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Thomas Keil Henthorn

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-Anesthesiology
Phone720/848-6723

    Collapse Research 
    Collapse research activities and funding
    R01GM047502     (HENTHORN, THOMAS K)May 1, 1992 - Sep 29, 2004
    NIH/NIGMS
    PULMONARY UPTAKE AND KINETICS OF IV ANESTHETICS
    Role: Principal Investigator

    P01GM047819     (HENTHORN, THOMAS K)Aug 1, 1992 - Jul 31, 1996
    NIH/NIGMS
    ADULT AND PEDIATRIC CLINICAL PHARMACOLOGY
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Jonkman K, Duma A, Olofsen E, Henthorn T, van Velzen M, Mooren R, Siebers L, van den Beukel J, Aarts L, Niesters M, Dahan A. Pharmacokinetics and Bioavailability of Inhaled Esketamine in Healthy Volunteers. Anesthesiology. 2017 Oct; 127(4):675-683. PMID: 28759464.
      View in: PubMed
    2. Klawitter J, Sempio C, Mörlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R, Foreman N, Galinkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MS Assay Using Online Extraction for the Analysis of 11 Cannabinoids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 2017 Oct; 39(5):556-564. PMID: 28640062.
      View in: PubMed
    3. Cohen MN, Christians U, Henthorn T, Vu Tran Z, Moll V, Zuk J, Galinkin J. Pharmacokinetics of single-dose intravenous ketorolac in infants aged 2-11 months. Anesth Analg. 2011 Mar; 112(3):655-60. PMID: 21233498.
      View in: PubMed
    4. Tissot van Patot MC, Serkova NJ, Haschke M, Kominsky DJ, Roach RC, Christians U, Henthorn TK, Honigman B. Enhanced leukocyte HIF-1alpha and HIF-1 DNA binding in humans after rapid ascent to 4300 m. Free Radic Biol Med. 2009 Jun 01; 46(11):1551-7. PMID: 19303436.
      View in: PubMed
    5. Elkiweri IA, Zhang YL, Christians U, Ng KY, Tissot van Patot MC, Henthorn TK. Competitive substrates for P-glycoprotein and organic anion protein transporters differentially reduce blood organ transport of fentanyl and loperamide: pharmacokinetics and pharmacodynamics in Sprague-Dawley rats. Anesth Analg. 2009 Jan; 108(1):149-59. PMID: 19095843; PMCID: PMC2637614.
    6. Avram MJ, Spyker DA, Henthorn TK, Cassella JV. The pharmacokinetics and bioavailability of prochlorperazine delivered as a thermally generated aerosol in a single breath to volunteers. Clin Pharmacol Ther. 2009 Jan; 85(1):71-7. PMID: 18830225.
      View in: PubMed
    7. Henthorn TK, Krejcie TC, Avram MJ. Early drug distribution: a generally neglected aspect of pharmacokinetics of particular relevance to intravenously administered anesthetic agents. Clin Pharmacol Ther. 2008 Jul; 84(1):18-22. PMID: 18563069.
      View in: PubMed
    8. Henthorn TK. The effect of altered physiological states on intravenous anesthetics. Handb Exp Pharmacol. 2008; (182):363-77. PMID: 18175100.
      View in: PubMed
    9. Troiani T, Serkova NJ, Gustafson DL, Henthorn TK, Lockerbie O, Merz A, Long M, Morrow M, Ciardiello F, Eckhardt SG. Investigation of two dosing schedules of vandetanib (ZD6474), an inhibitor of vascular endothelial growth factor receptor and epidermal growth factor receptor signaling, in combination with irinotecan in a human colon cancer xenograft model. Clin Cancer Res. 2007 Nov 01; 13(21):6450-8. PMID: 17975157.
      View in: PubMed
    10. Wischmeyer PE, Johnson BR, Wilson JE, Dingmann C, Bachman HM, Roller E, Tran ZV, Henthorn TK. A survey of propofol abuse in academic anesthesia programs. Anesth Analg. 2007 Oct; 105(4):1066-71, table of contents. PMID: 17898389.
      View in: PubMed
    11. Avram MJ, Henthorn TK, Spyker DA, Krejcie TC, Lloyd PM, Cassella JV, Rabinowitz JD. Recirculatory pharmacokinetic model of the uptake, distribution, and bioavailability of prochlorperazine administered as a thermally generated aerosol in a single breath to dogs. Drug Metab Dispos. 2007 Feb; 35(2):262-7. PMID: 17079359.
      View in: PubMed
    12. Fisher J, Hirshman E, Henthorn T, Arndt J, Passannante A. Midazolam amnesia and short-term/working memory processes. Conscious Cogn. 2006 Mar; 15(1):54-63. PMID: 16546038.
      View in: PubMed
    13. Avram MJ, Krejcie TC, Henthorn TK, Niemann CU. Beta-adrenergic blockade affects initial drug distribution due to decreased cardiac output and altered blood flow distribution. J Pharmacol Exp Ther. 2004 Nov; 311(2):617-24. PMID: 15197245.
      View in: PubMed
    14. Ng KY, Cho CW, Henthorn TK, Tanguay RL. Effect of heat preconditioning on the uptake and permeability of R123 in brain microvessel endothelial cells during mild heat treatment. J Pharm Sci. 2004 Apr; 93(4):896-907. PMID: 14999727.
      View in: PubMed
    15. Hirshman E, Fisher J, Henthorn T, Arndt J, Passannante A. Midazolam amnesia and retrieval from semantic memory: Developing methods to test theories of implicit memory. Brain Cogn. 2003 Dec; 53(3):427-32. PMID: 14642292.
      View in: PubMed
    16. Minto CF, Schnider TW, Gregg KM, Henthorn TK, Shafer SL. Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics. Anesthesiology. 2003 Aug; 99(2):324-33. PMID: 12883405.
      View in: PubMed
    17. Henthorn TK. Recirculatory pharmacokinetics. Which covariates affect the pharmacokinetics of intravenous agents? Adv Exp Med Biol. 2003; 523:27-33. PMID: 15088837.
      View in: PubMed
    18. Mandell MS, Wachs M, Niemann CU, Henthorn TK. Elimination of indocyanine green in the perioperative evaluation of donor liver function. Anesth Analg. 2002 Nov; 95(5):1182-4, table of contents. PMID: 12401588.
      View in: PubMed
    19. Avram MJ, Krejcie TC, Henthorn TK. The concordance of early antipyrine and thiopental distribution kinetics. J Pharmacol Exp Ther. 2002 Aug; 302(2):594-600. PMID: 12130720.
      View in: PubMed
    20. Cho CW, Liu Y, Cobb WN, Henthorn TK, Lillehei K, Christians U, Ng KY. Ultrasound-induced mild hyperthermia as a novel approach to increase drug uptake in brain microvessel endothelial cells. Pharm Res. 2002 Aug; 19(8):1123-9. PMID: 12240937.
      View in: PubMed
    21. Niemann CU, Yost CS, Mandell S, Henthorn TK. Evaluation of the splanchnic circulation with indocyanine green pharmacokinetics in liver transplant patients. Liver Transpl. 2002 May; 8(5):476-81. PMID: 12004348.
      View in: PubMed
    22. Liu Y, Cho CW, Yan X, Henthorn TK, Lillehei KO, Cobb WN, Ng KY. Ultrasound-Induced hyperthermia increases cellular uptake and cytotoxicity of P-glycoprotein substrates in multi-drug resistant cells. Pharm Res. 2001 Sep; 18(9):1255-61. PMID: 11683237.
      View in: PubMed
    23. Birmingham PK, Tobin MJ, Fisher DM, Henthorn TK, Hall SC, Coté CJ. Initial and subsequent dosing of rectal acetaminophen in children: a 24-hour pharmacokinetic study of new dose recommendations. Anesthesiology. 2001 Mar; 94(3):385-9. PMID: 11374595.
      View in: PubMed
    24. Cho CW, Liu Y, Yan X, Henthorn T, Ng KY. Carrier-mediated uptake of rhodamine 123: implications on its use for MDR research. Biochem Biophys Res Commun. 2000 Dec 09; 279(1):124-30. PMID: 11112427.
      View in: PubMed
    25. Avram MJ, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Henthorn TK. Isoflurane alters the recirculatory pharmacokinetics of physiologic markers. Anesthesiology. 2000 Jun; 92(6):1757-68. PMID: 10839928.
      View in: PubMed
    26. Niemann CU, Henthorn TK, Krejcie TC, Shanks CA, Enders-Klein C, Avram MJ. Indocyanine green kinetics characterize blood volume and flow distribution and their alteration by propranolol. Clin Pharmacol Ther. 2000 Apr; 67(4):342-50. PMID: 10801242.
      View in: PubMed
    27. Gonzalez R, Ebbinghaus S, Henthorn TK, Miller D, Kraft AS. Treatment of patients with metastatic melanoma with bryostatin-1--a phase II study. Melanoma Res. 1999 Dec; 9(6):599-606. PMID: 10661772.
      View in: PubMed
    28. Henthorn TK, Krejcie TC, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ. Ketamine distribution described by a recirculatory pharmacokinetic model is not stereoselective. Anesthesiology. 1999 Dec; 91(6):1733-43. PMID: 10598617.
      View in: PubMed
    29. Krejcie TC, Henthorn TK, Gentry WB, Niemann CU, Enders-Klein C, Shanks CA, Avram MJ. Modifications of blood volume alter the disposition of markers of blood volume, extracellular fluid, and total body water. J Pharmacol Exp Ther. 1999 Dec; 291(3):1308-16. PMID: 10565856.
      View in: PubMed
    30. Mandell MS, Henthorn T. Fibrinolysis in patients with fulminant hepatic failure. Liver Transpl Surg. 1999 Sep; 5(5):464. PMID: 10523124.
      View in: PubMed
    31. Henthorn TK, Liu Y, Mahapatro M, Ng KY. Active transport of fentanyl by the blood-brain barrier. J Pharmacol Exp Ther. 1999 May; 289(2):1084-9. PMID: 10215691.
      View in: PubMed
    32. Waters CM, Avram MJ, Krejcie TC, Henthorn TK. Uptake of fentanyl in pulmonary endothelium. J Pharmacol Exp Ther. 1999 Jan; 288(1):157-63. PMID: 9862766.
      View in: PubMed
    33. Henthorn TK, Krejcie TC, Avram MJ, Jensen TR, Waters CM. Transporter-mediated pulmonary endothelial uptake of fentanyl. Int J Clin Pharmacol Ther. 1998 Feb; 36(2):74-5. PMID: 9520148.
      View in: PubMed
    34. Dsida RM, Wheeler M, Birmingham PK, Henthorn TK, Avram MJ, Enders-Klein C, Maddalozzo J, Coté CJ. Premedication of pediatric tonsillectomy patients with oral transmucosal fentanyl citrate. Anesth Analg. 1998 Jan; 86(1):66-70. PMID: 9428853.
      View in: PubMed
    35. Avram MJ, Krejcie TC, Niemann CU, Klein C, Gentry WB, Shanks CA, Henthorn TK. The effect of halothane on the recirculatory pharmacokinetics of physiologic markers. Anesthesiology. 1997 Dec; 87(6):1381-93. PMID: 9416724.
      View in: PubMed
    36. Birmingham PK, Tobin MJ, Henthorn TK, Fisher DM, Berkelhamer MC, Smith FA, Fanta KB, Coté CJ. Twenty-four-hour pharmacokinetics of rectal acetaminophen in children: an old drug with new recommendations. Anesthesiology. 1997 Aug; 87(2):244-52. PMID: 9286887.
      View in: PubMed
    37. O'Hara DA, Hexem JG, Derbyshire GJ, Overdyk FJ, Chen B, Henthorn TK, Li KJ. The use of a PID controller to model vecuronium pharmacokinetics and pharmacodynamics during liver transplantation. Proportional-integral-derivative. IEEE Trans Biomed Eng. 1997 Jul; 44(7):610-9. PMID: 9210821.
      View in: PubMed
    38. Krejcie TC, Avram MJ, Gentry WB, Niemann CU, Janowski MP, Henthorn TK. A recirculatory model of the pulmonary uptake and pharmacokinetics of lidocaine based on analysis of arterial and mixed venous data from dogs. J Pharmacokinet Biopharm. 1997 Apr; 25(2):169-90. PMID: 9408858.
      View in: PubMed
    39. Krejcie TC, Jacquez JA, Avram MJ, Niemann CU, Shanks CA, Henthorn TK. Use of parallel Erlang density functions to analyze first-pass pulmonary uptake of multiple indicators in dogs. J Pharmacokinet Biopharm. 1996 Dec; 24(6):569-88. PMID: 9300351.
      View in: PubMed
    40. Krejcie TC, Henthorn TK, Niemann CU, Klein C, Gupta DK, Gentry WB, Shanks CA, Avram MJ. Recirculatory pharmacokinetic models of markers of blood, extracellular fluid and total body water administered concomitantly. J Pharmacol Exp Ther. 1996 Sep; 278(3):1050-7. PMID: 8819485.
      View in: PubMed
    41. Gentry WB, Krejcie TC, Henthorn TK, Avram MJ. Induction and maintenance of anesthesia in dogs by intravenous administration of methohexital. Am J Vet Res. 1996 Jul; 57(7):1044-9. PMID: 8807019.
      View in: PubMed
    42. Shanks CA, Avram MJ, Krejcie TC, Henthorn TK. Calculation of an effect compartment rate constant using recovery indices obtained with an isolated arm technique. Br J Anaesth. 1995 Jul; 75(1):109-12. PMID: 7669449.
      View in: PubMed
    43. Gentry WB, Krejcie TC, Henthorn TK, Shanks CA, Howard KA, Gupta DK, Avram MJ. Effect of infusion rate on thiopental dose-response relationships. Assessment of a pharmacokinetic-pharmacodynamic model. Anesthesiology. 1994 Aug; 81(2):316-24; discussion 25A. PMID: 8053580.
      View in: PubMed
    44. Krejcie TC, Henthorn TK, Shanks CA, Avram MJ. A recirculatory pharmacokinetic model describing the circulatory mixing, tissue distribution and elimination of antipyrine in dogs. J Pharmacol Exp Ther. 1994 May; 269(2):609-16. PMID: 8182527.
      View in: PubMed
    45. Shanks CA, Avram MJ, Krejcie TC, Henthorn TK, Gentry WB. A pharmacokinetic-pharmacodynamic model for quantal responses with thiopental. J Pharmacokinet Biopharm. 1993 Jun; 21(3):309-21. PMID: 8258770.
      View in: PubMed
    46. Avram MJ, Sanghvi R, Henthorn TK, Krejcie TC, Shanks CA, Fragen RJ, Howard KA, Kaczynski DA. Determinants of thiopental induction dose requirements. Anesth Analg. 1993 Jan; 76(1):10-7. PMID: 8418708.
      View in: PubMed
    47. Henthorn TK, Krejcie TC, Shanks CA, Avram MJ. Time-dependent distribution volume and kinetics of the pharmacodynamic effector site. J Pharm Sci. 1992 Nov; 81(11):1136-8. PMID: 1447720.
      View in: PubMed
    48. Henthorn TK, Krejcie TC, Avram MJ. The relationship between alfentanil distribution kinetics and cardiac output. Clin Pharmacol Ther. 1992 Aug; 52(2):190-6. PMID: 1505154.
      View in: PubMed
    49. Henthorn TK, Avram MJ, Krejcie TC, Shanks CA, Asada A, Kaczynski DA. Minimal compartmental model of circulatory mixing of indocyanine green. Am J Physiol. 1992 Mar; 262(3 Pt 2):H903-10. PMID: 1558199.
      View in: PubMed
    50. Avram MJ, Krejcie TC, Henthorn TK. The relationship of age to the pharmacokinetics of early drug distribution: the concurrent disposition of thiopental and indocyanine green. Anesthesiology. 1990 Mar; 72(3):403-11. PMID: 2310019.
      View in: PubMed
    51. Henthorn TK, Avram MJ, Krejcie TC. Alfentanil clearance is independent of the polymorphic debrisoquin hydroxylase. Anesthesiology. 1989 Nov; 71(5):635-9. PMID: 2817455.
      View in: PubMed
    52. Bertilsson L, Henthorn TK, Sanz E, Tybring G, Säwe J, Villén T. Importance of genetic factors in the regulation of diazepam metabolism: relationship to S-mephenytoin, but not debrisoquin, hydroxylation phenotype. Clin Pharmacol Ther. 1989 Apr; 45(4):348-55. PMID: 2495208.
      View in: PubMed
    53. Henthorn TK, Benitez J, Avram MJ, Martinez C, Llerena A, Cobaleda J, Krejcie TC, Gibbons RD. Assessment of the debrisoquin and dextromethorphan phenotyping tests by gaussian mixture distributions analysis. Clin Pharmacol Ther. 1989 Mar; 45(3):328-33. PMID: 2920506.
      View in: PubMed
    54. Henthorn TK, Spina E, Dumont E, von Bahr C. In vitro inhibition of a polymorphic human liver P-450 isozyme by narcotic analgesics. Anesthesiology. 1989 Feb; 70(2):339-42. PMID: 2563318.
      View in: PubMed
    55. Ambre JJ, Connelly TJ, Ruo TI, Henthorn TK. Induction and loss of acute tolerance to the cardiac chronotropic effect of cocaine in humans. NIDA Res Monogr. 1989; 95:355-6. PMID: 2640993.
      View in: PubMed
    56. Henthorn TK, Avram MJ, Krejcie TC. Intravascular mixing and drug distribution: the concurrent disposition of thiopental and indocyanine green. Clin Pharmacol Ther. 1989 Jan; 45(1):56-65. PMID: 2910638.
      View in: PubMed
    57. Katz JA, Kaeding CS, Hill JR, Henthorn TK. The pharmacokinetics of bupivacaine when injected intra-articularly after knee arthroscopy. Anesth Analg. 1988 Sep; 67(9):872-5. PMID: 3414999.
      View in: PubMed
    58. Avram MJ, Shanks CA, Henthorn TK, Ronai AK, Kinzer J, Wilkinson CJ. Metocurine kinetics in patients undergoing operations requiring cardiopulmonary bypass. Clin Pharmacol Ther. 1987 Nov; 42(5):576-81. PMID: 3315392.
      View in: PubMed
    59. Avram MJ, Henthorn TK, Shanks CA, Krejcie TC. The initial rate of change in distribution volume is the sum of intercompartmental clearances. J Pharm Sci. 1986 Sep; 75(9):919-20. PMID: 3783465.
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    60. Avram MJ, Henthorn TK, Krejcie TC. Assay for serum sufentanil level is not sensitive. Anesthesiology. 1986 Jul; 65(1):110-2. PMID: 2942059.
      View in: PubMed
    61. Atkinson AJ, Henthorn TK. Thiopental anesthesia in the elderly. Anesthesiology. 1985 Jun; 62(6):706-7. PMID: 4003791.
      View in: PubMed
    62. Spina E, Henthorn TK, Eleborg L, Nordin C, Säwe J. Desmethylimipramine overdose: nonlinear kinetics in a slow hydroxylator. Ther Drug Monit. 1985; 7(2):239-41. PMID: 4024220.
      View in: PubMed
    63. Frederiksen MC, Bowsher DJ, Ruo TI, Henthorn TK, Ts'ao CH, Green D, Atkinson AJ. Kinetics of epsilon-aminocaproic acid distribution, elimination, and antifibrinolytic effects in normal subjects. Clin Pharmacol Ther. 1984 Mar; 35(3):387-93. PMID: 6697646.
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    64. Fragen RJ, Avram MJ, Henthorn TK, Caldwell NJ. A pharmacokinetically designed etomidate infusion regimen for hypnosis. Anesth Analg. 1983 Jul; 62(7):654-60. PMID: 6859568.
      View in: PubMed
    65. Frederiksen MC, Henthorn TK, Ruo TI, Atkinson AJ. Pharmacokinetics of pentobarbital in the dog. J Pharmacol Exp Ther. 1983 May; 225(2):355-60. PMID: 6842399.
      View in: PubMed
    66. Shanks CA, Funk DI, Avram MJ, Henthorn TK. Gallamine administered by combined bolus and infusion. Anesth Analg. 1982 Oct; 61(10):847-52. PMID: 6289700.
      View in: PubMed
    67. Henthorn TK, Avram MJ, Frederiksen MC, Atkinson AJ. Heterogeneity of interstitial fluid space demonstrated by simultaneous kinetic analysis of the distribution and elimination of inulin and gallamine. J Pharmacol Exp Ther. 1982 Aug; 222(2):389-94. PMID: 7097559.
      View in: PubMed
    68. Ruo TI, Morita Y, Atkinson AJ, Henthorn T, Thenot JP. Identification of desethyl procainamide in patients: a new metabolite of procainamide. J Pharmacol Exp Ther. 1981 Feb; 216(2):357-62. PMID: 6162026.
      View in: PubMed
    69. Stec GP, Greenberger P, Ruo TI, Henthorn T, Morita Y, Atkinson AJ, Patterson R. Kinetics of theophylline transfer to breast milk. Clin Pharmacol Ther. 1980 Sep; 28(3):404-8. PMID: 7408400.
      View in: PubMed
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