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Stephen Karl Frankel

TitleAffiliate - NJH
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/315-7424

    Collapse Research 
    Collapse research activities and funding
    K08HL067848     (FRANKEL, STEPHEN K)Jan 1, 2003 - Dec 31, 2007
    NIH
    Death receptors, p53 and Akt in myofibroblast apoptosis.
    Role: Principal Investigator
    F32HL070550     (FRANKEL, STEPHEN K)Jul 1, 2002
    NIH
    Death receptors of p53 in myofibroblast apoptosis
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Liu H, Wei P, Aviszus K, Zhang Q, Linderberger J, Yang J, Liu J, Chen Z, Waheed H, Reynoso L, Downey GP, Frankel SK, Kappler JW, Marrack P, Zhang G. The Receptor Binding Domain of SARS-CoV-2 Lambda Variant Has a Better Chance Than the Delta Variant in Evading BNT162b2 COVID-19 mRNA Vaccine-Induced Humoral Immunity. Int J Mol Sci. 2022 Sep 26; 23(19). PMID: 36232627.
      View in: PubMed
    2. Liu H, Wei P, Zhang Q, Aviszus K, Linderberger J, Yang J, Liu J, Chen Z, Waheed H, Reynoso L, Downey GP, Frankel SK, Kappler J, Marrack P, Zhang G. The Lambda variant of SARS-CoV-2 has a better chance than the Delta variant to escape vaccines. bioRxiv. 2021 Aug 26. PMID: 34462744.
      View in: PubMed
    3. Liu H, Zhang Q, Wei P, Chen Z, Aviszus K, Yang J, Downing W, Jiang C, Liang B, Reynoso L, Downey GP, Frankel SK, Kappler J, Marrack P, Zhang G. The basis of a more contagious 501Y.V1 variant of SARS-CoV-2. Cell Res. 2021 06; 31(6):720-722. PMID: 33893398.
      View in: PubMed
    4. Liu H, Wei P, Zhang Q, Chen Z, Aviszus K, Downing W, Peterson S, Reynoso L, Downey GP, Frankel SK, Kappler J, Marrack P, Zhang G. 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to Bamlanivimab in vitro. bioRxiv. 2021 Feb 16. PMID: 33619479.
      View in: PubMed
    5. Liu H, Zhang Q, Wei P, Chen Z, Aviszus K, Yang J, Downing W, Peterson S, Jiang C, Liang B, Reynoso L, Downey GP, Frankel SK, Kappler J, Marrack P, Zhang G. The basis of a more contagious 501Y.V1 variant of SARS-COV-2. bioRxiv. 2021 Feb 02. PMID: 33564771.
      View in: PubMed
    6. Liu H, Wei P, Zhang Q, Chen Z, Aviszus K, Downing W, Peterson S, Reynoso L, Downey GP, Frankel SK, Kappler J, Marrack P, Zhang G. 501Y.V2 and 501Y.V3 variants of SARS-CoV-2 lose binding to bamlanivimab in vitro. MAbs. 2021 Jan-Dec; 13(1):1919285. PMID: 34074219.
      View in: PubMed
    7. Quan MV, Frankel SK, Maleki-Fischbach M, Tan LD. A rare case report of polyangiitis overlap syndrome: granulomatosis with polyangiitis and eosinophilic granulomatosis with polyangiitis. BMC Pulm Med. 2018 Nov 29; 18(1):181. PMID: 30497438.
      View in: PubMed
    8. Limaye AP, Stapleton RD, Peng L, Gunn SR, Kimball LE, Hyzy R, Exline MC, Files DC, Morris PE, Frankel SK, Mikkelsen ME, Hite D, Enfield KB, Steingrub J, O'Brien J, Parsons PE, Cuschieri J, Wunderink RG, Hotchkin DL, Chen YQ, Rubenfeld GD, Boeckh M. Effect of Ganciclovir on IL-6 Levels Among Cytomegalovirus-Seropositive Adults With Critical Illness: A Randomized Clinical Trial. JAMA. 2017 08 22; 318(8):731-740. PMID: 28829877.
      View in: PubMed
    9. Moss M, Nordon-Craft A, Malone D, Van Pelt D, Frankel SK, Warner ML, Kriekels W, McNulty M, Fairclough DL, Schenkman M. A Randomized Trial of an Intensive Physical Therapy Program for Patients with Acute Respiratory Failure. Am J Respir Crit Care Med. 2016 May 15; 193(10):1101-10. PMID: 26651376.
      View in: PubMed
    10. Solomon JJ, Chung JH, Cosgrove GP, Demoruelle MK, Fernandez-Perez ER, Fischer A, Frankel SK, Hobbs SB, Huie TJ, Ketzer J, Mannina A, Olson AL, Russell G, Tsuchiya Y, Yunt ZX, Zelarney PT, Brown KK, Swigris JJ. Predictors of mortality in rheumatoid arthritis-associated interstitial lung disease. Eur Respir J. 2016 Feb; 47(2):588-96. PMID: 26585429.
      View in: PubMed
    11. Strand MJ, Sprunger D, Cosgrove GP, Fernandez-Perez ER, Frankel SK, Huie TJ, Olson AL, Solomon J, Brown KK, Swigris JJ. Pulmonary function and survival in idiopathic vs secondary usual interstitial pneumonia. Chest. 2014 Sep; 146(3):775-785. PMID: 24700149.
      View in: PubMed
    12. Frankel SK, Moss M. The effect of organizational structure and processes of care on ICU mortality as revealed by the United States critical illness and injury trials group critical illness outcomes study. Crit Care Med. 2014 Feb; 42(2):463-4. PMID: 24434451.
      View in: PubMed
    13. Czaja CA, Merkel PA, Chan ED, Lenz LL, Wolf ML, Alam R, Frankel SK, Fischer A, Gogate S, Perez-Velez CM, Knight V. Rituximab as successful adjunct treatment in a patient with disseminated nontuberculous mycobacterial infection due to acquired anti-interferon-? autoantibody. Clin Infect Dis. 2014 Mar; 58(6):e115-8. PMID: 24336756.
      View in: PubMed
    14. Fischer A, Brown KK, Du Bois RM, Frankel SK, Cosgrove GP, Fernandez-Perez ER, Huie TJ, Krishnamoorthy M, Meehan RT, Olson AL, Solomon JJ, Swigris JJ. Mycophenolate mofetil improves lung function in connective tissue disease-associated interstitial lung disease. J Rheumatol. 2013 May; 40(5):640-6. PMID: 23457378.
      View in: PubMed
    15. Fern?ndez P?rez ER, Frankel SK. Peeling away the layers of the volume-outcome effect and harvesting hidden connections. Crit Care Med. 2012 Sep; 40(9):2713-5. PMID: 22903095.
      View in: PubMed
    16. Yunt ZX, Frankel SK, Brown KK. Diagnosis and management of pulmonary vasculitis. Ther Adv Respir Dis. 2012 Dec; 6(6):375-90. PMID: 22878624.
      View in: PubMed
    17. Frankel SK, Schwarz MI. The pulmonary vasculitides. Am J Respir Crit Care Med. 2012 Aug 01; 186(3):216-24. PMID: 22679011.
      View in: PubMed
    18. Fern?ndez P?rez ER, Olson AL, Frankel SK. Eosinophilic lung diseases. Med Clin North Am. 2011 Nov; 95(6):1163-87. PMID: 22032433.
      View in: PubMed
    19. Wynes MW, Edelman BL, Kostyk AG, Edwards MG, Coldren C, Groshong SD, Cosgrove GP, Redente EF, Bamberg A, Brown KK, Reisdorph N, Keith RC, Frankel SK, Riches DW. Increased cell surface Fas expression is necessary and sufficient to sensitize lung fibroblasts to Fas ligation-induced apoptosis: implications for fibroblast accumulation in idiopathic pulmonary fibrosis. J Immunol. 2011 Jul 01; 187(1):527-37. PMID: 21632719.
      View in: PubMed
    20. Frankel SK, Jayne D. The pulmonary vasculitides. Clin Chest Med. 2010 Sep; 31(3):519-36. PMID: 20692544.
      View in: PubMed
    21. Huie TJ, Olson AL, Cosgrove GP, Janssen WJ, Lara AR, Lynch DA, Groshong SD, Moss M, Schwarz MI, Brown KK, Frankel SK. A detailed evaluation of acute respiratory decline in patients with fibrotic lung disease: aetiology and outcomes. Respirology. 2010 Aug; 15(6):909-17. PMID: 20546190.
      View in: PubMed
    22. Huie TJ, Moss M, Frankel SK. What can biomarkers tell us about the pathogenesis of acute exacerbations of idiopathic pulmonary fibrosis? Am J Physiol Lung Cell Mol Physiol. 2010 Jul; 299(1):L1-2. PMID: 20472711.
      View in: PubMed
    23. Frankel SK, Schwarz MI. Update in idiopathic pulmonary fibrosis. Curr Opin Pulm Med. 2009 Sep; 15(5):463-9. PMID: 19550329.
      View in: PubMed
    24. Fischer A, Swigris JJ, du Bois RM, Lynch DA, Downey GP, Cosgrove GP, Frankel SK, Fernandez-Perez ER, Gillis JZ, Brown KK. Anti-synthetase syndrome in ANA and anti-Jo-1 negative patients presenting with idiopathic interstitial pneumonia. Respir Med. 2009 Nov; 103(11):1719-24. PMID: 19497723.
      View in: PubMed
    25. Swigris JJ, Swick J, Wamboldt FS, Sprunger D, du Bois R, Fischer A, Cosgrove GP, Frankel SK, Fernandez-Perez ER, Kervitsky D, Brown KK. Heart rate recovery after 6-min walk test predicts survival in patients with idiopathic pulmonary fibrosis. Chest. 2009 Sep; 136(3):841-848. PMID: 19395579.
      View in: PubMed
    26. Cha SI, Groshong SD, Frankel SK, Edelman BL, Cosgrove GP, Terry-Powers JL, Remigio LK, Curran-Everett D, Brown KK, Cool CD, Riches DW. Compartmentalized expression of c-FLIP in lung tissues of patients with idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol. 2010 Feb; 42(2):140-8. PMID: 19372246.
      View in: PubMed
    27. Olson AL, Huie TJ, Groshong SD, Cosgrove GP, Janssen WJ, Schwarz MI, Brown KK, Frankel SK. Acute exacerbations of fibrotic hypersensitivity pneumonitis: a case series. Chest. 2008 Oct; 134(4):844-850. PMID: 18842917.
      View in: PubMed
    28. Riches DW, Cosgrove GP, Frankel SK. Symposium: Thomas L. Petty Aspen Lung Conference: lung injury and repair. Introduction and perspective. Proc Am Thorac Soc. 2008 Apr 15; 5(3):287-9. PMID: 18403319.
      View in: PubMed
    29. Cosgrove GP, Frankel SK, Brown KK. Challenges in pulmonary fibrosis. 3: Cystic lung disease. Thorax. 2007 Sep; 62(9):820-29. PMID: 17726170.
      View in: PubMed
    30. Kendrick JB, Risbano M, Groshong SD, Frankel SK. A rare presentation of ischemic pseudomembranous colitis due to Escherichia coli O157:H7. Clin Infect Dis. 2007 Jul 15; 45(2):217-9. PMID: 17578781.
      View in: PubMed
    31. Fischer A, Misumi S, Curran-Everett D, Meehan RT, Ulrich SK, Swigris JJ, Frankel SK, Cosgrove GP, Lynch DA, Brown KK. Pericardial abnormalities predict the presence of echocardiographically defined pulmonary arterial hypertension in systemic sclerosis-related interstitial lung disease. Chest. 2007 Apr; 131(4):988-92. PMID: 17426200.
      View in: PubMed
    32. Swigris JJ, Olson AL, Fischer A, Lynch DA, Cosgrove GP, Frankel SK, Meehan RT, Brown KK. Mycophenolate mofetil is safe, well tolerated, and preserves lung function in patients with connective tissue disease-related interstitial lung disease. Chest. 2006 Jul; 130(1):30-6. PMID: 16840379.
      View in: PubMed
    33. Frankel SK, Cosgrove GP, Fischer A, Meehan RT, Brown KK. Update in the diagnosis and management of pulmonary vasculitis. Chest. 2006 Feb; 129(2):452-465. PMID: 16478866.
      View in: PubMed
    34. Frankel SK, Cosgrove GP, Cha SI, Cool CD, Wynes MW, Edelman BL, Brown KK, Riches DW. TNF-alpha sensitizes normal and fibrotic human lung fibroblasts to Fas-induced apoptosis. Am J Respir Cell Mol Biol. 2006 Mar; 34(3):293-304. PMID: 16272460.
      View in: PubMed
    35. Van Linden AA, Cottin V, Frankel SK, Riches DW. Hierarchical phosphorylation of the TNF-alpha receptor, TNF-R1, by p42Mapk/Erk at basic Pro-directed kinase sites. Biochemistry. 2005 May 10; 44(18):6980-9. PMID: 15865443.
      View in: PubMed
    36. Frankel SK, Moats-Staats BM, Cool CD, Wynes MW, Stiles AD, Riches DW. Human insulin-like growth factor-IA expression in transgenic mice promotes adenomatous hyperplasia but not pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 May; 288(5):L805-12. PMID: 15618451.
      View in: PubMed
    37. Frankel SK, Cool CD, Lynch DA, Brown KK. Idiopathic pleuroparenchymal fibroelastosis: description of a novel clinicopathologic entity. Chest. 2004 Dec; 126(6):2007-13. PMID: 15596706.
      View in: PubMed
    38. Wynes MW, Frankel SK, Riches DW. IL-4-induced macrophage-derived IGF-I protects myofibroblasts from apoptosis following growth factor withdrawal. J Leukoc Biol. 2004 Nov; 76(5):1019-27. PMID: 15316031.
      View in: PubMed
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