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Kristen Lynn Nowak

TitleAsst Professor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-4842
    Other Positions
    TitleAsst Professor Adjunct
    InstitutionUniversity of Colorado Boulder
    DepartmentIntegrative Physiology


    Collapse Biography 
    Collapse education and training
    Marquette University, Milwaukee, WIB.S.12/2005exercise science
    University of Colorado Boulder, Boulder, COM.S.05/2005integrative physiology
    University of Colorado Boulder, Boulder, COPh.D.12/2011integrative physiology
    University of Colorado Anschutz Medical Campus, Aurora, COpostdoctoral09/2014nephrology
    University of Colorado Anschutz Medical Campus, Aurora, COMPH05/2016epidemiology

    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    F31AG033994     (JABLONSKI NOWAK, KRISTEN)Jul 1, 2009 - Jun 30, 2011
    NIH
    Vascular Endothelial Dysfunction in Older Adults: Dietary Sodium Restriction
    Role: Principal Investigator
    12POST11920023     (Nowak Jablonski, Kristen)Jul 1, 2012 - Jun 30, 2014
    American Heart Association
    Interleukin-1 Trap to Treat Vascular Dysfunction in CKD
    Role Description: Post-doctoral fellowship
    Role: Principal Investigator
    R01DK097081     (CHONCHOL, MICHEL BENJAMIN)Jun 7, 2013 - Mar 31, 2016
    NIH/NIDDK
    Mineralocorticoid Antagonism and Endothelial Dysfunction
    Role: Co-Investigator
    K01DK103678     (JABLONSKI NOWAK, KRISTEN)Aug 1, 2015 - Jul 31, 2020
    NIH
    Curcumin Therapy to Treat Vascular Dysfunction in Children and Young Adults with ADPKD
    Role Description: The major goal of this project is to examine the effect of curcumin, a naturally occurring polyphenol with the unique ability to activate transcription of key antioxidants, suppress inflammation, and reduce proliferation, on vascular endothelial function and large-elastic artery stiffness in children and young adults with ADPKD.
    Role: Principal Investigator
    PRMRP 170914     (Chonchol, Michel)Aug 1, 2017 - Jul 31, 2021
    Department of Defense
    Statin Therapy in Adults with ADPKD
    Role Description: The goal of this clinical trial is to test the efficacy of pravastatin on slowing progression of renal disease in adult patients with early stage ADPKD.
    Role: Co-Investigator
    CO-J-18-37     (Nowak, Kristen)Mar 23, 2018 - Mar 23, 2019
    CCTSI
    Daily Caloric Restriction and Intermittent Fasting in Overweight and Obese Adults with Autosomal Dominant Polycystic Kidney Disease
    Role Description: This translational pilot and feasibility study will determine the feasibility of delivering a 12 week behavioral weight loss intervention in adults with overweight/obesity and early-stage ADPKD, based on either daily caloric restriction or intermittent fasting, as well as evaluate safety, acceptability, tolerability, and mechanistic insight into biological pathways that may be altered.
    Role: PI

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    List All   |   Timeline
    1. Andrews ES, Perrenoud L, Nowak KL, You Z, Pasch A, Chonchol M, Kendrick J, Jalal D. Examining the effects of uric acid-lowering on markers vascular of calcification and CKD-MBD; A post-hoc analysis of a randomized clinical trial. PLoS One. 2018; 13(10):e0205831. PMID: 30356327.
      View in: PubMed
    2. Kendrick J, Shah P, Andrews E, You Z, Nowak K, Pasch A, Chonchol M. Effect of Treatment of Metabolic Acidosis on Vascular Endothelial Function in Patients with CKD: A Pilot Randomized Cross-Over Study. Clin J Am Soc Nephrol. 2018 Oct 08; 13(10):1463-1470. PMID: 30237219.
      View in: PubMed
    3. Nowak KL, Wang W, Farmer-Bailey H, Gitomer B, Malaczewski M, Klawitter J, Jovanovich A, Chonchol M. Vascular Dysfunction, Oxidative Stress, and Inflammation in Autosomal Dominant Polycystic Kidney Disease. Clin J Am Soc Nephrol. 2018 Oct 08; 13(10):1493-1501. PMID: 30228110.
      View in: PubMed
    4. Nowak KL, Chonchol M. Does inflammation affect outcomes in dialysis patients? Semin Dial. 2018 Jul; 31(4):388-397. PMID: 29513906.
      View in: PubMed
    5. Nowak KL, Chonchol M, You Z, Gupta M, Gitomer B. Affected parent sex and severity of autosomal dominant polycystic kidney disease: a retrospective cohort study?. Clin Nephrol. 2018 Mar; 89(3):196-204. PMID: 29035198.
      View in: PubMed
    6. Nowak KL, Yaffe K, Orwoll ES, Ix JH, You Z, Barrett-Connor E, Hoffman AR, Chonchol M. Serum Sodium and Cognition in Older Community-Dwelling Men. Clin J Am Soc Nephrol. 2018 Mar 07; 13(3):366-374. PMID: 29439092.
      View in: PubMed
    7. Nowak KL, Fried L, Jovanovich A, Ix J, Yaffe K, You Z, Chonchol M. Dietary Sodium/Potassium Intake Does Not Affect Cognitive Function or Brain Imaging Indices. Am J Nephrol. 2018; 47(1):57-65. PMID: 29393090.
      View in: PubMed
    8. Nowak KL, Rossman MJ, Chonchol M, Seals DR. Strategies for Achieving Healthy Vascular Aging. Hypertension. 2018 Mar; 71(3):389-402. PMID: 29311256.
      View in: PubMed
    9. Nowak KL, You Z, Gitomer B, Brosnahan G, Torres VE, Chapman AB, Perrone RD, Steinman TI, Abebe KZ, Rahbari-Oskoui FF, Yu ASL, Harris PC, Bae KT, Hogan M, Miskulin D, Chonchol M. Overweight and Obesity Are Predictors of Progression in Early Autosomal Dominant Polycystic Kidney Disease. J Am Soc Nephrol. 2018 Feb; 29(2):571-578. PMID: 29118087.
      View in: PubMed
    10. Nowak KL, Hung A, Ikizler TA, Farmer-Bailey H, Salas-Cruz N, Sarkar S, Hoofnagle A, You Z, Chonchol M. Interleukin-1 inhibition, chronic kidney disease-mineral and bone disorder, and physical function?. Clin Nephrol. 2017 Sep; 88(9):132-143. PMID: 28699886.
      View in: PubMed
    11. Kendrick J, Andrews E, You Z, Moreau K, Nowak KL, Farmer-Bailey H, Seals DR, Chonchol M. Cholecalciferol, Calcitriol, and Vascular Function in CKD: A Randomized, Double-Blind Trial. Clin J Am Soc Nephrol. 2017 Sep 07; 12(9):1438-1446. PMID: 28784657.
      View in: PubMed
    12. Netea MG, Balkwill F, Chonchol M, Cominelli F, Donath MY, Giamarellos-Bourboulis EJ, Golenbock D, Gresnigt MS, Heneka MT, Hoffman HM, Hotchkiss R, Joosten LAB, Kastner DL, Korte M, Latz E, Libby P, Mandrup-Poulsen T, Mantovani A, Mills KHG, Nowak KL, O'Neill LA, Pickkers P, van der Poll T, Ridker PM, Schalkwijk J, Schwartz DA, Siegmund B, Steer CJ, Tilg H, van der Meer JWM, van de Veerdonk FL, Dinarello CA. A guiding map for inflammation. Nat Immunol. 2017 Jul 19; 18(8):826-831. PMID: 28722720.
      View in: PubMed
    13. Nowak KL, Farmer H, Cadnapaphornchai MA, Gitomer B, Chonchol M. Vascular dysfunction in children and young adults with autosomal dominant polycystic kidney disease. Nephrol Dial Transplant. 2017 02 01; 32(2):342-347. PMID: 28186577.
      View in: PubMed
    14. Nowak KL, Bartz TM, Dalrymple L, de Boer IH, Kestenbaum B, Shlipak MG, Garimella PS, Ix JH, Chonchol M. Fibroblast Growth Factor 23 and the Risk of Infection-Related Hospitalization in Older Adults. J Am Soc Nephrol. 2017 Apr; 28(4):1239-1246. PMID: 28122946.
      View in: PubMed
    15. Nowak KL, Chonchol M, Ikizler TA, Farmer-Bailey H, Salas N, Chaudhry R, Wang W, Smits G, Tengesdal I, Dinarello CA, Hung AM. IL-1 Inhibition and Vascular Function in CKD. J Am Soc Nephrol. 2017 Mar; 28(3):971-980. PMID: 27647856.
      View in: PubMed
    16. Jalal DI, Decker E, Perrenoud L, Nowak KL, Bispham N, Mehta T, Smits G, You Z, Seals D, Chonchol M, Johnson RJ. Vascular Function and Uric Acid-Lowering in Stage 3 CKD. J Am Soc Nephrol. 2017 03; 28(3):943-952. PMID: 27620990.
      View in: PubMed
    17. Nowak KL, Cadnapaphornchai MA, Chonchol MB, Schrier RW, Gitomer B. Long-Term Outcomes in Patients with Very-Early Onset Autosomal Dominant Polycystic Kidney Disease. Am J Nephrol. 2016; 44(3):171-8. PMID: 27548646.
      View in: PubMed
    18. Nowak KL and Brosnahan G. Current Progress in Nephrology, RK Visweswaran and C Ponticelli (Eds). Current progress in the understanding of ADPKD. 2016; 159-180.
    19. Jablonski KL, Donato AJ, Fleenor BS, Nowlan MJ, Walker AE, Kaplon RE, Ballak DB, Seals DR. Reduced large elastic artery stiffness with regular aerobic exercise in middle-aged and older adults: potential role of suppressed nuclear factor ? B signalling. J Hypertens. 2015 Dec; 33(12):2477-82. PMID: 26378681; PMCID: PMC4657448.
      View in: PubMed, PubMed Central
    20. Jovanovich AJ, Chonchol MB, Sobhi A, Kendrick JB, Cheung AK, Kaufman JS, Smits G, Jablonski KL. Mineral Metabolites, Angiotensin II Inhibition and Outcomes in Advanced Chronic Kidney Disease. Am J Nephrol. 2015; 42(5):361-8. PMID: 26606453.
      View in: PubMed
    21. Jablonski KL, Klawitter J, Chonchol M, Bassett CJ, Racine ML, Seals DR. Effect of dietary sodium restriction on human urinary metabolomic profiles. Clin J Am Soc Nephrol. 2015 Jul 07; 10(7):1227-34. PMID: 25901092; PMCID: PMC4491302.
      View in: PubMed, PubMed Central
    22. Jablonski KL, Chonchol M. Posthemodialysis weights and mortality: another narrow range target? Clin J Am Soc Nephrol. 2015 May 07; 10(5):729-31. PMID: 25862780; PMCID: PMC4422230.
      View in: PubMed, PubMed Central
    23. Jablonski KL and Chonchol M. Chronic Renal Disease, PL Kimmel and M Rosenberg (Eds). Management of mineral and bone disorders in CKD patients. 2015; 646-662.
    24. Jablonski KL, Kendrick JB. Renal outcomes and dietary potassium: the overshadowed electrolyte? Kidney Int. 2014 Dec; 86(6):1077-8. PMID: 25427082; PMCID: PMC4246421.
      View in: PubMed, PubMed Central
    25. Jovanovich AJ, Chonchol M, Brady CB, Kaufman JD, Kendrick J, Cheung AK, Jablonski KL. 25-vitamin D, 1,25-vitamin D, parathyroid hormone, fibroblast growth factor-23 and cognitive function in men with advanced CKD: a veteran population. Clin Nephrol. 2014 Nov; 82(5):S1-4. PMID: 25208315.
      View in: PubMed
    26. Jablonski KL, Chonchol M. Recent advances in the management of hemodialysis patients: a focus on cardiovascular disease. F1000Prime Rep. 2014; 6:72. PMID: 25165571; PMCID: PMC4126528.
      View in: PubMed, PubMed Central
    27. Miyazaki-Anzai S, Masuda M, Demos-Davies KM, Keenan AL, Saunders SJ, Masuda R, Jablonski K, Cavasin MA, Kendrick J, Chonchol M, McKinsey TA, Levi M, Miyazaki M. Endoplasmic reticulum stress effector CCAAT/enhancer-binding protein homologous protein (CHOP) regulates chronic kidney disease-induced vascular calcification. J Am Heart Assoc. 2014 Jun 24; 3(3):e000949. PMID: 24963104; PMCID: PMC4309099.
      View in: PubMed, PubMed Central
    28. Jablonski KL, Decker E, Perrenoud L, Kendrick J, Chonchol M, Seals DR, Jalal D. Assessment of vascular function in patients with chronic kidney disease. J Vis Exp. 2014 Jun 16; (88). PMID: 24962357; PMCID: PMC4193838.
      View in: PubMed, PubMed Central
    29. Jovanovich AJ, Ginde AA, Holmen J, Jablonski K, Allyn RL, Kendrick J, Chonchol M. Vitamin D level and risk of community-acquired pneumonia and sepsis. Nutrients. 2014 Jun 10; 6(6):2196-205. PMID: 24918697; PMCID: PMC4073143.
      View in: PubMed, PubMed Central
    30. Jablonski KL, Chonchol M. Vascular calcification in end-stage renal disease. Hemodial Int. 2013 Oct; 17 Suppl 1:S17-21. PMID: 24134325; PMCID: PMC3813300.
      View in: PubMed, PubMed Central
    31. Jablonski KL, Fedorova OV, Racine ML, Geolfos CJ, Gates PE, Chonchol M, Fleenor BS, Lakatta EG, Bagrov AY, Seals DR. Dietary sodium restriction and association with urinary marinobufagenin, blood pressure, and aortic stiffness. Clin J Am Soc Nephrol. 2013 Nov; 8(11):1952-9. PMID: 23929930; PMCID: PMC3817896.
      View in: PubMed, PubMed Central
    32. Jablonski KL, Chonchol M. Chronic kidney disease: Cystatin-C-based eGFR: what is it telling us? Nat Rev Nephrol. 2013 Jun; 9(6):318-9. PMID: 23591444.
      View in: PubMed
    33. DeVan AE, Eskurza I, Pierce GL, Walker AE, Jablonski KL, Kaplon RE, Seals DR. Regular aerobic exercise protects against impaired fasting plasma glucose-associated vascular endothelial dysfunction with aging. Clin Sci (Lond). 2013 Mar; 124(5):325-31. PMID: 23025811; PMCID: PMC3509933.
      View in: PubMed, PubMed Central
    34. Jablonski KL, Jovanovich A, Holmen J, Targher G, McFann K, Kendrick J, Chonchol M. Low 25-hydroxyvitamin D level is independently associated with non-alcoholic fatty liver disease. Nutr Metab Cardiovasc Dis. 2013 Aug; 23(8):792-8. PMID: 23415456.
      View in: PubMed
    35. Jablonski KL, Racine ML, Geolfos CJ, Gates PE, Chonchol M, McQueen MB, Seals DR. Dietary sodium restriction reverses vascular endothelial dysfunction in middle-aged/older adults with moderately elevated systolic blood pressure. J Am Coll Cardiol. 2013 Jan 22; 61(3):335-43. PMID: 23141486; PMCID: PMC3549053.
      View in: PubMed, PubMed Central
    36. Jablonski KL, Chonchol M. Cardiovascular disease: Should statin therapy be expanded in patients with CKD? Nat Rev Nephrol. 2012 Jul 03; 8(8):440-1. PMID: 22751508.
      View in: PubMed
    37. Pierce GL, Jablonski KL, Walker AE, Seibert SM, DeVan AE, Black SM, Sharma S, Seals DR. Tetrahydrobiopterin supplementation enhances carotid artery compliance in healthy older men: a pilot study. Am J Hypertens. 2012 Oct; 25(10):1050-4. PMID: 22673017; PMCID: PMC3482981.
      View in: PubMed, PubMed Central
    38. Jablonski KL, Chonchol M. Frequent hemodialysis: a way to improve physical function? Clin J Am Soc Nephrol. 2012 May; 7(5):707-10. PMID: 22516284.
      View in: PubMed
    39. Jalal DI, Jablonski KL, McFann K, Chonchol MB, Seals DR. Vascular endothelial function is not related to serum uric acid in healthy adults. Am J Hypertens. 2012 Apr; 25(4):407-13. PMID: 22237152; PMCID: PMC3309158.
      View in: PubMed, PubMed Central
    40. Seals DR, Jablonski KL, Donato AJ. Aging and vascular endothelial function in humans. Clin Sci (Lond). 2011 May; 120(9):357-75. PMID: 21244363; PMCID: PMC3482987.
      View in: PubMed, PubMed Central
    41. Jablonski KL, Chonchol M, Pierce GL, Walker AE, Seals DR. 25-Hydroxyvitamin D deficiency is associated with inflammation-linked vascular endothelial dysfunction in middle-aged and older adults. Hypertension. 2011 Jan; 57(1):63-9. PMID: 21115878.
      View in: PubMed
    42. Jablonski KL, Gates PE, Pierce GL, Seals DR. Low dietary sodium intake is associated with enhanced vascular endothelial function in middle-aged and older adults with elevated systolic blood pressure. Ther Adv Cardiovasc Dis. 2009 Oct; 3(5):347-56. PMID: 19723834; PMCID: PMC3480332.
      View in: PubMed, PubMed Central
    43. Donato AJ, Gano LB, Eskurza I, Silver AE, Gates PE, Jablonski K, Seals DR. Vascular endothelial dysfunction with aging: endothelin-1 and endothelial nitric oxide synthase. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H425-32. PMID: 19465546; PMCID: PMC2711733.
      View in: PubMed, PubMed Central
    44. Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR. Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell. 2008 Dec; 7(6):805-12. PMID: 18782346; PMCID: PMC3032405.
      View in: PubMed, PubMed Central
    45. Donato AJ, Eskurza I, Jablonski KL, Gano LB, Pierce GL, Seals DR. Cytochrome P-450 2C9 signaling does not contribute to age-associated vascular endothelial dysfunction in humans. J Appl Physiol (1985). 2008 Oct; 105(4):1359-63. PMID: 18669935; PMCID: PMC2576044.
      View in: PubMed, PubMed Central
    46. Jablonski KL, Seals DR, Eskurza I, Monahan KD, Donato AJ. High-dose ascorbic acid infusion abolishes chronic vasoconstriction and restores resting leg blood flow in healthy older men. J Appl Physiol (1985). 2007 Nov; 103(5):1715-21. PMID: 17965239.
      View in: PubMed
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