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David C. Irwin

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    R01HL125642     (IRWIN, DAVID CHARLES)Aug 1, 2015 - May 31, 2020
    NIH/NHLBI
    The contribution of free hemoglobin in the progression of pulmonary remodeling
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark KR, Buehler PW, Irwin DC. Correction: Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017; 12(3):e0173652. PMID: 28264019.
      View in: PubMed
    2. Loomis Z, Eigenberger P, Redinius K, Lisk C, Karoor V, Nozik-Grayck E, Ferguson SK, Hassell K, Nuss R, Stenmark K, Buehler P, Irwin DC. Hemoglobin induced cell trauma indirectly influences endothelial TLR9 activity resulting in pulmonary vascular smooth muscle cell activation. PLoS One. 2017; 12(2):e0171219. PMID: 28152051.
      View in: PubMed
    3. Tarshis S, Maltzahn J, Loomis Z, Irwin DC. Preventing High Altitude Cerebral Edema in Rats with Repurposed Anti-Angiogenesis Pharmacotherapy. Aerosp Med Hum Perform. 2016 Dec 01; 87(12):1031-1035. PMID: 28323589.
      View in: PubMed
    4. Schaer CA, Deuel JW, Schildknecht D, Mahmoudi L, Garcia-Rubio I, Owczarek C, Schauer S, Kissner R, Banerjee U, Palmer AF, Spahn DR, Irwin DC, Vallelian F, Buehler PW, Schaer DJ. Haptoglobin Preserves Vascular Nitric Oxide Signaling during Hemolysis. Am J Respir Crit Care Med. 2016 May 15; 193(10):1111-22. PMID: 26694989; PMCID: PMC4872667 [Available on 05/15/17].
    5. Scalzo RL, Binns SE, Klochak AL, Giordano GR, Paris HL, Sevits KJ, Beals JW, Biela LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. Methazolamide Plus Aminophylline Abrogates Hypoxia-Mediated Endurance Exercise Impairment. High Alt Med Biol. 2015 Dec; 16(4):331-42. PMID: 26680684.
      View in: PubMed
    6. Scalzo RL, Peltonen GL, Binns SE, Klochak AL, Szallar SE, Wood LM, Larson DG, Luckasen GJ, Irwin D, Schroeder T, Hamilton KL, Bell C. The Effects of Sympathetic Inhibition on Metabolic and Cardiopulmonary Responses to Exercise in Hypoxic Conditions. Wilderness Environ Med. 2015 Dec; 26(4):520-4. PMID: 26183071.
      View in: PubMed
    7. Irwin DC, Baek JH, Hassell K, Nuss R, Eigenberger P, Lisk C, Loomis Z, Maltzahn J, Stenmark KR, Nozik-Grayck E, Buehler PW. Hemoglobin-induced lung vascular oxidation, inflammation, and remodeling contribute to the progression of hypoxic pulmonary hypertension and is attenuated in rats with repeated-dose haptoglobin administration. Free Radic Biol Med. 2015 May; 82:50-62. PMID: 25656991; PMCID: PMC4387123.
    8. Irwin DC, Garat CV, Crossno JT, MacLean PS, Sullivan TM, Erickson PF, Jackman MR, Harral JW, Reusch JE, Klemm DJ. Obesity-related pulmonary arterial hypertension in rats correlates with increased circulating inflammatory cytokines and lipids and with oxidant damage in the arterial wall but not with hypoxia. Pulm Circ. 2014 Dec; 4(4):638-53. PMID: 25610600; PMCID: PMC4278624.
    9. Blueschke G, Hanna G, Fontanella AN, Palmer GM, Boico A, Min H, Dewhirst MW, Irwin DC, Zhao Y, Schroeder T. Automated measurement of microcirculatory blood flow velocity in pulmonary metastases of rats. J Vis Exp. 2014 Nov 30; (93):e51630. PMID: 25490280; PMCID: PMC4354379.
    10. Eigenberger P, Faino A, Maltzahn J, Lisk C, Frank E, Frank A, Loomis Z, Schroeder T, Strand M, Irwin D. A retrospective study of acute mountain sickness on Mt. Kilimanjaro using trekking company data. Aviat Space Environ Med. 2014 Nov; 85(11):1125-9. PMID: 25329946.
      View in: PubMed
    11. Nozik-Grayck E, Woods C, Taylor JM, Benninger RK, Johnson RD, Villegas LR, Stenmark KR, Harrison DG, Majka SM, Irwin D, Farrow KN. Selective depletion of vascular EC-SOD augments chronic hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Dec 01; 307(11):L868-76. PMID: 25326578; PMCID: PMC4254965.
    12. Wojciak-Stothard B, Abdul-Salam VB, Lao KH, Tsang H, Irwin DC, Lisk C, Loomis Z, Stenmark KR, Edwards JC, Yuspa SH, Howard LS, Edwards RJ, Rhodes CJ, Gibbs JS, Wharton J, Zhao L, Wilkins MR. Aberrant chloride intracellular channel 4 expression contributes to endothelial dysfunction in pulmonary arterial hypertension. Circulation. 2014 Apr 29; 129(17):1770-80. PMID: 24503951; PMCID: PMC4033409.
    13. Lisk C, Kominsky D, Ehrentraut S, Bonaventura J, Nuss R, Hassell K, Nozik-Grayck E, Irwin DC. Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism. Am J Respir Cell Mol Biol. 2013 Oct; 49(4):619-26. PMID: 23713977.
      View in: PubMed
    14. Lisk C, McCord J, Bose S, Sullivan T, Loomis Z, Nozik-Grayck E, Schroeder T, Hamilton K, Irwin DC. Nrf2 activation: a potential strategy for the prevention of acute mountain sickness. Free Radic Biol Med. 2013 Oct; 63:264-73. PMID: 23722164; PMCID: PMC4130652.
    15. Reuland DJ, Khademi S, Castle CJ, Irwin DC, McCord JM, Miller BF, Hamilton KL. Upregulation of phase II enzymes through phytochemical activation of Nrf2 protects cardiomyocytes against oxidant stress. Free Radic Biol Med. 2013 Mar; 56:102-11. PMID: 23201694.
      View in: PubMed
    16. Buehler PW, Baek JH, Lisk C, Connor I, Sullivan T, Kominsky D, Majka S, Stenmark KR, Nozik-Grayck E, Bonaventura J, Irwin DC. Free hemoglobin induction of pulmonary vascular disease: evidence for an inflammatory mechanism. Am J Physiol Lung Cell Mol Physiol. 2012 Aug 15; 303(4):L312-26. PMID: 22728465; PMCID: PMC3423829.
    17. Peltonen GL, Scalzo RL, Schweder MM, Larson DG, Luckasen GJ, Irwin D, Hamilton KL, Schroeder T, Bell C. Sympathetic inhibition attenuates hypoxia induced insulin resistance in healthy adult humans. J Physiol. 2012 Jun 01; 590(11):2801-9. PMID: 22495590; PMCID: PMC3424732.
    18. Cavasin MA, Demos-Davies K, Horn TR, Walker LA, Lemon DD, Birdsey N, Weiser-Evans MC, Harral J, Irwin DC, Anwar A, Yeager ME, Li M, Watson PA, Nemenoff RA, Buttrick PM, Stenmark KR, McKinsey TA. Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res. 2012 Mar 02; 110(5):739-48. PMID: 22282194; PMCID: PMC3682822.
    19. Lemon DD, Horn TR, Cavasin MA, Jeong MY, Haubold KW, Long CS, Irwin DC, McCune SA, Chung E, Leinwand LA, McKinsey TA. Cardiac HDAC6 catalytic activity is induced in response to chronic hypertension. J Mol Cell Cardiol. 2011 Jul; 51(1):41-50. PMID: 21539845; PMCID: PMC3113526.
    20. Clarke MB, Wright R, Irwin D, Bose S, Van Rheen Z, Birari R, Stenmark KR, McCord JM, Nozik-Grayck E. Sustained lung activity of a novel chimeric protein, SOD2/3, after intratracheal administration. Free Radic Biol Med. 2010 Dec 15; 49(12):2032-9. PMID: 20932897; PMCID: PMC3005855.
    21. Gotshall RW, Hamilton KL, Foreman B, van Patot MC, Irwin DC. Glutaraldehyde-polymerized bovine hemoglobin and phosphodiesterase-5 inhibition. Crit Care Med. 2009 Jun; 37(6):1988-93. PMID: 19384199; PMCID: PMC3816936.
    22. Irwin D, Buehler PW, Alayash AI, Jia Y, Bonventura J, Foreman B, White M, Jacobs R, Piteo B, TissotvanPatot MC, Hamilton KL, Gotshall RW. Mixed S-nitrosylated polymerized bovine hemoglobin species moderate hemodynamic effects in acutely hypoxic rats. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):200-9. PMID: 19395680; PMCID: PMC2822981.
    23. Irwin DC, McCord JM, Nozik-Grayck E, Beckly G, Foreman B, Sullivan T, White M, T Crossno J, Bailey D, Flores SC, Majka S, Klemm D, van Patot MC. A potential role for reactive oxygen species and the HIF-1alpha-VEGF pathway in hypoxia-induced pulmonary vascular leak. Free Radic Biol Med. 2009 Jul 01; 47(1):55-61. PMID: 19358884; PMCID: PMC2689923.
    24. Irwin DC, Foreman B, Morris K, White M, Sullivan T, Jacobs R, Monnet E, Hackett T, TissotvanPatot MC, Hamilton KL, Gotshall RW. Polymerized bovine hemoglobin decreases oxygen delivery during normoxia and acute hypoxia in the rat. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H1090-H1099. PMID: 18567708; PMCID: PMC2544506.
    25. Irwin DC, Subudhi AW, Klopp L, Peterson D, Roach R, Monnet E. Pulmonary edema induced by cerebral hypoxic insult in a canine model. Aviat Space Environ Med. 2008 May; 79(5):472-8. PMID: 18500043.
      View in: PubMed
    26. Irwin DC, Patot MT, Tucker A, Bowen R. Neutral endopeptidase null mice are less susceptible to high altitude-induced pulmonary vascular leak. High Alt Med Biol. 2005; 6(4):311-9. PMID: 16351565.
      View in: PubMed
    27. Irwin DC, Tissot van Patot MC, Tucker A, Bowen R. Direct ANP inhibition of hypoxia-induced inflammatory pathways in pulmonary microvascular and macrovascular endothelial monolayers. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L849-59. PMID: 15618455.
      View in: PubMed
    28. Irwin DC, Rhodes J, Baker DC, Nelson SE, Tucker A. Atrial natriuretic peptide blockade exacerbates high altitude pulmonary edema in endotoxin-primed rats. High Alt Med Biol. 2001; 2(3):349-60. PMID: 11682014.
      View in: PubMed
    29. Boswell CM, Irwin DC, Goodnight J, Stein KE. Strain-dependent restricted VH and VL usage by anti-bacterial levan monoclonal antibodies. J Immunol. 1992 Jun 15; 148(12):3864-72. PMID: 1602134.
      View in: PubMed
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