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Robert MacLaren

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-2622
    Other Positions
    TitleAssoc Director-Faculty
    InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
    DepartmentSOP-Administration


    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Alquraini M, Alshamsi F, Møller MH, Belley-Cote E, Almenawer S, Jaeschke R, MacLaren R, Alhazzani W. Sucralfate versus histamine 2 receptor antagonists for stress ulcer prophylaxis in adult critically ill patients: A meta-analysis and trial sequential analysis of randomized trials. J Crit Care. 2017 Mar 08; 40:21-30. PMID: 28315586.
      View in: PubMed
    2. MacLaren R. Measuring Gastric Emptying in the Critically Ill. JPEN J Parenter Enteral Nutr. 2017 Jan 01; 148607116686332. PMID: 28061316.
      View in: PubMed
    3. Kwon JO, MacLaren R. Comparison of Fresh-Frozen Plasma, Four-Factor Prothrombin Complex Concentrates, and Recombinant Factor VIIa to Facilitate Procedures in Critically Ill Patients with Coagulopathy from Liver Disease: A Retrospective Cohort Study. Pharmacotherapy. 2016 Oct; 36(10):1047-1054. PMID: 27547916.
      View in: PubMed
    4. Morris AA, Page RL, Baumgartner LJ, Mueller SW, MacLaren R, Fish DN, Kiser TH. Thiocyanate Accumulation in Critically Ill Patients Receiving Nitroprusside Infusions. J Intensive Care Med. 2016 Jul 19. PMID: 27435907.
      View in: PubMed
    5. Vander Weide LA, MacLaren R, Mueller SW. Authors' Response. J Intensive Care Med. 2016 Jun; 31(5):355-6. PMID: 27166085.
      View in: PubMed
    6. Beyer JT, Schoeppler KE, Zanotti G, Weiss GM, Mueller SW, MacLaren R, Fish DN, Kiser TH. Antithrombin Administration During Intravenous Heparin Anticoagulation in the Intensive Care Unit. Clin Appl Thromb Hemost. 2016 Jan 01; 1076029616668407. PMID: 27624738.
      View in: PubMed
    7. Breukink MB, Downes SM, Querques G, van Dijk EH, den Hollander AI, Blanco-Garavito R, Keunen JE, Souied EH, MacLaren RE, Hoyng CB, Fauser S, Boon CJ. Comparing half-dose photodynamic therapy with high-density subthreshold micropulse laser treatment in patients with chronic central serous chorioretinopathy (the PLACE trial): study protocol for a randomized controlled trial. Trials. 2015 Sep 21; 16:419. PMID: 26390920.
      View in: PubMed
    8. Kiser TH, Fish DN, Aquilante CL, Rower JE, Wempe MF, MacLaren R, Teitelbaum I. Evaluation of sulfobutylether-ß-cyclodextrin (SBECD) accumulation and voriconazole pharmacokinetics in critically ill patients undergoing continuous renal replacement therapy. Crit Care. 2015 Feb 03; 19:32. PMID: 25645660.
      View in: PubMed
    9. Roberts DM, Yates C, Megarbane B, Winchester JF, Maclaren R, Gosselin S, Nolin TD, Lavergne V, Hoffman RS, Ghannoum M. Recommendations for the role of extracorporeal treatments in the management of acute methanol poisoning: a systematic review and consensus statement. Crit Care Med. 2015 Feb; 43(2):461-72. PMID: 25493973.
      View in: PubMed
    10. Reynolds PM, Mueller SW, MacLaren R. A comparison of dexmedetomidine and placebo on the plasma concentrations of NGF, BDNF, GDNF, and epinephrine during severe alcohol withdrawal. Alcohol. 2015 Feb; 49(1):15-9. PMID: 25638740.
      View in: PubMed
    11. MacLaren R, Kassel LE, Kiser TH, Fish DN. Proton pump inhibitors and histamine-2 receptor antagonists in the intensive care setting: focus on therapeutic and adverse events. Expert Opin Drug Saf. 2015 Feb; 14(2):269-80. PMID: 25423448.
      View in: PubMed
    12. VanderWeide LA, Foster CJ, MacLaren R, Kiser TH, Fish DN, Mueller SW. Evaluation of Early Dexmedetomidine Addition to the Standard of Care for Severe Alcohol Withdrawal in the ICU: A Retrospective Controlled Cohort Study. J Intensive Care Med. 2016 Mar; 31(3):198-204. PMID: 25326428.
      View in: PubMed
    13. Preslaski CR, Mueller SW, Kiser TH, Fish DN, MacLaren R. A survey of prescriber perceptions about the prevention of stress-related mucosal bleeding in the intensive care unit. J Clin Pharm Ther. 2014 Dec; 39(6):658-62. PMID: 25243327.
      View in: PubMed
    14. MacLaren R, Campbell J. The authors reply. Crit Care Med. 2014 Sep; 42(9):e637-8. PMID: 25126823.
      View in: PubMed
    15. Rojas J, Fernandez I, Pastor JC, MacLaren RE, Ramkissoon Y, Harsum S, Charteris DG, Van Meurs JC, Amarakoon S, Garcia-Arumi J, Ruiz-Moreno JM, Rocha-Sousa A, Brion M, Carracedo A. Predicting proliferative vitreoretinopathy: temporal and external validation of models based on genetic and clinical variables. Br J Ophthalmol. 2015 Jan; 99(1):41-8. PMID: 25075124.
      View in: PubMed
    16. Barletta JF, Kanji S, MacLaren R, Lat I, Erstad BL. Pharmacoepidemiology of stress ulcer prophylaxis in the United States and Canada. J Crit Care. 2014 Dec; 29(6):955-60. PMID: 25081626.
      View in: PubMed
    17. Mueller SW, Preslaski CR, Kiser TH, Fish DN, Lavelle JC, Malkoski SP, MacLaren R. A randomized, double-blind, placebo-controlled dose range study of dexmedetomidine as adjunctive therapy for alcohol withdrawal. Crit Care Med. 2014 May; 42(5):1131-9. PMID: 24351375.
      View in: PubMed
    18. MacLaren R, Campbell J. Cost-effectiveness of histamine receptor-2 antagonist versus proton pump inhibitor for stress ulcer prophylaxis in critically ill patients*. Crit Care Med. 2014 Apr; 42(4):809-15. PMID: 24365863.
      View in: PubMed
    19. MacLaren R, Reynolds PM, Allen RR. Histamine-2 receptor antagonists vs proton pump inhibitors on gastrointestinal tract hemorrhage and infectious complications in the intensive care unit. JAMA Intern Med. 2014 Apr; 174(4):564-74. PMID: 24535015.
      View in: PubMed
    20. Reynolds PM, MacLaren R, Mueller SW, Fish DN, Kiser TH. Management of extravasation injuries: a focused evaluation of noncytotoxic medications. Pharmacotherapy. 2014 Jun; 34(6):617-32. PMID: 24420913.
      View in: PubMed
    21. MacLaren R, Preslaski CR, Mueller SW, Kiser TH, Fish DN, Lavelle JC, Malkoski SP. A randomized, double-blind pilot study of dexmedetomidine versus midazolam for intensive care unit sedation: patient recall of their experiences and short-term psychological outcomes. J Intensive Care Med. 2015 Mar; 30(3):167-75. PMID: 24227448.
      View in: PubMed
    22. MacLaren R, Gallagher J, Shin J, Varnado S, Nguyen L. Assessment of adverse events and predictors of neurological recovery after therapeutic hypothermia. Ann Pharmacother. 2014 Jan; 48(1):17-25. PMID: 24259643.
      View in: PubMed
    23. Preslaski CR, Lat I, MacLaren R, Poston J. Pharmacist contributions as members of the multidisciplinary ICU team. Chest. 2013 Nov; 144(5):1687-95. PMID: 24189862.
      View in: PubMed
    24. Preslaski CR, Mueller SW, Wempe MF, MacLaren R. Stability of dexmedetomidine in polyvinyl chloride bags containing 0.9% sodium chloride injection. Am J Health Syst Pharm. 2013 Aug 01; 70(15):1336-41. PMID: 23867490.
      View in: PubMed
    25. MacLaren R, Brett McQueen R, Campbell J. Clinical and financial impact of pharmacy services in the intensive care unit: pharmacist and prescriber perceptions. Pharmacotherapy. 2013 Apr; 33(4):401-10. PMID: 23468188.
      View in: PubMed
    26. MacLaren R, Krisl JC, Cochrane RE, Mueller SW. A case-based approach to the practical application of dexmedetomidine in critically ill adults. Pharmacotherapy. 2013 Feb; 33(2):165-86. PMID: 23386596.
      View in: PubMed
    27. Day AC, MacLaren RE, Bunce C, Stevens JD, Foster PJ. Outcomes of phacoemulsification and intraocular lens implantation in microphthalmos and nanophthalmos. J Cataract Refract Surg. 2013 Jan; 39(1):87-96. PMID: 23245362.
      View in: PubMed
    28. Crona D, MacLaren R. Gastrointestinal hormone concentrations associated with gastric feeding in critically ill patients. JPEN J Parenter Enteral Nutr. 2012 Mar; 36(2):189-96. PMID: 21799189.
      View in: PubMed
    29. Mueller SW, Winn R, Macht M, Fish DN, Kiser TH, MacLaren R. Neuromuscular blockade resistance during therapeutic hypothermia. Ann Pharmacother. 2011 Mar; 45(3):e15. PMID: 21386017.
      View in: PubMed
    30. Kiser TH, MacLaren R, Fish DN, Hassell KL, Teitelbaum I. Bivalirudin versus unfractionated heparin for prevention of hemofilter occlusion during continuous renal replacement therapy. Pharmacotherapy. 2010 Nov; 30(11):1117-26. PMID: 20973685.
      View in: PubMed
    31. Ogungbenro K, Vasist L, Maclaren R, Dukes G, Young M, Aarons L. A semi-mechanistic gastric emptying model for the population pharmacokinetic analysis of orally administered acetaminophen in critically ill patients. Pharm Res. 2011 Feb; 28(2):394-404. PMID: 20949310.
      View in: PubMed
    32. Dasta JF, Boucher BA, Brophy GM, Cohen H, Hassan E, Maclaren R, Muzykovsky K, Martin SJ, Pass SE, Seybert AL. Intravenous to oral conversion of antihypertensives: a toolkit for guideline development. Ann Pharmacother. 2010 Sep; 44(9):1430-47. PMID: 20702758.
      View in: PubMed
    33. Kiser TH, Obritsch MD, Jung R, MacLaren R, Fish DN. Efflux pump contribution to multidrug resistance in clinical isolates of Pseudomonas aeruginosa. Pharmacotherapy. 2010 Jul; 30(7):632-8. PMID: 20575627.
      View in: PubMed
    34. Yin H, Cheng L, Holt M, Hail N, Maclaren R, Ju C. Lactoferrin protects against acetaminophen-induced liver injury in mice. Hepatology. 2010 Mar; 51(3):1007-16. PMID: 20099297.
      View in: PubMed
    35. Owen PS, Tan EC, Kiser TH, Fish DN, MacLaren R. Reliability and accuracy of practitioner-calculated Acute Physiology and Chronic Health Evaluation II scores for determining the appropriateness of drotrecogin alfa (activated). Am J Health Syst Pharm. 2010 Jan 15; 67(2):136-43. PMID: 20065268.
      View in: PubMed
    36. Horinek EL, Kiser TH, Fish DN, MacLaren R. Propylene glycol accumulation in critically ill patients receiving continuous intravenous lorazepam infusions. Ann Pharmacother. 2009 Dec; 43(12):1964-71. PMID: 19920159.
      View in: PubMed
    37. Maclaren R. Unanswered questions of "ProCon"etic therapy. JPEN J Parenter Enteral Nutr. 2009 Nov-Dec; 33(6):724-5. PMID: 19892908.
      View in: PubMed
    38. Moore GD, Walker AM, MacLaren R. Fospropofol: a new sedative-hypnotic agent for monitored anesthesia care. Ann Pharmacother. 2009 Nov; 43(11):1802-8. PMID: 19826098.
      View in: PubMed
    39. MacLaren R. Immunosedation: a consideration for sepsis. Crit Care. 2009; 13(5):191. PMID: 19889196.
      View in: PubMed
    40. Kiser TH, Maclaren R, Fish DN. Treatment of hepatorenal syndrome. Pharmacotherapy. 2009 Oct; 29(10):1196-211. PMID: 19792993.
      View in: PubMed
    41. Mueller SW, MacLaren R, Fish DN, Kiser TH. Prefilter bivalirudin for preventing hemofilter occlusion in continuous renal replacement therapy. Ann Pharmacother. 2009 Jul; 43(7):1360-5. PMID: 19584380.
      View in: PubMed
    42. MacLaren R, Bond CA. Effects of pharmacist participation in intensive care units on clinical and economic outcomes of critically ill patients with thromboembolic or infarction-related events. Pharmacotherapy. 2009 Jul; 29(7):761-8. PMID: 19558249.
      View in: PubMed
    43. MacLaren R, Bond CA, Martin SJ, Fike D. Clinical and economic outcomes of involving pharmacists in the direct care of critically ill patients with infections. Crit Care Med. 2008 Dec; 36(12):3184-9. PMID: 18936700.
      View in: PubMed
    44. MacLaren R, Kiser TH, Fish DN, Wischmeyer PE. Erythromycin vs metoclopramide for facilitating gastric emptying and tolerance to intragastric nutrition in critically ill patients. JPEN J Parenter Enteral Nutr. 2008 Jul-Aug; 32(4):412-9. PMID: 18596312.
      View in: PubMed
    45. Owen PS, Golightly LK, MacLaren R, Ferretti KA, Badesch DB. Formulary management of recombinant factor VIIa at an academic medical center. Ann Pharmacother. 2008 Jun; 42(6):771-6. PMID: 18477731.
      View in: PubMed
    46. Landzinski J, Kiser TH, Fish DN, Wischmeyer PE, MacLaren R. Gastric motility function in critically ill patients tolerant vs intolerant to gastric nutrition. JPEN J Parenter Enteral Nutr. 2008 Jan-Feb; 32(1):45-50. PMID: 18165446.
      View in: PubMed
    47. MacLaren R. Key concepts in the management of difficult hemorrhagic cases. Pharmacotherapy. 2007 Sep; 27(9 Pt 2):93S-102S. PMID: 17723112.
      View in: PubMed
    48. Owen P, Monahan MF, MacLaren R. Implementing and assessing an evidence-based electrolyte dosing order form in the medical ICU. Intensive Crit Care Nurs. 2008 Feb; 24(1):8-19. PMID: 17686630.
      View in: PubMed
    49. MacLaren R, Stringer KA. Emerging role of anticoagulants and fibrinolytics in the treatment of acute respiratory distress syndrome. Pharmacotherapy. 2007 Jun; 27(6):860-73. PMID: 17542769.
      View in: PubMed
    50. MacLaren R, Forrest LK, Kiser TH. Adjunctive dexmedetomidine therapy in the intensive care unit: a retrospective assessment of impact on sedative and analgesic requirements, levels of sedation and analgesia, and ventilatory and hemodynamic parameters. Pharmacotherapy. 2007 Mar; 27(3):351-9. PMID: 17316147.
      View in: PubMed
    51. Juang P, Fish DN, Jung R, MacLaren R. Enteral glutamine supplementation in critically ill patients with burn injuries: a retrospective case-control evaluation. Pharmacotherapy. 2007 Jan; 27(1):11-9. PMID: 17192157.
      View in: PubMed
    52. Maclaren R. Factor VIIa: mounting evidence or anecdotal reports. J Postgrad Med. 2007 Jan-Mar; 53(1):4-5. PMID: 17244960.
      View in: PubMed
    53. MacLaren R, Sullivan PW. Economic evaluation of sustained sedation/analgesia in the intensive care unit. Expert Opin Pharmacother. 2006 Oct; 7(15):2047-68. PMID: 17020432.
      View in: PubMed
    54. Maclaren R, Devlin JW, Martin SJ, Dasta JF, Rudis MI, Bond CA. Critical care pharmacy services in United States hospitals. Ann Pharmacother. 2006 Apr; 40(4):612-8. PMID: 16569803.
      View in: PubMed
    55. Kiser TH, Jung R, MacLaren R, Fish DN. Evaluation of diagnostic tests and argatroban or lepirudin therapy in patients with suspected heparin-induced thrombocytopenia. Pharmacotherapy. 2005 Dec; 25(12):1736-45. PMID: 16305293.
      View in: PubMed
    56. Obritsch MD, Fish DN, MacLaren R, Jung R. Nosocomial infections due to multidrug-resistant Pseudomonas aeruginosa: epidemiology and treatment options. Pharmacotherapy. 2005 Oct; 25(10):1353-64. PMID: 16185180.
      View in: PubMed
    57. MacLaren R, Sullivan PW. Pharmacoeconomic modeling of lorazepam, midazolam, and propofol for continuous sedation in critically ill patients. Pharmacotherapy. 2005 Oct; 25(10):1319-28. PMID: 16185175.
      View in: PubMed
    58. MacLaren R, Weber LA, Brake H, Gardner MA, Tanzi M. A multicenter assessment of recombinant factor VIIa off-label usage: clinical experiences and associated outcomes. Transfusion. 2005 Sep; 45(9):1434-42. PMID: 16131375.
      View in: PubMed
    59. Kiser TH, Fish DN, Obritsch MD, Jung R, MacLaren R, Parikh CR. Vasopressin, not octreotide, may be beneficial in the treatment of hepatorenal syndrome: a retrospective study. Nephrol Dial Transplant. 2005 Sep; 20(9):1813-20. PMID: 15956066.
      View in: PubMed
    60. MacLaren R, Sullivan PW. Cost-effectiveness of recombinant human erythropoietin for reducing red blood cells transfusions in critically ill patients. Value Health. 2005 Mar-Apr; 8(2):105-16. PMID: 15804319.
      View in: PubMed
    61. Obritsch MD, Fish DN, MacLaren R, Jung R. National surveillance of antimicrobial resistance in Pseudomonas aeruginosa isolates obtained from intensive care unit patients from 1993 to 2002. Antimicrob Agents Chemother. 2004 Dec; 48(12):4606-10. PMID: 15561832.
      View in: PubMed
    62. Obritsch MD, Bestul DJ, Jung R, Fish DN, MacLaren R. The role of vasopressin in vasodilatory septic shock. Pharmacotherapy. 2004 Aug; 24(8):1050-63. PMID: 15338853.
      View in: PubMed
    63. Obritsch MD, Jung R, Fish DN, MacLaren R. Effects of continuous vasopressin infusion in patients with septic shock. Ann Pharmacother. 2004 Jul-Aug; 38(7-8):1117-22. PMID: 15178740.
      View in: PubMed
    64. Jung R, Fish DN, Obritsch MD, MacLaren R. Surveillance of multi-drug resistant Pseudomonas aeruginosa in an urban tertiary-care teaching hospital. J Hosp Infect. 2004 Jun; 57(2):105-11. PMID: 15183239.
      View in: PubMed
    65. MacLaren R, Gasper J, Jung R, Vandivier RW. Use of exogenous erythropoietin in critically ill patients. J Clin Pharm Ther. 2004 Jun; 29(3):195-208. PMID: 15153081.
      View in: PubMed
    66. Dugan HA, MacLaren R, Jung R. Duration of antimicrobial therapy for nosocomial pneumonia: possible strategies for minimizing antimicrobial use in intensive care units. J Clin Pharm Ther. 2003 Apr; 28(2):123-9. PMID: 12713609.
      View in: PubMed
    67. Jung R, MacLaren R. Proton-pump inhibitors for stress ulcer prophylaxis in critically ill patients. Ann Pharmacother. 2002 Dec; 36(12):1929-37. PMID: 12452757.
      View in: PubMed
    68. MacLaren R, Jung R. Stress-dose corticosteroid therapy for sepsis and acute lung injury or acute respiratory distress syndrome in critically ill adults. Pharmacotherapy. 2002 Sep; 22(9):1140-56. PMID: 12222550.
      View in: PubMed
    69. MacLaren R, Jarvis CL, Fish DN. Use of enteral nutrition for stress ulcer prophylaxis. Ann Pharmacother. 2001 Dec; 35(12):1614-23. PMID: 11793631.
      View in: PubMed
    70. Lugo RA, MacLaren R, Cash J, Pribble CG, Vernon DD. Enteral methadone to expedite fentanyl discontinuation and prevent opioid abstinence syndrome in the PICU. Pharmacotherapy. 2001 Dec; 21(12):1566-73. PMID: 11765307.
      View in: PubMed
    71. MacLaren R, Patrick WD, Hall RI, Rocker GM, Whelan GJ, Lima JJ. Comparison of cisapride and metoclopramide for facilitating gastric emptying and improving tolerance to intragastric enteral nutrition in critically III, mechanically ventilated adults. Clin Ther. 2001 Nov; 23(11):1855-66. PMID: 11768837.
      View in: PubMed
    72. MacLaren R, Wilson SJ, Campbell A, Anderson D, Rocker G. Evaluation and survey of intravenous vitamin K1 for treatment of coagulopathy in critically ill patients. Pharmacotherapy. 2001 Feb; 21(2):175-82. PMID: 11213854.
      View in: PubMed
    73. MacLaren R. Intolerance to intragastric enteral nutrition in critically ill patients: complications and management. Pharmacotherapy. 2000 Dec; 20(12):1486-98. PMID: 11130221.
      View in: PubMed
    74. MacLaren R, Plamondon JM, Ramsay KB, Rocker GM, Patrick WD, Hall RI. A prospective evaluation of empiric versus protocol-based sedation and analgesia. Pharmacotherapy. 2000 Jun; 20(6):662-72. PMID: 10853622.
      View in: PubMed
    75. MacLaren R, Kuhl DA, Gervasio JM, Brown RO, Dickerson RN, Livingston TN, Swift K, Headley S, Kudsk KA, Lima JJ. Sequential single doses of cisapride, erythromycin, and metoclopramide in critically ill patients intolerant to enteral nutrition: a randomized, placebo-controlled, crossover study. Crit Care Med. 2000 Feb; 28(2):438-44. PMID: 10708180.
      View in: PubMed
    76. MacLaren R, Shields CA. Respiratory failure following oral administration of metoclopramide. Ann Pharmacother. 1998 Oct; 32(10):1017-20. PMID: 9793592.
      View in: PubMed
    77. MacLaren R, Wachsman BA, Swift DK, Kuhl DA. Warfarin resistance associated with intravenous lipid administration: discussion of propofol and review of the literature. Pharmacotherapy. 1997 Nov-Dec; 17(6):1331-7. PMID: 9399621.
      View in: PubMed
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