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Jason Gien

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
    Collapse research activities and funding
    K08HL102261     (GIEN, JASON)Sep 1, 2010 - Jun 30, 2015
    NIH/NHLBI
    Rho-kinase signaling in lung development and persistent pulmonary hypertension
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2018 Oct 12. PMID: 30315405.
      View in: PubMed
    2. Murthy K, Porta NFM, Pallotto EK, Rintoul N, Keene S, Chicoine L, Gien J, Brozanski BS, Johnson YR, Haberman B, DiGeronimo R, Zaniletti I, Grover TR. Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 Sep 11. PMID: 30217691.
      View in: PubMed
    3. Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2018 Aug 28. PMID: 30155763.
      View in: PubMed
    4. Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2018 Sep 01; 315(3):L348-L359. PMID: 29722560.
      View in: PubMed
    5. Keene S, Murthy K, Pallotto E, Brozanski B, Gien J, Zaniletti I, Hulbert C, Seabrook R, Rintoul N, Chicoine L, Porta N, Grover TR. Acquired Infection and Antimicrobial Utilization During Initial NICU Hospitalization in Infants With Congenital Diaphragmatic Hernia. Pediatr Infect Dis J. 2018 May; 37(5):469-474. PMID: 29189614.
      View in: PubMed
    6. Gien J, Meyers ML, Kinsella JP. Assessment of Carina Position Antenatally and Postnatally in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 Jan; 192:93-98.e1. PMID: 29246364.
      View in: PubMed
    7. Deeney S, Howley LW, Hodges M, Liechty KW, Marwan AI, Gien J, Kinsella JP, Crombleholme TM. Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair. J Pediatr. 2018 Jan; 192:99-104.e4. PMID: 29106923.
      View in: PubMed
    8. Gien J, Murthy K, Pallotto EK, Brozanski B, Chicoine L, Zaniletti I, Seabrook R, Keene S, Alapati D, Porta N, Rintoul N, Grover TR. Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH). Early Hum Dev. 2017 Mar - Apr; 106-107:7-12. PMID: 28178582.
      View in: PubMed
    9. Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 02; 181:12-28.e1. PMID: 27908648.
      View in: PubMed
    10. Gien J, Tseng N, Seedorf G, Kuhn K, Abman SH. Endothelin-1-Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups. Am J Physiol Lung Cell Mol Physiol. 2016 12 01; 311(6):L1090-L1100. PMID: 27760762.
      View in: PubMed
    11. Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH, Baker CD. Retrospective Analysis of an Interdisciplinary Ventilator Care Program Intervention on Survival of Infants with Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Perinatol. 2017 01; 34(2):155-163. PMID: 27355979.
      View in: PubMed
    12. Aschner JL, Gien J, Ambalavanan N, Kinsella JP, Konduri GG, Lakshminrusimha S, Saugstad OD, Steinhorn RH. Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate. J Perinatol. 2016 06; 36 Suppl 2:S32-6. PMID: 27225964.
      View in: PubMed
    13. Gien J, Kinsella JP. Management of pulmonary hypertension in infants with congenital diaphragmatic hernia. J Perinatol. 2016 06; 36 Suppl 2:S28-31. PMID: 27225962.
      View in: PubMed
    14. Baker CD, Martin S, Thrasher J, Moore HM, Baker J, Abman SH, Gien J. A Standardized Discharge Process Decreases Length of Stay for Ventilator-Dependent Children. Pediatrics. 2016 04; 137(4). PMID: 26966133.
      View in: PubMed
    15. Murthy K, Pallotto EK, Gien J, Brozanski BS, Porta NF, Zaniletti I, Keene S, Chicoine LG, Rintoul NE, Dykes FD, Asselin JM, Short BL, Padula MA, Durand DJ, Reber KM, Evans JR, Grover TR. Predicting death or extended length of stay in infants with congenital diaphragmatic hernia. J Perinatol. 2016 08; 36(8):654-9. PMID: 26963428.
      View in: PubMed
    16. Gien J, Kinsella JP. Differences in preductal and postductal arterial blood gas measurements in infants with severe congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2016 Jul; 101(4):F314-8. PMID: 26514398.
      View in: PubMed
    17. Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. Am J Physiol Lung Cell Mol Physiol. 2015 Nov 01; 309(9):L1018-26. PMID: 26342089.
      View in: PubMed
    18. Grover TR, Murthy K, Brozanski B, Gien J, Rintoul N, Keene S, Najaf T, Chicoine L, Porta N, Zaniletti I, Pallotto EK. Short-term outcomes and medical and surgical interventions in infants with congenital diaphragmatic hernia. Am J Perinatol. 2015 Sep; 32(11):1038-44. PMID: 25825963.
      View in: PubMed
    19. Guaman MC, Gien J, Baker CD, Zhang H, Austin ED, Collaco JM. Point Prevalence, Clinical Characteristics, and Treatment Variation for Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2015 Aug; 32(10):960-7. PMID: 25738785; PMCID: PMC4617756.
    20. Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered pulmonary artery endothelial-smooth muscle cell interactions in experimental congenital diaphragmatic hernia. Pediatr Res. 2015 Apr; 77(4):511-9. PMID: 25580737; PMCID: PMC4363155.
    21. Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan; 166(1):178-83. PMID: 25306189; PMCID: PMC4274215.
    22. Gien J, Abman SH, Baker CD. Interdisciplinary care for ventilator-dependent infants with chronic lung disease. J Pediatr. 2014 Dec; 165(6):1274-5. PMID: 25258147.
      View in: PubMed
    23. Abman SH, Baker C, Gien J, Mourani P, Galambos C. The Robyn Barst Memorial Lecture: Differences between the fetal, newborn, and adult pulmonary circulations: relevance for age-specific therapies (2013 Grover Conference series). Pulm Circ. 2014 Sep; 4(3):424-40. PMID: 25621156.
      View in: PubMed
    24. Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015 Jan; 70(1):84-5. PMID: 25052575; PMCID: PMC4405163.
    25. Acker SN, Kinsella JP, Abman SH, Gien J. Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia. J Pediatr. 2014 Jul; 165(1):53-58.e1. PMID: 24840762; PMCID: PMC4116488.
    26. Gien J, Ing RJ, Twite MD, Campbell D, Mitchell M, Kinsella JP. Successful Surgical Management of Airway Perforation in Preterm Infants. J Pediatr Surg Case Rep. 2014 Feb 01; 2(2):47-51. PMID: 24791225.
      View in: PubMed
    27. Mandell E, Seedorf G, Gien J, Abman SH. Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 01; 306(5):L420-8. PMID: 24414254; PMCID: PMC3949057.
    28. Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Peroxisome proliferator activated receptor-?-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb; 306(3):L299-308. PMID: 24375792; PMCID: PMC3920199.
    29. Wolf D, Tseng N, Seedorf G, Roe G, Abman SH, Gien J. Endothelin-1 decreases endothelial PPAR? signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15; 306(4):L361-71. PMID: 24337925; PMCID: PMC3920227.
    30. Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Partrick DA, Gien J. Pulmonary artery endothelial cell dysfunction and decreased populations of highly proliferative endothelial cells in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol. 2013 Dec; 305(12):L943-52. PMID: 24124189; PMCID: PMC3882539.
    31. Delaney C, Gien J, Roe G, Isenberg N, Kailey J, Abman SH. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15; 304(12):L894-901. PMID: 23605003.
      View in: PubMed
    32. Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res. 2013 Mar; 73(3):252-62. PMID: 23202724; PMCID: PMC3767851.
    33. Delaney C, Gien J, Grover TR, Roe G, Abman SH. Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L937-44. PMID: 21908589; PMCID: PMC3233823.
    34. Rozance PJ, Seedorf GJ, Brown A, Roe G, O'Meara MC, Gien J, Tang JR, Abman SH. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L860-71. PMID: 21873446; PMCID: PMC3233832.
    35. Chester M, Seedorf G, Tourneux P, Gien J, Tseng N, Grover T, Wright J, Stasch JP, Abman SH. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L755-64. PMID: 21856817; PMCID: PMC3213988.
    36. Gien J, Kinsella JP. Pathogenesis and treatment of bronchopulmonary dysplasia. Curr Opin Pediatr. 2011 Jun; 23(3):305-13. PMID: 21494147; PMCID: PMC3767848.
    37. Chester M, Tourneux P, Seedorf G, Grover TR, Gien J, Abman SH. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L318-25. PMID: 19465519; PMCID: PMC2742799.
    38. Gien J, Seedorf GJ, Balasubramaniam V, Tseng N, Markham N, Abman SH. Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L680-7. PMID: 18621906; PMCID: PMC2575951.
    39. Gien J, Seedorf GJ, Balasubramaniam V, Markham N, Abman SH. Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1146-53. PMID: 17823355; PMCID: PMC2176095.
    40. Kunig AM, Balasubramaniam V, Markham NE, Seedorf G, Gien J, Abman SH. Recombinant human VEGF treatment transiently increases lung edema but enhances lung structure after neonatal hyperoxia. Am J Physiol Lung Cell Mol Physiol. 2006 Nov; 291(5):L1068-78. PMID: 16829629.
      View in: PubMed
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