Colorado PROFILES, The Colorado Clinical and Translational Sciences Institute (CCTSI)
Keywords
Last Name
Institution

Kristine A Kuhn

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-8258
    Other Positions
    TitleDivision Head
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOM-MED
    DivisionRHEUM GENRL OPERATIONS


    Collapse Research 
    Collapse research activities and funding
    U13AR079881     (KUHN, KRISTINE A.)Aug 10, 2021 - Jul 31, 2022
    NIH
    ACR Basic and Clinical Research Conference: Rheumatologic Complications of Emerging Viral Infections / SARS-CoV-2
    Role: Principal Investigator
    R01AR075033     (KUHN, KRISTINE A.)Apr 10, 2019 - Jul 31, 2029
    NIH
    Influence of bacterial tryptophan metabolism on inflammatory arthritis
    Role: Principal Investigator
    K08DK107905     (KUHN, KRISTINE A.)Apr 1, 2016 - Mar 31, 2021
    NIH
    Development of colonic intraepithelial lymphocytes and their role in epithelial and immune function
    Role: Principal Investigator
    T32AR007534     (KUHN, KRISTINE A.)Aug 1, 1986 - Aug 31, 2027
    NIH
    Research Training in Rheumatology
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Danielson SM, Kuhn KA. IL-10mpting TH17 cell fate in the gut. Sci Immunol. 2024 Jan 05; 9(91):eadn7536. PMID: 38181092.
      View in: PubMed
    2. Seymour BJ, Trent B, Allen BE, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production stimulates the development of collagen-induced arthritis in mice. J Clin Invest. 2023 Dec 19; 134(4). PMID: 38113112.
      View in: PubMed
    3. Loh L, Orlicky D, Spengler A, Levens C, Celli S, Domenico J, Klarquist J, Onyiah J, Matsuda J, Kuhn K, Gapin L. MAIT cells drive chronic inflammation in a genetically diverse murine model of spontaneous colitis. bioRxiv. 2023 Dec 01. PMID: 38076996.
      View in: PubMed
    4. Conran C, Kolfenbach J, Kuhn K, Striebich C, Moreland L. A Review of Difficult-to-Treat Rheumatoid Arthritis: Definition, Clinical Presentation, and Management. Curr Rheumatol Rep. 2023 12; 25(12):285-294. PMID: 37776482.
      View in: PubMed
    5. Alula KM, Dowdell AS, LeBere B, Lee JS, Levens CL, Kuhn KA, Kaipparettu BA, Thompson WE, Blumberg RS, Colgan SP, Theiss AL. Interplay of gut microbiota and host epithelial mitochondrial dysfunction is necessary for the development of spontaneous intestinal inflammation in mice. Microbiome. 2023 11 17; 11(1):256. PMID: 37978573.
      View in: PubMed
    6. Seymour BJ, Trent B, Allen B, Berlinberg AJ, Tangchittsumran J, Jubair WK, Chriswell ME, Liu S, Ornelas A, Stahly A, Alexeev EE, Dowdell AS, Sneed SL, Fechtner S, Kofonow JM, Robertson CE, Dillon SM, Wilson CC, Anthony RM, Frank DN, Colgan SP, Kuhn KA. Microbiota-dependent indole production is required for the development of collagen-induced arthritis. bioRxiv. 2023 Oct 13. PMID: 37873395.
      View in: PubMed
    7. Fechtner S, Allen BE, Chriswell ME, Jubair WK, Robertson CE, Kofonow JN, Frank DN, Holers VM, Kuhn KA. 3,3-dimethyl-1-butanol and its metabolite 3,3-dimethylbutyrate ameliorate collagen-induced arthritis independent of choline trimethylamine lyase activity. Res Sq. 2023 Sep 05. PMID: 37720032.
      View in: PubMed
    8. Kuhn KA, Stahly A, Konig MF, Carandang K, Herndon C, Backman C, Callahan LF, Schulert G, Fraenkel L, Ogdie A. Impact of the COVID-19 Pandemic on Early Career Investigators in Rheumatology: Recommendations to Address Challenges to Early Research Careers. Arthritis Care Res (Hoboken). 2023 05; 75(5):947-955. PMID: 36342380.
      View in: PubMed
    9. Chriswell ME, Lefferts AR, Clay MR, Hsu AR, Seifert J, Feser ML, Rims C, Bloom MS, Bemis EA, Liu S, Maerz MD, Frank DN, Demoruelle MK, Deane KD, James EA, Buckner JH, Robinson WH, Holers VM, Kuhn KA. Clonal IgA and IgG autoantibodies from individuals at risk for rheumatoid arthritis identify an arthritogenic strain of Subdoligranulum. Sci Transl Med. 2022 10 26; 14(668):eabn5166. PMID: 36288282.
      View in: PubMed
    10. Lefferts AR, Norman E, Claypool DJ, Kantheti U, Kuhn KA. Cytokine competent gut-joint migratory T Cells contribute to inflammation in the joint. Front Immunol. 2022; 13:932393. PMID: 36159826.
      View in: PubMed
    11. Kumar R, Maurya AK, Parker KD, Kant R, Ibrahim H, Kabir MI, Kumar D, Weber AM, Agarwal R, Kuhn KA, Ryan EP, Raina K. Gender-based effect of absence of gut microbiota on the protective efficacy of Bifidobacterium longum-fermented rice bran diet against inflammation-associated colon tumorigenesis. Mol Carcinog. 2022 10; 61(10):941-957. PMID: 35856887.
      View in: PubMed
    12. Nielsen SH, Stahly A, Regner EH, Bay-Jensen AC, Karsdal MA, Kuhn KA. Novel Biomarker of Collagen Degradation Can Identify Patients Affected With Both Axial Spondyloarthritis and Crohn Disease. J Rheumatol. 2022 12; 49(12):1335-1340. PMID: 35705233.
      View in: PubMed
    13. Holers VM, Kuhn KA, Demoruelle MK, Norris JM, Firestein GS, James EA, Robinson WH, Buckner JH, Deane KD. Mechanism-driven strategies for prevention of rheumatoid arthritis. Rheumatol Autoimmun. 2022 Sep; 2(3):109-119. PMID: 36312783.
      View in: PubMed
    14. Berlinberg AJ, Brar A, Stahly A, Gerich ME, Fennimore BP, Scott FI, Kuhn KA. A Novel Approach toward Less Invasive Multiomics Gut Analyses: a Pilot Study. Microbiol Spectr. 2022 04 27; 10(2):e0244621. PMID: 35343759.
      View in: PubMed
    15. Falloon K, Cohen B, Ananthakrishnan AN, Barnes EL, Bhattacharya A, Colombel JF, Cross RK, Driscoll MS, Fernandez AP, Ha C, Herfarth H, Horst S, Hou J, Husni ME, Kroshinsky D, Kuhn KA, Lowder CY, Martin G, Parikh D, Sayed CJ, Schocket L, Siaton BC, Vedak P, Weisman MH, Rieder F. A United States expert consensus to standardise definitions, follow-up, and treatment targets for extra-intestinal manifestations in inflammatory bowel disease. Aliment Pharmacol Ther. 2022 05; 55(9):1179-1191. PMID: 35277863.
      View in: PubMed
    16. Frank DN, Qiu Y, Cao Y, Zhang S, Lu L, Kofonow JM, Robertson CE, Liu Y, Wang H, Levens CL, Kuhn KA, Song J, Ramakrishnan VR, Lu SL. A dysbiotic microbiome promotes head and neck squamous cell carcinoma. Oncogene. 2022 Feb; 41(9):1269-1280. PMID: 35087236.
      View in: PubMed
    17. Schwartzman M, Ermann J, Kuhn KA, Schwartzman S, Weisman MH. Spondyloarthritis in inflammatory bowel disease cohorts: systematic literature review and critical appraisal of study designs. RMD Open. 2022 01; 8(1). PMID: 35046098.
      View in: PubMed
    18. Lapane KL, Dub? C, Ferrucci K, Khan S, Kuhn KA, Yi E, Kay J, Liu SH. Patient perspectives on health care provider practices leading to an axial spondyloarthritis diagnosis: an exploratory qualitative research study. BMC Fam Pract. 2021 12 20; 22(1):251. PMID: 34930136.
      View in: PubMed
    19. Dube CE, Lapane KL, Ferrucci KA, Beccia AL, Khan SK, Yi E, Kay J, Kuhn KA, Ogdie A, Liu SH. Personal Experiences with Diagnostic Delay Among Axial Spondyloarthritis Patients: A Qualitative Study. Rheumatol Ther. 2021 Jun; 8(2):1015-1030. PMID: 34059989.
      View in: PubMed
    20. Lefferts AR, Regner EH, Stahly A, O'Rourke B, Gerich ME, Fennimore BP, Scott FI, Freeman AE, Jones K, Kuhn KA. Circulating mature granzyme B+ T cells distinguish Crohn's disease-associated axial spondyloarthritis from axial spondyloarthritis and Crohn's disease. Arthritis Res Ther. 2021 05 22; 23(1):147. PMID: 34022940.
      View in: PubMed
    21. Mangalea MR, Paez-Espino D, Kieft K, Chatterjee A, Chriswell ME, Seifert JA, Feser ML, Demoruelle MK, Sakatos A, Anantharaman K, Deane KD, Kuhn KA, Holers VM, Duerkop BA. Individuals at risk for rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential. Cell Host Microbe. 2021 05 12; 29(5):726-739.e5. PMID: 33957082.
      View in: PubMed
    22. Ashrafi M, Kuhn KA, Weisman MH. The arthritis connection to inflammatory bowel disease (IBD): why has it taken so long to understand it? RMD Open. 2021 04; 7(1). PMID: 33863841.
      View in: PubMed
    23. Berlinberg AJ, Regner EH, Stahly A, Brar A, Reisz JA, Gerich ME, Fennimore BP, Scott FI, Freeman AE, Kuhn KA. Multi 'Omics Analysis of Intestinal Tissue in Ankylosing Spondylitis Identifies Alterations in the Tryptophan Metabolism Pathway. Front Immunol. 2021; 12:587119. PMID: 33746944.
      View in: PubMed
    24. Parker KD, Maurya AK, Ibrahim H, Rao S, Hove PR, Kumar D, Kant R, Raina B, Agarwal R, Kuhn KA, Raina K, Ryan EP. Dietary Rice Bran-Modified Human Gut Microbial Consortia Confers Protection against Colon Carcinogenesis Following Fecal Transfaunation. Biomedicines. 2021 Feb 03; 9(2). PMID: 33546192.
      View in: PubMed
    25. Trikha SRJ, Lee DM, Ecton KE, Wrigley SD, Vazquez AR, Litwin NS, Thomas KN, Wei Y, Battson ML, Johnson SA, Kuhn KA, Colgan SP, Gentile CL, Weir TL. Transplantation of an obesity-associated human gut microbiota to mice induces vascular dysfunction and glucose intolerance. Gut Microbes. 2021 Jan-Dec; 13(1):1940791. PMID: 34313540.
      View in: PubMed
    26. Okamato Y, Ghosh T, Okamoto T, Schuyler RP, Seifert J, Charry LL, Visser A, Feser M, Fleischer C, Pedrick C, August J, Moss L, Bemis EA, Norris JM, Kuhn KA, Demoruelle MK, Deane KD, Ghosh D, Holers VM, Hsieh EWY. Subjects at-risk for future development of rheumatoid arthritis demonstrate a PAD4-and TLR-dependent enhanced histone H3 citrullination and proinflammatory cytokine production in CD14hi monocytes. J Autoimmun. 2021 02; 117:102581. PMID: 33310262.
      View in: PubMed
    27. Wilson TM, Trent B, Kuhn KA, Demoruelle MK. Microbial Influences of Mucosal Immunity in Rheumatoid Arthritis. Curr Rheumatol Rep. 2020 10 06; 22(11):83. PMID: 33025188.
      View in: PubMed
    28. Berlinberg A, Kuhn KA. Barrier lymphocytes in spondyloarthritis. Curr Opin Rheumatol. 2020 07; 32(4):343-348. PMID: 32412993.
      View in: PubMed
    29. Berlinberg A, Kuhn KA. Molecular Biology Approaches to Understanding Spondyloarthritis. Rheum Dis Clin North Am. 2020 05; 46(2):203-211. PMID: 32340696.
      View in: PubMed
    30. Chriswell ME, Kuhn KA. Microbiota-mediated mucosal inflammation in arthritis. Best Pract Res Clin Rheumatol. 2019 12; 33(6):101492. PMID: 32151461.
      View in: PubMed
    31. Kuhn KA, Morrison TE. Introduction: Evolution of inflammatory arthritis from innate to adaptive immune mechanisms. Immunol Rev. 2020 03; 294(1):5-8. PMID: 32103544.
      View in: PubMed
    32. Siebert JC, Neff CP, Schneider JM, Regner EH, Ohri N, Kuhn KA, Palmer BE, Lozupone CA, G?rg C. VOLARE: visual analysis of disease-associated microbiome-immune system interplay. BMC Bioinformatics. 2019 Aug 20; 20(1):432. PMID: 31429723.
      View in: PubMed
    33. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs NF, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. Author Correction: The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2019 Jul 01; 10(1):2965. PMID: 31263097.
      View in: PubMed
    34. Hernandez G, Mills TS, Rabe JL, Chavez JS, Kuldanek S, Kirkpatrick G, Noetzli L, Jubair WK, Zanche M, Myers JR, Stevens BM, Fleenor CJ, Adane B, Dinarello CA, Ashton J, Jordan CT, Di Paola J, Hagman JR, Holers VM, Kuhn KA, Pietras EM. Pro-inflammatory cytokine blockade attenuates myeloid expansion in a murine model of rheumatoid arthritis. Haematologica. 2020 03; 105(3):585-597. PMID: 31101752.
      View in: PubMed
    35. Li SX, Sen S, Schneider JM, Xiong KN, Nusbacher NM, Moreno-Huizar N, Shaffer M, Armstrong AJS, Severs E, Kuhn K, Neff CP, McCarter M, Campbell T, Lozupone CA, Palmer BE. Gut microbiota from high-risk men who have sex with men drive immune activation in gnotobiotic mice and in vitro HIV infection. PLoS Pathog. 2019 04; 15(4):e1007611. PMID: 30947289.
      View in: PubMed
    36. Soderborg TK, Clark SE, Mulligan CE, Janssen RC, Babcock L, Ir D, Young B, Krebs N, Lemas DJ, Johnson LK, Weir T, Lenz LL, Frank DN, Hernandez TL, Kuhn KA, D'Alessandro A, Barbour LA, El Kasmi KC, Friedman JE. The gut microbiota in infants of obese mothers increases inflammation and susceptibility to NAFLD. Nat Commun. 2018 10 26; 9(1):4462. PMID: 30367045.
      View in: PubMed
    37. Holers VM, Demoruelle MK, Kuhn KA, Buckner JH, Robinson WH, Okamoto Y, Norris JM, Deane KD. Rheumatoid arthritis and the mucosal origins hypothesis: protection turns to?destruction. Nat Rev Rheumatol. 2018 09; 14(9):542-557. PMID: 30111803.
      View in: PubMed
    38. Regner EH, Ohri N, Stahly A, Gerich ME, Fennimore BP, Ir D, Jubair WK, G?rg C, Siebert J, Robertson CE, Caplan L, Frank DN, Kuhn KA. Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota. Arthritis Res Ther. 2018 07 20; 20(1):149. PMID: 30029674.
      View in: PubMed
    39. Jubair WK, Hendrickson JD, Severs EL, Schulz HM, Adhikari S, Ir D, Pagan JD, Anthony RM, Robertson CE, Frank DN, Banda NK, Kuhn KA. Modulation of Inflammatory Arthritis in Mice by Gut Microbiota Through Mucosal Inflammation and Autoantibody Generation. Arthritis Rheumatol. 2018 08; 70(8):1220-1233. PMID: 29534332.
      View in: PubMed
    40. Caplan L, Kuhn KA. Gastrointestinal and Hepatic Disease in Spondyloarthritis. Rheum Dis Clin North Am. 2018 02; 44(1):153-164. PMID: 29149924.
      View in: PubMed
    41. Deane KD, Demoruelle MK, Kelmenson LB, Kuhn KA, Norris JM, Holers VM. Genetic and environmental risk factors for rheumatoid arthritis. Best Pract Res Clin Rheumatol. 2017 02; 31(1):3-18. PMID: 29221595.
      View in: PubMed
    42. Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2018 03; 11(2):357-368. PMID: 28812548.
      View in: PubMed
    43. Hickey CA, Kuhn KA, Donermeyer DL, Porter NT, Jin C, Cameron EA, Jung H, Kaiko GE, Wegorzewska M, Malvin NP, Glowacki RW, Hansson GC, Allen PM, Martens EC, Stappenbeck TS. Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. Cell Host Microbe. 2015 May 13; 17(5):672-80. PMID: 25974305.
      View in: PubMed
    44. Saeedi BJ, Kao DJ, Kitzenberg DA, Dobrinskikh E, Schwisow KD, Masterson JC, Kendrick AA, Kelly CJ, Bayless AJ, Kominsky DJ, Campbell EL, Kuhn KA, Furuta GT, Colgan SP, Glover LE. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell. 2015 Jun 15; 26(12):2252-62. PMID: 25904334.
      View in: PubMed
    45. Kelly CJ, Zheng L, Campbell EL, Saeedi B, Scholz CC, Bayless AJ, Wilson KE, Glover LE, Kominsky DJ, Magnuson A, Weir TL, Ehrentraut SF, Pickel C, Kuhn KA, Lanis JM, Nguyen V, Taylor CT, Colgan SP. Crosstalk between Microbiota-Derived Short-Chain Fatty Acids and Intestinal Epithelial HIF Augments Tissue Barrier Function. Cell Host Microbe. 2015 May 13; 17(5):662-71. PMID: 25865369.
      View in: PubMed
    46. Kuhn KA, Manieri NA, Liu TC, Stappenbeck TS. IL-6 stimulates intestinal epithelial proliferation and repair after injury. PLoS One. 2014; 9(12):e114195. PMID: 25478789.
      View in: PubMed
    47. Kuhn KA, Pedraza I, Demoruelle MK. Mucosal immune responses to microbiota in the development of autoimmune disease. Rheum Dis Clin North Am. 2014 Nov; 40(4):711-25. PMID: 25437287.
      View in: PubMed
    48. Kuhn KA, Stappenbeck TS. Peripheral education of the immune system by the colonic microbiota. Semin Immunol. 2013 Nov 30; 25(5):364-9. PMID: 24169518.
      View in: PubMed
    49. Mikuls TR, Payne JB, Reinhardt RA, Thiele GM, Maziarz E, Cannella AC, Holers VM, Kuhn KA, O'Dell JR. Antibody responses to Porphyromonas gingivalis (P. gingivalis) in subjects with rheumatoid arthritis and periodontitis. Int Immunopharmacol. 2009 Jan; 9(1):38-42. PMID: 18848647.
      View in: PubMed
    50. Kuhn KA, Cozine CL, Tomooka B, Robinson WH, Holers VM. Complement receptor CR2/CR1 deficiency protects mice from collagen-induced arthritis and associates with reduced autoantibodies to type II collagen and citrullinated antigens. Mol Immunol. 2008 May; 45(10):2808-19. PMID: 18374982.
      View in: PubMed
    51. Kulik L, Marchbank KJ, Lyubchenko T, Kuhn KA, Liubchenko GA, Haluszczak C, Gipson MG, Gibson MG, Boackle SA, Holers VM. Intrinsic B cell hypo-responsiveness in mice prematurely expressing human CR2/CD21 during B cell development. Eur J Immunol. 2007 Mar; 37(3):623-33. PMID: 17301948.
      View in: PubMed
    52. Mikuls TR, Holers VM, Parrish L, Kuhn KA, Conn DL, Gilkeson G, Smith EA, Kamen DL, Jonas BL, Callahan LF, Alarc?n GS, Howard G, Moreland LW, Bridges SL. Anti-cyclic citrullinated peptide antibody and rheumatoid factor isotypes in African Americans with early rheumatoid arthritis. Arthritis Rheum. 2006 Sep; 54(9):3057-9. PMID: 16948136.
      View in: PubMed
    53. Kuhn KA, Kulik L, Tomooka B, Braschler KJ, Arend WP, Robinson WH, Holers VM. Antibodies against citrullinated proteins enhance tissue injury in experimental autoimmune arthritis. J Clin Invest. 2006 Apr; 116(4):961-73. PMID: 16585962.
      View in: PubMed
    54. Thornton S, Kuhn KA, Finkelman FD, Hirsch R. NK cells secrete high levels of IFN-gamma in response to in vivo administration of IL-2. Eur J Immunol. 2001 Nov; 31(11):3355-60. PMID: 11745353.
      View in: PubMed
    55. Laakmann G, Sch?le C, Lorkowski G, Baghai T, Kuhn K, Ehrentraut S. Buspirone and lorazepam in the treatment of generalized anxiety disorder in outpatients. Psychopharmacology (Berl). 1998 Apr; 136(4):357-66. PMID: 9600581.
      View in: PubMed
    56. Gay S, Martin GR, Muller PK, Timpl R, Kuhn K. Simultaneous synthesis of types I and III collagen by fibroblasts in culture. Proc Natl Acad Sci U S A. 1976 Nov; 73(11):4037-40. PMID: 1069290.
      View in: PubMed
    Kuhn's Networks
    Click the "See All" links for more information and interactive visualizations!
    Concepts Expand Description
    See all (225) concept(s)
    _
    Co-Authors Expand Description
    See all (52) people
    _
    Similar People Expand Description
    See all (60) people
    _
    Same Department Expand Description
    Search Department

    Copyright © 2024 The Regents of the University of Colorado, a body corporate. All rights reserved. (Harvard PROFILES RNS software version: 2.11.1)