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Christina Lee Roark

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-1567

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Anderson KM, Roark CL, Portas M, Aubrey MT, Rosloniec EF, Freed BM. A Molecular Analysis of the Shared Epitope Hypothesis: Binding of Arthritogenic Peptides to DRB1*04 Alleles. Arthritis Rheumatol. 2016 Jul; 68(7):1627-36. PMID: 26866513.
      View in: PubMed
    2. Roark CL, Anderson KM, Aubrey MT, Rosloniec EF, Freed BM. Arthritogenic peptide binding to DRB1*01 alleles correlates with susceptibility to rheumatoid arthritis. J Autoimmun. 2016 Aug; 72:25-32. PMID: 27143337.
      View in: PubMed
    3. Roark CL, Anderson KM, Simon LJ, Schuyler RP, Aubrey MT, Freed BM. Multiple HLA epitopes contribute to type 1 diabetes susceptibility. Diabetes. 2014 Jan; 63(1):323-31. PMID: 24357703; PMCID: PMC3868045.
    4. Roark CL, Huang Y, Jin N, Aydintug MK, Casper T, Sun D, Born WK, O'Brien RL. A canonical V?4Vd4+ ?d T cell population with distinct stimulation requirements which promotes the Th17 response. Immunol Res. 2013 Mar; 55(1-3):217-30. PMID: 22961659; PMCID: PMC3543513.
    5. Simonian PL, Wehrmann F, Roark CL, Born WK, O'Brien RL, Fontenot AP. ?d T cells protect against lung fibrosis via IL-22. J Exp Med. 2010 Sep 27; 207(10):2239-53. PMID: 20855496; PMCID: PMC2947077.
    6. O'Brien R, Jin N, Huang Y, Aydintug MK, Roark C, Born W. Characteristics of IL-17-producing gammadelta T cells. Immunity. 2010 Jan 29; 32(1):1; author reply 2-4. PMID: 20152161.
      View in: PubMed
    7. Born WK, Roark CL, Jin N, Wands JM, Kemal Aydintug M, Huang Y, Chain JL, Hahn YS, Simonian PL, Fontenot AP, O'Brien RL. Role of ?d T Cells in Lung Inflammation. Open Immunol J. 2009; 2:143-150. PMID: 26550059.
      View in: PubMed
    8. Simonian PL, Roark CL, Born WK, O'Brien RL, Fontenot AP. Gammadelta T cells and Th17 cytokines in hypersensitivity pneumonitis and lung fibrosis. Transl Res. 2009 Nov; 154(5):222-7. PMID: 19840763; PMCID: PMC2766087.
    9. Huang Y, Jin N, Roark CL, Aydintug MK, Wands JM, Huang H, O'Brien RL, Born WK. The influence of IgE-enhancing and IgE-suppressive gammadelta T cells changes with exposure to inhaled ovalbumin. J Immunol. 2009 Jul 15; 183(2):849-55. PMID: 19542369; PMCID: PMC2712735.
    10. Simonian PL, Roark CL, Wehrmann F, Lanham AM, Born WK, O'Brien RL, Fontenot AP. IL-17A-expressing T cells are essential for bacterial clearance in a murine model of hypersensitivity pneumonitis. J Immunol. 2009 May 15; 182(10):6540-9. PMID: 19414809; PMCID: PMC2766088.
    11. O'Brien RL, Roark CL, Born WK. IL-17-producing gammadelta T cells. Eur J Immunol. 2009 Mar; 39(3):662-6. PMID: 19283718; PMCID: PMC2698711.
    12. French JD, Roark CL, Born WK, O'Brien RL. Gammadelta T lymphocyte homeostasis is negatively regulated by beta2-microglobulin. J Immunol. 2009 Feb 15; 182(4):1892-900. PMID: 19201842; PMCID: PMC2703819.
    13. Jin N, Roark CL, Miyahara N, Taube C, Aydintug MK, Wands JM, Huang Y, Hahn YS, Gelfand EW, O'Brien RL, Born WK. Allergic airway hyperresponsiveness-enhancing gammadelta T cells develop in normal untreated mice and fail to produce IL-4/13, unlike Th2 and NKT cells. J Immunol. 2009 Feb 15; 182(4):2002-10. PMID: 19201853; PMCID: PMC2688721.
    14. O'Brien RL, Taylor MA, Hartley J, Nuhsbaum T, Dugan S, Lahmers K, Aydintug MK, Wands JM, Roark CL, Born WK. Protective role of gammadelta T cells in spontaneous ocular inflammation. Invest Ophthalmol Vis Sci. 2009 Jul; 50(7):3266-74. PMID: 19151391; PMCID: PMC2701479.
    15. Simonian PL, Roark CL, Wehrmann F, Lanham AK, Diaz del Valle F, Born WK, O'Brien RL, Fontenot AP. Th17-polarized immune response in a murine model of hypersensitivity pneumonitis and lung fibrosis. J Immunol. 2009 Jan 01; 182(1):657-65. PMID: 19109199; PMCID: PMC2766086.
    16. Hamada S, Umemura M, Shiono T, Tanaka K, Yahagi A, Begum MD, Oshiro K, Okamoto Y, Watanabe H, Kawakami K, Roark C, Born WK, O'Brien R, Ikuta K, Ishikawa H, Nakae S, Iwakura Y, Ohta T, Matsuzaki G. IL-17A produced by gammadelta T cells plays a critical role in innate immunity against listeria monocytogenes infection in the liver. J Immunol. 2008 Sep 01; 181(5):3456-63. PMID: 18714018; PMCID: PMC2859669.
    17. Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S, Jørgensen TN, Tucker RM, Roark CL, Kotzin BL, Evans LH, Izui S. Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. J Immunol. 2008 Aug 15; 181(4):2846-54. PMID: 18684976; PMCID: PMC2587122.
    18. Cook L, Miyahara N, Jin N, Wands JM, Taube C, Roark CL, Potter TA, Gelfand EW, O'Brien RL, Born WK. Evidence that CD8+ dendritic cells enable the development of gammadelta T cells that modulate airway hyperresponsiveness. J Immunol. 2008 Jul 01; 181(1):309-19. PMID: 18566396; PMCID: PMC2493442.
    19. Aydintug MK, Roark CL, Chain JL, Born WK, O'Brien RL. Macrophages express multiple ligands for gammadelta TCRs. Mol Immunol. 2008 Jun; 45(11):3253-63. PMID: 18455236; PMCID: PMC2600894.
    20. Roark CL, Simonian PL, Fontenot AP, Born WK, O'Brien RL. gammadelta T cells: an important source of IL-17. Curr Opin Immunol. 2008 Jun; 20(3):353-7. PMID: 18439808; PMCID: PMC2601685.
    21. Roark CL, French JD, Taylor MA, Bendele AM, Born WK, O'Brien RL. Exacerbation of collagen-induced arthritis by oligoclonal, IL-17-producing gamma delta T cells. J Immunol. 2007 Oct 15; 179(8):5576-83. PMID: 17911645; PMCID: PMC2768546.
    22. Jin N, Miyahara N, Roark CL, French JD, Aydintug MK, Matsuda JL, Gapin L, O'Brien RL, Gelfand EW, Born WK. Airway hyperresponsiveness through synergy of gammadelta} T cells and NKT cells. J Immunol. 2007 Sep 01; 179(5):2961-8. PMID: 17709511; PMCID: PMC4480876.
    23. Born WK, Jin N, Aydintug MK, Wands JM, French JD, Roark CL, O'Brien RL. gammadelta T lymphocytes-selectable cells within the innate system? J Clin Immunol. 2007 Mar; 27(2):133-44. PMID: 17333410.
      View in: PubMed
    24. O'Brien RL, Roark CL, Jin N, Aydintug MK, French JD, Chain JL, Wands JM, Johnston M, Born WK. gammadelta T-cell receptors: functional correlations. Immunol Rev. 2007 Feb; 215:77-88. PMID: 17291280.
      View in: PubMed
    25. Simonian PL, Roark CL, Diaz del Valle F, Palmer BE, Douglas IS, Ikuta K, Born WK, O'Brien RL, Fontenot AP. Regulatory role of gammadelta T cells in the recruitment of CD4+ and CD8+ T cells to lung and subsequent pulmonary fibrosis. J Immunol. 2006 Oct 01; 177(7):4436-43. PMID: 16982878.
      View in: PubMed
    26. Wands JM, Roark CL, Aydintug MK, Jin N, Hahn YS, Cook L, Yin X, Dal Porto J, Lahn M, Hyde DM, Gelfand EW, Mason RJ, O'Brien RL, Born WK. Distribution and leukocyte contacts of gammadelta T cells in the lung. J Leukoc Biol. 2005 Nov; 78(5):1086-96. PMID: 16204632.
      View in: PubMed
    27. French JD, Roark CL, Born WK, O'brien RL. {gamma}{delta} T cell homeostasis is established in competition with {alpha}{beta} T cells and NK cells. Proc Natl Acad Sci U S A. 2005 Oct 11; 102(41):14741-6. PMID: 16203967; PMCID: PMC1239947.
    28. Falta MT, Fontenot AP, Rosloniec EF, Crawford F, Roark CL, Bill J, Marrack P, Kappler J, Kotzin BL. Class II major histocompatibility complex-peptide tetramer staining in relation to functional avidity and T cell receptor diversity in the mouse CD4(+) T cell response to a rheumatoid arthritis-associated antigen. Arthritis Rheum. 2005 Jun; 52(6):1885-96. PMID: 15934080.
      View in: PubMed
    29. Jin N, Taube C, Sharp L, Hahn YS, Yin X, Wands JM, Roark CL, O'brien RL, Gelfand EW, Born WK. Mismatched antigen prepares gamma delta T cells for suppression of airway hyperresponsiveness. J Immunol. 2005 Mar 01; 174(5):2671-9. PMID: 15728474.
      View in: PubMed
    30. Tucker RM, Roark CL, Santiago-Raber ML, Izui S, Kotzin BL. Association between nuclear antigens and endogenous retrovirus in the generation of autoantibody responses in murine lupus. Arthritis Rheum. 2004 Nov; 50(11):3626-36. PMID: 15529369.
      View in: PubMed
    31. Aydintug MK, Roark CL, Yin X, Wands JM, Born WK, O'Brien RL. Detection of cell surface ligands for the gamma delta TCR using soluble TCRs. J Immunol. 2004 Apr 01; 172(7):4167-75. PMID: 15034029.
      View in: PubMed
    32. Roark CL, Aydintug MK, Lewis J, Yin X, Lahn M, Hahn YS, Born WK, Tigelaar RE, O'Brien RL. Subset-specific, uniform activation among V gamma 6/V delta 1+ gamma delta T cells elicited by inflammation. J Leukoc Biol. 2004 Jan; 75(1):68-75. PMID: 14525969.
      View in: PubMed
    33. Hahn YS, Taube C, Jin N, Takeda K, Park JW, Wands JM, Aydintug MK, Roark CL, Lahn M, O'Brien RL, Gelfand EW, Born WK. V gamma 4+ gamma delta T cells regulate airway hyperreactivity to methacholine in ovalbumin-sensitized and challenged mice. J Immunol. 2003 Sep 15; 171(6):3170-8. PMID: 12960345.
      View in: PubMed
    34. Roark CL, Kotzin BL. Characterization of CD4(+) T cell autoreactivity to self-MHC in New Zealand hybrid mice. Clin Immunol. 2001 Jan; 98(1):95-103. PMID: 11141331.
      View in: PubMed
    35. Tucker RM, Vyse TJ, Rozzo S, Roark CL, Izui S, Kotzin BL. Genetic control of glycoprotein 70 autoantigen production and its influence on immune complex levels and nephritis in murine lupus. J Immunol. 2000 Aug 01; 165(3):1665-72. PMID: 10903778.
      View in: PubMed
    36. Heyborne K, Fu YX, Kalataradi H, Reardon C, Roark C, Eyster C, Vollmer M, Born W, O'Brien R. Evidence that murine V gamma 5 and V gamma 6 gamma delta-TCR+ lymphocytes are derived from a common distinct lineage. J Immunol. 1993 Nov 01; 151(9):4523-7. PMID: 8409415.
      View in: PubMed
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