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Jason Gien

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS

    Collapse Research 
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    K08HL102261     (GIEN, JASON)Sep 1, 2010 - Jun 30, 2015
    NIH
    Rho-kinase signaling in lung development and persistent pulmonary hypertension
    Role: Principal Investigator

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    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Mahmood B, Murthy K, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Seabrook R, Ali N, Chapman R, Daniel J, Harrison A, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Grover TR. Predicting treatment of pulmonary hypertension at discharge in infants with congenital diaphragmatic hernia. J Perinatol. 2021 Oct 28. PMID: 34711937.
      View in: PubMed
    2. Phillips R, Meier M, Shahi N, Niemiec S, Ogle S, Reppucci ML, Acker S, Gien J, Liechty KW, Meyers ML, Marwan A. Correction to: The novel fetal MRI O/E CLV versus O/E LHR in predicting prognosis in congenital diaphragmatic hernias: can we teach an old dog new tricks? Pediatr Surg Int. 2021 Oct 15. PMID: 34652511.
      View in: PubMed
    3. Gist KM, Misfeldt A, Sahay RD, Gorga SM, Askenazi DJ, Bridges BC, Paden ML, Zappitelli M, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT, Cooper DS. Acute Kidney Injury and Fluid Overload in Pediatric Extracorporeal Cardio-Pulmonary Resuscitation: A Multicenter Retrospective Cohort Study. ASAIO J. 2021 Oct 12. PMID: 34643574.
      View in: PubMed
    4. Phillips R, Shahi N, Meier M, Niemiec S, Ogle S, Acker S, Gien J, Liechty KW, Meyers ML, Marwan A. The novel fetal MRI O/E CLV versus O/E LHR in predicting prognosis in congenital diaphragmatic hernias: can we teach an old dog new tricks? Pediatr Surg Int. 2021 Nov; 37(11):1499-1504. PMID: 34505169.
      View in: PubMed
    5. Liberio BM, Brinton JT, Gist KM, Soranno DE, Kirkley MJ, Gien J. Risk factors for acute kidney injury in neonates with congenital diaphragmatic hernia. J Perinatol. 2021 08; 41(8):1901-1909. PMID: 34120147.
      View in: PubMed
    6. Weems MF, Grover TR, Seabrook R, DiGeronimo R, Gien J, Keene S, Rintoul N, Daniel JM, Johnson Y, Guner Y, Zaniletti I, Murthy K. Analgesia, Sedation, and Neuromuscular Blockade in Infants with Congenital Diaphragmatic Hernia. Am J Perinatol. 2021 May 27. PMID: 34044457.
      View in: PubMed
    7. Gorga SM, Lima L, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Jetton JG, Murphy HJ, Fleming GM, Selewski DT, Basu RK. Fluid Balance Management Informs Renal Replacement Therapy Use During Pediatric Extracorporeal Membrane Oxygenation: A Survey Report From the Kidney Intervention During Extracorporeal Membrane Oxygenation Group. ASAIO J. 2021 May 10. PMID: 34570725.
      View in: PubMed
    8. Seabrook RB, Grover TR, Rintoul N, Weems M, Keene S, Brozanski B, DiGeronimo R, Haberman B, Hedrick H, Gien J, Ali N, Chapman R, Daniel J, Harrison HA, Johnson Y, Porta NFM, Uhing M, Zaniletti I, Murthy K. Treatment of pulmonary hypertension during initial hospitalization in a multicenter cohort of infants with congenital diaphragmatic hernia (CDH). J Perinatol. 2021 04; 41(4):803-813. PMID: 33649432.
      View in: PubMed
    9. Fleming H, Dempsey AG, Palmer C, Dempsey J, Friedman S, Galan HL, Gien J. Primary contributors to gastrostomy tube placement in infants with Congenital Diaphragmatic Hernia. J Pediatr Surg. 2021 Nov; 56(11):1949-1956. PMID: 33773801.
      View in: PubMed
    10. Murphy HJ, Gien J, Sahay R, King E, Selewski DT, Bridges BC, Cooper DS, Fleming GM, Paden ML, Zappitelli M, Gist KM, Basu RK, Jetton JG, Askenazi D. Acute Kidney Injury, Fluid Overload, and Renal Replacement Therapy Differ by Underlying Diagnosis in Neonatal Extracorporeal Support and Impact Mortality Disparately. Blood Purif. 2021; 50(6):808-817. PMID: 33461205.
      View in: PubMed
    11. Guglielmetti LC, Estrada AE, Phillips R, Staerkle RF, Gien J, Kinsella JP, Liechty KW, Marwan AI, Vuille-Dit-Bille RN. Congenital diaphragmatic hernias: Severe defect grade predicts the need for fundoplication. Medicine (Baltimore). 2020 Dec 04; 99(49):e23383. PMID: 33285723.
      View in: PubMed
    12. Chatterjee D, Ing RJ, Gien J. Update on Congenital Diaphragmatic Hernia. Anesth Analg. 2020 09; 131(3):808-821. PMID: 31335403.
      View in: PubMed
    13. Phillips RC, Shahi N, Leopold D, Levek C, Shirek G, Hilton S, Hyslop R, Gien J, Kinsella JP, Buckvold S, Liechty KW, Kim JS, Marwan AI. Thromboelastography-guided management of coagulopathy in neonates with congenital diaphragmatic hernia supported by extracorporeal membrane oxygenation. Pediatr Surg Int. 2020 Sep; 36(9):1027-1033. PMID: 32607833.
      View in: PubMed
    14. Gien J, Soranno D. Identifying the Patient at Risk for Acute Kidney Injury: Pediatric Sepsis Biomarker Risk Model Study. Am J Respir Crit Care Med. 2020 04 01; 201(7):764-766. PMID: 32032496.
      View in: PubMed
    15. McKinney RL, Keszler M, Truog WE, Norberg M, Sindelar R, Wallström L, Schulman B, Gien J, Abman SH. Multicenter Experience with Neurally Adjusted Ventilatory Assist in Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2021 08; 38(S 01):e162-e166. PMID: 32208500.
      View in: PubMed
    16. Gien J, Nuxoll C, Kinsella JP. Inhaled Nitric Oxide in Emergency Medical Transport of the Newborn. Neoreviews. 2020 03; 21(3):e157-e164. PMID: 32123120.
      View in: PubMed
    17. Wehrmann M, Patel SS, Haxel C, Cassidy C, Howley L, Cuneo B, Gien J, Kinsella JP. Implications of Atrial-Level Shunting by Echocardiography in Newborns with Congenital Diaphragmatic Hernia. J Pediatr. 2020 04; 219:43-47. PMID: 32014282.
      View in: PubMed
    18. Gorga SM, Sahay RD, Askenazi DJ, Bridges BC, Cooper DS, Paden ML, Zappitelli M, Gist KM, Gien J, Basu RK, Jetton JG, Murphy HJ, King E, Fleming GM, Selewski DT. Fluid overload and fluid removal in pediatric patients on extracorporeal membrane oxygenation requiring continuous renal replacement therapy: a multicenter retrospective cohort study. Pediatr Nephrol. 2020 05; 35(5):871-882. PMID: 31953749.
      View in: PubMed
    19. Leopold DK, Phillips RC, Shahi N, Gien J, Marwan AI, Kinsella JP, Mulligan J, Liechty KW, Moulton SL. Low postnatal CRI values are associated with the need for ECMO in newborns with CDH. J Pediatr Surg. 2020 Jan; 55(1):39-44. PMID: 31679772.
      View in: PubMed
    20. Charlton JR, Boohaker L, Askenazi D, Brophy PD, D'Angio C, Fuloria M, Gien J, Griffin R, Hingorani S, Ingraham S, Mian A, Ohls RK, Rastogi S, Rhee CJ, Revenis M, Sarkar S, Smith A, Starr M, Kent AL. Incidence and Risk Factors of Early Onset Neonatal AKI. Clin J Am Soc Nephrol. 2019 Oct 01; 2019(2):1. PMID: 34497098.
      View in: PubMed
    21. Dewberry L, Hilton S, Gien J, Liechty KW, Marwan AI. Flap repair in congenital diaphragmatic hernia leads to lower rates of recurrence. J Pediatr Surg. 2019 Dec; 54(12):2487-2491. PMID: 31515112.
      View in: PubMed
    22. Keene S, Grover TR, Murthy K, Pallotto EK, Brozanski B, Gien J, Zaniletti I, Johnson YR, Seabrook RB, Porta NFM, Haberman B, DiGeronimo R, Rintoul N. Extracorporeal membrane oxygenation and bloodstream infection in congenital diaphragmatic hernia. J Perinatol. 2019 10; 39(10):1384-1391. PMID: 31383944.
      View in: PubMed
    23. Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Correction to: Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2019 Feb; 34(2):363. PMID: 30315405.
      View in: PubMed
    24. Charlton JR, Boohaker L, Askenazi D, Brophy PD, D'Angio C, Fuloria M, Gien J, Griffin R, Hingorani S, Ingraham S, Mian A, Ohls RK, Rastogi S, Rhee CJ, Revenis M, Sarkar S, Smith A, Starr M, Kent AL. Incidence and Risk Factors of Early Onset Neonatal AKI. Clin J Am Soc Nephrol. 2019 02 07; 14(2):184-195. PMID: 31738181.
      View in: PubMed
    25. Charlton JR, Boohaker L, Askenazi D, Brophy PD, Fuloria M, Gien J, Griffin R, Hingorani S, Ingraham S, Mian A, Ohls RK, Rastogi S, Rhee CJ, Revenis M, Sarkar S, Starr M, Kent AL. Late onset neonatal acute kidney injury: results from the AWAKEN Study. Pediatr Res. 2019 02; 85(3):339-348. PMID: 30546043.
      View in: PubMed
    26. Murthy K, Porta NFM, Pallotto EK, Rintoul N, Keene S, Chicoine L, Gien J, Brozanski BS, Johnson YR, Haberman B, DiGeronimo R, Zaniletti I, Grover TR. Predicting Risk of Infection in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 12; 203:101-107.e2. PMID: 30217691.
      View in: PubMed
    27. Kirkley MJ, Boohaker L, Griffin R, Soranno DE, Gien J, Askenazi D, Gist KM. Acute kidney injury in neonatal encephalopathy: an evaluation of the AWAKEN database. Pediatr Nephrol. 2019 01; 34(1):169-176. PMID: 30155763.
      View in: PubMed
    28. Dodson RB, Powers KN, Gien J, Rozance PJ, Seedorf G, Astling D, Jones K, Crombleholme TM, Abman SH, Alvira CM. Intrauterine growth restriction decreases NF-?B signaling in fetal pulmonary artery endothelial cells of fetal sheep. . 2018 09 01; 315(3):L348-L359. PMID: 29722560.
      View in: PubMed
    29. Keene S, Murthy K, Pallotto E, Brozanski B, Gien J, Zaniletti I, Hulbert C, Seabrook R, Rintoul N, Chicoine L, Porta N, Grover TR. Acquired Infection and Antimicrobial Utilization During Initial NICU Hospitalization in Infants With Congenital Diaphragmatic Hernia. Pediatr Infect Dis J. 2018 05; 37(5):469-474. PMID: 29189614.
      View in: PubMed
    30. Gien J, Meyers ML, Kinsella JP. Assessment of Carina Position Antenatally and Postnatally in Infants with Congenital Diaphragmatic Hernia. J Pediatr. 2018 01; 192:93-98.e1. PMID: 29246364.
      View in: PubMed
    31. Deeney S, Howley LW, Hodges M, Liechty KW, Marwan AI, Gien J, Kinsella JP, Crombleholme TM. Impact of Objective Echocardiographic Criteria for Timing of Congenital Diaphragmatic Hernia Repair. J Pediatr. 2018 01; 192:99-104.e4. PMID: 29106923.
      View in: PubMed
    32. Gien J, Murthy K, Pallotto EK, Brozanski B, Chicoine L, Zaniletti I, Seabrook R, Keene S, Alapati D, Porta N, Rintoul N, Grover TR. Short-term weight gain velocity in infants with congenital diaphragmatic hernia (CDH). Early Hum Dev. 2017 Mar - Apr; 106-107:7-12. PMID: 28178582.
      View in: PubMed
    33. Abman SH, Collaco JM, Shepherd EG, Keszler M, Cuevas-Guaman M, Welty SE, Truog WE, McGrath-Morrow SA, Moore PE, Rhein LM, Kirpalani H, Zhang H, Gratny LL, Lynch SK, Curtiss J, Stonestreet BS, McKinney RL, Dysart KC, Gien J, Baker CD, Donohue PK, Austin E, Fike C, Nelin LD. Interdisciplinary Care of Children with Severe Bronchopulmonary Dysplasia. J Pediatr. 2017 02; 181:12-28.e1. PMID: 27908648.
      View in: PubMed
    34. Gien J, Tseng N, Seedorf G, Kuhn K, Abman SH. Endothelin-1-Rho kinase interactions impair lung structure and cause pulmonary hypertension after bleomycin exposure in neonatal rat pups. . 2016 12 01; 311(6):L1090-L1100. PMID: 27760762.
      View in: PubMed
    35. Gien J, Kinsella J, Thrasher J, Grenolds A, Abman SH, Baker CD. Retrospective Analysis of an Interdisciplinary Ventilator Care Program Intervention on Survival of Infants with Ventilator-Dependent Bronchopulmonary Dysplasia. Am J Perinatol. 2017 01; 34(2):155-163. PMID: 27355979.
      View in: PubMed
    36. Aschner JL, Gien J, Ambalavanan N, Kinsella JP, Konduri GG, Lakshminrusimha S, Saugstad OD, Steinhorn RH. Challenges, priorities and novel therapies for hypoxemic respiratory failure and pulmonary hypertension in the neonate. J Perinatol. 2016 06; 36 Suppl 2:S32-6. PMID: 27225964.
      View in: PubMed
    37. Gien J, Kinsella JP. Management of pulmonary hypertension in infants with congenital diaphragmatic hernia. J Perinatol. 2016 06; 36 Suppl 2:S28-31. PMID: 27225962.
      View in: PubMed
    38. Baker CD, Martin S, Thrasher J, Moore HM, Baker J, Abman SH, Gien J. A Standardized Discharge Process Decreases Length of Stay for Ventilator-Dependent Children. Pediatrics. 2016 04; 137(4). PMID: 26966133.
      View in: PubMed
    39. Murthy K, Pallotto EK, Gien J, Brozanski BS, Porta NF, Zaniletti I, Keene S, Chicoine LG, Rintoul NE, Dykes FD, Asselin JM, Short BL, Padula MA, Durand DJ, Reber KM, Evans JR, Grover TR. Predicting death or extended length of stay in infants with congenital diaphragmatic hernia. J Perinatol. 2016 08; 36(8):654-9. PMID: 26963428.
      View in: PubMed
    40. Gien J, Kinsella JP. Differences in preductal and postductal arterial blood gas measurements in infants with severe congenital diaphragmatic hernia. Arch Dis Child Fetal Neonatal Ed. 2016 Jul; 101(4):F314-8. PMID: 26514398.
      View in: PubMed
    41. Mandell E, Seedorf GJ, Ryan S, Gien J, Cramer SD, Abman SH. Antenatal endotoxin disrupts lung vitamin D receptor and 25-hydroxyvitamin D 1a-hydroxylase expression in the developing rat. . 2015 Nov 01; 309(9):L1018-26. PMID: 26342089.
      View in: PubMed
    42. Grover TR, Murthy K, Brozanski B, Gien J, Rintoul N, Keene S, Najaf T, Chicoine L, Porta N, Zaniletti I, Pallotto EK. Short-term outcomes and medical and surgical interventions in infants with congenital diaphragmatic hernia. Am J Perinatol. 2015 Sep; 32(11):1038-44. PMID: 25825963.
      View in: PubMed
    43. Guaman MC, Gien J, Baker CD, Zhang H, Austin ED, Collaco JM. Point Prevalence, Clinical Characteristics, and Treatment Variation for Infants with Severe Bronchopulmonary Dysplasia. Am J Perinatol. 2015 Aug; 32(10):960-7. PMID: 25738785.
      View in: PubMed
    44. Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Kuhn K, Partrick DA, Gien J. Altered pulmonary artery endothelial-smooth muscle cell interactions in experimental congenital diaphragmatic hernia. Pediatr Res. 2015 Apr; 77(4):511-9. PMID: 25580737.
      View in: PubMed
    45. Acker SN, Mandell EW, Sims-Lucas S, Gien J, Abman SH, Galambos C. Histologic identification of prominent intrapulmonary anastomotic vessels in severe congenital diaphragmatic hernia. J Pediatr. 2015 Jan; 166(1):178-83. PMID: 25306189.
      View in: PubMed
    46. Gien J, Abman SH, Baker CD. Interdisciplinary care for ventilator-dependent infants with chronic lung disease. J Pediatr. 2014 Dec; 165(6):1274-5. PMID: 25258147.
      View in: PubMed
    47. Abman SH, Baker C, Gien J, Mourani P, Galambos C. The Robyn Barst Memorial Lecture: Differences between the fetal, newborn, and adult pulmonary circulations: relevance for age-specific therapies (2013 Grover Conference series). Pulm Circ. 2014 Sep; 4(3):424-40. PMID: 25621156.
      View in: PubMed
    48. Galambos C, Sims-Lucas S, Ali N, Gien J, Dishop MK, Abman SH. Intrapulmonary vascular shunt pathways in alveolar capillary dysplasia with misalignment of pulmonary veins. Thorax. 2015 Jan; 70(1):84-5. PMID: 25052575.
      View in: PubMed
    49. Acker SN, Kinsella JP, Abman SH, Gien J. Vasopressin improves hemodynamic status in infants with congenital diaphragmatic hernia. J Pediatr. 2014 Jul; 165(1):53-58.e1. PMID: 24840762.
      View in: PubMed
    50. Gien J, Ing RJ, Twite MD, Campbell D, Mitchell M, Kinsella JP. Successful Surgical Management of Airway Perforation in Preterm Infants. J Pediatr Surg Case Rep. 2014 Feb 01; 2(2):47-51. PMID: 24791225.
      View in: PubMed
    51. Mandell E, Seedorf G, Gien J, Abman SH. Vitamin D treatment improves survival and infant lung structure after intra-amniotic endotoxin exposure in rats: potential role for the prevention of bronchopulmonary dysplasia. Am J Physiol Lung Cell Mol Physiol. 2014 Mar 01; 306(5):L420-8. PMID: 24414254.
      View in: PubMed
    52. Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Peroxisome proliferator activated receptor-?-Rho-kinase interactions contribute to vascular remodeling after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb; 306(3):L299-308. PMID: 24375792.
      View in: PubMed
    53. Wolf D, Tseng N, Seedorf G, Roe G, Abman SH, Gien J. Endothelin-1 decreases endothelial PPAR? signaling and impairs angiogenesis after chronic intrauterine pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2014 Feb 15; 306(4):L361-71. PMID: 24337925.
      View in: PubMed
    54. Acker SN, Seedorf GJ, Abman SH, Nozik-Grayck E, Partrick DA, Gien J. Pulmonary artery endothelial cell dysfunction and decreased populations of highly proliferative endothelial cells in experimental congenital diaphragmatic hernia. Am J Physiol Lung Cell Mol Physiol. 2013 Dec; 305(12):L943-52. PMID: 24124189.
      View in: PubMed
    55. Delaney C, Gien J, Roe G, Isenberg N, Kailey J, Abman SH. Serotonin contributes to high pulmonary vascular tone in a sheep model of persistent pulmonary hypertension of the newborn. Am J Physiol Lung Cell Mol Physiol. 2013 Jun 15; 304(12):L894-901. PMID: 23605003.
      View in: PubMed
    56. Gien J, Tseng N, Seedorf G, Roe G, Abman SH. Endothelin-1 impairs angiogenesis in vitro through Rho-kinase activation after chronic intrauterine pulmonary hypertension in fetal sheep. Pediatr Res. 2013 Mar; 73(3):252-62. PMID: 23202724.
      View in: PubMed
    57. Delaney C, Gien J, Grover TR, Roe G, Abman SH. Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L937-44. PMID: 21908589.
      View in: PubMed
    58. Rozance PJ, Seedorf GJ, Brown A, Roe G, O'Meara MC, Gien J, Tang JR, Abman SH. Intrauterine growth restriction decreases pulmonary alveolar and vessel growth and causes pulmonary artery endothelial cell dysfunction in vitro in fetal sheep. Am J Physiol Lung Cell Mol Physiol. 2011 Dec; 301(6):L860-71. PMID: 21873446.
      View in: PubMed
    59. Chester M, Seedorf G, Tourneux P, Gien J, Tseng N, Grover T, Wright J, Stasch JP, Abman SH. Cinaciguat, a soluble guanylate cyclase activator, augments cGMP after oxidative stress and causes pulmonary vasodilation in neonatal pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2011 Nov; 301(5):L755-64. PMID: 21856817.
      View in: PubMed
    60. Gien J, Kinsella JP. Pathogenesis and treatment of bronchopulmonary dysplasia. Curr Opin Pediatr. 2011 Jun; 23(3):305-13. PMID: 21494147.
      View in: PubMed
    61. Chester M, Tourneux P, Seedorf G, Grover TR, Gien J, Abman SH. Cinaciguat, a soluble guanylate cyclase activator, causes potent and sustained pulmonary vasodilation in the ovine fetus. Am J Physiol Lung Cell Mol Physiol. 2009 Aug; 297(2):L318-25. PMID: 19465519.
      View in: PubMed
    62. Gien J, Seedorf GJ, Balasubramaniam V, Tseng N, Markham N, Abman SH. Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L680-7. PMID: 18621906.
      View in: PubMed
    63. Gien J, Seedorf GJ, Balasubramaniam V, Markham N, Abman SH. Intrauterine pulmonary hypertension impairs angiogenesis in vitro: role of vascular endothelial growth factor nitric oxide signaling. Am J Respir Crit Care Med. 2007 Dec 01; 176(11):1146-53. PMID: 17823355.
      View in: PubMed
    64. Kunig AM, Balasubramaniam V, Markham NE, Seedorf G, Gien J, Abman SH. Recombinant human VEGF treatment transiently increases lung edema but enhances lung structure after neonatal hyperoxia. . 2006 Nov; 291(5):L1068-78. PMID: 16829629.
      View in: PubMed
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