 Mike A Swanson
| Title | Senior Instructor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-PEDS |
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| Phone | 303/724-6355 |
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 Research CMH-J-17-30 (M. Swanson)Mar 1, 2017 - Jun 1, 2018 Colorado Clinical & Translational Sciences Institute (CCTSI)
Development of Effective Treatments for NKH Based on the Stabilization of the Glycine Cleavage Enzyme System P-Protein
Role Description: The goal of this project is to identify compounds that stabilize GLDC by using high-throughput screening of 2 libraries (>22,000 compounds) probed by differential scanning fluorimetry.
Role: Principle Investigator |
Bibliographic
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Swanson MA, Garcia SM, Spector E, Kronquist K, Creadon-Swindell G, Walter M, Christensen E, Van Hove JLK, Sass JO. d-Glyceric aciduria does not cause nonketotic hyperglycinemia: A historic co-occurrence. Mol Genet Metab. 2017 06; 121(2):80-82. PMID: 28462797.
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Bravo-Alonso I, Navarrete R, Arribas-Carreira L, Perona A, Abia D, Couce ML, Garc?a-Cazorla A, Morais A, Domingo R, Ramos MA, Swanson MA, Van Hove JLK, Ugarte M, P?rez B, P?rez-Cerd? C, Rodr?guez-Pombo P. Nonketotic hyperglycinemia: Functional assessment of missense variants in GLDC to understand phenotypes of the disease. Hum Mutat. 2017 06; 38(6):678-691. PMID: 28244183.
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Coughlin CR, Swanson MA, Kronquist K, Acquaviva C, Hutchin T, Rodr?guez-Pombo P, V?is?nen ML, Spector E, Creadon-Swindell G, Br?s-Goldberg AM, Rahikkala E, Moilanen JS, Mahieu V, Matthijs G, Bravo-Alonso I, P?rez-Cerd? C, Ugarte M, Vianey-Saban C, Scharer GH, Van Hove JL. The genetic basis of classic nonketotic hyperglycinemia due to mutations in GLDC and AMT. Genet Med. 2017 01; 19(1):104-111. PMID: 27362913.
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Bjoraker KJ, Swanson MA, Coughlin CR, Christodoulou J, Tan ES, Fergeson M, Dyack S, Ahmad A, Friederich MW, Spector EB, Creadon-Swindell G, Hodge MA, Gaughan S, Burns C, Van Hove JL. Neurodevelopmental Outcome and Treatment Efficacy of Benzoate and Dextromethorphan in Siblings with Attenuated Nonketotic Hyperglycinemia. J Pediatr. 2016 Mar; 170:234-9. PMID: 26749113.
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Swanson MA, Coughlin CR, Scharer GH, Szerlong HJ, Bjoraker KJ, Spector EB, Creadon-Swindell G, Mahieu V, Matthijs G, Hennermann JB, Applegarth DA, Toone JR, Tong S, Williams K, Van Hove JL. Biochemical and molecular predictors for prognosis in nonketotic hyperglycinemia. Ann Neurol. 2015 Oct; 78(4):606-18. PMID: 26179960.
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Coughlin CR, Scharer GH, Friederich MW, Yu HC, Geiger EA, Creadon-Swindell G, Collins AE, Vanlander AV, Coster RV, Powell CA, Swanson MA, Minczuk M, Van Hove JL, Shaikh TH. Mutations in the mitochondrial cysteinyl-tRNA synthase gene, CARS2, lead to a severe epileptic encephalopathy and complex movement disorder. J Med Genet. 2015 Aug; 52(8):532-40. PMID: 25787132.
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Meyer V, Swanson MA, Clouston LJ, Boratynski PJ, Stein RA, Mchaourab HS, Rajca A, Eaton SS, Eaton GR. Room-temperature distance measurements of immobilized spin-labeled protein by DEER/PELDOR. Biophys J. 2015 Mar 10; 108(5):1213-9. PMID: 25762332.
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Chatfield KC, Coughlin CR, Friederich MW, Gallagher RC, Hesselberth JR, Lovell MA, Ofman R, Swanson MA, Thomas JA, Wanders RJ, Wartchow EP, Van Hove JL. Mitochondrial energy failure in HSD10 disease is due to defective mtDNA transcript processing. Mitochondrion. 2015 Mar; 21:1-10. PMID: 25575635.
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Baker PR, Friederich MW, Swanson MA, Shaikh T, Bhattacharya K, Scharer GH, Aicher J, Creadon-Swindell G, Geiger E, MacLean KN, Lee WT, Deshpande C, Freckmann ML, Shih LY, Wasserstein M, Rasmussen MB, Lund AM, Procopis P, Cameron JM, Robinson BH, Brown GK, Brown RM, Compton AG, Dieckmann CL, Collard R, Coughlin CR, Spector E, Wempe MF, Van Hove JL. Variant non ketotic hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX5. Brain. 2014 Feb; 137(Pt 2):366-79. PMID: 24334290.
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Rajca A, Wang Y, Boska M, Paletta JT, Olankitwanit A, Swanson MA, Mitchell DG, Eaton SS, Eaton GR, Rajca S. Organic radical contrast agents for magnetic resonance imaging. J Am Chem Soc. 2012 09 26; 134(38):15724-7. PMID: 22974177.
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Rivera EJ, Sethi R, Qu F, Krishnamurthy R, Muthupillai R, Alford M, Swanson MA, Eaton SS, Eaton GR, Wilson LJ . Nitroxyl radicals@US-Tubes: New spin labels for biomedical applications. Advanced Functional Materials. 2012; 22(17):3691-3698.
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Siddiqua A, Luo Y, Meyer V, Swanson MA, Yu X, Wei G, Zheng J, Eaton GR, Ma B, Nussinov R, Eaton SS, Margittai M. Conformational basis for asymmetric seeding barrier in filaments of three- and four-repeat tau. J Am Chem Soc. 2012 Jun 20; 134(24):10271-8. PMID: 22656332.
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Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS. Electron transfer flavoprotein domain II orientation monitored using double electron-electron resonance between an enzymatically reduced, native FAD cofactor, and spin labels. Protein Sci. 2011 Mar; 20(3):610-20. PMID: 21308847.
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Swanson MA, Kathirvelu V, Majtan T, Frerman FE, Eaton GR, Eaton SS. DEER distance measurement between a spin label and a native FAD semiquinone in electron transfer flavoprotein. J Am Chem Soc. 2009 Nov 11; 131(44):15978-9. PMID: 19886689.
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Swanson MA, Usselman RJ, Frerman FE, Eaton GR, Eaton SS. The iron-sulfur cluster of electron transfer flavoprotein-ubiquinone oxidoreductase is the electron acceptor for electron transfer flavoprotein. Biochemistry. 2008 Aug 26; 47(34):8894-901. PMID: 18672901.
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Detamore MS, Swanson MA, Frender KR, Hrenya CM . A kinetic-theory analysis of the scale-up of circulating fluidized beds. Powder Technology. 2001; 116(2-3):190-203.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2001 | 1 | | 2008 | 1 | | 2009 | 1 | | 2011 | 1 | | 2012 | 3 | | 2013 | 1 | | 2015 | 4 | | 2016 | 2 | | 2017 | 2 |
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