 Amy Celeste Keller
| Title | Asst Professor |
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| Institution | University of Colorado Denver - Anschutz Medical Campus |
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| Department | SOM-MED |
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| Phone | 303/724-3976 |
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 Overview Dr. Amy Keller is a Research Scientist at the Rocky Mountain Regional VA Medical Center as well as an Assistant Professor in the Division of Endocrinology, Metabolism and Diabetes at the University of Colorado Denver’s School of Medicine. Dr. Keller obtained her PhD in Plant Sciences, with an emphasis on medicinal plants used for diabetes, at the City University of New York, in New York City, New York. Dr. Keller’s overall science focus is on botanical therapies for the treatment of cardiovascular disease (CVD) in diabetes. Within this research, she also investigates the role of sex differences in CVD pathology and its therapies and is especially interested in the regulation of vascular function by localized adipose tissue.
Research I01BX005840 (KELLER, AMY CELESTE)Jul 1, 2023 - Jun 30, 2027 NIH
Delineating Mechanisms of Impaired Vasoreactivity in Thermoneutrality
Role: Principal Investigator |
| IK2BX003185 (KELLER, AMY CELESTE)Jul 1, 2017 - Jun 30, 2023 NIH
Repair of Vascular Contractility and Mitochondrial Function by NOS Recoupling
Role: Principal Investigator |
| F31AT004548 (KELLER, AMY CELESTE)Mar 1, 2008 - Feb 28, 2011 NIH
Antidiabetic Constituents from the Dominican Medicinal Plant Momordica charantia
Role: Principal Investigator |
Bibliographic
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Keller AC, Chun JH, Knaub LA, Henckel MM, Hull SE, Scalzo RL, Pott GB, Walker LA, Reusch JEB. Thermoneutrality induces vascular dysfunction and impaired metabolic function in male Wistar rats: a new model of vascular disease. J Hypertens. 2022 11 01; 40(11):2133-2146. PMID: 35881464.
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Chun JH, Henckel MM, Knaub LA, Hull SE, Pott GB, Ramirez DG, Reusch JE, Keller AC. (-)-Epicatechin Reverses Glucose Intolerance in Rats Housed at Thermoneutrality. Planta Med. 2022 Aug; 88(9-10):735-744. PMID: 35777366.
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Vaughan OR, Rosario FJ, Chan J, Cox LA, Ferchaud-Roucher V, Zemski-Berry KA, Reusch JEB, Keller AC, Powell TL, Jansson T. Maternal obesity causes fetal cardiac hypertrophy and alters adult offspring myocardial metabolism in mice. J Physiol. 2022 07; 600(13):3169-3191. PMID: 35545608.
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Chun JH, Henckel MM, Knaub LA, Hull SE, Pott GB, Walker LA, Reusch JE, Keller AC. (-)-Epicatechin Improves Vasoreactivity and Mitochondrial Respiration in Thermoneutral-Housed Wistar Rat Vasculature. Nutrients. 2022 Mar 05; 14(5). PMID: 35268072.
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Keller A, Hull SE, Elajaili H, Johnston A, Knaub LA, Chun JH, Walker L, Nozik-Grayck E, Reusch JEB. (-)-Epicatechin Modulates Mitochondrial Redox in Vascular Cell Models of Oxidative Stress. Oxid Med Cell Longev. 2020; 2020:6392629. PMID: 32587663.
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Park YM, Keller AC, Runchey SS, Miller BF, Kohrt WM, Van Pelt RE, Kang C, Jankowski CM, Moreau KL. Acute estradiol treatment reduces skeletal muscle protein breakdown markers in early- but not late-postmenopausal women. Steroids. 2019 06; 146:43-49. PMID: 30928279.
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Keller AC, Klawitter J, Hildreth KL, Christians U, Putnam K, Kohrt WM, Reusch JEB, Moreau KL. Elevated plasma homocysteine and cysteine are associated with endothelial dysfunction across menopausal stages in healthy women. J Appl Physiol (1985). 2019 06 01; 126(6):1533-1540. PMID: 30896357.
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Keller AC, Knaub LA, Scalzo RL, Hull SE, Johnston AE, Walker LA, Reusch JEB. Sepiapterin Improves Vascular Reactivity and Insulin-Stimulated Glucose in Wistar Rats. Oxid Med Cell Longev. 2018; 2018:7363485. PMID: 30344886.
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Scalzo RL, Knaub LA, Hull SE, Keller AC, Hunter K, Walker LA, Reusch JEB. Glucagon-like peptide-1 receptor antagonism impairs basal exercise capacity and vascular adaptation to aerobic exercise training in rats. Physiol Rep. 2018 07; 6(13):e13754. PMID: 29984491.
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Keller AC, Badani H, McClatchey PM, Baird NL, Bowlin JL, Bouchard R, Perng GC, Reusch JE, Kaufer BB, Gilden D, Shahzad A, Kennedy PG, Cohrs RJ. Varicella zoster virus infection of human fetal lung cells alters mitochondrial morphology. J Neurovirol. 2016 10; 22(5):674-682. PMID: 27245593.
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McClatchey PM, Keller AC, Bouchard R, Knaub LA, Reusch JE. Raw and processed microscope images of fixed cells at baseline and following various experimental perturbations. Data Brief. 2016 Mar; 6:998-1006. PMID: 26949731.
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Keller AC, Knaub LA, McClatchey PM, Connon CA, Bouchard R, Miller MW, Geary KE, Walker LA, Klemm DJ, Reusch JE. Differential Mitochondrial Adaptation in Primary Vascular Smooth Muscle Cells from a Diabetic Rat Model. Oxid Med Cell Longev. 2016; 2016:8524267. PMID: 27034743.
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McClatchey PM, Keller AC, Bouchard R, Knaub LA, Reusch JE. Fully automated software for quantitative measurements of mitochondrial morphology. Mitochondrion. 2016 Jan; 26:58-71. PMID: 26688338.
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Keller AC, Knaub LA, Miller MW, Birdsey N, Klemm DJ, Reusch JE. Saxagliptin restores vascular mitochondrial exercise response in the Goto-Kakizaki rat. J Cardiovasc Pharmacol. 2015 Feb; 65(2):137-47. PMID: 25264749.
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Wu SB, Yue GG, To MH, Keller AC, Lau CB, Kennelly EJ. Transport in Caco-2 cell monolayers of antidiabetic cucurbitane triterpenoids from Momordica charantia fruits. Planta Med. 2014 Jul; 80(11):907-11. PMID: 25116119.
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Geary K, Knaub LA, Schauer IE, Keller AC, Watson PA, Miller MW, Garat CV, Nadeau KJ, Cree-Green M, Pugazhenthi S, Regensteiner JG, Klemm DJ, Reusch JE. Targeting mitochondria to restore failed adaptation to exercise in diabetes. Biochem Soc Trans. 2014 Apr; 42(2):231-8. PMID: 24646223.
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Miller MW, Knaub LA, Olivera-Fragoso LF, Keller AC, Balasubramaniam V, Watson PA, Reusch JE. Nitric oxide regulates vascular adaptive mitochondrial dynamics. Am J Physiol Heart Circ Physiol. 2013 Jun 15; 304(12):H1624-33. PMID: 23585138.
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Knaub LA, McCune S, Chicco AJ, Miller M, Moore RL, Birdsey N, Lloyd MI, Villarreal J, Keller AC, Watson PA, Reusch JE. Impaired response to exercise intervention in the vasculature in metabolic syndrome. Diab Vasc Dis Res. 2013 May; 10(3):222-38. PMID: 23162060.
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Keller AC, Ma J, Kavalier A, He K, Brillantes AM, Kennelly EJ. Saponins from the traditional medicinal plant Momordica charantia stimulate insulin secretion in vitro. Phytomedicine. 2011 Dec 15; 19(1):32-7. PMID: 22133295.
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Ma J, Whittaker P, Keller AC, Mazzola EP, Pawar RS, White KD, Callahan JH, Kennelly EJ, Krynitsky AJ, Rader JI. Cucurbitane-type triterpenoids from Momordica charantia. Planta Med. 2010 Oct; 76(15):1758-61. PMID: 20379957.
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Keller AC, Vandebroek I, Liu Y, Balick MJ, Kronenberg F, Kennelly EJ, Brillantes AM. Costus spicatus tea failed to improve diabetic progression in C57BLKS/J db/db mice, a model of type 2 diabetes mellitus. J Ethnopharmacol. 2009 Jan 21; 121(2):248-54. PMID: 19027842.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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| Year | Publications |
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| 2008 | 1 | | 2010 | 1 | | 2011 | 1 | | 2012 | 1 | | 2013 | 1 | | 2014 | 2 | | 2015 | 2 | | 2016 | 3 | | 2018 | 2 | | 2019 | 2 | | 2020 | 1 | | 2022 | 4 |
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