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Randall B Wilkening

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PEDS
Phone303/724-2872

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    P01HD020761     (HAY, WILLIAM W)Sep 30, 1985 - Jun 30, 2001
    NIH/NICHD
    METABOLIC REGULATION OF FETAL GROWTH
    Role: Co-Principal Investigator

    R01HD041505     (WILKENING, RANDALL B)Jul 1, 2002 - Jun 30, 2008
    NIH/NICHD
    Fetoplacental amino acid metabolism in IUGR pregnancies
    Role: Principal Investigator

    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rozance PJ, Zastoupil L, Wesolowski SR, Goldstrohm DA, Strahan B, Cree-Green M, Sheffield-Moore M, Meschia G, Hay WW, Wilkening RB, Brown LD. Skeletal muscle protein accretion rates and hindlimb growth are reduced in late gestation intrauterine growth restricted fetal sheep. J Physiol. 2017 Sep 22. PMID: 28940557.
      View in: PubMed
    2. Benjamin JS, Culpepper CB, Brown LD, Wesolowski SR, Jonker SS, Davis MA, Limesand SW, Wilkening RB, Hay WW, Rozance PJ. Chronic anemic hypoxemia attenuates glucose-stimulated insulin secretion in fetal sheep. Am J Physiol Regul Integr Comp Physiol. 2017 Apr 01; 312(4):R492-R500. PMID: 28100476.
      View in: PubMed
    3. Houin SS, Rozance PJ, Brown LD, Hay WW, Wilkening RB, Thorn SR. Coordinated changes in hepatic amino acid metabolism and endocrine signals support hepatic glucose production during fetal hypoglycemia. Am J Physiol Endocrinol Metab. 2015 Feb 15; 308(4):E306-14. PMID: 25516551; PMCID: PMC4329495.
    4. Regnault TR, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC, Meschia G. Umbilical uptakes and transplacental concentration ratios of amino acids in severe fetal growth restriction. Pediatr Res. 2013 May; 73(5):602-11. PMID: 23407119.
      View in: PubMed
    5. Clark JA, Alves S, Gundlah C, Rocha B, Birzin ET, Cai SJ, Flick R, Hayes E, Ho K, Warrier S, Pai L, Yudkovitz J, Fleischer R, Colwell L, Li S, Wilkinson H, Schaeffer J, Wilkening R, Mattingly E, Hammond M, Rohrer SP. Selective estrogen receptor-beta (SERM-beta) compounds modulate raphe nuclei tryptophan hydroxylase-1 (TPH-1) mRNA expression and cause antidepressant-like effects in the forced swim test. Neuropharmacology. 2012 Nov; 63(6):1051-63. PMID: 22796107.
      View in: PubMed
    6. Regnault TR, Teng C, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC. The tissue and plasma concentration of polyols and sugars in sheep intrauterine growth retardation. Exp Biol Med (Maywood). 2010 Aug; 235(8):999-1006. PMID: 20576742.
      View in: PubMed
    7. Thorn SR, Regnault TR, Brown LD, Rozance PJ, Keng J, Roper M, Wilkening RB, Hay WW, Friedman JE. Intrauterine growth restriction increases fetal hepatic gluconeogenic capacity and reduces messenger ribonucleic acid translation initiation and nutrient sensing in fetal liver and skeletal muscle. Endocrinology. 2009 Jul; 150(7):3021-30. PMID: 19342452; PMCID: PMC2703533.
    8. de Vrijer B, Davidsen ML, Wilkening RB, Anthony RV, Regnault TR. Altered placental and fetal expression of IGFs and IGF-binding proteins associated with intrauterine growth restriction in fetal sheep during early and mid-pregnancy. Pediatr Res. 2006 Nov; 60(5):507-12. PMID: 16966353.
      View in: PubMed
    9. Regnault TR, de Vrijer B, Galan HL, Wilkening RB, Battaglia FC, Meschia G. Development and mechanisms of fetal hypoxia in severe fetal growth restriction. Placenta. 2007 Jul; 28(7):714-23. PMID: 16962658.
      View in: PubMed
    10. Hagen AS, Orbus RJ, Wilkening RB, Regnault TR, Anthony RV. Placental expression of angiopoietin-1, angiopoietin-2 and tie-2 during placental development in an ovine model of placental insufficiency-fetal growth restriction. Pediatr Res. 2005 Dec; 58(6):1228-32. PMID: 16306198.
      View in: PubMed
    11. Regnault TR, Friedman JE, Wilkening RB, Anthony RV, Hay WW. Fetoplacental transport and utilization of amino acids in IUGR--a review. Placenta. 2005 Apr; 26 Suppl A:S52-62. PMID: 15837069.
      View in: PubMed
    12. Galan HL, Anthony RV, Rigano S, Parker TA, de Vrijer B, Ferrazzi E, Wilkening RB, Regnault TR. Fetal hypertension and abnormal Doppler velocimetry in an ovine model of intrauterine growth restriction. Am J Obstet Gynecol. 2005 Jan; 192(1):272-9. PMID: 15672036.
      View in: PubMed
    13. de Vrijer B, Regnault TR, Wilkening RB, Meschia G, Battaglia FC. Placental uptake and transport of ACP, a neutral nonmetabolizable amino acid, in an ovine model of fetal growth restriction. Am J Physiol Endocrinol Metab. 2004 Dec; 287(6):E1114-24. PMID: 15315907.
      View in: PubMed
    14. Józwik M, Teng C, Wilkening RB, Meschia G, Battaglia FC. Reciprocal inhibition of umbilical uptake within groups of amino acids. Am J Physiol Endocrinol Metab. 2004 Mar; 286(3):E376-83. PMID: 14625207.
      View in: PubMed
    15. Wilkes PT, Meschia G, Teng C, Zhu Y, Wilkening RB, Battaglia FC. The effect of an elevated maternal lysine concentration on placental lysine transport in pregnant sheep. Am J Obstet Gynecol. 2003 Nov; 189(5):1494-500. PMID: 14634591.
      View in: PubMed
    16. Regnault TR, de Vrijer B, Galan HL, Davidsen ML, Trembler KA, Battaglia FC, Wilkening RB, Anthony RV. The relationship between transplacental O2 diffusion and placental expression of PlGF, VEGF and their receptors in a placental insufficiency model of fetal growth restriction. J Physiol. 2003 Jul 15; 550(Pt 2):641-56. PMID: 12740423; PMCID: PMC2343042.
    17. Paolini CL, Teng C, Józwik M, Meschia G, Wilkening RB, Battaglia FC. Umbilical threonine uptake during maternal threonine infusion in sheep. Placenta. 2003 Apr; 24(4):354-60. PMID: 12657509.
      View in: PubMed
    18. Timmerman M, Wilkening RB, Regnault TR. Induction of glutamate dehydrogenase in the ovine fetal liver by dexamethasone infusion during late gestation. Exp Biol Med (Maywood). 2003 Jan; 228(1):100-5. PMID: 12524480.
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    19. Battaglia FC, Regnault TR, Teng C, Wilkening RB, Meschia G. The role of glutamate in fetal hepatic glucogenesis. Forum Nutr. 2003; 56:82-4. PMID: 15806809.
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    20. Teng C, Battaglia FC, Meschia G, Narkewicz MR, Wilkening RB. Fetal hepatic and umbilical uptakes of glucogenic substrates during a glucagon-somatostatin infusion. Am J Physiol Endocrinol Metab. 2002 Mar; 282(3):E542-50. PMID: 11832355.
      View in: PubMed
    21. Teng CC, Tjoa S, Fennessey PV, Wilkening RB, Battaglia FC. Transplacental carbohydrate and sugar alcohol concentrations and their uptakes in ovine pregnancy. Exp Biol Med (Maywood). 2002 Mar; 227(3):189-95. PMID: 11856817.
      View in: PubMed
    22. Regnault TR, Orbus RJ, de Vrijer B, Davidsen ML, Galan HL, Wilkening RB, Anthony RV. Placental expression of VEGF, PlGF and their receptors in a model of placental insufficiency-intrauterine growth restriction (PI-IUGR). Placenta. 2002 Feb-Mar; 23(2-3):132-44. PMID: 11945079.
      View in: PubMed
    23. Józwik M, Teng C, Wilkening RB, Meschia G, Tooze J, Chung M, Battaglia FC. Effects of branched-chain amino acids on placental amino acid transfer and insulin and glucagon release in the ovine fetus. Am J Obstet Gynecol. 2001 Aug; 185(2):487-95. PMID: 11518915.
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    24. Galan HL, Regnault TR, Le Cras TD, Tyson RW, Anthony RV, Wilkening RB, Abman SH. Cotyledon and binucleate cell nitric oxide synthase expression in an ovine model of fetal growth restriction. J Appl Physiol (1985). 2001 Jun; 90(6):2420-6. PMID: 11356809.
      View in: PubMed
    25. Paolini CL, Meschia G, Fennessey PV, Pike AW, Teng C, Battaglia FC, Wilkening RB. An in vivo study of ovine placental transport of essential amino acids. Am J Physiol Endocrinol Metab. 2001 Jan; 280(1):E31-9. PMID: 11120656.
      View in: PubMed
    26. Timmerman M, Teng C, Wilkening RB, Chung M, Battaglia FC. Net amino acid flux across the fetal liver and placenta during spontaneous ovine parturition. Biol Neonate. 2001 Jan; 79(1):54-60. PMID: 11150831.
      View in: PubMed
    27. Timmerman M, Teng C, Wilkening RB, Fennessey P, Battaglia FC, Meschia G. Effect of dexamethasone on fetal hepatic glutamine-glutamate exchange. Am J Physiol Endocrinol Metab. 2000 May; 278(5):E839-45. PMID: 10780940.
      View in: PubMed
    28. Regnault TR, Orbus RJ, Battaglia FC, Wilkening RB, Anthony RV. Altered arterial concentrations of placental hormones during maximal placental growth in a model of placental insufficiency. J Endocrinol. 1999 Sep; 162(3):433-42. PMID: 10467235.
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    29. Holcomb RG, Wilkening RB. Fetal hepatic oxygen consumption under normal conditions in the fetal lamb. Biol Neonate. 1999 May; 75(5):310-8. PMID: 10095145.
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    30. Timmerman M, Chung M, Wilkening RB, Fennessey PV, Battaglia FC, Meschia G. Relationship of fetal alanine uptake and placental alanine metabolism to maternal plasma alanine concentration. Am J Physiol. 1998 Dec; 275(6 Pt 1):E942-50. PMID: 9843735.
      View in: PubMed
    31. Anderson AH, Fennessey PV, Meschia G, Wilkening RB, Battaglia FC. Placental transport of threonine and its utilization in the normal and growth-restricted fetus. Am J Physiol. 1997 May; 272(5 Pt 1):E892-900. PMID: 9176191.
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    32. Barbera A, Wilkening RB, Teng C, Battaglia FC, Meschia G. Metabolic alterations in the fetal hepatic and umbilical circulations during glucocorticoid-induced parturition in sheep. Pediatr Res. 1997 Feb; 41(2):242-8. PMID: 9029646.
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    33. Geddie G, Moores R, Meschia G, Fennessey P, Wilkening R, Battaglia FC. Comparison of leucine, serine and glycine transport across the ovine placenta. Placenta. 1996 Nov; 17(8):619-27. PMID: 8916211.
      View in: PubMed
    34. Ross JC, Fennessey PV, Wilkening RB, Battaglia FC, Meschia G. Placental transport and fetal utilization of leucine in a model of fetal growth retardation. Am J Physiol. 1996 Mar; 270(3 Pt 1):E491-503. PMID: 8638698.
      View in: PubMed
    35. Vaughn PR, Lobo C, Battaglia FC, Fennessey PV, Wilkening RB, Meschia G. Glutamine-glutamate exchange between placenta and fetal liver. Am J Physiol. 1995 Apr; 268(4 Pt 1):E705-11. PMID: 7733270.
      View in: PubMed
    36. Battaglia FC, Wilkening R, Meschia G. Unique organ specific characteristics of amino acid metabolism in early development. Trans Am Clin Climatol Assoc. 1995; 106:141-9; discussion 149-50. PMID: 7483169; PMCID: PMC2376528.
    37. Moores RR, Vaughn PR, Battaglia FC, Fennessey PV, Wilkening RB, Meschia G. Glutamate metabolism in fetus and placenta of late-gestation sheep. Am J Physiol. 1994 Jul; 267(1 Pt 2):R89-96. PMID: 7914073.
      View in: PubMed
    38. Wilkening RB, Boyle DW, Teng C, Meschia G, Battaglia FC. Amino acid uptake by the fetal ovine hindlimb under normal and euglycemic hyperinsulinemic states. Am J Physiol. 1994 Jan; 266(1 Pt 1):E72-8. PMID: 8304446.
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    39. Abman SH, Kinsella JP, Schaffer MS, Wilkening RB. Inhaled nitric oxide in the management of a premature newborn with severe respiratory distress and pulmonary hypertension. Pediatrics. 1993 Oct; 92(4):606-9. PMID: 8414836.
      View in: PubMed
    40. Guyton TS, De Wilt H, Fennessey PV, Meschia G, Wilkening RB, Battaglia FC. Alanine umbilical uptake, disposal rate, and decarboxylation rate in the fetal lamb. Am J Physiol. 1993 Sep; 265(3 Pt 1):E497-503. PMID: 8214057.
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    41. Wilkening RB, Boyle DW, Meschia G. Fetal pH improvement after 24 h of severe, nonlethal hypoxia. Biol Neonate. 1993; 63(2):129-32. PMID: 8448255.
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    42. Boyle DW, Meschia G, Wilkening RB. Metabolic adaptation of fetal hindlimb to severe, nonlethal hypoxia. Am J Physiol. 1992 Nov; 263(5 Pt 2):R1130-5. PMID: 1443231.
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    43. Thureen PJ, Trembler KA, Meschia G, Makowski EL, Wilkening RB. Placental glucose transport in heat-induced fetal growth retardation. Am J Physiol. 1992 Sep; 263(3 Pt 2):R578-85. PMID: 1415644.
      View in: PubMed
    44. Wilkening RB, Meschia G. Current topic: comparative physiology of placental oxygen transport. Placenta. 1992 Jan-Feb; 13(1):1-15. PMID: 1502133.
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    45. Wilkening RB, Meschia G. Effect of occluding one umbilical artery on placental oxygen transport. Am J Physiol. 1991 Apr; 260(4 Pt 2):H1319-25. PMID: 1901461.
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    46. Accurso FJ, Abman SH, Wilkening RB, Worthen GS, Henson P. Fetal pulmonary vasodilation after exogenous platelet-activating factor. J Appl Physiol (1985). 1991 Feb; 70(2):778-87. PMID: 2022570.
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    47. Molina RD, Meschia G, Wilkening RB. Uterine blood flow, oxygen and glucose uptakes at mid-gestation in the sheep. Proc Soc Exp Biol Med. 1990 Dec; 195(3):379-85. PMID: 2259706.
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    48. Boyle DW, Hirst K, Zerbe GO, Meschia G, Wilkening RB. Fetal hind limb oxygen consumption and blood flow during acute graded hypoxia. Pediatr Res. 1990 Aug; 28(2):94-100. PMID: 2395609.
      View in: PubMed
    49. Wilkening RB, Boyle DW. Effect of neuromuscular blockade on fetal oxidative metabolism. Biol Neonate. 1990; 58(1):57-60. PMID: 2390540.
      View in: PubMed
    50. Truog RD, Accurso FJ, Wilkening RB. Fetal pulmonary vasodilation by histamine: response to H1 and H2 stimulation. Dev Pharmacol Ther. 1990; 14(3):180-6. PMID: 1973090.
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    51. Wilkening RB, Boyle DW, Meschia G. Fetal neuromuscular blockade: effect on oxygen demand and placental transport. Am J Physiol. 1989 Sep; 257(3 Pt 2):H734-8. PMID: 2782432.
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    52. Wilkening RB, Meschia G. Effect of umbilical blood flow on transplacental diffusion of ethanol and oxygen. Am J Physiol. 1989 Mar; 256(3 Pt 2):H813-20. PMID: 2923240.
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    53. Conrad PD, Wilkening RB, Rosenberg AA. Safety of newborn discharge in less than 36 hours in an indigent population. Am J Dis Child. 1989 Jan; 143(1):98-101. PMID: 2910053.
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    54. Accurso FJ, Wilkening RB. Fetal pulmonary vasodilation and vasoreactivity during metabolic acidaemia. J Dev Physiol. 1988 Oct; 10(5):411-21. PMID: 3221058.
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    55. Wilkening RB, Molina RD, Meschia G. Placental oxygen transport in sheep with different hemoglobin types. Am J Physiol. 1988 Apr; 254(4 Pt 2):R585-9. PMID: 3354706.
      View in: PubMed
    56. Wilkening RB, Boyle DW, Meschia G. Measurement of blood flow and oxygen consumption in the pelvic limb of fetal sheep. Proc Soc Exp Biol Med. 1988 Apr; 187(4):498-505. PMID: 3353399.
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    57. Accurso FJ, Wilkening RB. Temporal response of the fetal pulmonary circulation to pharmacologic vasodilators. Proc Soc Exp Biol Med. 1988 Jan; 187(1):89-98. PMID: 3340622.
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    58. Abman SH, Accurso FJ, Wilkening RB, Meschia G. Persistent fetal pulmonary hypoperfusion after acute hypoxia. Am J Physiol. 1987 Oct; 253(4 Pt 2):H941-8. PMID: 2889374.
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    59. Bell AW, Wilkening RB, Meschia G. Some aspects of placental function in chronically heat-stressed ewes. J Dev Physiol. 1987 Feb; 9(1):17-29. PMID: 3559063.
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    60. Wilkening RB, Molina RD, Battaglia FC, Meschia G. Effect of insulin on glucose/oxygen and lactate/oxygen quotients across the hindlimb of fetal lambs. Biol Neonate. 1987; 51(1):18-23. PMID: 3548832.
      View in: PubMed
    61. Abman SH, Wilkening RB, Ward RM, Accurso FJ. Adaptation of fetal pulmonary blood flow to local infusion of tolazoline. Pediatr Res. 1986 Nov; 20(11):1131-5. PMID: 3797106.
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    62. Wilkening RB. Transplacental diffusion in a bicornuate uterus: comparison of uterine blood flow and oxygen uptake between horns. Proc Soc Exp Biol Med. 1986 Jun; 182(2):237-44. PMID: 3703876.
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    63. Accurso FJ, Alpert B, Wilkening RB, Petersen RG, Meschia G. Time-dependent response of fetal pulmonary blood flow to an increase in fetal oxygen tension. Respir Physiol. 1986 Jan; 63(1):43-52. PMID: 3081980.
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    64. Wilkening RB, Battaglia FC, Meschia G. The relationship of umbilical glucose uptake to uterine blood flow. J Dev Physiol. 1985 Oct; 7(5):313-9. PMID: 4056337.
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    65. Wilkening RB, Anderson S, Meschia G. Non-steady state placental transfer of highly diffusible molecules. J Dev Physiol. 1984 Apr; 6(2):121-9. PMID: 6725882.
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    66. Hay WW, Sparks JW, Wilkening RB, Battaglia FC, Meschia G. Fetal glucose uptake and utilization as functions of maternal glucose concentration. Am J Physiol. 1984 Mar; 246(3 Pt 1):E237-42. PMID: 6703052.
      View in: PubMed
    67. Hay WW, Sparks JW, Wilkening RB, Battaglia FC, Meschia G. Partition of maternal glucose production between conceptus and maternal tissues in sheep. Am J Physiol. 1983 Oct; 245(4):E347-50. PMID: 6624905.
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    68. Hay WW, Myers SA, Sparks JW, Wilkening RB, Meschia G, Battaglia FC. Glucose and lactate oxidation rates in the fetal lamb. Proc Soc Exp Biol Med. 1983 Sep; 173(4):553-63. PMID: 6412239.
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    69. Wilkening RB, Meschia G. Fetal oxygen uptake, oxygenation, and acid-base balance as a function of uterine blood flow. Am J Physiol. 1983 Jun; 244(6):H749-55. PMID: 6859277.
      View in: PubMed
    70. Wilkening RB, Anderson S, Martensson L, Meschia G. Placental transfer as a function of uterine blood flow. Am J Physiol. 1982 Mar; 242(3):H429-36. PMID: 7065203.
      View in: PubMed
    71. Battaglia FC, Wilkening RB. [Care of very low birth weight newborn infants]. Rev Prat. 1981 Jan 21; 31(5):353-4, 357-8, 361-3. PMID: 7466261.
      View in: PubMed
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