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Daniel N Frank

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus

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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Dillon SM, Castleman MJ, Frank DN, Austin GL, Gianella S, Cogswell AC, Landay AL, Barker E, Wilson CC. Brief Report: Inflammatory Colonic Innate Lymphoid Cells Are Increased During Untreated HIV-1 Infection and Associated With Markers of Gut Dysbiosis and Mucosal Immune Activation. J Acquir Immune Defic Syndr. 2017 Dec 01; 76(4):431-437. PMID: 28825942.
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    2. Liu C, Frank DN, Horch M, Chau S, Ir D, Horch EA, Tretina K, van Besien K, Lozupone CA, Nguyen VH. Associations between acute gastrointestinal GvHD and the baseline gut microbiota of allogeneic hematopoietic stem cell transplant recipients and donors. Bone Marrow Transplant. 2017 Oct 02. PMID: 28967895.
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    3. Sokoya M, Ramakrishnan VR, Frank DN, Rahkola J, Getz A, Kingdom TT, Kofonow JM, Nguyen Q, Janoff EN. Expression of immunoglobulin D is increased in chronic rhinosinusitis. Ann Allergy Asthma Immunol. 2017 Oct; 119(4):317-323.e1. PMID: 28958373.
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    4. Needell JC, Ir D, Robertson CE, Kroehl ME, Frank DN, Zipris D. Maternal treatment with short-chain fatty acids modulates the intestinal microbiota and immunity and ameliorates type 1 diabetes in the offspring. PLoS One. 2017; 12(9):e0183786. PMID: 28886045.
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    5. Xiong X, Bales ES, Ir D, Robertson CE, McManaman JL, Frank DN, Parkinson J. Perilipin-2 modulates dietary fat-induced microbial global gene expression profiles in the mouse intestine. Microbiome. 2017 Sep 06; 5(1):117. PMID: 28877764.
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    6. Kuhn KA, Schulz HM, Regner EH, Severs EL, Hendrickson JD, Mehta G, Whitney AK, Ir D, Ohri N, Robertson CE, Frank DN, Campbell EL, Colgan SP. Bacteroidales recruit IL-6-producing intraepithelial lymphocytes in the colon to promote barrier integrity. Mucosal Immunol. 2017 Aug 16. PMID: 28812548.
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    7. Tang M, Frank DN, Hendricks AE, Ir D, Esamai F, Liechty E, Hambidge KM, Krebs NF. Iron in Micronutrient Powder Promotes an Unfavorable Gut Microbiota in Kenyan Infants. Nutrients. 2017 Jul 19; 9(7). PMID: 28753958.
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    8. Needell JC, Dinarello CA, Ir D, Robertson CE, Ryan SM, Kroehl ME, Frank DN, Zipris D. Implication of the intestinal microbiome as a potential surrogate marker of immune responsiveness to experimental therapies in autoimmune diabetes. PLoS One. 2017; 12(3):e0173968. PMID: 28301545.
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    9. McCollister B, Kotter CV, Frank DN, Washburn T, Jobling MG. Erratum for McCollister et al., Whole-Genome Sequencing Identifies In Vivo Acquisition of a blaCTX-M-27-Carrying IncFII Transmissible Plasmid as the Cause of Ceftriaxone Treatment Failure for an Invasive Salmonella enterica Serovar Typhimurium Infection. Antimicrob Agents Chemother. 2017 Mar; 61(3). PMID: 28232307.
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    10. Dillon SM, Kibbie J, Lee EJ, Guo K, Santiago ML, Austin GL, Gianella S, Landay AL, Donovan AM, Frank DN, McCARTER MD, Wilson CC. Low abundance of colonic butyrate-producing bacteria in HIV infection is associated with microbial translocation and immune activation. AIDS. 2017 Feb 20; 31(4):511-521. PMID: 28002063.
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    11. Rick AM, Aguilar A, Cortes R, Gordillo R, Melgar M, Samayoa-Reyes G, Frank DN, Asturias EJ. Group B Streptococci Colonization in Pregnant Guatemalan Women: Prevalence, Risk Factors, and Vaginal Microbiome. Open Forum Infect Dis. 2017; 4(1):ofx020. PMID: 28480290.
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    12. Liu J, Williams B, Frank D, Dillon SM, Wilson CC, Landay AL. Inside Out: HIV, the Gut Microbiome, and the Mucosal Immune System. J Immunol. 2017 Jan 15; 198(2):605-614. PMID: 28069756.
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    13. Friedman JE, Young BE, Lemas DJ, Barbour LA, Frank DN, Santorico SA. Reply to M Gotteland and F Magne. Am J Clin Nutr. 2017 Jan; 105(1):234-236. PMID: 28049665.
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    14. Dillon SM, Frank DN, Wilson CC. The gut microbiome and HIV-1 pathogenesis: a two-way street. AIDS. 2016 Nov 28; 30(18):2737-2751. PMID: 27755100.
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    15. McCollister B, Kotter CV, Frank DN, Washburn T, Jobling MG. Whole-Genome Sequencing Identifies In Vivo Acquisition of a blaCTX-M-27-Carrying IncFII Transmissible Plasmid as the Cause of Ceftriaxone Treatment Failure for an Invasive Salmonella enterica Serovar Typhimurium Infection. Antimicrob Agents Chemother. 2016 Dec; 60(12):7224-7235. PMID: 27671066.
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    16. Ramakrishnan VR, Gitomer S, Kofonow JM, Robertson CE, Frank DN. Investigation of sinonasal microbiome spatial organization in chronic rhinosinusitis. Int Forum Allergy Rhinol. 2017 Jan; 7(1):16-23. PMID: 27627048.
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    17. Tang M, Frank DN, Sherlock L, Ir D, Robertson CE, Krebs NF. Effect of Vitamin E With Therapeutic Iron Supplementation on Iron Repletion and Gut Microbiome in US Iron Deficient Infants and Toddlers. J Pediatr Gastroenterol Nutr. 2016 Sep; 63(3):379-85. PMID: 27548249; PMCID: PMC4994979 [Available on 09/01/17].
    18. Brumbaugh DE, Arruda J, Robbins K, Ir D, Santorico SA, Robertson CE, Frank DN. Mode of Delivery Determines Neonatal Pharyngeal Bacterial Composition and Early Intestinal Colonization. J Pediatr Gastroenterol Nutr. 2016 Sep; 63(3):320-8. PMID: 27035381.
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    19. Barron MA, Frank DN, Claypool D, Ir D, Ning MF, Curtis D, Weinberg A. Antibody responses to influenza a H1N1 vaccine compared to the circulating strain in influenza vaccine recipients during the 2013/2014 season in North America. J Clin Virol. 2016 Oct; 83:56-60. PMID: 27591557.
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    20. Jobling MG, Raleigh EA, Frank DN. Complete Genome Sequence of Escherichia coli ER1821R, a Laboratory K-12 Derivative Engineered To Be Deficient in All Methylcytosine and Methyladenine Restriction Systems. Genome Announc. 2016 Aug 11; 4(4). PMID: 27516504; PMCID: PMC4982283.
    21. Lemas DJ, Young BE, Baker PR, Tomczik AC, Soderborg TK, Hernandez TL, de la Houssaye BA, Robertson CE, Rudolph MC, Ir D, Patinkin ZW, Krebs NF, Santorico SA, Weir T, Barbour LA, Frank DN, Friedman JE. Alterations in human milk leptin and insulin are associated with early changes in the infant intestinal microbiome. Am J Clin Nutr. 2016 May; 103(5):1291-300. PMID: 27140533; PMCID: PMC4841936 [Available on 05/01/17].
    22. Jarrett MJ, Vázquez-Torres A, Frank DN, McCollister BD, Henthorn PK, Ir D, Sheeder J, Guy MS, Anwar HQ, Behbakht K. Influence of Gelatin-Thrombin Matrix Tissue Sealant on Bacterial Colony Formation and Risk of Pelvic Infection. Infect Dis Obstet Gynecol. 2016; 2016:2649708. PMID: 27199534; PMCID: PMC4856941.
    23. Weinberg A, Curtis D, Ning MF, Claypool DJ, Jalbert E, Patterson J, Frank DN, Ir D, Armon C. Immune Responses to Circulating and Vaccine Viral Strains in HIV-Infected and Uninfected Children and Youth Who Received the 2013/2014 Quadrivalent Live-Attenuated Influenza Vaccine. Front Immunol. 2016; 7:142. PMID: 27148262; PMCID: PMC4831981.
    24. Hauser LJ, Ir D, Kingdom TT, Robertson CE, Frank DN, Ramakrishnan VR. Evaluation of bacterial transmission to the paranasal sinuses through sinus irrigation. Int Forum Allergy Rhinol. 2016 Aug; 6(8):800-6. PMID: 26990369.
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    25. Ramakrishnan VR, Hauser LJ, Frank DN. The sinonasal bacterial microbiome in health and disease. Curr Opin Otolaryngol Head Neck Surg. 2016 Feb; 24(1):20-5. PMID: 26575518; PMCID: PMC4751043.
    26. Orlandi RR, Kingdom TT, Hwang PH, Smith TL, Alt JA, Baroody FM, Batra PS, Bernal-Sprekelsen M, Bhattacharyya N, Chandra RK, Chiu A, Citardi MJ, Cohen NA, DelGaudio J, Desrosiers M, Dhong HJ, Douglas R, Ferguson B, Fokkens WJ, Georgalas C, Goldberg A, Gosepath J, Hamilos DL, Han JK, Harvey R, Hellings P, Hopkins C, Jankowski R, Javer AR, Kern R, Kountakis S, Kowalski ML, Lane A, Lanza DC, Lebowitz R, Lee HM, Lin SY, Lund V, Luong A, Mann W, Marple BF, McMains KC, Metson R, Naclerio R, Nayak JV, Otori N, Palmer JN, Parikh SR, Passali D, Peters A, Piccirillo J, Poetker DM, Psaltis AJ, Ramadan HH, Ramakrishnan VR, Riechelmann H, Roh HJ, Rudmik L, Sacks R, Schlosser RJ, Senior BA, Sindwani R, Stankiewicz JA, Stewart M, Tan BK, Toskala E, Voegels R, Wang de Y, Weitzel EK, Wise S, Woodworth BA, Wormald PJ, Wright ED, Zhou B, Kennedy DW. International Consensus Statement on Allergy and Rhinology: Rhinosinusitis. Int Forum Allergy Rhinol. 2016 Feb; 6 Suppl 1:S22-209. PMID: 26889651.
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    27. Pandrea I, Xu C, Stock JL, Frank DN, Ma D, Policicchio BB, He T, Kristoff J, Cornell E, Haret-Richter GS, Trichel A, Ribeiro RM, Tracy R, Wilson C, Landay AL, Apetrei C. Antibiotic and Antiinflammatory Therapy Transiently Reduces Inflammation and Hypercoagulation in Acutely SIV-Infected Pigtailed Macaques. PLoS Pathog. 2016 Jan; 12(1):e1005384. PMID: 26764484; PMCID: PMC4713071.
    28. Dillon SM, Lee EJ, Donovan AM, Guo K, Harper MS, Frank DN, McCarter MD, Santiago ML, Wilson CC. Enhancement of HIV-1 infection and intestinal CD4+ T cell depletion ex vivo by gut microbes altered during chronic HIV-1 infection. Retrovirology. 2016 Jan 14; 13:5. PMID: 26762145; PMCID: PMC4712466.
    29. Lee JT, Frank DN, Ramakrishnan V. Microbiome of the paranasal sinuses: Update and literature review. Am J Rhinol Allergy. 2016 Jan-Feb; 30(1):3-16. PMID: 26867525.
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    30. Shukla SK, Cook D, Meyer J, Vernon SD, Le T, Clevidence D, Robertson CE, Schrodi SJ, Yale S, Frank DN. Changes in Gut and Plasma Microbiome following Exercise Challenge in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). PLoS One. 2015; 10(12):e0145453. PMID: 26683192; PMCID: PMC4684203.
    31. Handorean A, Robertson CE, Harris JK, Frank D, Hull N, Kotter C, Stevens MJ, Baumgardner D, Pace NR, Hernandez M. Microbial aerosol liberation from soiled textiles isolated during routine residuals handling in a modern health care setting. Microbiome. 2015 Dec 09; 3:72. PMID: 26646166; PMCID: PMC4673858.
    32. Wagner BD, Frank DN, Zipris D. Response to Comment on Alkanani et al. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes 2015;64:3510-3520. Diabetes. 2015 Oct; 64(10):e41. PMID: 26405282.
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    33. Son JS, Zheng LJ, Rowehl LM, Tian X, Zhang Y, Zhu W, Litcher-Kelly L, Gadow KD, Gathungu G, Robertson CE, Ir D, Frank DN, Li E. Comparison of Fecal Microbiota in Children with Autism Spectrum Disorders and Neurotypical Siblings in the Simons Simplex Collection. PLoS One. 2015; 10(10):e0137725. PMID: 26427004; PMCID: PMC4591364.
    34. Yi J, Slaughter A, Kotter CV, Moore EE, Hauser CJ, Itagaki K, Wohlauer M, Frank DN, Silliman C, Banerjee A, Peltz E. A "CLEAN CASE" OF SYSTEMIC INJURY: MESENTERIC LYMPH AFTER HEMORRHAGIC SHOCK ELICITS A STERILE INFLAMMATORY RESPONSE. Shock. 2015 Oct; 44(4):336-40. PMID: 26196840; PMCID: PMC4575624 [Available on 10/01/16].
    35. Hauser LJ, Ir D, Kingdom TT, Robertson CE, Frank DN, Ramakrishnan VR. Investigation of bacterial repopulation after sinus surgery and perioperative antibiotics. Int Forum Allergy Rhinol. 2016 Jan; 6(1):34-40. PMID: 26388320.
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    36. Bessesen MT, Kotter CV, Wagner BD, Adams JC, Kingery S, Benoit JB, Robertson CE, Janoff EN, Frank DN. MRSA colonization and the nasal microbiome in adults at high risk of colonization and infection. J Infect. 2015 Dec; 71(6):649-57. PMID: 26335708.
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    37. Wieland A, Frank DN, Harnke B, Bambha K. Systematic review: microbial dysbiosis and nonalcoholic fatty liver disease. Aliment Pharmacol Ther. 2015 Nov; 42(9):1051-63. PMID: 26304302.
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    38. Ramakrishnan VR, Frank DN. Impact of cigarette smoking on the middle meatus microbiome in health and chronic rhinosinusitis. Int Forum Allergy Rhinol. 2015 Nov; 5(11):981-9. PMID: 26272413.
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    39. Zhang Y, Rowehl L, Krumsiek JM, Orner EP, Shaikh N, Tarr PI, Sodergren E, Weinstock GM, Boedeker EC, Xiong X, Parkinson J, Frank DN, Li E, Gathungu G. Correction: Identification of Candidate Adherent-Invasive E. coli Signature Transcripts by Genomic/Transcriptomic Analysis. PLoS One. 2015; 10(7):e0134759. PMID: 26218289; PMCID: PMC4517915.
    40. Frank DN, Bales ES, Monks J, Jackman MJ, MacLean PS, Ir D, Robertson CE, Orlicky DJ, McManaman JL. Perilipin-2 Modulates Lipid Absorption and Microbiome Responses in the Mouse Intestine. PLoS One. 2015; 10(7):e0131944. PMID: 26147095; PMCID: PMC4493139.
    41. Zhang Y, Rowehl L, Krumsiek JM, Orner EP, Shaikh N, Tarr PI, Sodergren E, Weinstock GM, Boedeker EC, Xiong X, Parkinson J, Frank DN, Li E, Gathungu G. Identification of Candidate Adherent-Invasive E. coli Signature Transcripts by Genomic/Transcriptomic Analysis. PLoS One. 2015; 10(6):e0130902. PMID: 26125937; PMCID: PMC4509574.
    42. Son JS, Khair S, Pettet DW, Ouyang N, Tian X, Zhang Y, Zhu W, Mackenzie GG, Robertson CE, Ir D, Frank DN, Rigas B, Li E. Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APCMin/+ Mice. PLoS One. 2015; 10(6):e0127985. PMID: 26121046; PMCID: PMC4485894.
    43. Feazel LM, Santorico SA, Robertson CE, Bashraheil M, Scott JA, Frank DN, Hammitt LL. Effects of Vaccination with 10-Valent Pneumococcal Non-Typeable Haemophilus influenza Protein D Conjugate Vaccine (PHiD-CV) on the Nasopharyngeal Microbiome of Kenyan Toddlers. PLoS One. 2015; 10(6):e0128064. PMID: 26083474; PMCID: PMC4471099.
    44. Alkanani AK, Hara N, Gottlieb PA, Ir D, Robertson CE, Wagner BD, Frank DN, Zipris D. Alterations in Intestinal Microbiota Correlate With Susceptibility to Type 1 Diabetes. Diabetes. 2015 Oct; 64(10):3510-20. PMID: 26068542; PMCID: PMC4587635 [Available on 10/01/16].
    45. Dillon SM, Lee EJ, Kotter CV, Austin GL, Gianella S, Siewe B, Smith DM, Landay AL, McManus MC, Robertson CE, Frank DN, McCarter MD, Wilson CC. Gut dendritic cell activation links an altered colonic microbiome to mucosal and systemic T-cell activation in untreated HIV-1 infection. Mucosal Immunol. 2016 Jan; 9(1):24-37. PMID: 25921339; PMCID: PMC4626441.
    46. Dominguez SR, Anderson LJ, Kotter CV, Littlehorn CA, Arms LE, Dowell E, Todd JK, Frank DN. Comparison of Whole-Genome Sequencing and Molecular-Epidemiological Techniques for Clostridium difficile Strain Typing. J Pediatric Infect Dis Soc. 2016 Sep; 5(3):329-32. PMID: 26407257.
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    47. Ramakrishnan VR, Hauser LJ, Feazel LM, Ir D, Robertson CE, Frank DN. Sinus microbiota varies among chronic rhinosinusitis phenotypes and predicts surgical outcome. J Allergy Clin Immunol. 2015 Aug; 136(2):334-42.e1. PMID: 25819063.
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    48. Ling AL, Robertson CE, Harris JK, Frank DN, Kotter CV, Stevens MJ, Pace NR, Hernandez MT. High-resolution microbial community succession of microbially induced concrete corrosion in working sanitary manholes. PLoS One. 2015; 10(3):e0116400. PMID: 25748024; PMCID: PMC4352008.
    49. Flass T, Tong S, Frank DN, Wagner BD, Robertson CE, Kotter CV, Sokol RJ, Zemanick E, Accurso F, Hoffenberg EJ, Narkewicz MR. Intestinal lesions are associated with altered intestinal microbiome and are more frequent in children and young adults with cystic fibrosis and cirrhosis. PLoS One. 2015; 10(2):e0116967. PMID: 25658710; PMCID: PMC4319904.
    50. Gitomer SA, Ramakrishnan VR, Malcolm KC, Kofonow JM, Ir D, Frank DN. Initial investigation of small colony variants of Staphylococcus aureus in chronic rhinosinusitis. Am J Rhinol Allergy. 2015 Jan-Feb; 29(1):29-34. PMID: 25590313.
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    51. Hull NM, Reens AL, Robertson CE, Stanish LF, Harris JK, Stevens MJ, Frank DN, Kotter C, Pace NR. Molecular analysis of single room humidifier bacteriology. Water Res. 2015 Feb 01; 69:318-27. PMID: 25574772.
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    52. Hauser LJ, Feazel LM, Ir D, Fang R, Wagner BD, Robertson CE, Frank DN, Ramakrishnan VR. Sinus culture poorly predicts resident microbiota. Int Forum Allergy Rhinol. 2015 Jan; 5(1):3-9. PMID: 25278448.
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    53. Ward EK, Schuster DP, Stowers KH, Royse AK, Ir D, Robertson CE, Frank DN, Austin GL. The effect of PPI use on human gut microbiota and weight loss in patients undergoing laparoscopic Roux-en-Y gastric bypass. Obes Surg. 2014 Sep; 24(9):1567-71. PMID: 24849914.
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    54. Markle JG, Frank DN, Adeli K, von Bergen M, Danska JS. Microbiome manipulation modifies sex-specific risk for autoimmunity. Gut Microbes. 2014 Jul 01; 5(4):485-93. PMID: 25007153.
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    55. Ling AL, Robertson CE, Harris JK, Frank DN, Kotter CV, Stevens MJ, Pace NR, Hernandez MT. Carbon dioxide and hydrogen sulfide associations with regional bacterial diversity patterns in microbially induced concrete corrosion. Environ Sci Technol. 2014 Jul 01; 48(13):7357-64. PMID: 24842376.
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    56. Dominguez SR, Dolan SA, West K, Dantes RB, Epson E, Friedman D, Littlehorn CA, Arms LE, Walton K, Servetar E, Frank DN, Kotter CV, Dowell E, Gould CV, Hilden JM, Todd JK. High colonization rate and prolonged shedding of Clostridium difficile in pediatric oncology patients. Clin Infect Dis. 2014 Aug 01; 59(3):401-3. PMID: 24785235.
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    57. Hambidge KM, Krebs NF, Westcott JE, Garces A, Goudar SS, Kodkany BS, Pasha O, Tshefu A, Bose CL, Figueroa L, Goldenberg RL, Derman RJ, Friedman JE, Frank DN, McClure EM, Stolka K, Das A, Koso-Thomas M, Sundberg S. Preconception maternal nutrition: a multi-site randomized controlled trial. BMC Pregnancy Childbirth. 2014 Mar 20; 14:111. PMID: 24650219; PMCID: PMC4000057.
    58. Dillon SM, Lee EJ, Kotter CV, Austin GL, Dong Z, Hecht DK, Gianella S, Siewe B, Smith DM, Landay AL, Robertson CE, Frank DN, Wilson CC. An altered intestinal mucosal microbiome in HIV-1 infection is associated with mucosal and systemic immune activation and endotoxemia. Mucosal Immunol. 2014 Jul; 7(4):983-94. PMID: 24399150; PMCID: PMC4062575.
    59. Ramakrishnan VR, Feazel LM, Gitomer SA, Ir D, Robertson CE, Frank DN. The microbiome of the middle meatus in healthy adults. PLoS One. 2013; 8(12):e85507. PMID: 24386477; PMCID: PMC3875580.
    60. Alkanani AK, Hara N, Lien E, Ir D, Kotter CV, Robertson CE, Wagner BD, Frank DN, Zipris D. Induction of diabetes in the RIP-B7.1 mouse model is critically dependent on TLR3 and MyD88 pathways and is associated with alterations in the intestinal microbiome. Diabetes. 2014 Feb; 63(2):619-31. PMID: 24353176.
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    61. Tong M, Li X, Wegener Parfrey L, Roth B, Ippoliti A, Wei B, Borneman J, McGovern DP, Frank DN, Li E, Horvath S, Knight R, Braun J. A modular organization of the human intestinal mucosal microbiota and its association with inflammatory bowel disease. PLoS One. 2013; 8(11):e80702. PMID: 24260458; PMCID: PMC3834335.
    62. Robertson CE, Harris JK, Wagner BD, Granger D, Browne K, Tatem B, Feazel LM, Park K, Pace NR, Frank DN. Explicet: graphical user interface software for metadata-driven management, analysis and visualization of microbiome data. Bioinformatics. 2013 Dec 01; 29(23):3100-1. PMID: 24021386; PMCID: PMC3834795.
    63. Khailova L, Frank DN, Dominguez JA, Wischmeyer PE. Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. Anesthesiology. 2013 Jul; 119(1):166-77. PMID: 23571641.
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    64. Robertson CE, Baumgartner LK, Harris JK, Peterson KL, Stevens MJ, Frank DN, Pace NR. Culture-independent analysis of aerosol microbiology in a metropolitan subway system. Appl Environ Microbiol. 2013 Jun; 79(11):3485-93. PMID: 23542619; PMCID: PMC3648054.
    65. Wu X, Berkow K, Frank DN, Li E, Gulati AS, Zhu W. Comparative analysis of microbiome measurement platforms using latent variable structural equation modeling. BMC Bioinformatics. 2013 Mar 05; 14:79. PMID: 23497007; PMCID: PMC3608994.
    66. Krebs NF, Sherlock LG, Westcott J, Culbertson D, Hambidge KM, Feazel LM, Robertson CE, Frank DN. Effects of different complementary feeding regimens on iron status and enteric microbiota in breastfed infants. J Pediatr. 2013 Aug; 163(2):416-23. PMID: 23452586; PMCID: PMC3674183.
    67. Markle JG, Frank DN, Mortin-Toth S, Robertson CE, Feazel LM, Rolle-Kampczyk U, von Bergen M, McCoy KD, Macpherson AJ, Danska JS. Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. Science. 2013 Mar 01; 339(6123):1084-8. PMID: 23328391.
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    68. Hara N, Alkanani AK, Ir D, Robertson CE, Wagner BD, Frank DN, Zipris D. The role of the intestinal microbiota in type 1 diabetes. Clin Immunol. 2013 Feb; 146(2):112-9. PMID: 23314185.
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    69. Ramakrishnan VR, Feazel LM, Abrass LJ, Frank DN. Prevalence and abundance of Staphylococcus aureus in the middle meatus of patients with chronic rhinosinusitis, nasal polyps, and asthma. Int Forum Allergy Rhinol. 2013 Apr; 3(4):267-71. PMID: 23055295.
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    70. Hara N, Alkanani AK, Ir D, Robertson CE, Wagner BD, Frank DN, Zipris D. Prevention of virus-induced type 1 diabetes with antibiotic therapy. J Immunol. 2012 Oct 15; 189(8):3805-14. PMID: 22988033.
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    71. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723; PMCID: PMC3428522.
    72. Frank DN, Manigart O, Leroy V, Meda N, Valéa D, Zhang W, Dabis F, Pace NR, Van de Perre P, Janoff EN. Altered vaginal microbiota are associated with perinatal mother-to-child transmission of HIV in African women from Burkina Faso. J Acquir Immune Defic Syndr. 2012 Jul 01; 60(3):299-306. PMID: 22343176.
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    73. Janoff EN, Gustafson C, Frank DN. The world within: living with our microbial guests and guides. Transl Res. 2012 Oct; 160(4):239-45. PMID: 22732305.
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    74. Zhang T, DeSimone RA, Jiao X, Rohlf FJ, Zhu W, Gong QQ, Hunt SR, Dassopoulos T, Newberry RD, Sodergren E, Weinstock G, Robertson CE, Frank DN, Li E. Host genes related to paneth cells and xenobiotic metabolism are associated with shifts in human ileum-associated microbial composition. PLoS One. 2012; 7(6):e30044. PMID: 22719822; PMCID: PMC3374611.
    75. Li E, Hamm CM, Gulati AS, Sartor RB, Chen H, Wu X, Zhang T, Rohlf FJ, Zhu W, Gu C, Robertson CE, Pace NR, Boedeker EC, Harpaz N, Yuan J, Weinstock GM, Sodergren E, Frank DN. Inflammatory bowel diseases phenotype, C. difficile and NOD2 genotype are associated with shifts in human ileum associated microbial composition. PLoS One. 2012; 7(6):e26284. PMID: 22719818; PMCID: PMC3374607.
    76. Lozupone C, Faust K, Raes J, Faith JJ, Frank DN, Zaneveld J, Gordon JI, Knight R. Identifying genomic and metabolic features that can underlie early successional and opportunistic lifestyles of human gut symbionts. Genome Res. 2012 Oct; 22(10):1974-84. PMID: 22665442; PMCID: PMC3460192.
    77. Xiong X, Frank DN, Robertson CE, Hung SS, Markle J, Canty AJ, McCoy KD, Macpherson AJ, Poussier P, Danska JS, Parkinson J. Generation and analysis of a mouse intestinal metatranscriptome through Illumina based RNA-sequencing. PLoS One. 2012; 7(4):e36009. PMID: 22558305; PMCID: PMC3338770.
    78. Kelly CJ, Colgan SP, Frank DN. Of microbes and meals: the health consequences of dietary endotoxemia. Nutr Clin Pract. 2012 Apr; 27(2):215-25. PMID: 22378797; PMCID: PMC4046172.
    79. Feazel LM, Robertson CE, Ramakrishnan VR, Frank DN. Microbiome complexity and Staphylococcus aureus in chronic rhinosinusitis. Laryngoscope. 2012 Feb; 122(2):467-72. PMID: 22253013; PMCID: PMC3398802.
    80. Frank DN, Zhu W, Sartor RB, Li E. Investigating the biological and clinical significance of human dysbioses. Trends Microbiol. 2011 Sep; 19(9):427-34. PMID: 21775143; PMCID: PMC3164499.
    81. Feazel LM, Frank DN, Ramakrishnan VR. Update on bacterial detection methods in chronic rhinosinusitis: implications for clinicians and research scientists. Int Forum Allergy Rhinol. 2011 Nov-Dec; 1(6):451-9. PMID: 22144054.
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    82. Frank DN. Growth and Development Symposium: promoting healthier humans through healthier livestock: animal agriculture enters the metagenomics era. J Anim Sci. 2011 Mar; 89(3):835-44. PMID: 20935136.
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    83. Frank DN, Robertson CE, Hamm CM, Kpadeh Z, Zhang T, Chen H, Zhu W, Sartor RB, Boedeker EC, Harpaz N, Pace NR, Li E. Disease phenotype and genotype are associated with shifts in intestinal-associated microbiota in inflammatory bowel diseases. Inflamm Bowel Dis. 2011 Jan; 17(1):179-84. PMID: 20839241; PMCID: PMC3834564.
    84. Frank DN, Feazel LM, Bessesen MT, Price CS, Janoff EN, Pace NR. The human nasal microbiota and Staphylococcus aureus carriage. PLoS One. 2010 May 17; 5(5):e10598. PMID: 20498722; PMCID: PMC2871794.
    85. Janoff EN, Frank DN. Pathogen-specific antibodies: codependent no longer. J Clin Invest. 2010 Apr; 120(4):1039-42. PMID: 20335652; PMCID: PMC2846075.
    86. Frank DN, Wilson SS, St Amand AL, Pace NR. Culture-independent microbiological analysis of foley urinary catheter biofilms. PLoS One. 2009 Nov 12; 4(11):e7811. PMID: 19907661; PMCID: PMC2771765.
    87. Frank DN. BARCRAWL and BARTAB: software tools for the design and implementation of barcoded primers for highly multiplexed DNA sequencing. BMC Bioinformatics. 2009 Oct 29; 10:362. PMID: 19874596; PMCID: PMC2777893.
    88. Feazel LM, Baumgartner LK, Peterson KL, Frank DN, Harris JK, Pace NR. Opportunistic pathogens enriched in showerhead biofilms. Proc Natl Acad Sci U S A. 2009 Sep 22; 106(38):16393-9. PMID: 19805310; PMCID: PMC2752528.
    89. Frank DN, Wysocki A, Specht-Glick DD, Rooney A, Feldman RA, St Amand AL, Pace NR, Trent JD. Microbial diversity in chronic open wounds. Wound Repair Regen. 2009 Mar-Apr; 17(2):163-72. PMID: 19320883.
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    90. Frank DN. XplorSeq: a software environment for integrated management and phylogenetic analysis of metagenomic sequence data. BMC Bioinformatics. 2008 Oct 07; 9:420. PMID: 18840282; PMCID: PMC2577119.
    91. Frank DN. Don't release other people's data without their consent. Nature. 2008 Oct 02; 455(7213):589. PMID: 18833251.
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    92. Peterson DA, Frank DN, Pace NR, Gordon JI. Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases. Cell Host Microbe. 2008 Jun 12; 3(6):417-27. PMID: 18541218; PMCID: PMC2872787.
    93. Frank DN. Mycobacterium avium subspecies paratuberculosis and Crohn's disease. Lancet Infect Dis. 2008 Jun; 8(6):345; author reply 345-6. PMID: 18501847.
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    94. Frank DN, Pace NR. Gastrointestinal microbiology enters the metagenomics era. Curr Opin Gastroenterol. 2008 Jan; 24(1):4-10. PMID: 18043225.
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    95. Feazel LM, Spear JR, Berger AB, Harris JK, Frank DN, Ley RE, Pace NR. Eucaryotic diversity in a hypersaline microbial mat. Appl Environ Microbiol. 2008 Jan; 74(1):329-32. PMID: 17993566; PMCID: PMC2223211.
    96. Frank DN, St Amand AL, Feldman RA, Boedeker EC, Harpaz N, Pace NR. Molecular-phylogenetic characterization of microbial community imbalances in human inflammatory bowel diseases. Proc Natl Acad Sci U S A. 2007 Aug 21; 104(34):13780-5. PMID: 17699621; PMCID: PMC1959459.
    97. Dalby AB, Frank DN, St Amand AL, Bendele AM, Pace NR. Culture-independent analysis of indomethacin-induced alterations in the rat gastrointestinal microbiota. Appl Environ Microbiol. 2006 Oct; 72(10):6707-15. PMID: 17021222; PMCID: PMC1610281.
    98. Furrie E, Senok AC, Frank DN, Sullivan KE. Pondering probiotics. Clin Immunol. 2006 Oct; 121(1):19-22. PMID: 16807114.
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    99. St Amand AL, Frank DN, De Groote MA, Basaraba RJ, Orme IM, Pace NR. Use of specific rRNA oligonucleotide probes for microscopic detection of Mycobacterium tuberculosis in culture and tissue specimens. J Clin Microbiol. 2005 Oct; 43(10):5369-71. PMID: 16208021; PMCID: PMC1248482.
    100. St Amand AL, Frank DN, De Groote MA, Pace NR. Use of specific rRNA oligonucleotide probes for microscopic detection of Mycobacterium avium complex organisms in tissue. J Clin Microbiol. 2005 Apr; 43(4):1505-14. PMID: 15814959; PMCID: PMC1081365.
    101. De Groote MA, Frank DN, Dowell E, Glode MP, Pace NR. Lactobacillus rhamnosus GG bacteremia associated with probiotic use in a child with short gut syndrome. Pediatr Infect Dis J. 2005 Mar; 24(3):278-80. PMID: 15750472.
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    102. Shukla SK, Paustian DL, Stockwell PJ, Morey RE, Jordan JG, Levett PN, Frank DN, Reed KD. Isolation of a fastidious Bergeyella species associated with cellulitis after a cat bite and a phylogenetic comparison with Bergeyella zoohelcum strains. J Clin Microbiol. 2004 Jan; 42(1):290-3. PMID: 14715767; PMCID: PMC321680.
    103. Shukla SK, Bernard KA, Harney M, Frank DN, Reed KD. Corynebacterium nigricans sp. nov.: proposed name for a black-pigmented Corynebacterium species recovered from the human female urogenital tract. J Clin Microbiol. 2003 Sep; 41(9):4353-8. PMID: 12958268; PMCID: PMC193809.
    104. Frank DN, Spiegelman GB, Davis W, Wagner E, Lyons E, Pace NR. Culture-independent molecular analysis of microbial constituents of the healthy human outer ear. J Clin Microbiol. 2003 Jan; 41(1):295-303. PMID: 12517864; PMCID: PMC149572.
    105. Shukla SK, Meier PR, Mitchell PD, Frank DN, Reed KD. Leptotrichia amnionii sp. nov., a novel bacterium isolated from the amniotic fluid of a woman after intrauterine fetal demise. J Clin Microbiol. 2002 Sep; 40(9):3346-9. PMID: 12202577; PMCID: PMC130742.
    106. Li X, Frank DN, Pace N, Zengel JM, Lindahl L. Phylogenetic analysis of the structure of RNase MRP RNA in yeasts. RNA. 2002 Jun; 8(6):740-51. PMID: 12088147; PMCID: PMC1370293.
    107. Shukla SK, Vevea DN, Frank DN, Pace NR, Reed KD. Isolation and characterization of a black-pigmented Corynebacterium sp. from a woman with spontaneous abortion. J Clin Microbiol. 2001 Mar; 39(3):1109-13. PMID: 11230435; PMCID: PMC87881.
    108. Harris JK, Haas ES, Williams D, Frank DN, Brown JW. New insight into RNase P RNA structure from comparative analysis of the archaeal RNA. RNA. 2001 Feb; 7(2):220-32. PMID: 11233979; PMCID: PMC1370080.
    109. Frank DN, Pace NR. Molecular-phylogenetic analyses of human gastrointestinal microbiota. Curr Opin Gastroenterol. 2001 Jan; 17(1):52-7. PMID: 17031150.
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    110. Frank DN, Adamidi C, Ehringer MA, Pitulle C, Pace NR. Phylogenetic-comparative analysis of the eukaryal ribonuclease P RNA. RNA. 2000 Dec; 6(12):1895-904. PMID: 11142387; PMCID: PMC1370057.
    111. Oh BK, Frank DN, Pace NR. Participation of the 3'-CCA of tRNA in the binding of catalytic Mg2+ ions by ribonuclease P. Biochemistry. 1998 May 19; 37(20):7277-83. PMID: 9585541.
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    112. Frank DN, Pace NR. Ribonuclease P: unity and diversity in a tRNA processing ribozyme. Annu Rev Biochem. 1998; 67:153-80. PMID: 9759486.
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    113. Frank DN, Pace NR. In vitro selection for altered divalent metal specificity in the RNase P RNA. Proc Natl Acad Sci U S A. 1997 Dec 23; 94(26):14355-60. PMID: 9405616; PMCID: PMC24975.
    114. Frank DN, Ellington AE, Pace NR. In vitro selection of RNase P RNA reveals optimized catalytic activity in a highly conserved structural domain. RNA. 1996 Dec; 2(12):1179-88. PMID: 8972768; PMCID: PMC1369446.
    115. Jones MH, Frank DN, Guthrie C. Characterization and functional ordering of Slu7p and Prp17p during the second step of pre-mRNA splicing in yeast. Proc Natl Acad Sci U S A. 1995 Oct 10; 92(21):9687-91. PMID: 7568198; PMCID: PMC40867.
    116. Frank DN, Harris ME, Pace NR. Rational design of self-cleaving pre-tRNA-ribonuclease P RNA conjugates. Biochemistry. 1994 Sep 06; 33(35):10800-8. PMID: 8075082.
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    117. Frank DN, Roiha H, Guthrie C. Architecture of the U5 small nuclear RNA. Mol Cell Biol. 1994 Mar; 14(3):2180-90. PMID: 8114748; PMCID: PMC358578.
    118. Frank D, Guthrie C. An essential splicing factor, SLU7, mediates 3' splice site choice in yeast. Genes Dev. 1992 Nov; 6(11):2112-24. PMID: 1427075.
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    119. Frank D, Patterson B, Guthrie C. Synthetic lethal mutations suggest interactions between U5 small nuclear RNA and four proteins required for the second step of splicing. Mol Cell Biol. 1992 Nov; 12(11):5197-205. PMID: 1406691; PMCID: PMC360453.
    120. Bone R, Frank D, Kettner CA, Agard DA. Structural analysis of specificity: alpha-lytic protease complexes with analogues of reaction intermediates. Biochemistry. 1989 Sep 19; 28(19):7600-9. PMID: 2611204.
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    121. Silen JL, Frank D, Fujishige A, Bone R, Agard DA. Analysis of prepro-alpha-lytic protease expression in Escherichia coli reveals that the pro region is required for activity. J Bacteriol. 1989 Mar; 171(3):1320-5. PMID: 2646278; PMCID: PMC209748.
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