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Robert Freedman

TitleProfessor-Clinical
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PSYCH
Phone303/724-4940

    Collapse Research 
    Collapse research activities and funding
    I01CX001021     (FREEDMAN, ROBERT)Oct 1, 2015 - Aug 31, 2016
    NIH
    Nicotinic Receptors and Schizophrenia
    Role: Principal Investigator
    I01CX000145     (FREEDMAN, ROBERT)Oct 1, 2009 - Sep 30, 2014
    NIH
    Nicotinic Receptors and Schizophrenia
    Role: Principal Investigator
    P50MH086383     (FREEDMAN, ROBERT)Aug 1, 2009 - Jul 31, 2015
    NIH
    Basic to Clinical Molecular Neurobiology of Nicotinic Receptors in Schizophrenia
    Role: Principal Investigator
    P50MH068582     (FREEDMAN, ROBERT)Sep 27, 2004 - Jun 30, 2010
    NIH
    Molecular Neurobiology of Schizophrenia
    Role: Principal Investigator
    R01MH061617     (FREEDMAN, ROBERT)Feb 1, 2001 - Jul 31, 2003
    NIH
    NICOTINIC SYNAPTIC TRANSMISSION IN THE HIPPOCAMPUS
    Role: Principal Investigator
    N01DA009901     (FREEDMAN, ROBERT)Sep 22, 2000 - Sep 21, 2005
    NIH/NIDA
    BRAIN BANK
    Role: Principal Investigator
    R01MH061412     (FREEDMAN, ROBERT)Apr 1, 2000 - Apr 30, 2012
    NIH
    Nicotinic Agonist in Schizophrenia
    Role: Principal Investigator
    R01MH059565     (FREEDMAN, ROBERT)Sep 30, 1999 - Aug 31, 2003
    NIH
    Molecular Genetics of Schizophrenia
    Role: Principal Investigator
    S15AA008415     (FREEDMAN, ROBERT)Sep 1, 1989 - Aug 31, 1990
    NIH
    ASIP---UNIVERSITY COLORADO HEALTH SCIENCES CENTER
    Role: Principal Investigator
    P50MH044212     (FREEDMAN, ROBERT)Apr 1, 1989 - Mar 31, 1999
    NIH
    GENETIC &NEUROBIOLOGICAL INVESTIGATION OF SCHIZOPHRENIA
    Role: Principal Investigator
    R01MH038321     (FREEDMAN, ROBERT)Apr 1, 1984 - Apr 30, 2006
    NIH
    ELECTROPHYSIOLOGY OF SENSORY GATING IN SCHIZOPHRENIA
    Role: Principal Investigator
    R37MH038321     (FREEDMAN, ROBERT)Apr 1, 1984 - Apr 30, 2000
    NIH
    ELECTROPHYSIOLOGY OF SENSORY GATING IN SCHIZOPHRENIA
    Role: Principal Investigator
    R01DA002429     (FREEDMAN, ROBERT)Aug 1, 1979 - Dec 31, 1992
    NIH
    EFFECTS OF PHENCYCLIDINE ON NEURONAL FUNCTION
    Role: Principal Investigator
    U01MH094247     (LIEBERMAN, JEFFREY A.)Dec 31, 2018
    NIH
    Human Trial of Allosteric Modulator Alpha7 Nicotinic Receptors in Schizophrenia
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Black American Maternal Prenatal Choline, Offspring Gestational Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2021 07 08; 47(4):896-905. PMID: 33184653.
      View in: PubMed
    2. Hunter SK, Hoffman MC, McCarthy L, D'Alessandro A, Wyrwa A, Noonan K, Christians U, Nakimuli-Mpungu E, Zeisel SH, Law AJ, Freedman R. Targeting Treatments to Health Disparities. Schizophr Bull. 2021 07 08; 47(4):886-887. PMID: 33940629.
      View in: PubMed
    3. Freedman R, Hunter SK, Law AJ, Hoffman MC. Prenatal prevention of psychiatric illness and childhood development population-wide. World Psychiatry. 2021 Jun; 20(2):226-227. PMID: 34002528.
      View in: PubMed
    4. Hoffman MC, Freedman R, Law AJ, Clark AM, Hunter SK. Maternal nutrients and effects of gestational COVID-19 infection on fetal brain development. Clin Nutr ESPEN. 2021 06; 43:1-8. PMID: 34024500.
      View in: PubMed
    5. Freedman R, Hunter SK, Law AJ, Clark AM, Roberts A, Hoffman MC. Choline, folic acid, Vitamin D, and fetal brain development in the psychosis spectrum. Schizophr Res. 2021 Apr 07. PMID: 33838984.
      View in: PubMed
    6. Hunter SK, Hoffman MC, D'Alessandro A, Wyrwa A, Noonan K, Zeisel SH, Law AJ, Freedman R. Prenatal choline, cannabis, and infection, and their association with offspring development of attention and social problems through 4 years of age. Psychol Med. 2021 Jan 25; 1-10. PMID: 33491615.
      View in: PubMed
    7. Freedman R, Hunter SK, Law AJ, D'Alessandro A, Noonan K, Wyrwa A, Camille Hoffman M. Maternal choline and respiratory coronavirus effects on fetal brain development. J Psychiatr Res. 2020 09; 128:1-4. PMID: 32474140.
      View in: PubMed
    8. Freedman R, Olsen-Dufour AM, Olincy A. P50 inhibitory sensory gating in schizophrenia: analysis of recent studies. Schizophr Res. 2020 04; 218:93-98. PMID: 32061454.
      View in: PubMed
    9. Hunter SK, Hoffman MC, D'Alessandro A, Noonan K, Wyrwa A, Freedman R, Law AJ. Male fetus susceptibility to maternal inflammation: C-reactive protein and brain development. Psychol Med. 2021 02; 51(3):450-459. PMID: 31787129.
      View in: PubMed
    10. Hoffman MC, Hunter SK, D'Alessandro A, Noonan K, Wyrwa A, Freedman R. Interaction of maternal choline levels and prenatal Marijuana's effects on the offspring. Psychol Med. 2020 07; 50(10):1716-1726. PMID: 31364525.
      View in: PubMed
    11. Freedman R, Hunter SK, Law AJ, Wagner BD, D'Alessandro A, Christians U, Noonan K, Wyrwa A, Hoffman MC. Higher Gestational Choline Levels in Maternal Infection Are Protective for Infant Brain Development. J Pediatr. 2019 05; 208:198-206.e2. PMID: 30879727.
      View in: PubMed
    12. Freedman R. A Farewell. Am J Psychiatry. 2018 12 01; 175(12):1155-1156. PMID: 30501411.
      View in: PubMed
    13. Freedman R, Hunter SK, Hoffman MC. Prenatal Primary Prevention of Mental Illness by Micronutrient Supplements in Pregnancy. Am J Psychiatry. 2018 07 01; 175(7):607-619. PMID: 29558816.
      View in: PubMed
    14. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 29869549.
      View in: PubMed
    15. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27799359.
      View in: PubMed
    16. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 27565651.
      View in: PubMed
    17. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 33060035.
      View in: PubMed
    18. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11796154.
      View in: PubMed
    19. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2310807.
      View in: PubMed
    20. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2765691.
      View in: PubMed
    21. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 1306484.
      View in: PubMed
    22. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3363020.
      View in: PubMed
    23. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9782083.
      View in: PubMed
    24. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9885785.
      View in: PubMed
    25. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10394470.
      View in: PubMed
    26. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9012828.
      View in: PubMed
    27. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 2505888.
      View in: PubMed
    28. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 10986337.
      View in: PubMed
    29. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9542789.
      View in: PubMed
    30. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 9674976.
      View in: PubMed
    31. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 11743948.
      View in: PubMed
    32. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24283725.
      View in: PubMed
    33. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 14585943.
      View in: PubMed
    34. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 17460613.
      View in: PubMed
    35. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 12751801.
      View in: PubMed
    36. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 19956085.
      View in: PubMed
    37. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 15205879.
      View in: PubMed
    38. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 16500337.
      View in: PubMed
    39. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 25553496.
      View in: PubMed
    40. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26120259.
      View in: PubMed
    41. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3437995.
      View in: PubMed
    42. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8274580.
      View in: PubMed
    43. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8398945.
      View in: PubMed
    44. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24755895.
      View in: PubMed
    45. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 26441157.
      View in: PubMed
    46. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 8776738.
      View in: PubMed
    47. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 3205385.
      View in: PubMed
    48. Rulifson G, Bielefeldt AR. Evolution of Students' Varied Conceptualizations About Socially Responsible Engineering: A Four Year Longitudinal Study. Sci Eng Ethics. 2019 06; 25(3):939-974. PMID: 24012626.
      View in: PubMed
    49. Freedman R. AJP at 175: Remembering Our Past as We Envision Our Future. Am J Psychiatry. 2018 01 01; 175(1):1. PMID: 29301421.
      View in: PubMed
    50. Pine DS, Freedman R. Perspective on Selective Serotonin Reuptake Inhibitors in Children and Adolescents. Am J Psychiatry. 2017 05 01; 174(5):407-408. PMID: 28263661.
      View in: PubMed
    51. Freedman R. Further Investigation of Ketamine. Am J Psychiatry. 2016 08 01; 173(8):761-2. PMID: 27477135.
      View in: PubMed
    52. Wasser T, Richards M, Radhakrishnan R, Freedman R. The American Journal of Psychiatry Residents' Journal: Training the Next Generation of Academic Psychiatrists. Am J Psychiatry. 2016 May 01; 173(5):461-4. PMID: 27133407.
      View in: PubMed
    53. Freedman R, Michels R. Dissecting the Brain Mechanisms of Violence. Am J Psychiatry. 2016 Mar 01; 173(3):213-4. PMID: 26926125.
      View in: PubMed
    54. Ross RG, Hunter SK, Hoffman MC, McCarthy L, Chambers BM, Law AJ, Leonard S, Zerbe GO, Freedman R. Perinatal Phosphatidylcholine Supplementation and Early Childhood Behavior Problems: Evidence for CHRNA7 Moderation. Am J Psychiatry. 2016 05 01; 173(5):509-16. PMID: 26651393.
      View in: PubMed
    55. Freedman R. Publishing what's important. Acta Psychiatr Scand. 2015 Dec; 132(6):417-8. PMID: 26396088.
      View in: PubMed
    56. Ross RG, Freedman R. Endophenotypes in Schizophrenia for the Perinatal Period: Criteria for Validation. Schizophr Bull. 2015 Jul; 41(4):824-34. PMID: 25943124.
      View in: PubMed
    57. Sinkus ML, Graw S, Freedman R, Ross RG, Lester HA, Leonard S. The human CHRNA7 and CHRFAM7A genes: A review of the genetics, regulation, and function. Neuropharmacology. 2015 Sep; 96(Pt B):274-88. PMID: 25701707.
      View in: PubMed
    58. Freedman R. a7-nicotinic acetylcholine receptor agonists for cognitive enhancement in schizophrenia. Annu Rev Med. 2014; 65:245-61. PMID: 24111888.
      View in: PubMed
    59. Diwadkar VA, Murphy ER, Freedman RR. Temporal sequencing of brain activations during naturally occurring thermoregulatory events. Cereb Cortex. 2014 Nov; 24(11):3006-13. PMID: 23787950.
      View in: PubMed
    60. Ross RG, Hunter SK, McCarthy L, Beuler J, Hutchison AK, Wagner BD, Leonard S, Stevens KE, Freedman R. Perinatal choline effects on neonatal pathophysiology related to later schizophrenia risk. Am J Psychiatry. 2013 Mar; 170(3):290-8. PMID: 23318559.
      View in: PubMed
    61. Sinkus ML, Adams CE, Logel J, Freedman R, Leonard S. Expression of immune genes on chromosome 6p21.3-22.1 in schizophrenia. Brain Behav Immun. 2013 Aug; 32:51-62. PMID: 23395714.
      View in: PubMed
    62. Hunter SK, Mendoza JH, D'Anna K, Zerbe GO, McCarthy L, Hoffman C, Freedman R, Ross RG. Antidepressants may mitigate the effects of prenatal maternal anxiety on infant auditory sensory gating. Am J Psychiatry. 2012 Jun; 169(6):616-24. PMID: 22581104.
      View in: PubMed
    63. Stephens SH, Franks A, Berger R, Palionyte M, Fingerlin TE, Wagner B, Logel J, Olincy A, Ross RG, Freedman R, Leonard S. Multiple genes in the 15q13-q14 chromosomal region are associated with schizophrenia. Psychiatr Genet. 2012 Feb; 22(1):1-14. PMID: 21970977.
      View in: PubMed
    64. Olincy A, Freedman R. Nicotinic mechanisms in the treatment of psychotic disorders: a focus on the a7 nicotinic receptor. Handb Exp Pharmacol. 2012; (213):211-32. PMID: 23027417.
      View in: PubMed
    65. Tregellas JR, Tanabe J, Rojas DC, Shatti S, Olincy A, Johnson L, Martin LF, Soti F, Kem WR, Leonard S, Freedman R. Effects of an alpha 7-nicotinic agonist on default network activity in schizophrenia. Biol Psychiatry. 2011 Jan 01; 69(1):7-11. PMID: 20728875.
      View in: PubMed
    66. Hunter SK, Kisley MA, McCarthy L, Freedman R, Ross RG. Diminished cerebral inhibition in neonates associated with risk factors for schizophrenia: parental psychosis, maternal depression, and nicotine use. Schizophr Bull. 2011 Nov; 37(6):1200-8. PMID: 20403924.
      View in: PubMed
    67. Freedman RR. Treatment of menopausal hot flashes with 5-hydroxytryptophan. Maturitas. 2010 Apr; 65(4):383-5. PMID: 20031347.
      View in: PubMed
    68. Ross RG, Stevens KE, Proctor WR, Leonard S, Kisley MA, Hunter SK, Freedman R, Adams CE. Research review: Cholinergic mechanisms, early brain development, and risk for schizophrenia. J Child Psychol Psychiatry. 2010 May; 51(5):535-49. PMID: 19925602.
      View in: PubMed
    69. Freedman R. Learning to review. J Clin Psychiatry. 2009 Nov; 70(11):1599-600. PMID: 20031100.
      View in: PubMed
    70. Freedman R, Goldowitz D. Studies on the hippocampal formation: From basic development to clinical applications: Studies on schizophrenia. Prog Neurobiol. 2010 Feb 09; 90(2):263-75. PMID: 19853005.
      View in: PubMed
    71. Sinkus ML, Lee MJ, Gault J, Logel J, Short M, Freedman R, Christian SL, Lyon J, Leonard S. A 2-base pair deletion polymorphism in the partial duplication of the alpha7 nicotinic acetylcholine gene (CHRFAM7A) on chromosome 15q14 is associated with schizophrenia. Brain Res. 2009 Sep 29; 1291:1-11. PMID: 19631623.
      View in: PubMed
    72. Stephens SH, Logel J, Barton A, Franks A, Schultz J, Short M, Dickenson J, James B, Fingerlin TE, Wagner B, Hodgkinson C, Graw S, Ross RG, Freedman R, Leonard S. Association of the 5'-upstream regulatory region of the alpha7 nicotinic acetylcholine receptor subunit gene (CHRNA7) with schizophrenia. Schizophr Res. 2009 Apr; 109(1-3):102-12. PMID: 19181484.
      View in: PubMed
    73. Simosky JK, Freedman R, Stevens KE. Olanzapine improves deficient sensory inhibition in DBA/2 mice. Brain Res. 2008 Oct 03; 1233:129-36. PMID: 18687314.
      View in: PubMed
    74. Freedman R, Olincy A, Buchanan RW, Harris JG, Gold JM, Johnson L, Allensworth D, Guzman-Bonilla A, Clement B, Ball MP, Kutnick J, Pender V, Martin LF, Stevens KE, Wagner BD, Zerbe GO, Soti F, Kem WR. Initial phase 2 trial of a nicotinic agonist in schizophrenia. Am J Psychiatry. 2008 Aug; 165(8):1040-7. PMID: 18381905.
      View in: PubMed
    75. Martin LF, Hall MH, Ross RG, Zerbe G, Freedman R, Olincy A. Physiology of schizophrenia, bipolar disorder, and schizoaffective disorder. Am J Psychiatry. 2007 Dec; 164(12):1900-6. PMID: 18056246.
      View in: PubMed
    76. Leonard S, Mexal S, Freedman R. Smoking, Genetics and Schizophrenia: Evidence for Self Medication. J Dual Diagn. 2007 Nov 01; 3(3-4):43-59. PMID: 19122786.
      View in: PubMed
    77. Tregellas JR, Davalos DB, Rojas DC, Waldo MC, Gibson L, Wylie K, Du YP, Freedman R. Increased hemodynamic response in the hippocampus, thalamus and prefrontal cortex during abnormal sensory gating in schizophrenia. Schizophr Res. 2007 May; 92(1-3):262-72. PMID: 17336502.
      View in: PubMed
    78. Leonard S, Freedman R. Genetics of chromosome 15q13-q14 in schizophrenia. Biol Psychiatry. 2006 Jul 15; 60(2):115-22. PMID: 16843094.
      View in: PubMed
    79. Mexal S, Berger R, Adams CE, Ross RG, Freedman R, Leonard S. Brain pH has a significant impact on human postmortem hippocampal gene expression profiles. Brain Res. 2006 Aug 23; 1106(1):1-11. PMID: 16843448.
      View in: PubMed
    80. Freedman RR, Roehrs TA. Effects of REM sleep and ambient temperature on hot flash-induced sleep disturbance. Menopause. 2006 Jul-Aug; 13(4):576-83. PMID: 16837879.
      View in: PubMed
    81. Freedman RR, Johanson CE, Tancer ME. Thermoregulatory effects of 3,4-methylenedioxymethamphetamine (MDMA) in humans. Psychopharmacology (Berl). 2005 Dec; 183(2):248-56. PMID: 16163516.
      View in: PubMed
    82. Tanabe J, Tregellas JR, Martin LF, Freedman R. Effects of nicotine on hippocampal and cingulate activity during smooth pursuit eye movement in schizophrenia. Biol Psychiatry. 2006 Apr 15; 59(8):754-61. PMID: 16259965.
      View in: PubMed
    83. Mexal S, Frank M, Berger R, Adams CE, Ross RG, Freedman R, Leonard S. Differential modulation of gene expression in the NMDA postsynaptic density of schizophrenic and control smokers. Brain Res Mol Brain Res. 2005 Oct 03; 139(2):317-32. PMID: 16122832.
      View in: PubMed
    84. Tregellas JR, Tanabe JL, Martin LF, Freedman R. FMRI of response to nicotine during a smooth pursuit eye movement task in schizophrenia. Am J Psychiatry. 2005 Feb; 162(2):391-3. PMID: 15677609.
      View in: PubMed
    85. Freedman R, Ross R, Leonard S, Myles-Worsley M, Adams CE, Waldo M, Tregellas J, Martin L, Olincy A, Tanabe J, Kisley MA, Hunter S, Stevens KE. Early biomarkers of psychosis. Dialogues Clin Neurosci. 2005; 7(1):17-29. PMID: 16060593.
      View in: PubMed
    86. Davalos DB, Kisley MA, Freedman R. Behavioral and electrophysiological indices of temporal processing dysfunction in schizophrenia. J Neuropsychiatry Clin Neurosci. 2005; 17(4):517-25. PMID: 16387992.
      View in: PubMed
    87. Adler LE, Olincy A, Cawthra EM, McRae KA, Harris JG, Nagamoto HT, Waldo MC, Hall MH, Bowles A, Woodward L, Ross RG, Freedman R. Varied effects of atypical neuroleptics on P50 auditory gating in schizophrenia patients. Am J Psychiatry. 2004 Oct; 161(10):1822-8. PMID: 15465979.
      View in: PubMed
    88. Harris JG, Kongs S, Allensworth D, Martin L, Tregellas J, Sullivan B, Zerbe G, Freedman R. Effects of nicotine on cognitive deficits in schizophrenia. Neuropsychopharmacology. 2004 Jul; 29(7):1378-85. PMID: 15138435.
      View in: PubMed
    89. Tregellas JR, Tanabe JL, Miller DE, Ross RG, Olincy A, Freedman R. Neurobiology of smooth pursuit eye movement deficits in schizophrenia: an fMRI study. Am J Psychiatry. 2004 Feb; 161(2):315-21. PMID: 14754781.
      View in: PubMed
    90. Gault J, Hopkins J, Berger R, Drebing C, Logel J, Walton C, Short M, Vianzon R, Olincy A, Ross RG, Adler LE, Freedman R, Leonard S. Comparison of polymorphisms in the alpha7 nicotinic receptor gene and its partial duplication in schizophrenic and control subjects. Am J Med Genet B Neuropsychiatr Genet. 2003 Nov 15; 123B(1):39-49. PMID: 14582144.
      View in: PubMed
    91. Freedman R, Olincy A, Ross RG, Waldo MC, Stevens KE, Adler LE, Leonard S. The genetics of sensory gating deficits in schizophrenia. Curr Psychiatry Rep. 2003 Jun; 5(2):155-61. PMID: 12685995.
      View in: PubMed
    92. Freedman R. Electrophysiological phenotypes. Methods Mol Med. 2003; 77:215-25. PMID: 12298371.
      View in: PubMed
    93. Adams CE, Broide RS, Chen Y, Winzer-Serhan UH, Henderson TA, Leslie FM, Freedman R. Development of the alpha7 nicotinic cholinergic receptor in rat hippocampal formation. Brain Res Dev Brain Res. 2002 Dec 15; 139(2):175-87. PMID: 12480132.
      View in: PubMed
    94. Leonard S, Gault J, Hopkins J, Logel J, Vianzon R, Short M, Drebing C, Berger R, Venn D, Sirota P, Zerbe G, Olincy A, Ross RG, Adler LE, Freedman R. Association of promoter variants in the alpha7 nicotinic acetylcholine receptor subunit gene with an inhibitory deficit found in schizophrenia. Arch Gen Psychiatry. 2002 Dec; 59(12):1085-96. PMID: 12470124.
      View in: PubMed
    95. Tregellas JR, Tanabe JL, Miller DE, Freedman R. Monitoring eye movements during fMRI tasks with echo planar images. Hum Brain Mapp. 2002 Dec; 17(4):237-43. PMID: 12395391.
      View in: PubMed
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    98. Harris JG, Young DA, Rojas DC, Cajade-Law A, Scherzinger A, Nawroz S, Adler LE, Cullum CM, Simon J, Freedman R. Increased hippocampal volume in schizophrenics' parents with ancestral history of schizophrenia. Schizophr Res. 2002 May 01; 55(1-2):11-7. PMID: 11955959.
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    99. Tanabe J, Miller D, Tregellas J, Freedman R, Meyer FG. Comparison of detrending methods for optimal fMRI preprocessing. Neuroimage. 2002 Apr; 15(4):902-7. PMID: 11906230.
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    100. Simosky JK, Stevens KE, Freedman R. Nicotinic agonists and psychosis. Curr Drug Targets CNS Neurol Disord. 2002 Apr; 1(2):149-62. PMID: 12769624.
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    101. Freedman R, Adler LE, Olincy A, Waldo MC, Ross RG, Stevens KE, Leonard S. Input dysfunction, schizotypy, and genetic models of schizophrenia. Schizophr Res. 2002 Mar 01; 54(1-2):25-32. PMID: 11853975.
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    103. Simosky JK, Stevens KE, Kem WR, Freedman R. Intragastric DMXB-A, an alpha7 nicotinic agonist, improves deficient sensory inhibition in DBA/2 mice. Biol Psychiatry. 2001 Oct 01; 50(7):493-500. PMID: 11600102.
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    104. Kisley MA, Olincy A, Freedman R. The effect of state on sensory gating: comparison of waking, REM and non-REM sleep. Clin Neurophysiol. 2001 Jul; 112(7):1154-65. PMID: 11516727.
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    105. Adler LE, Olincy A, Cawthra E, Hoffer M, Nagamoto HT, Amass L, Freedman R. Reversal of diminished inhibitory sensory gating in cocaine addicts by a nicotinic cholinergic mechanism. Neuropsychopharmacology. 2001 Jun; 24(6):671-9. PMID: 11331147.
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    106. Freedman R, Leonard S, Gault JM, Hopkins J, Cloninger CR, Kaufmann CA, Tsuang MT, Farone SV, Malaspina D, Svrakic DM, Sanders A, Gejman P. Linkage disequilibrium for schizophrenia at the chromosome 15q13-14 locus of the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7). Am J Med Genet. 2001 Jan 08; 105(1):20-2. PMID: 11424985.
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    107. Freedman R, Adams CE, Leonard S. The alpha7-nicotinic acetylcholine receptor and the pathology of hippocampal interneurons in schizophrenia. J Chem Neuroanat. 2000 Dec; 20(3-4):299-306. PMID: 11207427.
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    108. Olincy A, Ross RG, Harris JG, Young DA, McAndrews MA, Cawthra E, McRae KA, Sullivan B, Adler LE, Freedman R. The P50 auditory event-evoked potential in adult attention-deficit disorder: comparison with schizophrenia. Biol Psychiatry. 2000 Jun 01; 47(11):969-77. PMID: 10838065.
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    109. Leonard S, Breese C, Adams C, Benhammou K, Gault J, Stevens K, Lee M, Adler L, Olincy A, Ross R, Freedman R. Smoking and schizophrenia: abnormal nicotinic receptor expression. Eur J Pharmacol. 2000 Mar 30; 393(1-3):237-42. PMID: 10771019.
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    110. Waldo MC, Adler LE, Leonard S, Olincy A, Ross RG, Harris JG, Freedman R. Familial transmission of risk factors in the first-degree relatives of schizophrenic people. Biol Psychiatry. 2000 Feb 01; 47(3):231-9. PMID: 10682220.
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    111. Stevens KE, Kem WR, Freedman R. Selective alpha 7 nicotinic receptor stimulation normalizes chronic cocaine-induced loss of hippocampal sensory inhibition in C3H mice. Biol Psychiatry. 1999 Nov 15; 46(10):1443-50. PMID: 10578459.
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    112. Waldo MC, Freedman R. Neurobiological abnormalities in the relatives of schizophrenics. J Psychiatr Res. 1999 Nov-Dec; 33(6):491-5. PMID: 10628524.
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    113. Ross RG, Olincy A, Harris JG, Radant A, Adler LE, Compagnon N, Freedman R. The effects of age on a smooth pursuit tracking task in adults with schizophrenia and normal subjects. Biol Psychiatry. 1999 Aug 01; 46(3):383-91. PMID: 10435204.
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    114. Ross RG, Olincy A, Harris JG, Radant A, Hawkins M, Adler LE, Freedman R. Evidence for bilineal inheritance of physiological indicators of risk in childhood-onset schizophrenia. Am J Med Genet. 1999 Apr 16; 88(2):188-99. PMID: 10206241.
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    115. Freedman R, Adler LE, Leonard S. Alternative phenotypes for the complex genetics of schizophrenia. Biol Psychiatry. 1999 Mar 01; 45(5):551-8. PMID: 10088045.
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    116. Ross RG, Olincy A, Harris JG, Radant A, Adler LE, Freedman R. Anticipatory saccades during smooth pursuit eye movements and familial transmission of schizophrenia. Biol Psychiatry. 1998 Oct 15; 44(8):690-7. PMID: 9798072.
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    117. Freedman R, Adler LE, Nagamoto HT, Waldo MC. Selection of digital filtering parameters and P50 amplitude. Biol Psychiatry. 1998 Jun 15; 43(12):921-2. PMID: 9627749.
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    118. Leonard S, Gault J, Adams C, Breese CR, Rollins Y, Adler LE, Olincy A, Freedman R. Nicotinic receptors, smoking and schizophrenia. Restor Neurol Neurosci. 1998 Jun; 12(2-3):195-201. PMID: 12671315.
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    119. Frazier CJ, Rollins YD, Breese CR, Leonard S, Freedman R, Dunwiddie TV. Acetylcholine activates an alpha-bungarotoxin-sensitive nicotinic current in rat hippocampal interneurons, but not pyramidal cells. J Neurosci. 1998 Feb 15; 18(4):1187-95. PMID: 9454829.
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    120. Adler LE, Olincy A, Waldo M, Harris JG, Griffith J, Stevens K, Flach K, Nagamoto H, Bickford P, Leonard S, Freedman R. Schizophrenia, sensory gating, and nicotinic receptors. Schizophr Bull. 1998; 24(2):189-202. PMID: 9613620.
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    121. Adams CE, Freedman R. Nicotinic antagonist alpha-bungarotoxin binding to rat hippocampal neurons containing nitric oxide synthase. Brain Res. 1997 Nov 21; 776(1-2):111-6. PMID: 9439802.
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    122. Breese CR, Adams C, Logel J, Drebing C, Rollins Y, Barnhart M, Sullivan B, Demasters BK, Freedman R, Leonard S. Comparison of the regional expression of nicotinic acetylcholine receptor alpha7 mRNA and [125I]-alpha-bungarotoxin binding in human postmortem brain. J Comp Neurol. 1997 Oct 27; 387(3):385-98. PMID: 9335422.
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    123. Stevens KE, Freedman R, Collins AC, Hall M, Leonard S, Marks MJ, Rose GM. Genetic correlation of inhibitory gating of hippocampal auditory evoked response and alpha-bungarotoxin-binding nicotinic cholinergic receptors in inbred mouse strains. Neuropsychopharmacology. 1996 Aug; 15(2):152-62. PMID: 8840351.
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    124. Harris JG, Adler LE, Young DA, Cullum CM, Rilling LM, Cicerello A, Intemann PM, Freedman R. Neuropsychological dysfunction in parents of schizophrenics. Schizophr Res. 1996 Jul 05; 20(3):253-60. PMID: 8827851.
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    125. Ross RG, Hommer D, Radant A, Roath M, Freedman R. Early expression of smooth-pursuit eye movement abnormalities in children of schizophrenic parents. J Am Acad Child Adolesc Psychiatry. 1996 Jul; 35(7):941-9. PMID: 8768356.
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    126. Leonard S, Adams C, Breese CR, Adler LE, Bickford P, Byerley W, Coon H, Griffith JM, Miller C, Myles-Worsley M, Nagamoto HT, Rollins Y, Stevens KE, Waldo M, Freedman R. Nicotinic receptor function in schizophrenia. Schizophr Bull. 1996; 22(3):431-45. PMID: 8873294.
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    127. Waldo M, Myles-Worsley M, Madison A, Byerley W, Freedman R. Sensory gating deficits in parents of schizophrenics. Am J Med Genet. 1995 Dec 18; 60(6):506-11. PMID: 8825886.
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    128. Adams CE, DeMasters BK, Freedman R. Regional zinc staining in postmortem hippocampus from schizophrenic patients. Schizophr Res. 1995 Dec; 18(1):71-7. PMID: 8929763.
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    129. Miller CL, Freedman R. The activity of hippocampal interneurons and pyramidal cells during the response of the hippocampus to repeated auditory stimuli. Neuroscience. 1995 Nov; 69(2):371-81. PMID: 8552235.
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    130. Khan AS, Freedman R, Byerley W, Leonard S. Temperature gradient gel electrophoresis analysis of the beta-NGF gene in schizophrenia. J Psychiatry Neurosci. 1995 May; 20(3):199-209. PMID: 7786881.
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    131. Breese CR, Freedman R, Leonard SS. Glutamate receptor subtype expression in human postmortem brain tissue from schizophrenics and alcohol abusers. Brain Res. 1995 Mar 13; 674(1):82-90. PMID: 7773698.
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    132. Freedman R, Adler LE, Bickford P, Byerley W, Coon H, Cullum CM, Griffith JM, Harris JG, Leonard S, Miller C, et al. Schizophrenia and nicotinic receptors. Harv Rev Psychiatry. 1994 Nov-Dec; 2(4):179-92. PMID: 9384901.
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    133. Schultz LD, Markus HZ, Hofmann KJ, Montgomery DL, Dunwiddie CT, Kniskern PJ, Freedman RB, Ellis RW, Tuite MF. Using molecular genetics to improve the production of recombinant proteins by the yeast Saccharomyces cerevisiae. Ann N Y Acad Sci. 1994 May 02; 721:148-57. PMID: 8010665.
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    134. Freedman RS, Bowen JM, Delcos L, Edwards CL, Wallace S, Atkinson EN, Ioannides CG, Kasi LP, Scott W, Patenia R. Active intralymphatic immunotherapy of uterine cervical carcinoma with viral oncolysate: a pilot study. Int J Gynecol Cancer. 1994 Mar; 4(2):101-110. PMID: 11578392.
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    135. Griffith JM, Adler LE, Freedman R. Fine motor performance in schizophrenia. Neuropsychobiology. 1994; 29(4):179-84. PMID: 8047244.
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    136. Adler LE, Hoffer LD, Wiser A, Freedman R. Normalization of auditory physiology by cigarette smoking in schizophrenic patients. Am J Psychiatry. 1993 Dec; 150(12):1856-61. PMID: 8238642.
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    137. Griffith JM, Waldo M, Adler LE, Freedman R. Normalization of auditory sensory gating in schizophrenic patients after a brief period for sleep. Psychiatry Res. 1993 Oct; 49(1):29-39. PMID: 8140180.
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    138. Miller CL, Freedman R. Medial septal neuron activity in relation to an auditory sensory gating paradigm. Neuroscience. 1993 Jul; 55(2):373-80. PMID: 7690909.
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    139. Leonard S, Logel J, Luthman D, Casanova M, Kirch D, Freedman R. Biological stability of mRNA isolated from human postmortem brain collections. Biol Psychiatry. 1993 Mar 15; 33(6):456-66. PMID: 8098224.
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    140. Miller CL, Bickford PC, Luntz-Leybman V, Adler LE, Gerhardt GA, Freedman R. Phencyclidine and auditory sensory gating in the hippocampus of the rat. Neuropharmacology. 1992 Oct; 31(10):1041-8. PMID: 1436386.
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    141. Luntz-Leybman V, Bickford PC, Freedman R. Cholinergic gating of response to auditory stimuli in rat hippocampus. Brain Res. 1992 Jul 31; 587(1):130-6. PMID: 1525643.
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    142. Freedman R, Waldo M, Bickford-Wimer P, Nagamoto H. Elementary neuronal dysfunctions in schizophrenia. Schizophr Res. 1991 Mar-Apr; 4(2):233-43. PMID: 1645590.
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    143. Adler LE, Gerhardt GA, Franks R, Baker N, Nagamoto H, Drebing C, Freedman R. Sensory physiology and catecholamines in schizophrenia and mania. Psychiatry Res. 1990 Mar; 31(3):297-309. PMID: 2333360.
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    144. Drebing CJ, Freedman R, Waldo M, Gerhardt GA. Unconjugated methoxylated catecholamine metabolites in human saliva. Quantitation methodology and comparison with plasma levels. Biomed Chromatogr. 1989 Sep; 3(5):217-20. PMID: 2804429.
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    145. Parfitt KD, Freedman R, Bickford-Wimer PC. Electrophysiological effects of locally applied noradrenergic agents at cerebellar Purkinje neurons: receptor specificity. Brain Res. 1988 Oct 18; 462(2):242-51. PMID: 2847850.
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    146. Hoffer BJ, Rose G, Parfitt K, Freedman R, Bickford-Wimer PC. Age-related changes in cerebellar noradrenergic function. Ann N Y Acad Sci. 1988; 515:269-86. PMID: 3364888.
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    147. Freedman R, Nagamoto H. Brain evoked potentials as predictors of risk. Recent Dev Alcohol. 1988; 6:323-31. PMID: 3363184.
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    148. de la Garza R, McGuire TJ, Freedman R, Hoffer BJ. The electrophysiological effects of nicotine in the rat cerebellum: evidence for direct postsynaptic actions. Neurosci Lett. 1987 Oct 05; 80(3):303-8. PMID: 3683986.
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    149. Gratton A, Hoffer BJ, Freedman R. Electrophysiological effects of phencyclidine in the medial prefrontal cortex of the rat. Neuropharmacology. 1987 Sep; 26(9):1275-83. PMID: 3670556.
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    150. Freedman R, Adler LE, Baker N, Waldo M, Mizner G. Candidate for inherited neurobiological dysfunction in schizophrenia. Somat Cell Mol Genet. 1987 Jul; 13(4):479-84. PMID: 3455019.
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    151. Freedman R, Adler LE, Gerhardt GA, Waldo M, Baker N, Rose GM, Drebing C, Nagamoto H, Bickford-Wimer P, Franks R. Neurobiological studies of sensory gating in schizophrenia. Schizophr Bull. 1987; 13(4):669-78. PMID: 2894074.
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