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Tin Tin Su

TitleProfessor
InstitutionUniversity of Colorado Boulder
DepartmentBiology-MCD Instruction
Phone303/735-3245
    Other Positions
    TitleFaculty Fellow
    InstitutionUniversity of Colorado Boulder
    DepartmentBiology-MCD Instruction


    Collapse Research 
    Collapse research activities and funding
    R35GM130374     (SU, TIN TIN)Jan 1, 2019 - Dec 31, 2023
    NIH
    Cellular Plasticity and Regeneration after Radiation Damage in Drosophila
    Role: Principal Investigator
    R01GM106317     (SU, TIN TIN)Aug 1, 2014 - Dec 31, 2018
    NIH
    Consequences of Cell Death in Drosophila
    Role: Principal Investigator
    R01GM087276     (SU, TIN TIN)Sep 30, 2009 - Aug 31, 2014
    NIH
    Regulation of Radiation Induced Cell Death in Drosophila
    Role: Principal Investigator
    R21DE017494     (SU, TIN TIN)May 1, 2007 - Apr 30, 2010
    NIH
    An in vivo Screen for Radiation Sensitizers
    Role: Principal Investigator
    R21GM073973     (SU, TIN TIN)Feb 1, 2006 - Jan 31, 2008
    NIH
    Cell Growth and Radiation Survival in Drosophila
    Role: Principal Investigator
    R01GM066441     (SU, TIN TIN)May 1, 2002 - Apr 30, 2008
    NIH
    Cell Cycle Regulation by Checkpoints in Drosophila
    Role: Principal Investigator
    F32GM015032     (SU, TIN TIN)Jan 31, 1993
    NIH
    TRANSCRIPTIONAL REGULATION OF STRING EXPRESSION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Colon Plaza S, Su TT. Ionizing radiation induces cells with past caspase activity that contribute to the adult organ in Drosophila and show reduced Loss of Heterozygosity. Cell Death Discov. 2024 Jan 05; 10(1):6. PMID: 38182576.
      View in: PubMed
    2. Brown J, Su TT. E2F1, DIAP1, and the presence of a homologous chromosome promote while JNK inhibits radiation-induced loss of heterozygosity in Drosophila melanogaster. Genetics. 2024 Jan 03; 226(1). PMID: 37874851.
      View in: PubMed
    3. Su TT. How to initiate tissue regeneration by generating mutually exclusive cell states. PLoS Biol. 2023 06; 21(6):e3002155. PMID: 37279465.
      View in: PubMed
    4. Brown J, Su TT. E2F1 promotes, JNK and DIAP1 inhibit, and chromosomal position has little effect on radiation-induced Loss of Heterozygosity in Drosophila. bioRxiv. 2023 May 18. PMID: 37214983.
      View in: PubMed
    5. Gomes NP, Frederick B, Jacobsen JR, Chapnick D, Su TT. A High Throughput Screen with a Clonogenic Endpoint to Identify Radiation Modulators of Cancer. Radiat Res. 2023 02 01; 199(2):132-147. PMID: 36583948.
      View in: PubMed
    6. Colon-Plaza S, Su TT. Non-Apoptotic Role of Apoptotic Caspases in the Drosophila Nervous System. Front Cell Dev Biol. 2022; 10:839358. PMID: 35223857.
      View in: PubMed
    7. Ledru M, Clark CA, Brown J, Verghese S, Ferrara S, Goodspeed A, Su TT. Differential gene expression analysis identified determinants of cell fate plasticity during radiation-induced regeneration in Drosophila. PLoS Genet. 2022 01; 18(1):e1009989. PMID: 34990447.
      View in: PubMed
    8. Tokamov SA, Su T, Ullyot A, Fehon RG. Negative feedback couples Hippo pathway activation with Kibra degradation independent of Yorkie-mediated transcription. Elife. 2021 02 08; 10. PMID: 33555257.
      View in: PubMed
    9. Frederick BA, Gupta R, Atilano-Roque A, Su TT, Raben D. Combined EGFR1 and PARP1 Inhibition Enhances the Effect of Radiation in Head and Neck Squamous Cell Carcinoma Models. Radiat Res. 2020 11 10; 194(5):519-531. PMID: 32936912.
      View in: PubMed
    10. Brown J, Bush I, Bozon J, Su TT. Cells with loss-of-heterozygosity after exposure to ionizing radiation in Drosophila are culled by p53-dependent and p53-independent mechanisms. PLoS Genet. 2020 10; 16(10):e1009056. PMID: 33075096.
      View in: PubMed
    11. Su TT. Non-apoptotic roles of apoptotic proteases: new tricks for an old dog. Open Biol. 2020 08; 10(8):200130. PMID: 32810419.
      View in: PubMed
    12. Ni Q, Zhang F, Liu Y, Wang Z, Yu G, Liang B, Niu G, Su T, Zhu G, Lu G, Zhang L, Chen X. A bi-adjuvant nanovaccine that potentiates immunogenicity of neoantigen for combination immunotherapy of colorectal cancer. Sci Adv. 2020 03; 6(12):eaaw6071. PMID: 32206706.
      View in: PubMed
    13. Keysar SB, Gomes N, Miller B, Jackson BC, Le PN, Morton JJ, Reisinger J, Chimed TS, Gomez KE, Nieto C, Frederick B, Pronk GJ, Somerset HL, Tan AC, Wang XJ, Raben D, Su TT, Jimeno A. Inhibiting Translation Elongation with SVC112 Suppresses Cancer Stem Cells and Inhibits Growth in Head and Neck Squamous Carcinoma. Cancer Res. 2020 03 01; 80(5):1183-1198. PMID: 31911553.
      View in: PubMed
    14. Myat MM, Louis D, Mavrommatis A, Collins L, Mattis J, Ledru M, Verghese S, Su TT. Regulators of cell movement during development and regeneration in Drosophila. Open Biol. 2019 05 31; 9(5):180245. PMID: 31039676.
      View in: PubMed
    15. Su TT. Drug screening in Drosophila; why, when, and when not? Wiley Interdiscip Rev Dev Biol. 2019 11; 8(6):e346. PMID: 31056843.
      View in: PubMed
    16. Xiong M, Wang X, Su T, Yang B, Li M, Zheng D. Relationship between psychological health and quality of life of people affected by leprosy in the community in Guangdong province, China: a cross-sectional study. BMC Public Health. 2019 Apr 23; 19(1):424. PMID: 31014307.
      View in: PubMed
    17. Xu J, Su T, Tokamov SA, Fehon RG. Live Imaging of Hippo Pathway Components in Drosophila Imaginal Discs. Methods Mol Biol. 2019; 1893:53-59. PMID: 30565124.
      View in: PubMed
    18. Su TT. What Drosophila Can Teach Us About Radiation Biology of Human Cancers. Adv Exp Med Biol. 2019; 1167:225-236. PMID: 31520358.
      View in: PubMed
    19. Su TT. Cellular plasticity, caspases and autophagy; that which does not kill us, well, makes us different. Open Biol. 2018 11 28; 8(11). PMID: 30487302.
      View in: PubMed
    20. Verghese S, Su TT. Ionizing radiation induces stem cell-like properties in a caspase-dependent manner in Drosophila. PLoS Genet. 2018 11; 14(11):e1007659. PMID: 30462636.
      View in: PubMed
    21. Duronio RJ, O'Farrell PH, Sluder G, Su TT. Sophisticated lessons from simple organisms: appreciating the value of curiosity-driven research. Dis Model Mech. 2017 12 19; 10(12):1381-1389. PMID: 29259023.
      View in: PubMed
    22. Xiong M, Li M, Zheng D, Wang X, Su T, Chen Y, Yang B. Evaluation of the economic burden of leprosy among migrant and resident patients in Guangdong Province, China. BMC Infect Dis. 2017 12 11; 17(1):760. PMID: 29228917.
      View in: PubMed
    23. Verghese S, Su TT. STAT, Wingless, and Nurf-38 determine the accuracy of regeneration after radiation damage in Drosophila. PLoS Genet. 2017 Oct; 13(10):e1007055. PMID: 29028797.
      View in: PubMed
    24. Su T, Ludwig MZ, Xu J, Fehon RG. Kibra and Merlin Activate the Hippo Pathway Spatially Distinct from and Independent of Expanded. Dev Cell. 2017 03 13; 40(5):478-490.e3. PMID: 28292426.
      View in: PubMed
    25. Verghese S, Su TT. Drosophila Wnt and STAT Define Apoptosis-Resistant Epithelial Cells for Tissue Regeneration after Irradiation. PLoS Biol. 2016 09; 14(9):e1002536. PMID: 27584613.
      View in: PubMed
    26. Stickel SA, Gomes NP, Frederick B, Raben D, Su TT. Bouvardin is a Radiation Modulator with a Novel Mechanism of Action. Radiat Res. 2015 Oct; 184(4):392-403. PMID: 26414509.
      View in: PubMed
    27. Xing Y, Su TT, Ruohola-Baker H. Tie-mediated signal from apoptotic cells protects stem cells in Drosophila melanogaster. Nat Commun. 2015 May 11; 6:7058. PMID: 25959206.
      View in: PubMed
    28. Su TT. Non-autonomous consequences of cell death and other perks of being metazoan. AIMS Genet. 2015; 2(1):54-69. PMID: 26069889.
      View in: PubMed
    29. Stickel S, Gomes N, Su TT. The Role of Translational Regulation in Survival after Radiation Damage; an Opportunity for Proteomics Analysis. Proteomes. 2014 Jun; 2(2):272-290. PMID: 26269784.
      View in: PubMed
    30. Bilak A, Uyetake L, Su TT. Dying cells protect survivors from radiation-induced cell death in Drosophila. PLoS Genet. 2014 Mar; 10(3):e1004220. PMID: 24675716.
      View in: PubMed
    31. Stickel S, Su TT. Oncogenic mutations produce similar phenotypes in Drosophila tissues of diverse origins. Biol Open. 2014 Mar 15; 3(3):201-9. PMID: 24570398.
      View in: PubMed
    32. van Bergeijk P, Heimiller J, Uyetake L, Su TT. Genome-wide expression analysis identifies a modulator of ionizing radiation-induced p53-independent apoptosis in Drosophila melanogaster. PLoS One. 2012; 7(5):e36539. PMID: 22666323.
      View in: PubMed
    33. Gladstone M, Frederick B, Zheng D, Edwards A, Yoon P, Stickel S, DeLaney T, Chan DC, Raben D, Su TT. A translation inhibitor identified in a Drosophila screen enhances the effect of ionizing radiation and taxol in mammalian models of cancer. Dis Model Mech. 2012 May; 5(3):342-50. PMID: 22344740.
      View in: PubMed
    34. Gladstone M, Su TT. Radiation responses and resistance. Int Rev Cell Mol Biol. 2012; 299:235-53. PMID: 22959305.
      View in: PubMed
    35. Gladstone M, Su TT. Chemical genetics and drug screening in Drosophila cancer models. J Genet Genomics. 2011 Oct 20; 38(10):497-504. PMID: 22035870.
      View in: PubMed
    36. Su TT. Safeguarding genetic information in Drosophila. Chromosoma. 2011 Dec; 120(6):547-55. PMID: 21927823.
      View in: PubMed
    37. Edwards A, Gladstone M, Yoon P, Raben D, Frederick B, Su TT. Combinatorial effect of maytansinol and radiation in Drosophila and human cancer cells. Dis Model Mech. 2011 Jul; 4(4):496-503. PMID: 21504911.
      View in: PubMed
    38. Smith MK, Trujillo C, Su TT. The benefits of using clickers in small-enrollment seminar-style biology courses. CBE Life Sci Educ. 2011; 10(1):14-7. PMID: 21364096.
      View in: PubMed
    39. Gladstone M, Su TT. Screening for radiation sensitizers of Drosophila checkpoint mutants. Methods Mol Biol. 2011; 782:105-17. PMID: 21870288.
      View in: PubMed
    40. Su TT. Heterochromatin replication: better late than ever. Curr Biol. 2010 Dec 07; 20(23):R1018-20. PMID: 21145016.
      View in: PubMed
    41. Wichmann A, Uyetake L, Su TT. E2F1 and E2F2 have opposite effects on radiation-induced p53-independent apoptosis in Drosophila. Dev Biol. 2010 Oct 01; 346(1):80-9. PMID: 20659447.
      View in: PubMed
    42. Su TT. The effect of a DNA damaging agent on embryonic cell cycles of the cnidarian Hydractinia echinata. PLoS One. 2010 Jul 23; 5(7):e11760. PMID: 20668699.
      View in: PubMed
    43. Garcia K, Stumpff J, Duncan T, Su TT. Tyrosines in the kinesin-5 head domain are necessary for phosphorylation by Wee1 and for mitotic spindle integrity. Curr Biol. 2009 Oct 13; 19(19):1670-6. PMID: 19800237.
      View in: PubMed
    44. Bilak A, Su TT. Regulation of Drosophila melanogaster pro-apoptotic gene hid. Apoptosis. 2009 Aug; 14(8):943-9. PMID: 19554451.
      View in: PubMed
    45. Yi X, Lemstra W, Vos MJ, Shang Y, Kampinga HH, Su TT, Sibon OC. A long-term flow cytometry assay to analyze the role of specific genes of Drosophila melanogaster S2 cells in surviving genotoxic stress. Cytometry A. 2008 Jul; 73(7):637-42. PMID: 18496848.
      View in: PubMed
    46. Garcia K, Su TT. Cell cycle regulation. Fly (Austin). 2008 May-Jun; 2(3):133-7. PMID: 18820450.
      View in: PubMed
    47. Jaklevic B, Uyetake L, Wichmann A, Bilak A, English CN, Su TT. Modulation of ionizing radiation-induced apoptosis by bantam microRNA in Drosophila. Dev Biol. 2008 Aug 01; 320(1):122-30. PMID: 18550049.
      View in: PubMed
    48. Garcia K, Wichmann A, Su TT. Cell cycle regulation. Fly (Austin). 2007 Mar-Apr; 1(2):125-31. PMID: 19378458.
      View in: PubMed
    49. Garcia K, Duncan T, Su TT. Analysis of the cell division cycle in Drosophila. Methods. 2007 Feb; 41(2):198-205. PMID: 17189862.
      View in: PubMed
    50. LaRocque JR, Jaklevic B, Su TT, Sekelsky J. Drosophila ATR in double-strand break repair. Genetics. 2007 Mar; 175(3):1023-33. PMID: 17194776.
      View in: PubMed
    51. Wichmann A, Jaklevic B, Su TT. Ionizing radiation induces caspase-dependent but Chk2- and p53-independent cell death in Drosophila melanogaster. Proc Natl Acad Sci U S A. 2006 Jun 27; 103(26):9952-7. PMID: 16785441.
      View in: PubMed
    52. Su TT. Cellular responses to DNA damage: one signal, multiple choices. Annu Rev Genet. 2006; 40:187-208. PMID: 16805666.
      View in: PubMed
    53. Stumpff J, Kellogg DR, Krohne KA, Su TT. Drosophila Wee1 interacts with members of the gammaTURC and is required for proper mitotic-spindle morphogenesis and positioning. Curr Biol. 2005 Sep 06; 15(17):1525-34. PMID: 16139207.
      View in: PubMed
    54. Purdy A, Uyetake L, Cordeiro MG, Su TT. Regulation of mitosis in response to damaged or incompletely replicated DNA require different levels of Grapes (Drosophila Chk1). J Cell Sci. 2005 Aug 01; 118(Pt 15):3305-15. PMID: 16079276.
      View in: PubMed
    55. de Vries HI, Uyetake L, Lemstra W, Brunsting JF, Su TT, Kampinga HH, Sibon OC. Grp/DChk1 is required for G2-M checkpoint activation in Drosophila S2 cells, whereas Dmnk/DChk2 is dispensable. J Cell Sci. 2005 May 01; 118(Pt 9):1833-42. PMID: 15860729.
      View in: PubMed
    56. Stumpff J, Duncan T, Homola E, Campbell SD, Su TT. Drosophila Wee1 kinase regulates Cdk1 and mitotic entry during embryogenesis. Curr Biol. 2004 Dec 14; 14(23):2143-8. PMID: 15589158.
      View in: PubMed
    57. Purdy A, Su TT. Telomeres: not all breaks are equal. Curr Biol. 2004 Aug 10; 14(15):R613-4. PMID: 15296775.
      View in: PubMed
    58. Duncan T, Su TT. Embryogenesis: coordinating cell division with gastrulation. Curr Biol. 2004 Apr 20; 14(8):R305-7. PMID: 15084299.
      View in: PubMed
    59. Su TT, Stumpff J. Promiscuity rules? The dispensability of cyclin E and Cdk2. Sci STKE. 2004 Mar 09; 2004(224):pe11. PMID: 15026579.
      View in: PubMed
    60. Jaklevic BR, Su TT. Relative contribution of DNA repair, cell cycle checkpoints, and cell death to survival after DNA damage in Drosophila larvae. Curr Biol. 2004 Jan 06; 14(1):23-32. PMID: 14711410.
      View in: PubMed
    61. O'Farrell PH, Stumpff J, Su TT. Embryonic cleavage cycles: how is a mouse like a fly? Curr Biol. 2004 Jan 06; 14(1):R35-45. PMID: 14711435.
      View in: PubMed
    62. Jaklevic B, Purdy A, Su TT. Control of mitotic entry after DNA damage in Drosophila. Methods Mol Biol. 2004; 280:245-56. PMID: 15187258.
      View in: PubMed
    63. Jaklevic B, Su TT. Cell turnover: flexible coupling meets the needs of development. Curr Biol. 2003 Oct 14; 13(20):R805-7. PMID: 14561421.
      View in: PubMed
    64. De Felice B, Wilson RR, Mondola P, Matrone G, Damiano S, Garbi C, Nezi L, Su TT. Characterization of DIP1, a novel nuclear protein in Drosophila melanogaster. Biochem Biophys Res Commun. 2003 Jul 25; 307(2):224-8. PMID: 12859943.
      View in: PubMed
    65. Lauren?on A, Purdy A, Sekelsky J, Hawley RS, Su TT. Phenotypic analysis of separation-of-function alleles of MEI-41, Drosophila ATM/ATR. Genetics. 2003 Jun; 164(2):589-601. PMID: 12807779.
      View in: PubMed
    66. Tin Su T. Cell cycle: how, when and why cells get rid of cyclin A. Curr Biol. 2001 Jun 26; 11(12):R467-9. PMID: 11448787.
      View in: PubMed
    67. Su TT, Jaklevic B. DNA damage leads to a Cyclin A-dependent delay in metaphase-anaphase transition in the Drosophila gastrula. Curr Biol. 2001 Jan 09; 11(1):8-17. PMID: 11166174.
      View in: PubMed
    68. Su TT, Walker J, Stumpff J. Activating the DNA damage checkpoint in a developmental context. Curr Biol. 2000 Feb 10; 10(3):119-26. PMID: 10679321.
      View in: PubMed
    69. Su TT. The regulation of cell growth and proliferation during organogenesis. In Vivo. 2000 Jan-Feb; 14(1):141-8. PMID: 10757071.
      View in: PubMed
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