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Pei-San Tsai

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentIntegrative Physiology
Phone303/735-1877

    Collapse Research 
    Collapse research activities and funding
    IOS1352944     (Pei-San Tsai)Aug 1, 2014 - Jul 31, 2018
    NSF
    Multifunctional Nature of Protostomian Gonadotropin-Releasing Hormone-Like Molecules
    Role: Principal Investigator

    R01HD083260     (TSAI, PEISAN)Jul 26, 2016 - Apr 30, 2021
    NIH
    Postnatal Plasticity in the GnRH System
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dela Cruz C, Horton CA, Sanders KN, Andersen ND, Tsai PS. Conditional Fgfr1 Deletion in GnRH Neurons Leads to Minor Disruptions in the Reproductive Axis of Male and Female Mice. Front Endocrinol (Lausanne). 2020; 11:588459. PMID: 33679600.
      View in: PubMed
    2. Aldhaleai A, Tsai PA. Fabrication of Transparent and Microstructured Superhydrophobic Substrates Using Additive Manufacturing. Langmuir. 2021 Jan 12; 37(1):348-356. PMID: 33377783.
      View in: PubMed
    3. Ho TM, Tsai PA. Microfluidic salt precipitation: implications for geological CO2 storage. Lab Chip. 2020 10 21; 20(20):3806-3814. PMID: 32924049.
      View in: PubMed
    4. Liu L, Cai G, Tsai PA. Drop Impact on Heated Nanostructures. Langmuir. 2020 Sep 01; 36(34):10051-10060. PMID: 32794773.
      View in: PubMed
    5. Saadat M, Tsai PA, Ho TH, Øye G, Dudek M. Development of a Microfluidic Method to Study Enhanced Oil Recovery by Low Salinity Water Flooding. ACS Omega. 2020 Jul 21; 5(28):17521-17530. PMID: 32715237.
      View in: PubMed
    6. Bigdeli MB, Tsai PA. Making Photonic Crystals via Evaporation of Nanoparticle-Laden Droplets on Superhydrophobic Microstructures. Langmuir. 2020 May 05; 36(17):4835-4841. PMID: 32309954.
      View in: PubMed
    7. Aldhaleai A, Tsai PA. Effect of a Cationic Surfactant on Droplet Wetting on Superhydrophobic Surfaces. Langmuir. 2020 Apr 28; 36(16):4308-4316. PMID: 32298121.
      View in: PubMed
    8. Bussonnière A, Liu Q, Tsai PA. Cavitation Nuclei Regeneration in a Water-Particle Suspension. Phys Rev Lett. 2020 Jan 24; 124(3):034501. PMID: 32031863.
      View in: PubMed
    9. Shardt N, Bigdeli MB, Elliott JAW, Tsai PA. How Surfactants Affect Droplet Wetting on Hydrophobic Microstructures. J Phys Chem Lett. 2019 Dec 05; 10(23):7510-7515. PMID: 31763845.
      View in: PubMed
    10. Dastvareh B, Azaiez J, Tsai PA. Nanocatalytic chemohydrodynamic instability: Deposition effects. Phys Rev E. 2019 Nov; 100(5-1):053102. PMID: 31869975.
      View in: PubMed
    11. Martillotti AW, Tsai PS. An Adipokinetic Hormone Acts as a Volume Regulator in the Intertidal Gastropod Mollusk, Aplysia californica. Front Endocrinol (Lausanne). 2018; 9:493. PMID: 30197626.
      View in: PubMed
    12. Bongrand G, Tsai PA. Manipulation of viscous fingering in a radially tapered cell geometry. Phys Rev E. 2018 Jun; 97(6-1):061101. PMID: 30011440.
      View in: PubMed
    13. Tsai PS. Gonadotropin-releasing hormone by any other name would smell as sweet. Gen Comp Endocrinol. 2018 08 01; 264:58-63. PMID: 28927877.
      View in: PubMed
    14. Bussonnière A, Bigdeli MB, Chueh DY, Liu Q, Chen P, Tsai PA. Universal wetting transition of an evaporating water droplet on hydrophobic micro- and nano-structures. Soft Matter. 2017 Feb 07; 13(5):978-984. PMID: 28091660.
      View in: PubMed
    15. Kavanaugh SI, Tsai PS. Functional Authentication of a Novel Gastropod Gonadotropin-Releasing Hormone Receptor Reveals Unusual Features and Evolutionary Insight. PLoS One. 2016; 11(7):e0160292. PMID: 27467252.
      View in: PubMed
    16. Plachetzki DC, Tsai PS, Kavanaugh SI, Sower SA. Ancient origins of metazoan gonadotropin-releasing hormone and their receptors revealed by phylogenomic analyses. Gen Comp Endocrinol. 2016 08 01; 234:10-9. PMID: 27318276.
      View in: PubMed
    17. Miller AV, Kavanaugh SI, Tsai PS. Disruption of the Suprachiasmatic Nucleus in Fibroblast Growth Factor Signaling-Deficient Mice. Front Endocrinol (Lausanne). 2016; 7:11. PMID: 26903947.
      View in: PubMed
    18. Zhang W, Johnson JI, Tsai PS. Fgf8-Deficient Mice Compensate for Reduced GnRH Neuronal Population and Exhibit Normal Testicular Function. Front Endocrinol (Lausanne). 2015; 6:151. PMID: 26441841.
      View in: PubMed
    19. Johnson JI, Kavanaugh SI, Nguyen C, Tsai PS. Localization and functional characterization of a novel adipokinetic hormone in the mollusk, Aplysia californica. PLoS One. 2014; 9(8):e106014. PMID: 25162698.
      View in: PubMed
    20. Brooks LR, Pals HL, Enix CL, Woolaver RA, Paul ED, Lowry CA, Tsai PS. Fibroblast growth factor 8 deficiency compromises the functional response of the serotonergic system to stress. PLoS One. 2014; 9(7):e101420. PMID: 24992493.
      View in: PubMed
    21. Brooks LR, Enix CL, Rich SC, Magno JA, Lowry CA, Tsai PS. Fibroblast growth factor deficiencies impact anxiety-like behavior and the serotonergic system. Behav Brain Res. 2014 May 01; 264:74-81. PMID: 24512770.
      View in: PubMed
    22. Jung LH, Kavanaugh SI, Sun B, Tsai PS. Localization of a molluscan gonadotropin-releasing hormone in Aplysia californica by in situ hybridization and immunocytochemistry. Gen Comp Endocrinol. 2014 Jan 01; 195:132-7. PMID: 24246309.
      View in: PubMed
    23. Miraoui H, Dwyer AA, Sykiotis GP, Plummer L, Chung W, Feng B, Beenken A, Clarke J, Pers TH, Dworzynski P, Keefe K, Niedziela M, Raivio T, Crowley WF, Seminara SB, Quinton R, Hughes VA, Kumanov P, Young J, Yialamas MA, Hall JE, Van Vliet G, Chanoine JP, Rubenstein J, Mohammadi M, Tsai PS, Sidis Y, Lage K, Pitteloud N. Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 are identified in individuals with congenital hypogonadotropic hypogonadism. Am J Hum Genet. 2013 May 02; 92(5):725-43. PMID: 23643382.
      View in: PubMed
    24. Tsai PA, Riesing K, Stone HA. Density-driven convection enhanced by an inclined boundary: implications for geological CO2 storage. Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Jan; 87(1):011003. PMID: 23410275.
      View in: PubMed
    25. Rochester JR, Chung WC, Hayes TB, Tsai PS. Opposite-sex housing reactivates the declining GnRH system in aged transgenic male mice with FGF signaling deficiency. Am J Physiol Endocrinol Metab. 2012 Dec 15; 303(12):E1428-39. PMID: 23047985.
      View in: PubMed
    26. Brooks LR, Le CD, Chung WC, Tsai PS. Maternal behavior in transgenic mice with reduced fibroblast growth factor receptor function in gonadotropin-releasing hormone neurons. Behav Brain Funct. 2012 Sep 05; 8:47. PMID: 22950531.
      View in: PubMed
    27. Tata BK, Chung WC, Brooks LR, Kavanaugh SI, Tsai PS. Fibroblast growth factor signaling deficiencies impact female reproduction and kisspeptin neurons in mice. Biol Reprod. 2012 Apr; 86(4):119. PMID: 22278983.
      View in: PubMed
    28. Sun B, Kavanaugh SI, Tsai PS. Gonadotropin-releasing hormone in protostomes: insights from functional studies on Aplysia californica. Gen Comp Endocrinol. 2012 May 01; 176(3):321-6. PMID: 22172342.
      View in: PubMed
    29. Sun B, Tsai PS. A gonadotropin-releasing hormone-like molecule modulates the activity of diverse central neurons in a gastropod mollusk, aplysia californica. Front Endocrinol (Lausanne). 2011; 2:36. PMID: 22654804.
      View in: PubMed
    30. McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D, Farooqi IS, Raza J, Walker J, Kavanaugh SI, Tsai PS, Pitteloud N, Martinez-Barbera JP, Dattani MT. Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction. J Clin Endocrinol Metab. 2011 Oct; 96(10):E1709-18. PMID: 21832120.
      View in: PubMed
    31. Tsai PS. Hormones and Reproduction of Vertebrates. Vol 2: Amphibians. Neuroendocrine control of reproduction in amphibians. Academic Press, London. 2011.
    32. Tsai PS, Brooks LR, Rochester JR, Kavanaugh SI, Chung WC. Fibroblast growth factor signaling in the developing neuroendocrine hypothalamus. Front Neuroendocrinol. 2011 Jan; 32(1):95-107. PMID: 21129392.
      View in: PubMed
    33. Brooks LR, Chung WC, Tsai PS. Abnormal hypothalamic oxytocin system in fibroblast growth factor 8-deficient mice. Endocrine. 2010 Oct; 38(2):174-80. PMID: 21046478.
      View in: PubMed
    34. Chung WC, Matthews TA, Tata BK, Tsai PS. Compound deficiencies in multiple fibroblast growth factor signalling components differentially impact the murine gonadotrophin-releasing hormone system. J Neuroendocrinol. 2010 Aug; 22(8):944-50. PMID: 20553372.
      View in: PubMed
    35. Mott NN, Chung WC, Tsai PS, Pak TR. Differential fibroblast growth factor 8 (FGF8)-mediated autoregulation of its cognate receptors, Fgfr1 and Fgfr3, in neuronal cell lines. PLoS One. 2010 Apr 12; 5(4):e10143. PMID: 20405041.
      View in: PubMed
    36. Tsai PS, Sun B, Rochester JR, Wayne NL. Gonadotropin-releasing hormone-like molecule is not an acute reproductive activator in the gastropod, Aplysia californica. Gen Comp Endocrinol. 2010 Apr 01; 166(2):280-8. PMID: 19800884.
      View in: PubMed
    37. Falardeau J, Chung WC, Beenken A, Raivio T, Plummer L, Sidis Y, Jacobson-Dickman EE, Eliseenkova AV, Ma J, Dwyer A, Quinton R, Na S, Hall JE, Huot C, Alois N, Pearce SH, Cole LW, Hughes V, Mohammadi M, Tsai P, Pitteloud N. Decreased FGF8 signaling causes deficiency of gonadotropin-releasing hormone in humans and mice. J Clin Invest. 2008 Aug; 118(8):2822-31. PMID: 18596921.
      View in: PubMed
    38. Tsai PS, Zhang L. The emergence and loss of gonadotropin-releasing hormone in protostomes: orthology, phylogeny, structure, and function. Biol Reprod. 2008 Nov; 79(5):798-805. PMID: 18614699.
      View in: PubMed
    39. Chung WC, Moyle SS, Tsai PS. Fibroblast growth factor 8 signaling through fibroblast growth factor receptor 1 is required for the emergence of gonadotropin-releasing hormone neurons. Endocrinology. 2008 Oct; 149(10):4997-5003. PMID: 18566132.
      View in: PubMed
    40. Zhang L, Tello JA, Zhang W, Tsai PS. Molecular cloning, expression pattern, and immunocytochemical localization of a gonadotropin-releasing hormone-like molecule in the gastropod mollusk, Aplysia californica. Gen Comp Endocrinol. 2008 Apr 01; 156(2):201-9. PMID: 18178211.
      View in: PubMed
    41. Zhang L, Kessler AE, Tsai PS. Characterization and steroidal regulation of gonadotropin beta subunits in the male leopard frog, Rana pipiens. Gen Comp Endocrinol. 2007 Jan 01; 150(1):66-74. PMID: 16920113.
      View in: PubMed
    42. Tsai PS, Gill JC. Mechanisms of disease: Insights into X-linked and autosomal-dominant Kallmann syndrome. Nat Clin Pract Endocrinol Metab. 2006 Mar; 2(3):160-71. PMID: 16932275.
      View in: PubMed
    43. Gill JC, Tsai PS. Expression of a dominant negative FGF receptor in developing GNRH1 neurons disrupts axon outgrowth and targeting to the median eminence. Biol Reprod. 2006 Mar; 74(3):463-72. PMID: 16280414.
      View in: PubMed
    44. Tsai PS. Gonadotropin-releasing hormone in invertebrates: structure, function, and evolution. Gen Comp Endocrinol. 2006 Aug; 148(1):48-53. PMID: 16256989.
      View in: PubMed
    45. Tsai PS, Jones JT. Steroid-induced changes in the morphology of GnRH neurons in the male leopard frog, Rana pipiens: correlation with plasma gonadotropin and gonadal size. Gen Comp Endocrinol. 2005 Apr; 141(2):152-60. PMID: 15748716.
      View in: PubMed
    46. Tsai PS, Kessler AE, Jones JT, Wahr KB. Alteration of the hypothalamic-pituitary-gonadal axis in estrogen- and androgen-treated adult male leopard frog, Rana pipiens. Reprod Biol Endocrinol. 2005 Jan 10; 3:2. PMID: 15642123.
      View in: PubMed
    47. Tsai PS, Moenter SM, Postigo HR, El Majdoubi M, Pak TR, Gill JC, Paruthiyil S, Werner S, Weiner RI. Targeted expression of a dominant-negative fibroblast growth factor (FGF) receptor in gonadotropin-releasing hormone (GnRH) neurons reduces FGF responsiveness and the size of GnRH neuronal population. Mol Endocrinol. 2005 Jan; 19(1):225-36. PMID: 15459253.
      View in: PubMed
    48. Gill JC, Moenter SM, Tsai PS. Developmental regulation of gonadotropin-releasing hormone neurons by fibroblast growth factor signaling. Endocrinology. 2004 Aug; 145(8):3830-9. PMID: 15117872.
      View in: PubMed
    49. Tsai PS, Lunden JB, Jones JT. Effects of steroid hormones on spermatogenesis and GnRH release in male Leopard frogs, Rana pipiens. Gen Comp Endocrinol. 2003 Dec; 134(3):330-8. PMID: 14636640.
      View in: PubMed
    50. Tsai PS, Moenter SM, Cavolina JM. Development of a novel enzyme immunoassay for the measurement of in vitro GnRH release from rat and bullfrog hypothalamic explants. Comp Biochem Physiol A Mol Integr Physiol. 2003 Nov; 136(3):693-700. PMID: 14613797.
      View in: PubMed
    51. Pak TR, Lynch GR, Tsai PS. Steroidal modulation of in vitro gonadotropin secretion in prepubertal and adult male Siberian hamsters. J Exp Zool A Comp Exp Biol. 2003 Jul 01; 298(1):53-9. PMID: 12840839.
      View in: PubMed
    52. Tsai PS, Maldonado TA, Lunden JB. Localization of gonadotropin-releasing hormone in the central nervous system and a peripheral chemosensory organ of Aplysia californica. Gen Comp Endocrinol. 2003 Jan; 130(1):20-8. PMID: 12535621.
      View in: PubMed
    53. Pak TR, Lynch GR, Tsai PS. Estrogen accelerates gonadal recrudescence in photo-regressed male siberian hamsters. Endocrinology. 2002 Oct; 143(10):4131-4. PMID: 12239125.
      View in: PubMed
    54. Pak TR, Lynch GR, Ziegler DM, Lunden JB, Tsai PS. Disruption of pubertal onset by exogenous testosterone and estrogen in two species of rodents. Am J Physiol Endocrinol Metab. 2003 Jan; 284(1):E206-12. PMID: 12388134.
      View in: PubMed
    55. Pak TR, Lynch GR, Tsai PS. Differential alteration of the reproductive axis by testosterone and estrogen in peripubertal and adult male Siberian hamsters (Phodopus sungorus). Biol Reprod. 2002 Sep; 67(3):706-11. PMID: 12193375.
      View in: PubMed
    56. Pak TR, Lynch GR, Tsai PS. Testosterone and estrogen act via different pathways to inhibit puberty in the male Siberian hamster (Phodopus sungorus). Endocrinology. 2001 Aug; 142(8):3309-16. PMID: 11459772.
      View in: PubMed
    57. Zhang L, Wayne NL, Sherwood NM, Postigo HR, Tsai PS. Biological and immunological characterization of multiple GnRH in an opisthobranch mollusk, Aplysia californica. Gen Comp Endocrinol. 2000 Apr; 118(1):77-89. PMID: 10753569.
      View in: PubMed
    58. Vitalis EA, Costantin JL, Tsai PS, Sakakibara H, Paruthiyil S, Iiri T, Martini JF, Taga M, Choi AL, Charles AC, Weiner RI. Role of the cAMP signaling pathway in the regulation of gonadotropin-releasing hormone secretion in GT1 cells. Proc Natl Acad Sci U S A. 2000 Feb 15; 97(4):1861-6. PMID: 10677547.
      View in: PubMed
    59. Licht P, Hayes T, Tsai P, Cunha G, Kim H, Golbus M, Hayward S, Martin MC, Jaffe RB, Glickman SE. Androgens and masculinization of genitalia in the spotted hyaena (Crocuta crocuta). 1. Urogenital morphology and placental androgen production during fetal life. J Reprod Fertil. 1998 May; 113(1):105-16. PMID: 9713383.
      View in: PubMed
    60. Tsai PS, Weiner, RI. GnRH Neurons: Gene to Behavior. Cell Biology of GT1 GnRH neurons. Brain Schuppan Publishers, Tokyo. 1997.
    61. Tsai PS, Weiner RI. Regulation of gonadotropin-releasing hormone neurons by basic fibroblast growth factor. Trends Endocrinol Metab. 1996 Mar; 7(2):65-8. PMID: 18406728.
      View in: PubMed
    62. Tsai PS, Werner S, Weiner RI. Basic fibroblast growth factor is a neurotropic factor in GT1 gonadotropin-releasing hormone neuronal cell lines. Endocrinology. 1995 Sep; 136(9):3831-8. PMID: 7649090.
      View in: PubMed
    63. Licht P, Tsai PS, Sotowska-Brochocka J. The nature and distribution of gonadotropin-releasing hormones in brains and plasma of ranid frogs. Gen Comp Endocrinol. 1994 May; 94(2):186-98. PMID: 7926629.
      View in: PubMed
    64. Tsai PS, Hayes TB, Licht P. Role of aromatization in testosterone-induced inhibition of luteinizing hormone secretion in female turtles, Trachemys scripta. Biol Reprod. 1994 Jan; 50(1):144-51. PMID: 8312438.
      View in: PubMed
    65. Iguchi T, Edery M, Tasi PS, Ozawa S, Sato T, Bern HA. Epidermal growth factor receptor levels in reproductive organs of female mice exposed neonatally to diethylstilbestrol. . 1993 Oct; 204(1):110-6. PMID: 8372093.
      View in: PubMed
    66. Tsai PS, Licht P. In vivo GnRH responsiveness of LH secretion in the female turtle, Trachemys scripta, in relation to the reproductive stage. Gen Comp Endocrinol. 1993 Jun; 90(3):328-37. PMID: 8224759.
      View in: PubMed
    67. Tsai PS, Licht P. Differential distribution of chicken-I and chicken-II GnRH in the turtle brain. Peptides. 1993 Mar-Apr; 14(2):221-6. PMID: 8483800.
      View in: PubMed
    68. Tsai PS, Licht P. GnRH-induced desensitization of in vitro luteinizing hormone secretion in the turtle, Trachemys scripta. Gen Comp Endocrinol. 1993 Feb; 89(2):238-47. PMID: 8454169.
      View in: PubMed
    69. Tsai PS, Bern HA. Estrogen-independent growth of mouse vaginal epithelium in organ culture. J Exp Zool. 1991 Aug; 259(2):238-45. PMID: 1783893.
      View in: PubMed
    70. Tsai PS, Uchima FD, Hamamoto ST, Bern HA. Proliferation and differentiation of prepubertal mouse vaginal epithelial cells in vitro and the specificity of estrogen-induced growth retardation. In Vitro Cell Dev Biol. 1991 Jun; 27A(6):461-8. PMID: 1869487.
      View in: PubMed
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