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Paco Sam Herson

TitleProfessor Adjoint
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-PHARM General Operations

    Collapse Research 
    Collapse research activities and funding
    R01HL168892     (HERSON, PACO S)Mar 15, 2023 - Feb 29, 2028
    NIH
    Vascular mechanisms of sepsis-induced cognitive dysfunction
    Role: Principal Investigator
    R01NS118786     (BAYER, K. ULRICH)Jan 15, 2021 - Nov 30, 2025
    NIH
    CaMKII in global cerebral ischemia: mechanisms and therapeutic intervention
    Role: Co-Principal Investigator
    R01GM125095     (SCHMIDT, ERIC PETER)Jul 15, 2017 - May 31, 2021
    NIH
    Targeting circulating endothelial glycocalyx fragments to reduce septic encephalopathy
    Role: Co-Principal Investigator
    R01NS092645     (HERSON, PACO S)Feb 1, 2016 - Jan 31, 2021
    NIH
    Targeting TRPM2 channels to improve synaptic and cognitive function after cerebral ischemia
    Role: Principal Investigator
    R21NS082933     (MARR, DAVID WM)Sep 30, 2013 - Aug 31, 2016
    NIH
    Bead-Based Approach for Combined Mechanical and Pharmacological Treatment of Acut
    Role: Co-Principal Investigator
    R01NS080851     (HERSON, PACO S)May 1, 2013 - Apr 30, 2019
    NIH
    CaMKII in global cerebral ischemia
    Role: Principal Investigator
    R01NS065855     (ADELMAN, JOHN P)Jun 1, 2009 - May 31, 2014
    NIH
    SK2 Channels as Novel Neuroprotective Targets Against Cerebral Ischemia
    Role: Co-Principal Investigator
    R01NS058792     (ADELMAN, JOHN P)Sep 30, 2007 - May 31, 2013
    NIH
    GABA-A Receptor Rescue as a Neuroprotective Strategy in Cerebral Ischemia
    Role: Co-Principal Investigator
    R21NS052591     (HERSON, PACO S)Sep 1, 2005 - Jun 30, 2008
    NIH
    Sex differences in Purkinje cell sensitivity to ischemia
    Role: Principal Investigator
    R01NS046072     (HERSON, PACO S)Sep 30, 2002 - Jan 31, 2025
    NIH
    Sex differences in brain injury following pediatric cardiac arrest
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Oshima K, Siddiqui N, Orfila JE, Carter D, Laing J, Han X, Zakharevich I, Iozzo RV, Ghasabyan A, Moore H, Zhang F, Linhardt RJ, Moore EE, Quillinan N, Schmidt EP, Herson PS, Hippensteel JA. A role for decorin in improving motor deficits after traumatic brain injury. Matrix Biol. 2024 Jan; 125:88-99. PMID: 38135163.
      View in: PubMed
    2. Higgins HM, Chen L, Ravare BC, Jeppson KA, Bina HT, Herson PS, Monte AA, Poisson SN, Dylla L. Response to: Acute ischemic stroke and cardioemboli: Does sex matter? Am J Emerg Med. 2023 12; 74:170-171. PMID: 37867013.
      View in: PubMed
    3. Higgins HM, Chen L, Ravare BC, Jeppson KA, Bina HT, Herson PS, Monte AA, Poisson SN, Dylla L. Sex differences in acute ischemic stroke presentation are a matter of infarct location. Am J Emerg Med. 2023 12; 74:95-99. PMID: 37802001.
      View in: PubMed
    4. Fine-Raquet B, Manzella FM, Joksimovic SM, Dietz RM, Orfila JE, Sampath D, Tesic V, Atluri N, Covey DF, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal exposure to a neuroactive steroid alters low-frequency oscillations in the subiculum. Exp Biol Med (Maywood). 2023 04; 248(7):578-587. PMID: 37309730.
      View in: PubMed
    5. Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory in mice and is neuroprotective in pigs. J Biol Chem. 2023 05; 299(5):104693. PMID: 37037305.
      View in: PubMed
    6. Le TD, Gurney JM, Singh KP, Nessen SC, Schneider ALC, Agimi Y, Bebarta VS, Herson PS, Stout KC, Cardin S, Crowder AT, Ling GSF, Stackle ME, Pusateri AE. Trends in Traumatic Brain Injury Among U.S. Service Members Deployed in Iraq and Afghanistan, 2002-2016. Am J Prev Med. 2023 08; 65(2):230-238. PMID: 36870787.
      View in: PubMed
    7. Basak JM, Falk M, Mitchell DN, Coakley KA, Quillinan N, Orfila JE, Herson PS. Targeting BACE1-mediated production of amyloid beta improves hippocampal synaptic function in an experimental model of ischemic stroke. J Cereb Blood Flow Metab. 2023 11; 43(2_suppl):66-77. PMID: 37150606.
      View in: PubMed
    8. Frazier AP, Mitchell DN, Given KS, Hunn G, Burch AM, Childs CR, Moreno-Garcia M, Corigilano MR, Quillinan N, Macklin WB, Herson PS, Dingman AL. Chronic changes in oligodendrocyte sub-populations after middle cerebral artery occlusion in neonatal mice. Glia. 2023 06; 71(6):1429-1450. PMID: 36794545.
      View in: PubMed
    9. Rumian NL, Brown CN, Hendry-Hofer TB, Rossetti T, Orfila JE, Tullis JE, Dwoskin LP, Buonarati OR, Lisman JE, Quillinan N, Herson PS, Bebarta VS, Bayer KU. Short-term CaMKII inhibition with tatCN19o does not erase pre-formed memory and is neuroprotective in non-rodents. bioRxiv. 2023 Jan 23. PMID: 36747773.
      View in: PubMed
    10. Joksimovic SM, Ghodsi SM, Heinsbroek JA, Orfila JE, Busquet N, Tesic V, Valdez R, Fine-Raquet B, Jevtovic-Todorovic V, Raol YH, Herson PS, Todorovic SM. CaV3.1?T-type calcium channels are important for spatial memory processing in the dorsal subiculum. Neuropharmacology. 2023 03 15; 226:109400. PMID: 36586474.
      View in: PubMed
    11. Dylla L, Higgins HM, Piper C, Poisson SN, Herson PS, Monte AA. Sex as a biological variable in determining the metabolic changes influencing acute ischemic stroke outcomes-Where is the data: A systematic review. Front Neurol. 2022; 13:1026431. PMID: 36504643.
      View in: PubMed
    12. Dietz RM, Dingman AL, Herson PS. Cerebral ischemia in the developing brain. J Cereb Blood Flow Metab. 2022 10; 42(10):1777-1796. PMID: 35765984.
      View in: PubMed
    13. Zimmermann CJ, Herson PS, Neeves KB, Marr DWM. Multimodal microwheel swarms for targeting in three-dimensional networks. Sci Rep. 2022 03 24; 12(1):5078. PMID: 35332242.
      View in: PubMed
    14. Nimjee SM, Akhter AS, Zakeri A, Herson PS. Sex differences in thrombosis as it affects acute ischemic stroke. Neurobiol Dis. 2022 04; 165:105647. PMID: 35114362.
      View in: PubMed
    15. Dylla L, Rice JD, Poisson SN, Monte AA, Higgins HM, Ginde AA, Herson PS. Analysis of Stroke Care Among 2019-2020 National Emergency Medical Services Information System Encounters. J Stroke Cerebrovasc Dis. 2022 Mar; 31(3):106278. PMID: 34998044.
      View in: PubMed
    16. Garcia JD, Gookin SE, Crosby KC, Schwartz SL, Tiemeier E, Kennedy MJ, Dell'Acqua ML, Herson PS, Quillinan N, Smith KR. Stepwise disassembly of GABAergic synapses during pathogenic excitotoxicity. Cell Rep. 2021 12 21; 37(12):110142. PMID: 34936876.
      View in: PubMed
    17. Disharoon D, Trewyn BG, Herson PS, Marr DWM, Neeves KB. Breaking the fibrinolytic speed limit with microwheel co-delivery of tissue plasminogen activator and plasminogen. J Thromb Haemost. 2022 02; 20(2):486-497. PMID: 34882946.
      View in: PubMed
    18. Rumian NL, Chalmers NE, Tullis JE, Herson PS, Bayer KU. CaMKIIa knockout protects from ischemic neuronal cell death after resuscitation from cardiac arrest. Brain Res. 2021 12 15; 1773:147699. PMID: 34687697.
      View in: PubMed
    19. Dietz RM, Orfila JE, Chalmers N, Minjarez C, Vigil J, Deng G, Quillinan N, Herson PS. Functional Restoration following Global Cerebral Ischemia in Juvenile Mice following Inhibition of Transient Receptor Potential M2 (TRPM2) Ion Channels. Neural Plast. 2021; 2021:8774663. PMID: 34659399.
      View in: PubMed
    20. Tullis JE, Buonarati OR, Coultrap SJ, Bourke AM, Tiemeier EL, Kennedy MJ, Herson PS, Bayer KU. GluN2B S1303 phosphorylation by CaMKII or DAPK1: no indication for involvement in ischemia or LTP. iScience. 2021 Oct 22; 24(10):103214. PMID: 34704002.
      View in: PubMed
    21. Cruz Del Angel Y, Orfila JE, Herson PS, Brooks-Kayal A, Gonz?lez MI. Down-regulation of AMPA receptors and long-term potentiation during early epileptogenesis. Epilepsy Behav. 2021 Sep 27; 124:108320. PMID: 34592633.
      View in: PubMed
    22. Giannotti G, Gong S, Fayette N, Heinsbroek JA, Orfila JE, Herson PS, Ford CP, Peters J. Extinction blunts paraventricular thalamic contributions to heroin relapse. Cell Rep. 2021 08 24; 36(8):109605. PMID: 34433067.
      View in: PubMed
    23. D'Souza A, Burch A, Dave KM, Sreeram A, Reynolds MJ, Dobbins DX, Kamte YS, Zhao W, Sabatelle C, Joy GM, Soman V, Chandran UR, Shiva SS, Quillinan N, Herson PS, Manickam DS. Microvesicles transfer mitochondria and increase mitochondrial function in brain endothelial cells. J Control Release. 2021 10 10; 338:505-526. PMID: 34450196.
      View in: PubMed
    24. Dylla L, Herson PS, Poisson SN, Rice JD, Ginde AA. Association Between Chronic Inflammatory Diseases and Stroke-Associated Pneumonia - An Epidemiological Study. J Stroke Cerebrovasc Dis. 2021 Apr; 30(4):105605. PMID: 33482567.
      View in: PubMed
    25. Johnson AC, Li Z, Orfila JE, Herson PS, Cipolla MJ. Hippocampal network dysfunction as a mechanism of early-onset dementia after preeclampsia and eclampsia. Prog Neurobiol. 2021 04; 199:101938. PMID: 33130230.
      View in: PubMed
    26. Torres AC, Bebarta VS, April MD, Maddry JK, Herson PS, Bebarta EK, Schauer S. Ketamine Administration in Prehospital Combat Injured Patients With Traumatic Brain Injury: A 10-Year Report of Survival. Cureus. 2020 Jul 17; 12(7):e9248. PMID: 32821594.
      View in: PubMed
    27. Tseng N, Lambie SC, Huynh CQ, Sanford B, Patel M, Herson PS, Ormond DR. Mitochondrial transfer from mesenchymal stem cells improves neuronal metabolism after oxidant injury in vitro: The role of Miro1. J Cereb Blood Flow Metab. 2021 04; 41(4):761-770. PMID: 32501156.
      View in: PubMed
    28. Manzella FM, Joksimovic SM, Orfila JE, Fine BR, Dietz RM, Sampath D, Fiedler HK, Tesic V, Atluri N, Raol YH, Jevtovic-Todorovic V, Herson PS, Todorovic SM. Neonatal Ketamine Alters High-Frequency Oscillations and Synaptic Plasticity in the Subiculum But Does not Affect Sleep Macrostructure in Adolescent Rats. Front Syst Neurosci. 2020; 14:26. PMID: 32528257.
      View in: PubMed
    29. Maddry JK, Arana AA, Perez CA, Medellin KL, Paciocco JA, Mora AG, Holder WG, Davis WT, Herson PS, Bebarta VS. Influence of Time to Transport to a Higher Level Facility on the Clinical Outcomes of US Combat Casualties with TBI: A Multicenter 7-Year Study. Mil Med. 2020 02 13; 185(1-2):e138-e145. PMID: 31334769.
      View in: PubMed
    30. Buonarati OR, Cook SG, Goodell DJ, Chalmers NE, Rumian NL, Tullis JE, Restrepo S, Coultrap SJ, Quillinan N, Herson PS, Bayer KU. CaMKII versus DAPK1 Binding to GluN2B in Ischemic Neuronal Cell Death after Resuscitation from Cardiac Arrest. Cell Rep. 2020 01 07; 30(1):1-8.e4. PMID: 31914378.
      View in: PubMed
    31. Cruz-Torres I, Backos DS, Herson PS. Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX. Mol Pharmacol. 2020 02; 97(2):102-111. PMID: 31772034.
      View in: PubMed
    32. Chalmers NE, Yonchek J, Steklac KE, Ramsey M, Bayer KU, Herson PS, Quillinan N. Calcium/Calmodulin-Dependent Kinase (CaMKII) Inhibition Protects Against Purkinje Cell Damage Following CA/CPR in Mice. Mol Neurobiol. 2020 Jan; 57(1):150-158. PMID: 31520314.
      View in: PubMed
    33. Dietz RM, Cruz-Torres I, Orfila JE, Patsos OP, Shimizu K, Chalmers N, Deng G, Tiemeier E, Quillinan N, Herson PS. Reversal of Global Ischemia-Induced Cognitive Dysfunction by Delayed Inhibition of TRPM2 Ion Channels. Transl Stroke Res. 2020 04; 11(2):254-266. PMID: 31250378.
      View in: PubMed
    34. Zhang X, Han X, Xia K, Xu Y, Yang Y, Oshima K, Haeger SM, Perez MJ, McMurtry SA, Hippensteel JA, Ford JA, Herson PS, Liu J, Schmidt EP, Linhardt RJ. Circulating heparin oligosaccharides rapidly target the hippocampus in sepsis, potentially impacting cognitive functions. Proc Natl Acad Sci U S A. 2019 05 07; 116(19):9208-9213. PMID: 31010931.
      View in: PubMed
    35. Hippensteel JA, Anderson BJ, Orfila JE, McMurtry SA, Dietz RM, Su G, Ford JA, Oshima K, Yang Y, Zhang F, Han X, Yu Y, Liu J, Linhardt RJ, Meyer NJ, Herson PS, Schmidt EP. Circulating heparan sulfate fragments mediate septic cognitive dysfunction. J Clin Invest. 2019 04 01; 129(4):1779-1784. PMID: 30720464.
      View in: PubMed
    36. Dingman AL, Rodgers KM, Dietz RM, Hickey SP, Frazier AP, Clevenger AC, Yonchek JC, Traystman RJ, Macklin WB, Herson PS. Oligodendrocyte Progenitor Cell Proliferation and Fate after White Matter Stroke in Juvenile and Adult Mice. Dev Neurosci. 2019 Mar 12; 1-16. PMID: 30861520.
      View in: PubMed
    37. Orfila JE, Dietz RM, Rodgers KM, Dingman A, Patsos OP, Cruz-Torres I, Grewal H, Strnad F, Schroeder C, Herson PS. Experimental pediatric stroke shows age-specific recovery of cognition and role of hippocampal Nogo-A receptor signaling. J Cereb Blood Flow Metab. 2020 03; 40(3):588-599. PMID: 30762478.
      View in: PubMed
    38. Ritchey Z, Mirsky DM, Weitzenkamp D, Bernard TJ, Herson PS, Stence NV. Age-associated hippocampal volume changes in childhood arterial ischemic stroke. Childs Nerv Syst. 2019 02; 35(2):295-300. PMID: 30535770.
      View in: PubMed
    39. Quillinan N, Dingman AL, Deng G, Tatum S, Orfila JE, Clevenger AC, Klawitter J, Traystman RJ, Herson PS. Single dose of 17?-estradiol provides transient neuroprotection in female juvenile mice after cardiac-arrest and cardiopulmonary resuscitation. Neurochem Int. 2019 07; 127:80-86. PMID: 30471325.
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    40. Won SJ, Minnella AM, Wu L, Eun CH, Rome E, Herson PS, Shaw AE, Bamburg JR, Swanson RA. Cofilin-actin rod formation in neuronal processes after brain ischemia. PLoS One. 2018; 13(10):e0198709. PMID: 30325927.
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    41. Bushnell CD, Chaturvedi S, Gage KR, Herson PS, Hurn PD, Jim?nez MC, Kittner SJ, Madsen TE, McCullough LD, McDermott M, Reeves MJ, Rundek T. Sex differences in stroke: Challenges and opportunities. J Cereb Blood Flow Metab. 2018 12; 38(12):2179-2191. PMID: 30114967.
      View in: PubMed
    42. Orfila JE, McKinnon N, Moreno M, Deng G, Chalmers N, Dietz RM, Herson PS, Quillinan N. Cardiac Arrest Induces Ischemic Long-Term Potentiation of Hippocampal CA1 Neurons That Occludes Physiological Long-Term Potentiation. Neural Plast. 2018; 2018:9275239. PMID: 29853851.
      View in: PubMed
    43. Rodgers KM, Ahrendsen JT, Patsos OP, Strnad FA, Yonchek JC, Traystman RJ, Macklin WB, Herson PS. Endogenous Neuronal Replacement in the Juvenile Brain Following Cerebral Ischemia. Neuroscience. 2018 06 01; 380:1-13. PMID: 29649514.
      View in: PubMed
    44. Cook SG, Bourke AM, O'Leary H, Zaegel V, Lasda E, Mize-Berge J, Quillinan N, Tucker CL, Coultrap SJ, Herson PS, Bayer KU. Analysis of the CaMKIIa and ? splice-variant distribution among brain regions reveals isoform-specific differences in holoenzyme formation. Sci Rep. 2018 04 03; 8(1):5448. PMID: 29615706.
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    45. Dietz RM, Orfila JE, Rodgers KM, Patsos OP, Deng G, Chalmers N, Quillinan N, Traystman RJ, Herson PS. Juvenile cerebral ischemia reveals age-dependent BDNF-TrkB signaling changes: Novel mechanism of recovery and therapeutic intervention. J Cereb Blood Flow Metab. 2018 12; 38(12):2223-2235. PMID: 29611441.
      View in: PubMed
    46. Clevenger AC, Kim H, Salcedo E, Yonchek JC, Rodgers KM, Orfila JE, Dietz RM, Quillinan N, Traystman RJ, Herson PS. Endogenous Sex Steroids Dampen Neuroinflammation and Improve Outcome of Traumatic Brain Injury in Mice. J Mol Neurosci. 2018 Mar; 64(3):410-420. PMID: 29450697.
      View in: PubMed
    47. Gould EA, Busquet N, Shepherd D, Dietz RM, Herson PS, Simoes de Souza FM, Li A, George NM, Restrepo D, Macklin WB. Mild myelin disruption elicits early alteration in behavior and proliferation in the subventricular zone. Elife. 2018 02 13; 7. PMID: 29436368.
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    48. Oshima K, Haeger SM, Hippensteel JA, Herson PS, Schmidt EP. More than a biomarker: the systemic consequences of heparan sulfate fragments released during endothelial surface layer degradation (2017 Grover Conference Series). Pulm Circ. 2018 Jan-Mar; 8(1):2045893217745786. PMID: 29199903.
      View in: PubMed
    49. Orfila JE, Grewal H, Dietz RM, Strnad F, Shimizu T, Moreno M, Schroeder C, Yonchek J, Rodgers KM, Dingman A, Bernard TJ, Quillinan N, Macklin WB, Traystman RJ, Herson PS. Delayed inhibition of tonic inhibition enhances functional recovery following experimental ischemic stroke. J Cereb Blood Flow Metab. 2019 06; 39(6):1005-1014. PMID: 29283314.
      View in: PubMed
    50. Joksimovic SM, Eggan P, Izumi Y, Joksimovic SL, Tesic V, Dietz RM, Orfila JE, DiGruccio MR, Herson PS, Jevtovic-Todorovic V, Zorumski CF, Todorovic SM. The role of T-type calcium channels in the subiculum: to burst or not to burst? J Physiol. 2017 10 01; 595(19):6327-6348. PMID: 28744923.
      View in: PubMed
    51. Tasci TO, Disharoon D, Schoeman RM, Rana K, Herson PS, Marr DWM, Neeves KB. Enhanced Fibrinolysis with Magnetically Powered Colloidal Microwheels. Small. 2017 09; 13(36). PMID: 28719063.
      View in: PubMed
    52. Stence NV, Pabst LL, Hollatz AL, Mirsky DM, Herson PS, Poisson S, Traystman RJ, Bernard TJ. Predicting Progression of Intracranial Arteriopathies in Childhood Stroke With Vessel Wall Imaging. Stroke. 2017 08; 48(8):2274-2277. PMID: 28679853.
      View in: PubMed
    53. Deng G, Orfila JE, Dietz RM, Moreno-Garcia M, Rodgers KM, Coultrap SJ, Quillinan N, Traystman RJ, Bayer KU, Herson PS. Autonomous CaMKII Activity as a Drug Target for Histological and Functional Neuroprotection after Resuscitation from Cardiac Arrest. Cell Rep. 2017 01 31; 18(5):1109-1117. PMID: 28147268.
      View in: PubMed
    54. Quillinan N, Deng G, Shimizu K, Cruz-Torres I, Schroeder C, Traystman RJ, Herson PS. Long-term depression in Purkinje neurons is persistently impaired following cardiac arrest and cardiopulmonary resuscitation in mice. J Cereb Blood Flow Metab. 2017 Aug; 37(8):3053-3064. PMID: 28168893.
      View in: PubMed
    55. Weitzel LR, Sampath D, Shimizu K, White AM, Herson PS, Raol YH. EEG power as a biomarker to predict the outcome after cardiac arrest and cardiopulmonary resuscitation induced global ischemia. Life Sci. 2016 Nov 15; 165:21-25. PMID: 27640888.
      View in: PubMed
    56. Quillinan N, Herson PS, Traystman RJ. Neuropathophysiology of Brain Injury. Anesthesiol Clin. 2016 Sep; 34(3):453-64. PMID: 27521191.
      View in: PubMed
    57. Ahrendsen JT, Grewal HS, Hickey SP, Culp CM, Gould EA, Shimizu T, Strnad FA, Traystman RJ, Herson PS, Macklin WB. Juvenile striatal white matter is resistant to ischemia-induced damage. Glia. 2016 11; 64(11):1972-86. PMID: 27463063.
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    58. Kelly KK, MacPherson AM, Grewal H, Strnad F, Jones JW, Yu J, Pierzchalski K, Kane MA, Herson PS, Siegenthaler JA. Col1a1+ perivascular cells in the brain are a source of retinoic acid following stroke. BMC Neurosci. 2016 07 15; 17(1):49. PMID: 27422020.
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    59. Colbert JF, Traystman RJ, Poisson SN, Herson PS, Ginde AA. Sex-Related Differences in the Risk of Hospital-Acquired Sepsis and Pneumonia Post Acute Ischemic Stroke. J Stroke Cerebrovasc Dis. 2016 Oct; 25(10):2399-404. PMID: 27363622.
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    60. Shimizu T, Dietz RM, Cruz-Torres I, Strnad F, Garske AK, Moreno M, Venna VR, Quillinan N, Herson PS. Extended therapeutic window of a novel peptide inhibitor of TRPM2 channels following focal cerebral ischemia. Exp Neurol. 2016 09; 283(Pt A):151-6. PMID: 27317297.
      View in: PubMed
    61. Dietz RM, Deng G, Orfila JE, Hui X, Traystman RJ, Herson PS. Therapeutic hypothermia protects against ischemia-induced impairment of synaptic plasticity following juvenile cardiac arrest in sex-dependent manner. Neuroscience. 2016 06 14; 325:132-41. PMID: 27033251.
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    62. Tasci TO, Herson PS, Neeves KB, Marr DW. Surface-enabled propulsion and control of colloidal microwheels. Nat Commun. 2016 Jan 04; 7:10225. PMID: 26725747.
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    63. Shimizu K, Quillinan N, Orfila JE, Herson PS. Sirtuin-2 mediates male specific neuronal injury following experimental cardiac arrest through activation of TRPM2 ion channels. Exp Neurol. 2016 Jan; 275 Pt 1:78-83. PMID: 26522013.
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    64. Bell MT, Puskas F, Bennett DT, Cleveland JC, Herson PS, Mares JM, Meng X, Weyant MJ, Fullerton DA, Brett Reece T. Clinical indicators of paraplegia underplay universal spinal cord neuronal injury from transient aortic occlusion. Brain Res. 2015 Aug 27; 1618:55-60. PMID: 26005132.
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    65. Sippel TR, Shimizu T, Strnad F, Traystman RJ, Herson PS, Waziri A. Arginase I release from activated neutrophils induces peripheral immunosuppression in a murine model of stroke. J Cereb Blood Flow Metab. 2015 Oct; 35(10):1657-63. PMID: 25966956.
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    66. Grace PM, Shimizu K, Strand KA, Rice KC, Deng G, Watkins LR, Herson PS. (+)-Naltrexone is neuroprotective and promotes alternative activation in the mouse hippocampus after cardiac arrest/cardiopulmonary resuscitation. Brain Behav Immun. 2015 Aug; 48:115-22. PMID: 25774010.
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    67. Freeman KA, Puskas F, Bell MT, Mares JM, Foley LS, Weyant MJ, Cleveland JC, Fullerton DA, Meng X, Herson PS, Reece TB. Alpha-2 agonist attenuates ischemic injury in spinal cord neurons. J Surg Res. 2015 May 01; 195(1):21-8. PMID: 25655994.
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    68. Quillinan N, Grewal H, Klawitter J, Herson PS. Sex Steroids Do Not Modulate TRPM2-Mediated Injury in Females following Middle Cerebral Artery Occlusion(1,2,3). eNeuro. 2014 Nov-Dec; 1(1). PMID: 26464961.
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    69. Quillinan N, Grewal H, Deng G, Shimizu K, Yonchek JC, Strnad F, Traystman RJ, Herson PS. Region-specific role for GluN2B-containing NMDA receptors in injury to Purkinje cells and CA1 neurons following global cerebral ischemia. Neuroscience. 2015 Jan 22; 284:555-565. PMID: 25450957.
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    70. Herson PS, Traystman RJ. Animal models of stroke: translational potential at present and in 2050. Future Neurol. 2014 Sep; 9(5):541-551. PMID: 25530721.
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    71. Orfila JE, Shimizu K, Garske AK, Deng G, Maylie J, Traystman RJ, Quillinan N, Adelman JP, Herson PS. Increasing small conductance Ca2+-activated potassium channel activity reverses ischemia-induced impairment of long-term potentiation. Eur J Neurosci. 2014 Oct; 40(8):3179-88. PMID: 25080203.
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    72. Deng G, Carter J, Traystman RJ, Wagner DH, Herson PS. Pro-inflammatory T-lymphocytes rapidly infiltrate into the brain and contribute to neuronal injury following cardiac arrest and cardiopulmonary resuscitation. J Neuroimmunol. 2014 Sep 15; 274(1-2):132-40. PMID: 25084739.
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    73. Hutchens MP, Fujiyoshi T, Koerner IP, Herson PS. Extracranial hypothermia during cardiac arrest and cardiopulmonary resuscitation is neuroprotective in vivo. Ther Hypothermia Temp Manag. 2014 Jun; 4(2):79-87. PMID: 24865403.
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    74. Quillinan N, Deng G, Grewal H, Herson PS. Androgens and stroke: good, bad or indifferent? Exp Neurol. 2014 Sep; 259:10-5. PMID: 24512750.
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    75. Traystman RJ, Herson PS. Misleading results: translational challenges. Science. 2014 Jan 24; 343(6169):369-70. PMID: 24458624.
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    76. Fairbanks SL, Vest R, Verma S, Traystman RJ, Herson PS. Sex stratified neuronal cultures to study ischemic cell death pathways. J Vis Exp. 2013 Dec 09; (82):e50758. PMID: 24378980.
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    77. Deng G, Yonchek JC, Quillinan N, Strnad FA, Exo J, Herson PS, Traystman RJ. A novel mouse model of pediatric cardiac arrest and cardiopulmonary resuscitation reveals age-dependent neuronal sensitivities to ischemic injury. J Neurosci Methods. 2014 Jan 30; 222:34-41. PMID: 24192226.
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    78. Bell MT, Puskas F, Bennett DT, Herson PS, Quillinan N, Fullerton DA, Reece TB. Dexmedetomidine, an a-2a adrenergic agonist, promotes ischemic tolerance in a murine model of spinal cord ischemia-reperfusion. J Thorac Cardiovasc Surg. 2014 Jan; 147(1):500-6. PMID: 24035379.
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    79. Bell MT, Puskas F, Agoston VA, Cleveland JC, Freeman KA, Gamboni F, Herson PS, Meng X, Smith PD, Weyant MJ, Fullerton DA, Reece TB. Toll-like receptor 4-dependent microglial activation mediates spinal cord ischemia-reperfusion injury. Circulation. 2013 Sep 10; 128(11 Suppl 1):S152-6. PMID: 24030400.
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    80. Herson PS, Palmateer J, Hurn PD. Biological sex and mechanisms of ischemic brain injury. Transl Stroke Res. 2013 Aug; 4(4):413-9. PMID: 23930140.
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    81. Bell MT, Agoston VA, Freeman KA, Puskas F, Herson PS, Mares J, Fullerton DA, Reece TB. Interruption of spinal cord microglial signaling by alpha-2 agonist dexmedetomidine in a murine model of delayed paraplegia. J Vasc Surg. 2014 Apr; 59(4):1090-7. PMID: 23850057.
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    82. Wang J, Fujiyoshi T, Kosaka Y, Raybuck JD, Lattal KM, Ikeda M, Herson PS, Koerner IP. Inhibition of soluble epoxide hydrolase after cardiac arrest/cardiopulmonary resuscitation induces a neuroprotective phenotype in activated microglia and improves neuronal survival. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1574-81. PMID: 23820647.
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    83. Shimizu T, Macey TA, Quillinan N, Klawitter J, Perraud AL, Traystman RJ, Herson PS. Androgen and PARP-1 regulation of TRPM2 channels after ischemic injury. J Cereb Blood Flow Metab. 2013 Oct; 33(10):1549-55. PMID: 23801245.
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    84. Nakayama S, Vest R, Traystman RJ, Herson PS. Sexually dimorphic response of TRPM2 inhibition following cardiac arrest-induced global cerebral ischemia in mice. J Mol Neurosci. 2013 Sep; 51(1):92-8. PMID: 23532768.
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    85. Herson PS, Bombardier CG, Parker SM, Shimizu T, Klawitter J, Klawitter J, Quillinan N, Exo JL, Goldenberg NA, Traystman RJ. Experimental pediatric arterial ischemic stroke model reveals sex-specific estrogen signaling. Stroke. 2013 Mar; 44(3):759-63. PMID: 23349190.
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    86. Kelley MH, Ortiz J, Shimizu K, Grewal H, Quillinan N, Herson PS. Alterations in Purkinje cell GABAA receptor pharmacology following oxygen and glucose deprivation and cerebral ischemia reveal novel contribution of ?1 -subunit-containing receptors. Eur J Neurosci. 2013 Feb; 37(4):555-63. PMID: 23176253.
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    87. Verma S, Quillinan N, Yang YF, Nakayama S, Cheng J, Kelley MH, Herson PS. TRPM2 channel activation following in vitro ischemia contributes to male hippocampal cell death. Neurosci Lett. 2012 Nov 14; 530(1):41-6. PMID: 23041043.
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    88. Hutchens MP, Fujiyoshi T, Komers R, Herson PS, Anderson S. Estrogen protects renal endothelial barrier function from ischemia-reperfusion in vitro and in vivo. Am J Physiol Renal Physiol. 2012 Aug 01; 303(3):F377-85. PMID: 22622457.
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    89. Ren X, Akiyoshi K, Grafe MR, Vandenbark AA, Hurn PD, Herson PS, Offner H. Myelin specific cells infiltrate MCAO lesions and exacerbate stroke severity. Metab Brain Dis. 2012 Mar; 27(1):7-15. PMID: 21989743.
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    90. Akiyoshi K, Dziennis S, Palmateer J, Ren X, Vandenbark AA, Offner H, Herson PS, Hurn PD. Recombinant T cell receptor ligands improve outcome after experimental cerebral ischemia. Transl Stroke Res. 2011 Sep 01; 2(3):404-10. PMID: 21961027.
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    91. Hutchens MP, Traystman RJ, Fujiyoshi T, Nakayama S, Herson PS. Normothermic cardiac arrest and cardiopulmonary resuscitation: a mouse model of ischemia-reperfusion injury. J Vis Exp. 2011 Aug 30; (54). PMID: 21897359.
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    92. Allen D, Nakayama S, Kuroiwa M, Nakano T, Palmateer J, Kosaka Y, Ballesteros C, Watanabe M, Bond CT, Luj?n R, Maylie J, Adelman JP, Herson PS. SK2 channels are neuroprotective for ischemia-induced neuronal cell death. J Cereb Blood Flow Metab. 2011 Dec; 31(12):2302-12. PMID: 21712833.
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    93. Ren X, Akiyoshi K, Dziennis S, Vandenbark AA, Herson PS, Hurn PD, Offner H. Regulatory B cells limit CNS inflammation and neurologic deficits in murine experimental stroke. J Neurosci. 2011 Jun 08; 31(23):8556-63. PMID: 21653859.
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    94. Kelley MH, Kuroiwa M, Taguchi N, Herson PS. Sex difference in sensitivity to allopregnanolone neuroprotection in mice correlates with effect on spontaneous inhibitory post synaptic currents. Neuropharmacology. 2011 Sep; 61(4):724-9. PMID: 21640735.
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    95. Jia J, Verma S, Nakayama S, Quillinan N, Grafe MR, Hurn PD, Herson PS. Sex differences in neuroprotection provided by inhibition of TRPM2 channels following experimental stroke. J Cereb Blood Flow Metab. 2011 Nov; 31(11):2160-8. PMID: 21587268.
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    96. Dziennis S, Mader S, Akiyoshi K, Ren X, Ayala P, Burrows GG, Vandenbark AA, Herson PS, Hurn PD, Offner HA. Therapy with recombinant T-cell receptor ligand reduces infarct size and infiltrating inflammatory cells in brain after middle cerebral artery occlusion in mice. Metab Brain Dis. 2011 Jun; 26(2):123-33. PMID: 21472429.
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    97. Nakano T, Hurn PD, Herson PS, Traystman RJ. Testosterone exacerbates neuronal damage following cardiac arrest and cardiopulmonary resuscitation in mouse. Brain Res. 2010 Oct 21; 1357:124-30. PMID: 20709035.
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    98. Cheng J, Uchida M, Zhang W, Grafe MR, Herson PS, Hurn PD. Role of salt-induced kinase 1 in androgen neuroprotection against cerebral ischemia. J Cereb Blood Flow Metab. 2011 Jan; 31(1):339-50. PMID: 20588319.
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    99. Liu M, Kelley MH, Herson PS, Hurn PD. Neuroprotection of sex steroids. Minerva Endocrinol. 2010 Jun; 35(2):127-43. PMID: 20595940.
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    100. Zhu W, Wang L, Zhang L, Palmateer JM, Libal NL, Hurn PD, Herson PS, Murphy SJ. Isoflurane preconditioning neuroprotection in experimental focal stroke is androgen-dependent in male mice. Neuroscience. 2010 Aug 25; 169(2):758-69. PMID: 20580788.
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    101. Hutchens MP, Nakano T, Kosaka Y, Dunlap J, Zhang W, Herson PS, Murphy SJ, Anderson S, Hurn PD. Estrogen is renoprotective via a nonreceptor-dependent mechanism after cardiac arrest in vivo. Anesthesiology. 2010 Feb; 112(2):395-405. PMID: 20068453.
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    102. Herson PS, Hurn PD. Gender and the injured brain. Prog Brain Res. 2010; 186:177-87. PMID: 21094893.
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    103. Vagnerova K, Liu K, Ardeshiri A, Cheng J, Murphy SJ, Hurn PD, Herson PS. Poly (ADP-ribose) polymerase-1 initiated neuronal cell death pathway--do androgens matter? Neuroscience. 2010 Mar 17; 166(2):476-81. PMID: 20035840.
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    104. Uchida M, Palmateer JM, Herson PS, DeVries AC, Cheng J, Hurn PD. Dose-dependent effects of androgens on outcome after focal cerebral ischemia in adult male mice. J Cereb Blood Flow Metab. 2009 Aug; 29(8):1454-62. PMID: 19436313.
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    105. Herson PS, Koerner IP, Hurn PD. Sex, sex steroids, and brain injury. Semin Reprod Med. 2009 May; 27(3):229-39. PMID: 19401954.
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    106. Kelley MH, Taguchi N, Ardeshiri A, Kuroiwa M, Hurn PD, Traystman RJ, Herson PS. Ischemic insult to cerebellar Purkinje cells causes diminished GABAA receptor function and allopregnanolone neuroprotection is associated with GABAA receptor stabilization. J Neurochem. 2008 Nov; 107(3):668-78. PMID: 18699862.
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    107. Ardeshiri A, Kelley MH, Korner IP, Hurn PD, Herson PS. Mechanism of progesterone neuroprotection of rat cerebellar Purkinje cells following oxygen-glucose deprivation. Eur J Neurosci. 2006 Nov; 24(9):2567-74. PMID: 17100844.
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    108. Adelman JP, Herson PS. Making scents of olfactory adaptation. Nat Neurosci. 2004 Jul; 7(7):689-90. PMID: 15220925.
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    109. Bond CT, Herson PS, Strassmaier T, Hammond R, Stackman R, Maylie J, Adelman JP. Small conductance Ca2+-activated K+ channel knock-out mice reveal the identity of calcium-dependent afterhyperpolarization currents. J Neurosci. 2004 Jun 09; 24(23):5301-6. PMID: 15190101.
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    110. Maylie J, Bond CT, Herson PS, Lee WS, Adelman JP. Small conductance Ca2+-activated K+ channels and calmodulin. J Physiol. 2004 Jan 15; 554(Pt 2):255-61. PMID: 14500775.
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    111. Jacobson D, Pribnow D, Herson PS, Maylie J, Adelman JP. Determinants contributing to estrogen-regulated expression of SK3. Biochem Biophys Res Commun. 2003 Apr 04; 303(2):660-8. PMID: 12659870.
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    112. Herson PS, Virk M, Rustay NR, Bond CT, Crabbe JC, Adelman JP, Maylie J. A mouse model of episodic ataxia type-1. Nat Neurosci. 2003 Apr; 6(4):378-83. PMID: 12612586.
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    113. Herson PS, Adelman JP. It takes two to tango, but three to ISA. Neuron. 2003 Feb 06; 37(3):370-2. PMID: 12575944.
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    114. Smith MA, Herson PS, Lee K, Pinnock RD, Ashford ML. Hydrogen-peroxide-induced toxicity of rat striatal neurones involves activation of a non-selective cation channel. J Physiol. 2003 Mar 01; 547(Pt 2):417-25. PMID: 12562896.
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    115. Neelands TR, Herson PS, Jacobson D, Adelman JP, Maylie J. Small-conductance calcium-activated potassium currents in mouse hyperexcitable denervated skeletal muscle. J Physiol. 2001 Oct 15; 536(Pt 2):397-407. PMID: 11600675.
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    116. Herson PS, Lee K, Pinnock RD, Hughes J, Ashford ML. Hydrogen peroxide induces intracellular calcium overload by activation of a non-selective cation channel in an insulin-secreting cell line. J Biol Chem. 1999 Jan 08; 274(2):833-41. PMID: 9873022.
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    117. Herson PS, Ashford ML. Reduced glutathione inhibits beta-NAD+-activated non-selective cation currents in the CRI-G1 rat insulin-secreting cell line. J Physiol. 1999 Jan 01; 514 ( Pt 1):47-57. PMID: 9831715.
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    118. Herson PS, Dulock KA, Ashford ML. Characterization of a nicotinamide-adenine dinucleotide-dependent cation channel in the CRI-G1 rat insulinoma cell line. J Physiol. 1997 Nov 15; 505 ( Pt 1):65-76. PMID: 9409472.
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    119. Harvey J, McKenna F, Herson PS, Spanswick D, Ashford ML. Leptin activates ATP-sensitive potassium channels in the rat insulin-secreting cell line, CRI-G1. J Physiol. 1997 Nov 01; 504 ( Pt 3):527-35. PMID: 9401961.
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    120. Herson PS, Ashford ML. Activation of a novel non-selective cation channel by alloxan and H2O2 in the rat insulin-secreting cell line CRI-G1. J Physiol. 1997 May 15; 501 ( Pt 1):59-66. PMID: 9174994.
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    121. Tucker SJ, Bond CT, Herson P, Pessia M, Adelman JP. Inhibitory interactions between two inward rectifier K+ channel subunits mediated by the transmembrane domains. J Biol Chem. 1996 Mar 08; 271(10):5866-70. PMID: 8621458.
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