Kristen Lynn Nowak
Title | Associate Professor |
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Institution | University of Colorado Denver - Anschutz Medical Campus |
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Department | SOM-MED |
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Phone | 303/724-4842 |
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Biography Marquette University, Milwaukee, WI | B.S. | 12/2005 | exercise science | University of Colorado Boulder, Boulder, CO | M.S. | 05/2005 | integrative physiology | University of Colorado Boulder, Boulder, CO | Ph.D. | 12/2011 | integrative physiology | University of Colorado Anschutz Medical Campus, Aurora, CO | postdoctoral | 09/2014 | nephrology | University of Colorado Anschutz Medical Campus, Aurora, CO | MPH | 05/2016 | epidemiology |
Overview Research F31AG033994 (JABLONSKI NOWAK, KRISTEN)Jul 1, 2009 - Jun 30, 2011 NIH Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium Restriction Role: Principal Investigator |
| 12POST11920023 (Nowak Jablonski, Kristen)Jul 1, 2012 - Jun 30, 2014 American Heart Association Interleukin-1 Trap to Treat Vascular Dysfunction in CKD Role Description: Post-doctoral fellowship Role: Principal Investigator |
| R01DK097081 (CHONCHOL, MICHEL BENJAMIN)Jun 7, 2013 - Mar 31, 2016 NIH/NIDDK Mineralocorticoid Antagonism and Endothelial Dysfunction Role: Co-Investigator |
| K01DK103678 (JABLONSKI NOWAK, KRISTEN)Aug 1, 2015 - Jul 31, 2020 NIH Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD Role Description: The major goal of this project is to examine the effect of curcumin, a naturally occurring polyphenol with the unique ability to activate transcription of key antioxidants, suppress inflammation, and reduce proliferation, on vascular endothelial function and large-elastic artery stiffness in children and young adults with ADPKD. Role: Principal Investigator |
| PRMRP 170914 (Chonchol, Michel)Aug 1, 2017 - Jul 31, 2021 Department of Defense Statin Therapy in Adults with ADPKD Role Description: The goal of this clinical trial is to test the efficacy of pravastatin on slowing progression of renal disease in adult patients with early stage ADPKD. Role: Co-Investigator |
| CO-J-18-37 (Nowak, Kristen)Mar 23, 2018 - Mar 23, 2019 CCTSI Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults with Autosomal Dominant Polycystic Kidney Disease Role Description: This translational pilot and feasibility study will determine the feasibility of delivering a 12 week behavioral weight loss intervention in adults with overweight/obesity and early-stage ADPKD, based on either daily caloric restriction or intermittent fasting, as well as evaluate safety, acceptability, tolerability, and mechanistic insight into biological pathways that may be altered. Role: PI |
| R03DK118215 (JABLONSKI NOWAK, KRISTEN)Sep 15, 2018 - Jul 31, 2020 NIH Daily caloric restriction and intermittent fasting in overweight and obese adults with autosomal dominant polycystic kidney disease Role: Principal Investigator |
Bibliographic
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Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. Author Correction: A guiding map for inflammation. Nat Immunol. 2021 Feb; 22(2):254. PMID: 33288963.
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Nowak KL, Farmer-Bailey H, Cadnapaphornchai MA, You Z, George D, Wang W, Jovanovich A, Soranno DE, Gitomer B, Chonchol M. Curcumin therapy to treat vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease: Design and baseline characteristics of participants. Contemp Clin Trials Commun. 2020 Sep; 19:100635. PMID: 33294724.
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Grau L, Gitomer B, McNair B, Wolf M, Harris P, Brosnahan G, Torres V, Steinman T, Yu A, Chapman A, Chonchol M, Nowak KL. Interactions between FGF23 and Genotype in Autosomal Dominant Polycystic Kidney Disease. Kidney360. 2020 Jul; 1(7):648-656. PMID: 33305291.
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Wang W, Chonchol M, Seals DR, Nowak KL. Dietary sodium restriction decreases urinary NGAL in older adults with moderately elevated systolic blood pressure free from chronic kidney disease. J Investig Med. 2020 10; 68(7):1271-1275. PMID: 32699180.
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Nowak KL, Chonchol M, Jovanovich A, You Z, Ambrosius WT, Cho ME, Glasser S, Lash J, Simmons DL, Taylor A, Weiner D, Rastogi A, Oparil S, Supiano MA. Arterial stiffness and kidney disease progression in the systolic blood pressure intervention trial?. Clin Nephrol. 2020 Jul; 94(1):26-35. PMID: 32449678.
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Nowak KL, Jovanovich A, Farmer-Bailey H, Bispham N, Struemph T, Malaczewski M, Wang W, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Chronic Kidney Disease. Kidney360. 2020 Jun; 1(6):501-509. PMID: 33305290.
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Nowak KL, Hopp K. Metabolic Reprogramming in Autosomal Dominant Polycystic Kidney Disease: Evidence and Therapeutic Potential. Clin J Am Soc Nephrol. 2020 04 07; 15(4):577-584. PMID: 32086281.
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Nowak KL, Edelstein CL. Apoptosis and autophagy in polycystic kidney disease (PKD). Cell Signal. 2020 04; 68:109518. PMID: 31881325.
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Hanudel MR, Salusky IB, Pereira RC, Wang W, You Z, Nowak KL, Brosnahan GM, Torres VE, Chapman AB, Perrone RD, Steinman TI, Bae KT, Gitomer BY, Chonchol MB. Erythropoietin and Fibroblast Growth Factor 23 in Autosomal Dominant Polycystic Kidney Disease Patients. Kidney Int Rep. 2019 Dec; 4(12):1742-1748. PMID: 31844811.
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Nowak KL, Chonchol M, Jovanovich A, You Z, Bates J, Foy C, Glasser S, Killeen AA, Kostis J, Rodriguez CJ, Segal M, Simmons DL, Taylor A, Lovato LC, Ambrosius WT, Supiano MA. Serum Sodium and Pulse Pressure in SPRINT. Am J Hypertens. 2019 06 11; 32(7):649-656. PMID: 30977767.
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Bispham NZ, Nowak KL. Drinking Water: The Saltier The Better? J Am Heart Assoc. 2019 05 07; 8(9):e012758. PMID: 31060416.
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Hung AM, Tsuchida Y, Nowak KL, Sarkar S, Chonchol M, Whitfield V, Salas N, Dikalova A, Yancey PG, Huang J, Linton MF, Ikizler TA, Kon V. IL-1 Inhibition and Function of the HDL-Containing Fraction of Plasma in Patients with Stages 3 to 5 CKD. Clin J Am Soc Nephrol. 2019 05 07; 14(5):702-711. PMID: 31015261.
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Jovanovich A, You Z, Isakova T, Nowak K, Cheung A, Wolf M, Chonchol M, Kendrick J. Fibroblast Growth Factor 23 Trajectories in Chronic Hemodialysis Patients: Lessons from the HEMO Study. Am J Nephrol. 2019; 49(4):263-270. PMID: 30820005.
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Nowak KL, Gitomer B, Farmer-Bailey H, Wang W, Malaczewski M, Klawitter J, You Z, George D, Patel N, Jovanovich A, Chonchol M. Mineralocorticoid Antagonism and Vascular Function in Early Autosomal Dominant Polycystic Kidney Disease: A Randomized Controlled Trial. Am J Kidney Dis. 2019 08; 74(2):213-223. PMID: 30803706.
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Andrews ES, Perrenoud L, Nowak KL, You Z, Pasch A, Chonchol M, Kendrick J, Jalal D. Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. PLoS One. 2018; 13(10):e0205831. PMID: 30356327.
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Kendrick J, Shah P, Andrews E, You Z, Nowak K, Pasch A, Chonchol M. Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1463-1470. PMID: 30237219.
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Nowak KL, Wang W, Farmer-Bailey H, Gitomer B, Malaczewski M, Klawitter J, Jovanovich A, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2018 10 08; 13(10):1493-1501. PMID: 30228110.
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Nowak KL, Chonchol M. Does inflammation affect outcomes in dialysis patients? Semin Dial. 2018 07; 31(4):388-397. PMID: 29513906.
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Nowak KL, Chonchol M, You Z, Gupta M, Gitomer B. Affected parent sex and severity of autosomal dominant polycystic kidney disease: a retrospective cohort study?. Clin Nephrol. 2018 Mar; 89(3):196-204. PMID: 29035198.
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Nowak KL, Yaffe K, Orwoll ES, Ix JH, You Z, Barrett-Connor E, Hoffman AR, Chonchol M. Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol. 2018 03 07; 13(3):366-374. PMID: 29439092.
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Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M. Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol. 2018; 47(1):57-65. PMID: 29393090.
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Nowak KL, Rossman MJ, Chonchol M, Seals DR. Strategies for Achieving Healthy Vascular Aging. Hypertension. 2018 03; 71(3):389-402. PMID: 29311256.
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Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, Steinman TI, Abebe KZ, Rahbari-Oskoui FF, Yu ASL, Harris PC, Bae KT, Hogan M, Miskulin D, Chonchol M. Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2018 02; 29(2):571-578. PMID: 29118087.
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Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M. Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function?. Clin Nephrol. 2017 Sep; 88(9):132-143. PMID: 28699886.
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Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M. Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial. Clin J Am Soc Nephrol. 2017 Sep 07; 12(9):1438-1446. PMID: 28784657.
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Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. PMID: 28722720.
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Nowak KL, Farmer H, Cadnapaphornchai MA, Gitomer B, Chonchol M. Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2017 02 01; 32(2):342-347. PMID: 28186577.
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Nowak KL, Bartz TM, Dalrymple L, de Boer IH, Kestenbaum B, Shlipak MG, Garimella PS, Ix JH, Chonchol M. Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol. 2017 Apr; 28(4):1239-1246. PMID: 28122946.
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Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM. IL-1 Inhibition and Vascular Function in CKD. J Am Soc Nephrol. 2017 Mar; 28(3):971-980. PMID: 27647856.
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Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 03; 28(3):943-952. PMID: 27620990.
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Nowak KL, Cadnapaphornchai MA, Chonchol MB, Schrier RW, Gitomer B. Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2016; 44(3):171-8. PMID: 27548646.
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Nowak KL and Brosnahan G. Current Progress in Nephrology, RK Visweswaran and C Ponticelli (Eds). Current progress in the understanding of ADPKD. 2016; 159-180.
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Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling. J Hypertens. 2015 Dec; 33(12):2477-82. PMID: 26378681.
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Jovanovich AJ, Chonchol MB, Sobhi A, Kendrick JB, Cheung AK, Kaufman JS, Smits G, Jablonski KL. Mineral Metabolites, Angiotensin II Inhibition and Outcomes in Advanced Chronic Kidney Disease. Am J Nephrol. 2015; 42(5):361-8. PMID: 26606453.
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Jablonski KL, Chonchol M. Posthemodialysis weights and mortality: another narrow range target? Clin J Am Soc Nephrol. 2015 May 07; 10(5):729-31. PMID: 25862780.
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Jablonski KL and Chonchol M. Chronic Renal Disease, PL Kimmel and M Rosenberg (Eds). Management of mineral and bone disorders in CKD patients. 2015; 646-662.
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Jablonski KL, Kendrick JB. Renal outcomes and dietary potassium: the overshadowed electrolyte? Kidney Int. 2014 Dec; 86(6):1077-8. PMID: 25427082.
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Jovanovich AJ, Chonchol M, Brady CB, Kaufman JD, Kendrick J, Cheung AK, Jablonski KL. 25-vitamin D, 1,25-vitamin D, parathyroid hormone, fibroblast growth factor-23 and cognitive function in men with advanced CKD: a veteran population. Clin Nephrol. 2014 Nov; 82(5):S1-4. PMID: 25208315.
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Jablonski KL, Chonchol M. Recent advances in the management of hemodialysis patients: a focus on cardiovascular disease. F1000Prime Rep. 2014; 6:72. PMID: 25165571.
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Miyazaki-Anzai S, Masuda M, Demos-Davies KM, Keenan AL, Saunders SJ, Masuda R, Jablonski K, Cavasin MA, Kendrick J, Chonchol M, McKinsey TA, Levi M, Miyazaki M. Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification. J Am Heart Assoc. 2014 Jun 24; 3(3):e000949. PMID: 24963104.
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Jablonski KL, Decker E, Perrenoud L, Kendrick J, Chonchol M, Seals DR, Jalal D. Assessment of vascular function in patients with chronic kidney disease. J Vis Exp. 2014 Jun 16; (88). PMID: 24962357.
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Jovanovich AJ, Ginde AA, Holmen J, Jablonski K, Allyn RL, Kendrick J, Chonchol M. Vitamin D level and risk of community-acquired pneumonia and sepsis. Nutrients. 2014 Jun 10; 6(6):2196-205. PMID: 24918697.
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Jablonski KL, Chonchol M. Vascular calcification in end-stage renal disease. Hemodial Int. 2013 Oct; 17 Suppl 1:S17-21. PMID: 24134325.
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Jablonski KL, Fedorova OV, Racine ML, Geolfos CJ, Gates PE, Chonchol M, Fleenor BS, Lakatta EG, Bagrov AY, Seals DR. Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clin J Am Soc Nephrol. 2013 Nov; 8(11):1952-9. PMID: 23929930.
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Jablonski KL, Chonchol M. Chronic kidney disease: Cystatin-C-based eGFR: what is it telling us? Nat Rev Nephrol. 2013 Jun; 9(6):318-9. PMID: 23591444.
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DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond). 2013 Mar; 124(5):325-31. PMID: 23025811.
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Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol. 2013 Jan 22; 61(3):335-43. PMID: 23141486.
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Jablonski KL, Chonchol M. Cardiovascular disease: Should statin therapy be expanded in patients with CKD? Nat Rev Nephrol. 2012 Jul 03; 8(8):440-1. PMID: 22751508.
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Pierce GL, Jablonski KL, Walker AE, Seibert SM, DeVan AE, Black SM, Sharma S, Seals DR. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens. 2012 Oct; 25(10):1050-4. PMID: 22673017.
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Jablonski KL, Chonchol M. Frequent hemodialysis: a way to improve physical function? Clin J Am Soc Nephrol. 2012 May; 7(5):707-10. PMID: 22516284.
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Jalal DI, Jablonski KL, McFann K, Chonchol MB, Seals DR. Vascular endothelial function is not related to serum uric acid in healthy adults. Am J Hypertens. 2012 Apr; 25(4):407-13. PMID: 22237152.
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Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011 May; 120(9):357-75. PMID: 21244363.
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Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011 Jan; 57(1):63-9. PMID: 21115878.
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Jablonski KL, Gates PE, Pierce GL, Seals DR. Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Ther Adv Cardiovasc Dis. 2009 Oct; 3(5):347-56. PMID: 19723834.
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Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. . 2009 Jul; 297(1):H425-32. PMID: 19465546.
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Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008 Dec; 7(6):805-12. PMID: 18782346.
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Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol (1985). 2008 Oct; 105(4):1359-63. PMID: 18669935.
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Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol (1985). 2007 Nov; 103(5):1715-21. PMID: 17965239.
This graph shows the total number of publications by year, by first, middle/unknown, or last author.
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Year | Publications |
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2007 | 1 | 2008 | 2 | 2009 | 2 | 2010 | 1 | 2011 | 1 | 2012 | 5 | 2013 | 4 | 2014 | 6 | 2015 | 4 | 2016 | 5 | 2017 | 5 | 2018 | 8 | 2019 | 7 | 2020 | 6 | 2021 | 1 |
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