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Richard A Radcliffe

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOP-Administration
Phone303/724-3362

    Collapse Research 
    Collapse research activities and funding
    R01AA013177     (RADCLIFFE, RICHARD A)May 1, 2002 - Mar 31, 2006
    NIH/NIAAA
    Gene Expression and -Drug-Induced Sensitivity to Alcohol
    Role: Principal Investigator

    R03AA014345     (RADCLIFFE, RICHARD A)Apr 1, 2004 - Mar 31, 2007
    NIH/NIAAA
    Zebrafish model: molecular basis of acute EtOH tolerance
    Role: Principal Investigator

    R01AA016957     (RADCLIFFE, RICHARD A)Jul 1, 2007 - Mar 31, 2014
    NIH/NIAAA
    Genetic Studies of Alcohol Tolerance
    Role: Principal Investigator

    R01AA018120     (RADCLIFFE, RICHARD A)Jul 10, 2010 - Jun 30, 2015
    NIH/NIAAA
    Genetics of Alcohol Sensitivity in Rats
    Role: Principal Investigator

    UH2DA040142     (STITZEL, JERRY A)Jun 15, 2015 - May 31, 2018
    NIH/NIDA
    Nicotine consumption QTL: Fine mapping, selective breeding and sequencing
    Role: Co-Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Rudra P, Shi WJ, Vestal B, Russell PH, Odell A, Dowell RD, Radcliffe RA, Saba LM, Kechris K. Model based heritability scores for high-throughput sequencing data. BMC Bioinformatics. 2017 Mar 02; 18(1):143. PMID: 28253840.
      View in: PubMed
    2. Gritz SM, Larson C, Radcliffe RA. Atp1a2 contributes modestly to alcohol-related behaviors. Alcohol. 2016 Nov; 56:29-37. PMID: 27814792.
      View in: PubMed
    3. Dowell R, Odell A, Richmond P, Malmer D, Halper-Stromberg E, Bennett B, Larson C, Leach S, Radcliffe RA. Genome characterization of the selected long- and short-sleep mouse lines. Mamm Genome. 2016 Dec; 27(11-12):574-586. PMID: 27651241.
      View in: PubMed
    4. Bennett B, Larson C, Richmond PA, Odell AT, Saba LM, Tabakoff B, Dowell R, Radcliffe RA. Quantitative trait locus mapping of acute functional tolerance in the LXS recombinant inbred strains. Alcohol Clin Exp Res. 2015 Apr; 39(4):611-20. PMID: 25833023; PMCID: PMC4384187.
    5. Ru Y, Kechris KJ, Tabakoff B, Hoffman P, Radcliffe RA, Bowler R, Mahaffey S, Rossi S, Calin GA, Bemis L, Theodorescu D. The multiMiR R package and database: integration of microRNA-target interactions along with their disease and drug associations. Nucleic Acids Res. 2014; 42(17):e133. PMID: 25063298; PMCID: PMC4176155.
    6. Radcliffe RA, Larson C, Bennett B. Genetic studies of acute tolerance, rapid tolerance, and drinking in the dark in the LXS recombinant inbred strains. Alcohol Clin Exp Res. 2013 Dec; 37(12):2019-28. PMID: 23889059; PMCID: PMC4145009.
    7. Gritz SM, Radcliffe RA. Genetic effects of ATP1A2 in familial hemiplegic migraine type II and animal models. Hum Genomics. 2013 Apr 05; 7:8. PMID: 23561701; PMCID: PMC3639839.
    8. Darlington TM, Ehringer MA, Larson C, Phang TL, Radcliffe RA. Transcriptome analysis of Inbred Long Sleep and Inbred Short Sleep mice. Genes Brain Behav. 2013 Mar; 12(2):263-74. PMID: 23433184; PMCID: PMC3581861.
    9. Good RL, Liang LP, Patel M, Radcliffe RA. Mouse strain- and age-dependent effects of binge methamphetamine on dopaminergic signaling. Neurotoxicology. 2011 Dec; 32(6):751-9. PMID: 21798282; PMCID: PMC3236638.
    10. Hicklin TR, Wu PH, Radcliffe RA, Freund RK, Goebel-Goody SM, Correa PR, Proctor WR, Lombroso PJ, Browning MD. Alcohol inhibition of the NMDA receptor function, long-term potentiation, and fear learning requires striatal-enriched protein tyrosine phosphatase. Proc Natl Acad Sci U S A. 2011 Apr 19; 108(16):6650-5. PMID: 21464302; PMCID: PMC3081035.
    11. Good RL, Radcliffe RA. Methamphetamine-induced locomotor changes are dependent on age, dose and genotype. Pharmacol Biochem Behav. 2011 Mar; 98(1):101-11. PMID: 21163294; PMCID: PMC3395365.
    12. Dwyer-Nield LD, McQuillan J, Hill-Baskin A, Radcliffe RA, You M, Nadeau JH, Malkinson AM. Epistatic interactions govern chemically-induced lung tumor susceptibility and Kras mutation site in murine C57BL/6J-ChrA/J chromosome substitution strains. Int J Cancer. 2010 Jan 01; 126(1):125-32. PMID: 19609923; PMCID: PMC2783521.
    13. Radcliffe RA, Erwin VG, Bludeau P, Deng X, Fay T, Floyd KL, Deitrich RA. A major QTL for acute ethanol sensitivity in the alcohol tolerant and non-tolerant selected rat lines. Genes Brain Behav. 2009 Aug; 8(6):611-25. PMID: 19500156; PMCID: PMC2880637.
    14. Tyagi A, Singh RP, Ramasamy K, Raina K, Redente EF, Dwyer-Nield LD, Radcliffe RA, Malkinson AM, Agarwal R. Growth inhibition and regression of lung tumors by silibinin: modulation of angiogenesis by macrophage-associated cytokines and nuclear factor-kappaB and signal transducers and activators of transcription 3. Cancer Prev Res (Phila). 2009 Jan; 2(1):74-83. PMID: 19139021; PMCID: PMC2615181.
    15. Crowell CK, Qin Q, Grampp GE, Radcliffe RA, Rogers GN, Scheinman RI. Sodium butyrate alters erythropoietin glycosylation via multiple mechanisms. Biotechnol Bioeng. 2008 Jan 01; 99(1):201-13. PMID: 17570711.
      View in: PubMed
    16. Radcliffe RA, Bludeau P, Deng XS, Erwin VG, Deitrich RA. Short-term selection for acute ethanol tolerance and sensitization from an F2 population derived from the high and low alcohol-sensitive selectively bred rat lines. Alcohol. 2007 Dec; 41(8):557-66. PMID: 18047909; PMCID: PMC2185819.
    17. Botta P, Mameli M, Floyd KL, Radcliffe RA, Valenzuela CF. Ethanol sensitivity of GABAergic currents in cerebellar granule neurons is not increased by a single amino acid change (R100Q) in the alpha6 GABAA receptor subunit. J Pharmacol Exp Ther. 2007 Nov; 323(2):684-91. PMID: 17704355.
      View in: PubMed
    18. Botta P, Radcliffe RA, Carta M, Mameli M, Daly E, Floyd KL, Deitrich RA, Valenzuela CF. Modulation of GABAA receptors in cerebellar granule neurons by ethanol: a review of genetic and electrophysiological studies. Alcohol. 2007 May; 41(3):187-99. PMID: 17521847; PMCID: PMC1986723.
    19. Radcliffe RA, Bludeau P, Asperi W, Fay T, Deng XS, Erwin VG, Deitrich RA. Confirmation of quantitative trait loci for ethanol sensitivity and neurotensin receptor density in crosses derived from the inbred high and low alcohol sensitive selectively bred rat lines. Psychopharmacology (Berl). 2006 Oct; 188(3):343-54. PMID: 16953387.
      View in: PubMed
    20. Radcliffe RA, Floyd KL, Lee MJ. Rapid ethanol tolerance mediated by adaptations in acute tolerance in inbred mouse strains. Pharmacol Biochem Behav. 2006 Jul; 84(3):524-34. PMID: 16899285.
      View in: PubMed
    21. Bowers BJ, Radcliffe RA, Smith AM, Miyamoto-Ditmon J, Wehner JM. Microarray analysis identifies cerebellar genes sensitive to chronic ethanol treatment in PKCgamma mice. Alcohol. 2006 Aug; 40(1):19-33. PMID: 17157717; PMCID: PMC1931504.
    22. Radcliffe RA, Lee MJ, Williams RW. Prediction of cis-QTLs in a pair of inbred mouse strains with the use of expression and haplotype data from public databases. Mamm Genome. 2006 Jun; 17(6):629-42. PMID: 16783643.
      View in: PubMed
    23. Smith AM, Bowers BJ, Radcliffe RA, Wehner JM. Microarray analysis of the effects of a gamma-protein kinase C null mutation on gene expression in striatum: a role for transthyretin in mutant phenotypes. Behav Genet. 2006 Nov; 36(6):869-81. PMID: 16767509.
      View in: PubMed
    24. Radcliffe RA, Floyd KL, Drahnak JA, Deitrich RA. Genetic dissociation between ethanol sensitivity and rapid tolerance in mouse and rat strains selectively bred for differential ethanol sensitivity. Alcohol Clin Exp Res. 2005 Sep; 29(9):1580-9. PMID: 16205358.
      View in: PubMed
    25. Radcliffe RA, Erwin VG, Draski L, Hoffmann S, Edwards J, Deng XS, Bludeau P, Fay T, Lundquist K, Asperi W, Deitrich RA. Quantitative trait loci mapping for ethanol sensitivity and neurotensin receptor density in an F2 intercross derived from inbred high and low alcohol sensitivity selectively bred rat lines. Alcohol Clin Exp Res. 2004 Dec; 28(12):1796-804. PMID: 15608595.
      View in: PubMed
    26. Wehner JM, Radcliffe RA. Cued and contextual fear conditioning in mice. Curr Protoc Neurosci. 2004 Sep; Chapter 8:Unit 8.5C. PMID: 18428608.
      View in: PubMed
    27. Radcliffe RA, Hoffmann SE, Deng XS, Asperi W, Fay T, Bludeau P, Erwin VG, Deitrich RA. Behavioral characterization of alcohol-tolerant and alcohol-nontolerant rat lines and an f(2) generation. Behav Genet. 2004 Jul; 34(4):453-63. PMID: 15082942.
      View in: PubMed
    28. Radcliffe RA. Multiskilled mouse rivals Renaissance rat. Nature. 2004 May 06; 429(6987):15. PMID: 15129251.
      View in: PubMed
    29. Bernert H, Sekikawa K, Radcliffe RA, Iraqi F, You M, Malkinson AM. Tnfa and Il-10 deficiencies have contrasting effects on lung tumor susceptibility: gender-dependent modulation of IL-10 haploinsufficiency. Mol Carcinog. 2003 Nov; 38(3):117-23. PMID: 14587096.
      View in: PubMed
    30. Talbot CJ, Radcliffe RA, Fullerton J, Hitzemann R, Wehner JM, Flint J. Fine scale mapping of a genetic locus for conditioned fear. Mamm Genome. 2003 Apr; 14(4):223-30. PMID: 12682774.
      View in: PubMed
    31. Balogh SA, Radcliffe RA, Logue SF, Wehner JM. Contextual and cued fear conditioning in C57BL/6J and DBA/2J mice: context discrimination and the effects of retention interval. Behav Neurosci. 2002 Dec; 116(6):947-57. PMID: 12492293.
      View in: PubMed
    32. Malkinson A, Radcliffe R, Bauer A, Dwyer-Nield L, Kleeberger S. Quantitative trait loci that regulate susceptibility to both butylated hydroxytoluene-induced pulmonary inflammation and lung tumor promotion in CXB recombinant inbred mice. Chest. 2002 Mar; 121(3 Suppl):82S. PMID: 11893704.
      View in: PubMed
    33. Malkinson AM, Radcliffe RA, Bauer AK. Quantitative trait locus mapping of susceptibilities to butylated hydroxytoluene-induced lung tumor promotion and pulmonary inflammation in CXB mice. Carcinogenesis. 2002 Mar; 23(3):411-7. PMID: 11895855.
      View in: PubMed
    34. Erwin VG, Gehle VM, Davidson K, Radcliffe RA. Confirmation of correlations and common quantitative trait loci between neurotensin receptor density and hypnotic sensitivity to ethanol. Alcohol Clin Exp Res. 2001 Dec; 25(12):1699-707. PMID: 11781501.
      View in: PubMed
    35. Erwin VG, Radcliffe R, Deitrich RA. Neurotensin levels in specific brain regions and hypnotic sensitivity to ethanol and pentobarbital as a function of time after haloperidol administration in selectively bred rat lines. J Pharmacol Exp Ther. 2001 Nov; 299(2):698-704. PMID: 11602683.
      View in: PubMed
    36. Vissel B, Royle GA, Christie BR, Schiffer HH, Ghetti A, Tritto T, Perez-Otano I, Radcliffe RA, Seamans J, Sejnowski T, Wehner JM, Collins AC, O'Gorman S, Heinemann SF. The role of RNA editing of kainate receptors in synaptic plasticity and seizures. Neuron. 2001 Jan; 29(1):217-27. PMID: 11182093.
      View in: PubMed
    37. Wehner JM, Radcliffe RA, Bowers BJ. Quantitative genetics and mouse behavior. Annu Rev Neurosci. 2001; 24:845-67. PMID: 11520920.
      View in: PubMed
    38. Radcliffe RA, Bohl ML, Lowe MV, Cycowski CS, Wehner JM. Mapping of quantitative trait loci for hypnotic sensitivity to ethanol in crosses derived from the C57BL/6 and DBA/2 mouse strains. Alcohol Clin Exp Res. 2000 Sep; 24(9):1335-42. PMID: 11003198.
      View in: PubMed
    39. Wick MJ, Radcliffe RA, Bowers BJ, Mascia MP, L├╝scher B, Harris RA, Wehner JM. Behavioural changes produced by transgenic overexpression of gamma2L and gamma2S subunits of the GABAA receptor. Eur J Neurosci. 2000 Jul; 12(7):2634-8. PMID: 10947837.
      View in: PubMed
    40. Radcliffe RA, Lowe MV, Wehner JM. Confirmation of contextual fear conditioning QTLs by short-term selection. Behav Genet. 2000 May; 30(3):183-91. PMID: 11105392.
      View in: PubMed
    41. Turri MG, Talbot CJ, Radcliffe RA, Wehner JM, Flint J. High-resolution mapping of quantitative trait loci for emotionality in selected strains of mice. Mamm Genome. 1999 Nov; 10(11):1098-101. PMID: 10556431.
      View in: PubMed
    42. Radcliffe RA, Erwin VG, Wehner JM. Acute functional tolerance to ethanol and fear conditioning are genetically correlated in mice. Alcohol Clin Exp Res. 1998 Nov; 22(8):1673-9. PMID: 9835280.
      View in: PubMed
    43. Radcliffe RA, Erwin VG. Genetic relationship between central beta-endorphin and novelty-induced locomotor activity. Pharmacol Biochem Behav. 1998 Jul; 60(3):709-18. PMID: 9678655.
      View in: PubMed
    44. Radcliffe RA, Jones BC, Erwin VG. Mapping of provisional quantitative trait loci influencing temporal variation in locomotor activity in the LS x SS recombinant inbred strains. Behav Genet. 1998 Jan; 28(1):39-47. PMID: 9573645.
      View in: PubMed
    45. Radcliffe RA, Walter NA, Sikela JM, Erwin VG. Discovery of a new Pomc1 allele in the LS x SS recombinant inbred strains: relationship to locomotor behavior. Behav Genet. 1998 Jan; 28(1):49-55. PMID: 9573646.
      View in: PubMed
    46. Wehner JM, Radcliffe RA, Rosmann ST, Christensen SC, Rasmussen DL, Fulker DW, Wiles M. Quantitative trait locus analysis of contextual fear conditioning in mice. Nat Genet. 1997 Nov; 17(3):331-4. PMID: 9354800.
      View in: PubMed
    47. Erwin VG, Radcliffe RA, Gehle VM, Jones BC. Common quantitative trait loci for alcohol-related behaviors and central nervous system neurotensin measures: locomotor activation. J Pharmacol Exp Ther. 1997 Feb; 280(2):919-26. PMID: 9023307.
      View in: PubMed
    48. Radcliffe RA, Erwin VG. Alterations in locomotor activity after microinjections of GBR-12909, selective dopamine antagonists or neurotensin into the medial prefrontal cortex. J Pharmacol Exp Ther. 1996 Jun; 277(3):1467-76. PMID: 8667212.
      View in: PubMed
    49. Erwin VG, Radcliffe RA. Characterization of neurotensin-stimulated phosphoinositide hydrolysis in brain regions of long sleep and short sleep mice. Brain Res. 1993 Nov 26; 629(1):59-66. PMID: 7904533.
      View in: PubMed
    50. Jones BC, Reed CL, Radcliffe RA, Erwin VG. Pharmacogenetics of cocaine: I. Locomotor activity and self-selection. Pharmacogenetics. 1993 Aug; 3(4):182-8. PMID: 8220437.
      View in: PubMed
    51. Erwin VG, Radcliffe R, Hinkle B, Jones BC. Genetic-based differences in neurotensin levels and receptors in brains of LS x SS mice. Peptides. 1993 Jul-Aug; 14(4):821-8. PMID: 8234031.
      View in: PubMed
    52. Jones BC, Campbell AD, Radcliffe RA, Erwin VG. Psychomotor stimulant effect of cocaine is affected by genetic makeup and experimental history. Ann N Y Acad Sci. 1992 Jun 28; 654:456-8. PMID: 1632602.
      View in: PubMed
    53. Erwin VG, Campbell AD, Radcliffe R. Effects of chronic ethanol administration on neurotensinergic processes: correlations with tolerance in LS and SS mice. Ann N Y Acad Sci. 1992 Jun 28; 654:441-3. PMID: 1321578.
      View in: PubMed
    54. Erwin VG, Radcliffe RA, Jones BC. Chronic ethanol consumption produces genotype-dependent tolerance to ethanol in LS/Ibg and SS/Ibg mice. Pharmacol Biochem Behav. 1992 Feb; 41(2):275-81. PMID: 1574515.
      View in: PubMed
    55. Jones BC, Campbell AD, Radcliffe RA, Erwin VG. Cocaine actions, brain levels and receptors in selected lines of mice. Pharmacol Biochem Behav. 1991 Dec; 40(4):941-8. PMID: 1816581.
      View in: PubMed
    56. Erwin VG, Jones BC, Radcliffe R. Further characterization of LSxSS recombinant inbred strains of mice: activating and hypothermic effects of ethanol. Alcohol Clin Exp Res. 1990 Apr; 14(2):200-4. PMID: 2190485.
      View in: PubMed
    57. Erwin VG, Jones BC, Radcliffe R. Low doses of ethanol reduce neurotensin levels in discrete brain regions from LS/Ibg and SS/Ibg mice. Alcohol Clin Exp Res. 1990 Feb; 14(1):42-7. PMID: 2178471.
      View in: PubMed
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