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Richard William Vandivier

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED

    Collapse Research 
    Collapse research activities and funding
    K08HL072018     (VANDIVIER, RICHARD W)Feb 17, 2003 - Jan 31, 2009
    NIH/NHLBI
    Clearance of Apoptotic Cells in Cystic Fibrosis
    Role: Principal Investigator
    R13HL142192     (VANDIVIER, RICHARD W)May 1, 2018 - Apr 30, 2019
    NIH/NHLBI
    Aspen Lung Conference on COPD: Translating Resilience and Pathogenesis to Personalized Therapy for COPD
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Klein JD, Chamberlin ME, Kress EA, Geraci MW, Rosenblatt S, Boykan R, Jenssen B, Rosenblatt SM, Milberger S, Adams WG, Goldstein AO, Rigotti NA, Hovell MF, Holm AL, Vandivier RW, Croxton TL, Young PL, Blissard L, Jewell K, Richardson L, Ostrow J, Resnick EA. Asking the Right Questions About Secondhand Smoke. Nicotine Tob Res. 2021 01 07; 23(1):57-62. PMID: 31407779.
      View in: PubMed
    2. Koff PB, Min SJ, Freitag TJ, Diaz DLP, James SS, Voelkel NF, Linderman DJ, Diaz Del Valle F, Zakrajsek JK, Albert RK, Bull TM, Beck A, Stelzner TJ, Ritzwoller DP, Kveton CM, Carwin S, Ghosh M, Keith RL, Westfall JM, Vandivier RW. Impact of Proactive Integrated Care on Chronic Obstructive Pulmonary Disease. Chronic Obstr Pulm Dis. 2021 Jan; 8(1). PMID: 33238087.
      View in: PubMed
    3. Althoff MD, Holguin F, Yang F, Grunwald GK, Moss M, Vandivier RW, Ho PM, Kiser TH, Burnham EL. Noninvasive Ventilation Use in Critically Ill Patients with Acute Asthma Exacerbations. Am J Respir Crit Care Med. 2020 12 01; 202(11):1520-1530. PMID: 32663410.
      View in: PubMed
    4. Prohaska CC, Sottile PD, Nordon-Craft A, Gallagher MD, Burnham EL, Clark BJ, Ho M, Kiser TH, Vandivier RW, Liu W, Schenkman M, Moss M. Patterns of utilization and effects of hospital-specific factors on physical, occupational, and speech therapy for critically ill patients with acute respiratory failure in the USA: results of a 5-year sample. Crit Care. 2019 05 16; 23(1):175. PMID: 31097017.
      View in: PubMed
    5. Kiser TH, Reynolds PM, Moss M, Burnham EL, Ho PM, Vandivier RW. Impact of Macrolide Antibiotics on Hospital Readmissions and Other Clinically Important Outcomes in Critically Ill Patients with Acute Exacerbations of Chronic Obstructive Pulmonary Disease: A Propensity Score-Matched Cohort Study. Pharmacotherapy. 2019 03; 39(3):242-252. PMID: 30663791.
      View in: PubMed
    6. Logue EC, Neff CP, Mack DG, Martin AK, Fiorillo S, Lavelle J, Vandivier RW, Campbell TB, Palmer BE, Fontenot AP. Upregulation of Chitinase 1 in Alveolar Macrophages of HIV-Infected Smokers. J Immunol. 2019 03 01; 202(5):1363-1372. PMID: 30665939.
      View in: PubMed
    7. Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. The authors reply. Crit Care Med. 2018 12; 46(12):e1224-e1225. PMID: 30444823.
      View in: PubMed
    8. Van Matre ET, Reynolds PM, MacLaren R, Mueller SW, Wright GC, Moss M, Burnham EL, Ho PM, Vandivier RW, Kiser TH. Evaluation of unfractionated heparin versus low-molecular-weight heparin and fondaparinux for pharmacologic venous thromboembolic prophylaxis in critically ill patients with cancer. J Thromb Haemost. 2018 12; 16(12):2492-2500. PMID: 30347498.
      View in: PubMed
    9. Kiser TH, Burnham EL, Clark B, Ho PM, Allen RR, Moss M, Vandivier RW. Half-Dose Versus Full-Dose Alteplase for Treatment of Pulmonary Embolism. Crit Care Med. 2018 10; 46(10):1617-1625. PMID: 29979222.
      View in: PubMed
    10. Ghosh M, Miller YE, Vandivier RW. Reply to Sohal: Airway Basal Cell Reprogramming and Epithelial-Mesenchymal Transition: A Potential Key to Understanding Early Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 06 15; 197(12):1645-1646. PMID: 29385351.
      View in: PubMed
    11. Breathett K, Liu WG, Allen LA, Daugherty SL, Blair IV, Jones J, Grunwald GK, Moss M, Kiser TH, Burnham E, Vandivier RW, Clark BJ, Lewis EF, Mazimba S, Battaglia C, Ho PM, Peterson PN. African Americans Are Less Likely to Receive Care by a Cardiologist During an Intensive Care Unit Admission for Heart Failure. JACC Heart Fail. 2018 05; 6(5):413-420. PMID: 29724363.
      View in: PubMed
    12. Sottile PD, Kiser TH, Burnham EL, Ho PM, Allen RR, Vandivier RW, Moss M. An Observational Study of the Efficacy of Cisatracurium Compared with Vecuronium in Patients with or at Risk for Acute Respiratory Distress Syndrome. Am J Respir Crit Care Med. 2018 04 01; 197(7):897-904. PMID: 29241014.
      View in: PubMed
    13. Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. The authors reply. Crit Care Med. 2018 04; 46(4):e347-e348. PMID: 29538131.
      View in: PubMed
    14. Ghosh M, Miller YE, Nakachi I, Kwon JB, Barón AE, Brantley AE, Merrick DT, Franklin WA, Keith RL, Vandivier RW. Exhaustion of Airway Basal Progenitor Cells in Early and Established Chronic Obstructive Pulmonary Disease. Am J Respir Crit Care Med. 2018 04 01; 197(7):885-896. PMID: 29211494.
      View in: PubMed
    15. Kelmenson DA, Held N, Allen RR, Quan D, Burnham EL, Clark BJ, Ho PM, Kiser TH, Vandivier RW, Moss M. Outcomes of ICU Patients With a Discharge Diagnosis of Critical Illness Polyneuromyopathy: A Propensity-Matched Analysis. Crit Care Med. 2017 Dec; 45(12):2055-2060. PMID: 29019851.
      View in: PubMed
    16. Samuelson DR, Burnham EL, Maffei VJ, Vandivier RW, Blanchard EE, Shellito JE, Luo M, Taylor CM, Welsh DA. The respiratory tract microbial biogeography in alcohol use disorder. . 2018 01 01; 314(1):L107-L117. PMID: 28860145.
      View in: PubMed
    17. Kiser TH, Sevransky JE, Krishnan JA, Tonascia J, Wise RA, Checkley W, Walsh J, Sullivan JB, Wilson KC, Barker A, Moss M, Vandivier RW. A Survey of Corticosteroid Dosing for Exacerbations of Chronic Obstructive Pulmonary Disease Requiring Assisted Ventilation. Chronic Obstr Pulm Dis. 2017 Jul 15; 4(3):186-193. PMID: 28848930.
      View in: PubMed
    18. Vandivier RW, Ghosh M. Understanding the Relevance of the Mouse Cigarette Smoke Model of COPD: Peering through the Smoke. Am J Respir Cell Mol Biol. 2017 07; 57(1):3-4. PMID: 28665224.
      View in: PubMed
    19. Bonilla Arcos D, Krishnan JA, Vandivier RW, Sevransky JE, Checkley W, Kiser TH, Sullivan JL, Walsh JW, Wise RA, Wilson KC. High-Dose Versus Low-Dose Systemic Steroids in the Treatment of Acute Exacerbations of Chronic Obstructive Pulmonary Disease: Systematic Review. Chronic Obstr Pulm Dis. 2016 Feb 17; 3(2):580-588. PMID: 28848882.
      View in: PubMed
    20. Moazed F, Burnham EL, Vandivier RW, O'Kane CM, Shyamsundar M, Hamid U, Abbott J, Thickett DR, Matthay MA, McAuley DF, Calfee CS. Cigarette smokers have exaggerated alveolar barrier disruption in response to lipopolysaccharide inhalation. Thorax. 2016 12; 71(12):1130-1136. PMID: 26839359.
      View in: PubMed
    21. Rice JL, Stream AR, Fox DL, Geraci MW, Vandivier RW, Dorosz JL, Bull TM. Speckle Tracking Echocardiography to Evaluate for Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease. COPD. 2016 10; 13(5):595-600. PMID: 26829151.
      View in: PubMed
    22. Gaydos J, McNally A, Guo R, Vandivier RW, Simonian PL, Burnham EL. Alcohol abuse and smoking alter inflammatory mediator production by pulmonary and systemic immune cells. . 2016 Mar 15; 310(6):L507-18. PMID: 26747782.
      View in: PubMed
    23. Kiser TH, Vandivier RW. Severe acute exacerbations of chronic obstructive pulmonary disease: does the dosage of corticosteroids and type of antibiotic matter? Curr Opin Pulm Med. 2015 Mar; 21(2):142-8. PMID: 25575365.
      View in: PubMed
    24. Vandivier RW. Learning to act on secondhand tobacco smoke exposure to limit risk for coronary heart disease. JAMA Intern Med. 2015 Jan; 175(1):136. PMID: 25383686.
      View in: PubMed
    25. Kiser TH, Allen RR, Valuck RJ, Moss M, Vandivier RW. Outcomes associated with corticosteroid dosage in critically ill patients with acute exacerbations of chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2014 May 01; 189(9):1052-64. PMID: 24617842.
      View in: PubMed
    26. Merrill SP, Reynolds P, Kalra A, Biehl J, Vandivier RW, Mueller SW. Early administration of infliximab for severe ipilimumab-related diarrhea in a critically ill patient. Ann Pharmacother. 2014 Jun; 48(6):806-10. PMID: 24651165.
      View in: PubMed
    27. Tanaka T, Doe JM, Horstmann SA, Ahmad S, Ahmad A, Min SJ, Reynolds PR, Suram S, Gaydos J, Burnham EL, Vandivier RW. Neuroendocrine signaling via the serotonin transporter regulates clearance of apoptotic cells. J Biol Chem. 2014 Apr 11; 289(15):10466-75. PMID: 24570000.
      View in: PubMed
    28. Graham BB, Chabon J, Gebreab L, Poole J, Debella E, Davis L, Tanaka T, Sanders L, Dropcho N, Bandeira A, Vandivier RW, Champion HC, Butrous G, Wang XJ, Wynn TA, Tuder RM. Transforming growth factor-ß signaling promotes pulmonary hypertension caused by Schistosoma mansoni. Circulation. 2013 Sep 17; 128(12):1354-64. PMID: 23958565.
      View in: PubMed
    29. Bhargava R, Janssen W, Altmann C, Andrés-Hernando A, Okamura K, Vandivier RW, Ahuja N, Faubel S. Intratracheal IL-6 protects against lung inflammation in direct, but not indirect, causes of acute lung injury in mice. PLoS One. 2013; 8(5):e61405. PMID: 23667439.
      View in: PubMed
    30. Vandivier RW, Linderman DJ, Koff PB. A comprehensive care management program to prevent chronic obstructive pulmonary disease hospitalizations. Ann Intern Med. 2012 Oct 02; 157(7):530; author reply 530-1. PMID: 23027327.
      View in: PubMed
    31. Kearns MT, Dalal S, Horstmann SA, Richens TR, Tanaka T, Doe JM, Boe DM, Voelkel NF, Taraseviciene-Stewart L, Janssen WJ, Lee CG, Elias JA, Bratton D, Tuder RM, Henson PM, Vandivier RW. Vascular endothelial growth factor enhances macrophage clearance of apoptotic cells. . 2012 Apr 01; 302(7):L711-8. PMID: 22307908.
      View in: PubMed
    32. Linderman DJ, Koff PB, Freitag TJ, Min SJ, Vandivier RW. Effect of integrated care on advanced chronic obstructive pulmonary disease in high-mortality rural areas. Arch Intern Med. 2011 Dec 12; 171(22):2059-61. PMID: 22158579.
      View in: PubMed
    33. Burnham EL, Phang TL, House R, Vandivier RW, Moss M, Gaydos J. Alveolar macrophage gene expression is altered in the setting of alcohol use disorders. Alcohol Clin Exp Res. 2011 Feb; 35(2):284-94. PMID: 21121937.
      View in: PubMed
    34. Petrusca DN, Gu Y, Adamowicz JJ, Rush NI, Hubbard WC, Smith PA, Berdyshev EV, Birukov KG, Lee CH, Tuder RM, Twigg HL, Vandivier RW, Petrache I. Sphingolipid-mediated inhibition of apoptotic cell clearance by alveolar macrophages. J Biol Chem. 2010 Dec 17; 285(51):40322-32. PMID: 20956540.
      View in: PubMed
    35. Fernandez-Boyanapalli R, Frasch SC, Riches DW, Vandivier RW, Henson PM, Bratton DL. PPAR? activation normalizes resolution of acute sterile inflammation in murine chronic granulomatous disease. Blood. 2010 Nov 25; 116(22):4512-22. PMID: 20693431.
      View in: PubMed
    36. Boé DM, Richens TR, Horstmann SA, Burnham EL, Janssen WJ, Henson PM, Moss M, Vandivier RW. Acute and chronic alcohol exposure impair the phagocytosis of apoptotic cells and enhance the pulmonary inflammatory response. Alcohol Clin Exp Res. 2010 Oct; 34(10):1723-32. PMID: 20608904.
      View in: PubMed
    37. Borges VM, Vandivier RW, McPhillips KA, Kench JA, Morimoto K, Groshong SD, Richens TR, Graham BB, Muldrow AM, Van Heule L, Henson PM, Janssen WJ. TNFalpha inhibits apoptotic cell clearance in the lung, exacerbating acute inflammation. . 2009 Oct; 297(4):L586-95. PMID: 19648283.
      View in: PubMed
    38. Vandivier RW, Richens TR, Horstmann SA, deCathelineau AM, Ghosh M, Reynolds SD, Xiao YQ, Riches DW, Plumb J, Vachon E, Downey GP, Henson PM. Dysfunctional cystic fibrosis transmembrane conductance regulator inhibits phagocytosis of apoptotic cells with proinflammatory consequences. . 2009 Oct; 297(4):L677-86. PMID: 19633071.
      View in: PubMed
    39. Boé DM, Vandivier RW, Burnham EL, Moss M. Alcohol abuse and pulmonary disease. J Leukoc Biol. 2009 Nov; 86(5):1097-104. PMID: 19602670.
      View in: PubMed
    40. Richens TR, Linderman DJ, Horstmann SA, Lambert C, Xiao YQ, Keith RL, Boé DM, Morimoto K, Bowler RP, Day BJ, Janssen WJ, Henson PM, Vandivier RW. Cigarette smoke impairs clearance of apoptotic cells through oxidant-dependent activation of RhoA. Am J Respir Crit Care Med. 2009 Jun 01; 179(11):1011-21. PMID: 19264974.
      View in: PubMed
    41. Koff PB, Jones RH, Cashman JM, Voelkel NF, Vandivier RW. Proactive integrated care improves quality of life in patients with COPD. Eur Respir J. 2009 May; 33(5):1031-8. PMID: 19129289.
      View in: PubMed
    42. Fernandez-Boyanapalli RF, Frasch SC, McPhillips K, Vandivier RW, Harry BL, Riches DW, Henson PM, Bratton DL. Impaired apoptotic cell clearance in CGD due to altered macrophage programming is reversed by phosphatidylserine-dependent production of IL-4. Blood. 2009 Feb 26; 113(9):2047-55. PMID: 18952895.
      View in: PubMed
    43. Xiao YQ, Freire-de-Lima CG, Schiemann WP, Bratton DL, Vandivier RW, Henson PM. Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol. 2008 Sep 01; 181(5):3575-85. PMID: 18714031.
      View in: PubMed
    44. Janssen WJ, McPhillips KA, Dickinson MG, Linderman DJ, Morimoto K, Xiao YQ, Oldham KM, Vandivier RW, Henson PM, Gardai SJ. Surfactant proteins A and D suppress alveolar macrophage phagocytosis via interaction with SIRP alpha. Am J Respir Crit Care Med. 2008 Jul 15; 178(2):158-67. PMID: 18420961.
      View in: PubMed
    45. Henson PM, Vandivier RW, Douglas IS. Cell death, remodeling, and repair in chronic obstructive pulmonary disease? Proc Am Thorac Soc. 2006 Nov; 3(8):713-7. PMID: 17065379.
      View in: PubMed
    46. Kalil AC, Sevransky JE, Myers DE, Esposito C, Vandivier RW, Eichacker P, Susla GM, Solomon SB, Csako G, Costello R, Sittler KJ, Banks S, Natanson C, Danner RL. Preclinical trial of L-arginine monotherapy alone or with N-acetylcysteine in septic shock. Crit Care Med. 2006 Nov; 34(11):2719-28. PMID: 16971848.
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    47. Jehle AW, Gardai SJ, Li S, Linsel-Nitschke P, Morimoto K, Janssen WJ, Vandivier RW, Wang N, Greenberg S, Dale BM, Qin C, Henson PM, Tall AR. ATP-binding cassette transporter A7 enhances phagocytosis of apoptotic cells and associated ERK signaling in macrophages. J Cell Biol. 2006 Aug 14; 174(4):547-56. PMID: 16908670.
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    48. Henson PM, Cosgrove GP, Vandivier RW. State of the art. Apoptosis and cell homeostasis in chronic obstructive pulmonary disease. Proc Am Thorac Soc. 2006 Aug; 3(6):512-6. PMID: 16921132.
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    49. Morimoto K, Janssen WJ, Fessler MB, Xiao YQ, McPhillips KA, Borges VM, Kench JA, Henson PM, Vandivier RW. Statins enhance clearance of apoptotic cells through modulation of Rho-GTPases. Proc Am Thorac Soc. 2006 Aug; 3(6):516-7. PMID: 16921133.
      View in: PubMed
    50. Morimoto K, Janssen WJ, Fessler MB, McPhillips KA, Borges VM, Bowler RP, Xiao YQ, Kench JA, Henson PM, Vandivier RW. Lovastatin enhances clearance of apoptotic cells (efferocytosis) with implications for chronic obstructive pulmonary disease. J Immunol. 2006 Jun 15; 176(12):7657-65. PMID: 16751413.
      View in: PubMed
    51. Vandivier RW, Henson PM, Douglas IS. Burying the dead: the impact of failed apoptotic cell removal (efferocytosis) on chronic inflammatory lung disease. Chest. 2006 Jun; 129(6):1673-82. PMID: 16778289.
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    52. Henson PM, Vandivier RW. The matrix degrades, neutrophils invade. Nat Med. 2006 Mar; 12(3):280-1. PMID: 16520772.
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    53. Vachon E, Martin R, Plumb J, Kwok V, Vandivier RW, Glogauer M, Kapus A, Wang X, Chow CW, Grinstein S, Downey GP. CD44 is a phagocytic receptor. Blood. 2006 May 15; 107(10):4149-58. PMID: 16455948.
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    54. Voelkel NF, Vandivier RW, Tuder RM. Vascular endothelial growth factor in the lung. . 2006 Feb; 290(2):L209-21. PMID: 16403941.
      View in: PubMed
    55. Stuart LM, Henson PM, Vandivier RW. Collectins: opsonins for apoptotic cells and regulators of inflammation. Curr Dir Autoimmun. 2006; 9:143-61. PMID: 16394659.
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    56. Sevransky J, Vandivier RW, Gerstenberger E, Correa R, Ferantz V, Banks SM, Danner RL, Eichacker PQ, Natanson C. Prophylactic high-dose N(omega)-monomethyl-L-arginine prevents the late cardiac dysfunction associated with lethal tumor necrosis factor-alpha challenge in dogs. Shock. 2005 Mar; 23(3):281-8. PMID: 15718929.
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    57. Vandivier RW, Voelkel NF. The challenges of chronic obstructive pulmonary diseases (COPD)--a perspective. COPD. 2005 Mar; 2(1):177-84. PMID: 17136979.
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    58. MacLaren R, Gasper J, Jung R, Vandivier RW. Use of exogenous erythropoietin in critically ill patients. J Clin Pharm Ther. 2004 Jun; 29(3):195-208. PMID: 15153081.
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    59. Ameshima S, Golpon H, Cool CD, Chan D, Vandivier RW, Gardai SJ, Wick M, Nemenoff RA, Geraci MW, Voelkel NF. Peroxisome proliferator-activated receptor gamma (PPARgamma) expression is decreased in pulmonary hypertension and affects endothelial cell growth. Circ Res. 2003 May 30; 92(10):1162-9. PMID: 12714563.
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    60. Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M, Walport MJ, Fisher JH, Henson PM, Greene KE. Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex. J Immunol. 2002 Oct 01; 169(7):3978-86. PMID: 12244199.
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    61. Teder P, Vandivier RW, Jiang D, Liang J, Cohn L, Puré E, Henson PM, Noble PW. Resolution of lung inflammation by CD44. Science. 2002 Apr 05; 296(5565):155-8. PMID: 11935029.
      View in: PubMed
    62. Vandivier RW, Fadok VA, Ogden CA, Hoffmann PR, Brain JD, Accurso FJ, Fisher JH, Greene KE, Henson PM. Impaired clearance of apoptotic cells from cystic fibrosis airways. Chest. 2002 Mar; 121(3 Suppl):89S. PMID: 11893715.
      View in: PubMed
    63. Vandivier RW, Fadok VA, Hoffmann PR, Bratton DL, Penvari C, Brown KK, Brain JD, Accurso FJ, Henson PM. Elastase-mediated phosphatidylserine receptor cleavage impairs apoptotic cell clearance in cystic fibrosis and bronchiectasis. J Clin Invest. 2002 Mar; 109(5):661-70. PMID: 11877474.
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    64. Preas HL, Jubran A, Vandivier RW, Reda D, Godin PJ, Banks SM, Tobin MJ, Suffredini AF. Effect of endotoxin on ventilation and breath variability: role of cyclooxygenase pathway. Am J Respir Crit Care Med. 2001 Aug 15; 164(4):620-6. PMID: 11520726.
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    65. Vandivier RW, Eidsath A, Banks SM, Preas HL, Leighton SB, Godin PJ, Suffredini AF, Danner RL. Down-regulation of nitric oxide production by ibuprofen in human volunteers. J Pharmacol Exp Ther. 1999 Jun; 289(3):1398-403. PMID: 10336532.
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    66. O'Grady NP, Tropea M, Preas HL, Reda D, Vandivier RW, Banks SM, Suffredini AF. Detection of macrophage inflammatory protein (MIP)-1alpha and MIP-1beta during experimental endotoxemia and human sepsis. J Infect Dis. 1999 Jan; 179(1):136-41. PMID: 9841832.
      View in: PubMed
    67. Preas HL, Reda D, Tropea M, Vandivier RW, Banks SM, Agosti JM, Suffredini AF. Effects of recombinant soluble type I interleukin-1 receptor on human inflammatory responses to endotoxin. Blood. 1996 Oct 01; 88(7):2465-72. PMID: 8839837.
      View in: PubMed
    68. Godin PJ, Fleisher LA, Eidsath A, Vandivier RW, Preas HL, Banks SM, Buchman TG, Suffredini AF. Experimental human endotoxemia increases cardiac regularity: results from a prospective, randomized, crossover trial. Crit Care Med. 1996 Jul; 24(7):1117-24. PMID: 8674322.
      View in: PubMed
    69. Yan L, Vandivier RW, Suffredini AF, Danner RL. Human polymorphonuclear leukocytes lack detectable nitric oxide synthase activity. J Immunol. 1994 Aug 15; 153(4):1825-34. PMID: 7519215.
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