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Kristen Lynn Nowak

TitleAssociate Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4842

    Collapse Biography 
    Collapse education and training
    Marquette University, Milwaukee, WIB.S.12/2005exercise science
    University of Colorado Boulder, Boulder, COM.S.05/2005integrative physiology
    University of Colorado Boulder, Boulder, COPh.D.12/2011integrative physiology
    University of Colorado Anschutz Medical Campus, Aurora, COpostdoctoral09/2014nephrology
    University of Colorado Anschutz Medical Campus, Aurora, COMPH05/2016epidemiology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    F31AG033994     (JABLONSKI NOWAK, KRISTEN)Jul 1, 2009 - Jun 30, 2011
    NIH
    Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium Restriction
    Role: Principal Investigator
    12POST11920023     (Nowak Jablonski, Kristen)Jul 1, 2012 - Jun 30, 2014
    American Heart Association
    Interleukin-1 Trap to Treat Vascular Dysfunction in CKD
    Role Description: Post-doctoral fellowship
    Role: Principal Investigator
    R01DK097081     (CHONCHOL, MICHEL BENJAMIN)Jun 7, 2013 - Mar 31, 2017
    NIH
    Mineralocorticoid Antagonism and Endothelial Dysfunction
    Role: Co-Investigator
    K01DK103678     (JABLONSKI NOWAK, KRISTEN)Aug 1, 2015 - Jul 31, 2020
    NIH
    Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD
    Role Description: The major goal of this project is to examine the effect of curcumin, a naturally occurring polyphenol with the unique ability to activate transcription of key antioxidants, suppress inflammation, and reduce proliferation, on vascular endothelial function and large-elastic artery stiffness in children and young adults with ADPKD.
    Role: Principal Investigator
    PRMRP 170914     (Chonchol, Michel)Aug 1, 2017 - Jul 31, 2021
    Department of Defense
    Statin Therapy in Adults with ADPKD
    Role Description: The goal of this clinical trial is to test the efficacy of pravastatin on slowing progression of renal disease in adult patients with early stage ADPKD.
    Role: Co-Investigator
    CO-J-18-37     (Nowak, Kristen)Mar 23, 2018 - Mar 23, 2019
    CCTSI
    Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults with Autosomal Dominant Polycystic Kidney Disease
    Role Description: This translational pilot and feasibility study will determine the feasibility of delivering a 12 week behavioral weight loss intervention in adults with overweight/obesity and early-stage ADPKD, based on either daily caloric restriction or intermittent fasting, as well as evaluate safety, acceptability, tolerability, and mechanistic insight into biological pathways that may be altered.
    Role: PI
    R03DK118215     (JABLONSKI NOWAK, KRISTEN)Sep 15, 2018 - Jul 31, 2020
    NIH
    Daily caloric restriction and intermittent fasting in overweight and obese adults with autosomal dominant polycystic kidney disease
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. Author Correction: A guiding map for inflammation. Nat Immunol. 2021 Feb; 22(2):254. PMID: 33288963.
      View in: PubMed
    2. Nowak KL, Farmer-Bailey H, Cadnapaphornchai MA, You Z, George D, Wang W, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants. Contemp Clin Trials Commun. 2020 Sep; 19:100635. PMID: 33294724.
      View in: PubMed
    3. Grau L, Gitomer B, McNair B, Wolf M, Harris P, Brosnahan G, Torres V, Steinman T, Yu A, Chapman A, Chonchol M, Nowak KL. Interactions between FGF23 and Genotype in Autosomal Dominant Polycystic Kidney Disease. Kidney360. 2020 Jul; 1(7):648-656. PMID: 33305291.
      View in: PubMed
    4. Wang W, Chonchol M, Seals DR, Nowak KL. Dietary sodium restriction decreases urinary NGAL in older adults with moderately elevated systolic blood pressure free from chronic kidney disease. J Investig Med. 2020 10; 68(7):1271-1275. PMID: 32699180.
      View in: PubMed
    5. Nowak KL, Chonchol M, Jovanovich A, You Z, Ambrosius WT, Cho ME, Glasser S, Lash J, Simmons DL, Taylor A, Weiner D, Rastogi A, Oparil S, Supiano MA. Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial?. Clin Nephrol. 2020 Jul; 94(1):26-35. PMID: 32449678.
      View in: PubMed
    6. Nowak KL, Jovanovich A, Farmer-Bailey H, Bispham N, Struemph T, Malaczewski M, Wang W, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Chronic Kidney Disease. Kidney360. 2020 Jun; 1(6):501-509. PMID: 33305290.
      View in: PubMed
    7. Nowak KL, Hopp K. Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential. Clin J Am Soc Nephrol. 2020 04 07; 15(4):577-584. PMID: 32086281.
      View in: PubMed
    8. Nowak KL, Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cell Signal. 2020 04; 68:109518. PMID: 31881325.
      View in: PubMed
    9. Hanudel MR, Salusky IB, Pereira RC, Wang W, You Z, Nowak KL, Brosnahan GM, Torres VE, Chapman AB, Perrone RD, Steinman TI, Bae KT, Gitomer BY, Chonchol MB. Erythropoietin and Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease Patients. Kidney Int Rep. 2019 Dec; 4(12):1742-1748. PMID: 31844811.
      View in: PubMed
    10. Nowak KL, Chonchol M, Jovanovich A, You Z, Bates J, Foy C, Glasser S, Killeen AA, Kostis J, Rodriguez CJ, Segal M, Simmons DL, Taylor A, Lovato LC, Ambrosius WT, Supiano MA. Serum Sodium and Pulse Pressure in SPRINT. Am J Hypertens. 2019 06 11; 32(7):649-656. PMID: 30977767.
      View in: PubMed
    11. Bispham NZ, Nowak KL. Drinking Water: The Saltier The Better? J Am Heart Assoc. 2019 05 07; 8(9):e012758. PMID: 31060416.
      View in: PubMed
    12. Hung AM, Tsuchida Y, Nowak KL, Sarkar S, Chonchol M, Whitfield V, Salas N, Dikalova A, Yancey PG, Huang J, Linton MF, Ikizler TA, Kon V. IL-1 Inhibition and Function of the HDL-Containing Fraction of Plasma in Patients with Stages 3 to 5 CKD. Clin J Am Soc Nephrol. 2019 05 07; 14(5):702-711. PMID: 31015261.
      View in: PubMed
    13. Jovanovich A, You Z, Isakova T, Nowak K, Cheung A, Wolf M, Chonchol M, Kendrick J. Fibroblast Growth Factor 23 Trajectories in Chronic Hemodialysis Patients: Lessons from the HEMO Study. Am J Nephrol. 2019; 49(4):263-270. PMID: 30820005.
      View in: PubMed
    14. Nowak KL, Gitomer B, Farmer-Bailey H, Wang W, Malaczewski M, Klawitter J, You Z, George D, Patel N, Jovanovich A, Chonchol M. Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial. Am J Kidney Dis. 2019 08; 74(2):213-223. PMID: 30803706.
      View in: PubMed
    15. Andrews ES, Perrenoud L, Nowak KL, You Z, Pasch A, Chonchol M, Kendrick J, Jalal D. Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. PLoS One. 2018; 13(10):e0205831. PMID: 30356327.
      View in: PubMed
    16. Kendrick J, Shah P, Andrews E, You Z, Nowak K, Pasch A, Chonchol M. Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1463-1470. PMID: 30237219.
      View in: PubMed
    17. Nowak KL, Wang W, Farmer-Bailey H, Gitomer B, Malaczewski M, Klawitter J, Jovanovich A, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1493-1501. PMID: 30228110.
      View in: PubMed
    18. Nowak KL, Chonchol M. Does inflammation affect outcomes in dialysis patients? Semin Dial. 2018 07; 31(4):388-397. PMID: 29513906.
      View in: PubMed
    19. Nowak KL, Chonchol M, You Z, Gupta M, Gitomer B. Affected parent sex and severity of autosomal dominant polycystic kidney disease: a retrospective cohort study?. Clin Nephrol. 2018 Mar; 89(3):196-204. PMID: 29035198.
      View in: PubMed
    20. Nowak KL, Yaffe K, Orwoll ES, Ix JH, You Z, Barrett-Connor E, Hoffman AR, Chonchol M. Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol. 2018 03 07; 13(3):366-374. PMID: 29439092.
      View in: PubMed
    21. Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M. Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol. 2018; 47(1):57-65. PMID: 29393090.
      View in: PubMed
    22. Nowak KL, Rossman MJ, Chonchol M, Seals DR. Strategies for Achieving Healthy Vascular Aging. Hypertension. 2018 03; 71(3):389-402. PMID: 29311256.
      View in: PubMed
    23. Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, Steinman TI, Abebe KZ, Rahbari-Oskoui FF, Yu ASL, Harris PC, Bae KT, Hogan M, Miskulin D, Chonchol M. Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2018 02; 29(2):571-578. PMID: 29118087.
      View in: PubMed
    24. Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M. Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function?. Clin Nephrol. 2017 Sep; 88(9):132-143. PMID: 28699886.
      View in: PubMed
    25. Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M. Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial. Clin J Am Soc Nephrol. 2017 Sep 07; 12(9):1438-1446. PMID: 28784657.
      View in: PubMed
    26. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. PMID: 28722720.
      View in: PubMed
    27. Nowak KL, Farmer H, Cadnapaphornchai MA, Gitomer B, Chonchol M. Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2017 02 01; 32(2):342-347. PMID: 28186577.
      View in: PubMed
    28. Nowak KL, Bartz TM, Dalrymple L, de Boer IH, Kestenbaum B, Shlipak MG, Garimella PS, Ix JH, Chonchol M. Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol. 2017 Apr; 28(4):1239-1246. PMID: 28122946.
      View in: PubMed
    29. Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM. IL-1 Inhibition and Vascular Function in CKD. J Am Soc Nephrol. 2017 Mar; 28(3):971-980. PMID: 27647856.
      View in: PubMed
    30. Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 03; 28(3):943-952. PMID: 27620990.
      View in: PubMed
    31. Nowak KL, Cadnapaphornchai MA, Chonchol MB, Schrier RW, Gitomer B. Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2016; 44(3):171-8. PMID: 27548646.
      View in: PubMed
    32. Nowak KL and Brosnahan G. Current Progress in Nephrology, RK Visweswaran and C Ponticelli (Eds). Current progress in the understanding of ADPKD. 2016; 159-180.
    33. Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling. J Hypertens. 2015 Dec; 33(12):2477-82. PMID: 26378681.
      View in: PubMed
    34. Jovanovich AJ, Chonchol MB, Sobhi A, Kendrick JB, Cheung AK, Kaufman JS, Smits G, Jablonski KL. Mineral Metabolites, Angiotensin II Inhibition and Outcomes in Advanced Chronic Kidney Disease. Am J Nephrol. 2015; 42(5):361-8. PMID: 26606453.
      View in: PubMed
    35. Jablonski KL, Chonchol M. Posthemodialysis weights and mortality: another narrow range target? Clin J Am Soc Nephrol. 2015 May 07; 10(5):729-31. PMID: 25862780.
      View in: PubMed
    36. Jablonski KL and Chonchol M. Chronic Renal Disease, PL Kimmel and M Rosenberg (Eds). Management of mineral and bone disorders in CKD patients. 2015; 646-662.
    37. Jablonski KL, Kendrick JB. Renal outcomes and dietary potassium: the overshadowed electrolyte? Kidney Int. 2014 Dec; 86(6):1077-8. PMID: 25427082.
      View in: PubMed
    38. Jovanovich AJ, Chonchol M, Brady CB, Kaufman JD, Kendrick J, Cheung AK, Jablonski KL. 25-vitamin D, 1,25-vitamin D, parathyroid hormone, fibroblast growth factor-23 and cognitive function in men with advanced CKD: a veteran population. Clin Nephrol. 2014 Nov; 82(5):S1-4. PMID: 25208315.
      View in: PubMed
    39. Jablonski KL, Chonchol M. Recent advances in the management of hemodialysis patients: a focus on cardiovascular disease. F1000Prime Rep. 2014; 6:72. PMID: 25165571.
      View in: PubMed
    40. Miyazaki-Anzai S, Masuda M, Demos-Davies KM, Keenan AL, Saunders SJ, Masuda R, Jablonski K, Cavasin MA, Kendrick J, Chonchol M, McKinsey TA, Levi M, Miyazaki M. Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification. J Am Heart Assoc. 2014 Jun 24; 3(3):e000949. PMID: 24963104.
      View in: PubMed
    41. Jablonski KL, Decker E, Perrenoud L, Kendrick J, Chonchol M, Seals DR, Jalal D. Assessment of vascular function in patients with chronic kidney disease. J Vis Exp. 2014 Jun 16; (88). PMID: 24962357.
      View in: PubMed
    42. Jovanovich AJ, Ginde AA, Holmen J, Jablonski K, Allyn RL, Kendrick J, Chonchol M. Vitamin D level and risk of community-acquired pneumonia and sepsis. Nutrients. 2014 Jun 10; 6(6):2196-205. PMID: 24918697.
      View in: PubMed
    43. Jablonski KL, Chonchol M. Vascular calcification in end-stage renal disease. Hemodial Int. 2013 Oct; 17 Suppl 1:S17-21. PMID: 24134325.
      View in: PubMed
    44. Jablonski KL, Fedorova OV, Racine ML, Geolfos CJ, Gates PE, Chonchol M, Fleenor BS, Lakatta EG, Bagrov AY, Seals DR. Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clin J Am Soc Nephrol. 2013 Nov; 8(11):1952-9. PMID: 23929930.
      View in: PubMed
    45. Jablonski KL, Chonchol M. Chronic kidney disease: Cystatin-C-based eGFR: what is it telling us? Nat Rev Nephrol. 2013 Jun; 9(6):318-9. PMID: 23591444.
      View in: PubMed
    46. DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond). 2013 Mar; 124(5):325-31. PMID: 23025811.
      View in: PubMed
    47. Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol. 2013 Jan 22; 61(3):335-43. PMID: 23141486.
      View in: PubMed
    48. Jablonski KL, Chonchol M. Cardiovascular disease: Should statin therapy be expanded in patients with CKD? Nat Rev Nephrol. 2012 Jul 03; 8(8):440-1. PMID: 22751508.
      View in: PubMed
    49. Pierce GL, Jablonski KL, Walker AE, Seibert SM, DeVan AE, Black SM, Sharma S, Seals DR. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens. 2012 Oct; 25(10):1050-4. PMID: 22673017.
      View in: PubMed
    50. Jablonski KL, Chonchol M. Frequent hemodialysis: a way to improve physical function? Clin J Am Soc Nephrol. 2012 May; 7(5):707-10. PMID: 22516284.
      View in: PubMed
    51. Jalal DI, Jablonski KL, McFann K, Chonchol MB, Seals DR. Vascular endothelial function is not related to serum uric acid in healthy adults. Am J Hypertens. 2012 Apr; 25(4):407-13. PMID: 22237152.
      View in: PubMed
    52. Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011 May; 120(9):357-75. PMID: 21244363.
      View in: PubMed
    53. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011 Jan; 57(1):63-9. PMID: 21115878.
      View in: PubMed
    54. Jablonski KL, Gates PE, Pierce GL, Seals DR. Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Ther Adv Cardiovasc Dis. 2009 Oct; 3(5):347-56. PMID: 19723834.
      View in: PubMed
    55. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. . 2009 Jul; 297(1):H425-32. PMID: 19465546.
      View in: PubMed
    56. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008 Dec; 7(6):805-12. PMID: 18782346.
      View in: PubMed
    57. Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol (1985). 2008 Oct; 105(4):1359-63. PMID: 18669935.
      View in: PubMed
    58. Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol (1985). 2007 Nov; 103(5):1715-21. PMID: 17965239.
      View in: PubMed
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