome Res. 2016 11 04; 15(11):4126-4134. PMID: 27356587.
      View in: PubMed
    21. Harrison TM, Mahmood Z, Lau EP, Karacozoff AM, Burggren AC, Small GW, Bookheimer SY. An Alzheimer's Disease Genetic Risk Score Predicts Longitudinal Thinning of Hippocampal Complex Subregions in Healthy Older Adults. eNeuro. 2016 May-Jun; 3(3). PMID: 27482534.
      View in: PubMed
    22. Lau E, Cao Q, Ng DC, Bleakley BJ, Dincer TU, Bot BM, Wang D, Liem DA, Lam MP, Ge J, Ping P. A large dataset of protein dynamics in the mammalian heart proteome. Sci Data. 2016 Mar 15; 3:160015. PMID: 26977904.
      View in: PubMed
    23. Lenartowicz A, Lu S, Rodriguez C, Lau EP, Walshaw PD, McCracken JT, Cohen MS, Loo SK. Alpha desynchronization and fronto-parietal connectivity during spatial working memory encoding deficits in ADHD: A simultaneous EEG-fMRI study. Neuroimage Clin. 2016; 11:210-223. PMID: 26955516.
      View in: PubMed
    24. Kudelko M, Chan CW, Sharma R, Yao Q, Lau E, Chu IK, Cheah KS, Tanner JA, Chan D. Label-Free Quantitative Proteomics Reveals Survival Mechanisms Developed by Hypertrophic Chondrocytes under ER Stress. J Proteome Res. 2016 Jan 04; 15(1):86-99. PMID: 26587667.
      View in: PubMed
    25. Lam MP, Venkatraman V, Cao Q, Wang D, Dincer TU, Lau E, Su AI, Xing Y, Ge J, Ping P, Van Eyk JE. Prioritizing Proteomics Assay Development for Clinical Translation. J Am Coll Cardiol. 2015 Jul 14; 66(2):202-4. PMID: 26160638.
      View in: PubMed
    26. Lau E, Huang D, Cao Q, Dincer TU, Black CM, Lin AJ, Lee JM, Wang D, Liem DA, Lam MP, Ping P. Spatial and temporal dynamics of the cardiac mitochondrial proteome. Expert Rev Proteomics. 2015 Apr; 12(2):133-46. PMID: 25752359.
      View in: PubMed
    27. Chan XC, Black CM, Lin AJ, Ping P, Lau E. Mitochondrial protein turnover: methods to measure turnover rates on a large scale. J Mol Cell Cardiol. 2015 Jan; 78:54-61. PMID: 25451168.
      View in: PubMed
    28. Zong N, Ping P, Lau E, Choi HJ, Ng DC, Meyer D, Fang C, Li H, Wang D, Zelaya IM, Yates JR, Lam MP. Lysine ubiquitination and acetylation of human cardiac 20S proteasomes. Proteomics Clin Appl. 2014 Aug; 8(7-8):590-594. PMID: 24957502.
      View in: PubMed
    29. Wang D, Liem DA, Lau E, Ng DC, Bleakley BJ, Cadeiras M, Deng MC, Lam MP, Ping P. Characterization of human plasma proteome dynamics using deuterium oxide. Proteomics Clin Appl. 2014 Aug; 8(7-8):610-9. PMID: 24946186.
      View in: PubMed
    30. Kerr WT, Hwang ES, Raman KR, Barritt SE, Patel AB, Le JM, Hori JM, Davis EC, Braesch CT, Janio EA, Lau EP, Cho AY, Anderson A, Silverman DH, Salamon N, Engel J, Stern JM, Cohen MS. Multimodal diagnosis of epilepsy using conditional dependence and multiple imputation. Int Workshop Pattern Recognit Neuroimaging. 2014 Jun; 1-4. PMID: 25311448.
      View in: PubMed
    31. Lam MP, Wang D, Lau E, Liem DA, Kim AK, Ng DC, Liang X, Bleakley BJ, Liu C, Tabaraki JD, Cadeiras M, Wang Y, Deng MC, Ping P. Protein kinetic signatures of the remodeling heart following isoproterenol stimulation. J Clin Invest. 2014 Apr; 124(4):1734-44. PMID: 24614109.
      View in: PubMed
    32. Lotz C, Lin AJ, Black CM, Zhang J, Lau E, Deng N, Wang Y, Zong NC, Choi JH, Xu T, Liem DA, Korge P, Weiss JN, Hermjakob H, Yates JR, Apweiler R, Ping P. Characterization, design, and function of the mitochondrial proteome: from organs to organisms. J Proteome Res. 2014 Feb 07; 13(2):433-46. PMID: 24070373.
      View in: PubMed
    33. Lam MP, Lau E, Liem DA, Ping P. Cyclophilin D and acetylation: a new link in cardiac signaling. Circ Res. 2013 Dec 06; 113(12):1268-9. PMID: 24311610.
      View in: PubMed
    34. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. Response to Pomozi et al's research commentary. Circ Res. 2013 May 24; 112(11):e152-3. PMID: 23625949.
      View in: PubMed
    35. Kerr WT, Nguyen ST, Cho AY, Lau EP, Silverman DH, Douglas PK, Reddy NM, Anderson A, Bramen J, Salamon N, Stern JM, Cohen MS. Computer-Aided Diagnosis and Localization of Lateralized Temporal Lobe Epilepsy Using Interictal FDG-PET. Front Neurol. 2013; 4:31. PMID: 23565107.
      View in: PubMed
    36. Kerr WT, Lau EP. Poisson noise obscures hypometabolic lesions in PET. Yale J Biol Med. 2012 Dec; 85(4):541-9. PMID: 23239953.
      View in: PubMed
    37. Kerr WT, Lau EP, Owens GE, Trefler A. The future of medical diagnostics: large digitized databases. Yale J Biol Med. 2012 Sep; 85(3):363-77. PMID: 23012584.
      View in: PubMed
    38. Lam MP, Lau E, Scruggs SB, Wang D, Kim TY, Liem DA, Zhang J, Ryan CM, Faull KF, Ping P. Site-specific quantitative analysis of cardiac mitochondrial protein phosphorylation. J Proteomics. 2013 Apr 09; 81:15-23. PMID: 23022582.
      View in: PubMed
    39. Kerr WT, Anderson A, Lau EP, Cho AY, Xia H, Bramen J, Douglas PK, Braun ES, Stern JM, Cohen MS. Automated diagnosis of epilepsy using EEG power spectrum. Epilepsia. 2012 Nov; 53(11):e189-92. PMID: 22967005.
      View in: PubMed
    40. Kim TY, Wang D, Kim AK, Lau E, Lin AJ, Liem DA, Zhang J, Zong NC, Lam MP, Ping P. Metabolic labeling reveals proteome dynamics of mouse mitochondria. Mol Cell Proteomics. 2012 Dec; 11(12):1586-94. PMID: 22915825.
      View in: PubMed
    41. Martin LJ, Lau E, Singh H, Vergnes L, Tarling EJ, Mehrabian M, Mungrue I, Xiao S, Shih D, Castellani L, Ping P, Reue K, Stefani E, Drake TA, Bostrom K, Lusis AJ. ABCC6 localizes to the mitochondria-associated membrane. Circ Res. 2012 Aug 17; 111(5):516-20. PMID: 22811557.
      View in: PubMed
    42. Kerr WT, Anderson A, Xia H, Braun ES, Lau EP, Cho AY, Cohen MS. Parameter Selection in Mutual Information-Based Feature Selection in Automated Diagnosis of Multiple Epilepsies Using Scalp EEG. Int Workshop Pattern Recognit Neuroimaging. 2012 Jul; 45-48. PMID: 25241830.
      View in: PubMed
    43. Zhang J, Lin A, Powers J, Lam MP, Lotz C, Liem D, Lau E, Wang D, Deng N, Korge P, Zong NC, Cai H, Weiss J, Ping P. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial proteome design: from molecular identity to pathophysiological regulation. J Gen Physiol. 2012 Jun; 139(6):395-406. PMID: 22641634.
      View in: PubMed
    44. Lau E, Wang D, Zhang J, Yu H, Lam MP, Liang X, Zong N, Kim TY, Ping P. Substrate- and isoform-specific proteome stability in normal and stressed cardiac mitochondria. Circ Res. 2012 Apr 27; 110(9):1174-8. PMID: 22456183.
      View in: PubMed
    45. Lam MP, Scruggs SB, Kim TY, Zong C, Lau E, Wang D, Ryan CM, Faull KF, Ping P. An MRM-based workflow for quantifying cardiac mitochondrial protein phosphorylation in murine and human tissue. J Proteomics. 2012 Aug 03; 75(15):4602-9. PMID: 22387130.
      View in: PubMed
    46. Lam MP, Lau E, Siu SO, Ng DC, Kong RP, Chiu PC, Yeung WS, Lo C, Chu IK. Online combination of reversed-phase/reversed-phase and porous graphitic carbon liquid chromatography for multicomponent separation of proteomics and glycoproteomics samples. Electrophoresis. 2011 Nov; 32(21):2930-40. PMID: 22009802.
      View in: PubMed
    47. Siu SO, Lam MP, Lau E, Kong RP, Lee SM, Chu IK. Fully automatable two-dimensional reversed-phase capillary liquid chromatography with online tandem mass spectrometry for shotgun proteomics. Proteomics. 2011 Jun; 11(11):2308-19. PMID: 21548098.
      View in: PubMed
    48. Lau E, Lam MP, Siu SO, Kong RP, Chan WL, Zhou Z, Huang J, Lo C, Chu IK. Combinatorial use of offline SCX and online RP-RP liquid chromatography for iTRAQ-based quantitative proteomics applications. Mol Biosyst. 2011 May; 7(5):1399-408. PMID: 21350782.
      View in: PubMed
    49. Lam MP, Siu SO, Lau E, Mao X, Sun HZ, Chiu PC, Yeung WS, Cox DM, Chu IK. Online coupling of reverse-phase and hydrophilic interaction liquid chromatography for protein and glycoprotein characterization. Anal Bioanal Chem. 2010 Sep; 398(2):791-804. PMID: 20632160.
      View in: PubMed
    50. Liu H, Lau E, Lam MPY, Chu H, Li S, Huang G, Guo P, Wang J, Jiang L, Chu IK, Lo C, Tao Y. OsNOA1/RIF1 is a functional homolog of AtNOA1/RIF1: implication for a highly conserved plant cGTPase essential for chloroplast function. New Phytol. 2010 Jul; 187(1):83-105. PMID: 20456051.
      View in: PubMed
    51. Siu SO, Lam MP, Lau E, Yeung WS, Cox DM, Chu IK. N-linked glycoprotein analysis using dual-extraction ultrahigh-performance liquid chromatography and electrospray tandem mass spectrometry. Methods Mol Biol. 2010; 600:133-43. PMID: 19882125.
      View in: PubMed
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