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Edward C Dempsey

TitleProfessor
InstitutionUniversity of Colorado Denver - Anschutz Medical Campus
DepartmentSOM-MED
Phone303/724-3679

    Collapse Research 
    Collapse research activities and funding
    R01HL078927     (DEMPSEY, EDWARD CHARLES)Jul 1, 2005 - Jun 30, 2010
    NIH/NHLBI
    Neprilysin Apoptosis and Hypoxic Pulmonary Hypertension
    Role: Principal Investigator
    R03HL095439     (DEMPSEY, EDWARD CHARLES)Sep 19, 2008 - Jul 31, 2012
    NIH/NHLBI
    Selected Peptidases and Pulmonary Vascular Remodeling in Chronic Obstructive Pulm
    Role: Principal Investigator
    I01BX000591     (DEMPSEY, EDWARD CHARLES)Jan 1, 2011 - Dec 31, 2014
    VA
    Neprilysin and Pulmonary Vascular Remodeling: Cellular and Molecular Mechanisms
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Karoor V, Fini MA, Loomis Z, Sullivan T, Hersh LB, Gerasimovskaya E, Irwin D, Dempsey EC. Sustained Activation of Rho GTPases Promotes a Synthetic Pulmonary Artery Smooth Muscle Cell Phenotype in Neprilysin Null Mice. Arterioscler Thromb Vasc Biol. 2018 Jan; 38(1):154-163. PMID: 29191928.
      View in: PubMed
    2. Wick MJ, Loomis ZL, Harral JW, Le M, Wehling CA, Miller YE, Dempsey EC. Protection against vascular leak in neprilysin transgenic mice with complex overexpression pattern. Transgenic Res. 2016 12; 25(6):773-784. PMID: 27369050.
      View in: PubMed
    3. Karoor V, Oka M, Walchak SJ, Hersh LB, Miller YE, Dempsey EC. Neprilysin regulates pulmonary artery smooth muscle cell phenotype through a platelet-derived growth factor receptor-dependent mechanism. Hypertension. 2013 Apr; 61(4):921-30. PMID: 23381789; PMCID: PMC3667616.
      View in: PubMed, PubMed Central
    4. Miller YE, Karoor V, Dempsey EC, Fagan KA. Sleep-disordered breathing, hypoxemia, and cancer mortality. Am J Respir Crit Care Med. 2013 Feb 01; 187(3):330-1. PMID: 23378442.
      View in: PubMed
    5. Karoor V, Le M, Merrick D, Fagan KA, Dempsey EC, Miller YE. Alveolar hypoxia promotes murine lung tumor growth through a VEGFR-2/EGFR-dependent mechanism. Cancer Prev Res (Phila). 2012 Aug; 5(8):1061-71. PMID: 22700853; PMCID: PMC4169262.
      View in: PubMed, PubMed Central
    6. Wick MJ, Buesing EJ, Wehling CA, Loomis ZL, Cool CD, Zamora MR, Miller YE, Colgan SP, Hersh LB, Voelkel NF, Dempsey EC. Decreased neprilysin and pulmonary vascular remodeling in chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2011 Feb 01; 183(3):330-40. PMID: 20813891; PMCID: PMC3056229.
      View in: PubMed, PubMed Central
    7. Karoor V, Le M, Merrick D, Dempsey EC, Miller YE. Vascular endothelial growth factor receptor 2-targeted chemoprevention of murine lung tumors. Cancer Prev Res (Phila). 2010 Sep; 3(9):1141-7. PMID: 20647338; PMCID: PMC2933287.
      View in: PubMed, PubMed Central
    8. Kelly K, Kittelson J, Franklin WA, Kennedy TC, Klein CE, Keith RL, Dempsey EC, Lewis M, Jackson MK, Hirsch FR, Bunn PA, Miller YE. A randomized phase II chemoprevention trial of 13-CIS retinoic acid with or without alpha tocopherol or observation in subjects at high risk for lung cancer. Cancer Prev Res (Phila). 2009 May; 2(5):440-9. PMID: 19401528; PMCID: PMC3103211.
      View in: PubMed, PubMed Central
    9. Dempsey EC, Wick MJ, Karoor V, Barr EJ, Tallman DW, Wehling CA, Walchak SJ, Laudi S, Le M, Oka M, Majka S, Cool CD, Fagan KA, Klemm DJ, Hersh LB, Gerard NP, Gerard C, Miller YE. Neprilysin null mice develop exaggerated pulmonary vascular remodeling in response to chronic hypoxia. Am J Pathol. 2009 Mar; 174(3):782-96. PMID: 19234135; PMCID: PMC2665740.
      View in: PubMed, PubMed Central
    10. Irwin D, Helm K, Campbell N, Imamura M, Fagan K, Harral J, Carr M, Young KA, Klemm D, Gebb S, Dempsey EC, West J, Majka S. Neonatal lung side population cells demonstrate endothelial potential and are altered in response to hyperoxia-induced lung simplification. Am J Physiol Lung Cell Mol Physiol. 2007 Oct; 293(4):L941-51. PMID: 17693487.
      View in: PubMed
    11. Dempsey EC, Cool CD, Littler CM. Lung disease and PKCs. Pharmacol Res. 2007 Jun; 55(6):545-59. PMID: 17582782.
      View in: PubMed
    12. Crossno JT, Garat CV, Reusch JE, Morris KG, Dempsey EC, McMurtry IF, Stenmark KR, Klemm DJ. Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. Am J Physiol Lung Cell Mol Physiol. 2007 Apr; 292(4):L885-97. PMID: 17189321.
      View in: PubMed
    13. Case D, Irwin D, Ivester C, Harral J, Morris K, Imamura M, Roedersheimer M, Patterson A, Carr M, Hagen M, Saavedra M, Crossno J, Young KA, Dempsey EC, Poirier F, West J, Majka S. Mice deficient in galectin-1 exhibit attenuated physiological responses to chronic hypoxia-induced pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2007 Jan; 292(1):L154-64. PMID: 16951131.
      View in: PubMed
    14. Petty TL, Dempsey EC, Collins T, Pluss W, Lipkus I, Cutter GR, Chalmers R, Mitchell A, Weil KC. Impact of customized videotape education on quality of life in patients with chronic obstructive pulmonary disease. J Cardiopulm Rehabil. 2006 Mar-Apr; 26(2):112-7. PMID: 16569981.
      View in: PubMed
    15. Rockwell LC, Dempsey EC, Moore LG. Chronic hypoxia diminishes the proliferative response of Guinea pig uterine artery vascular smooth muscle cells in vitro. High Alt Med Biol. 2006; 7(3):237-44. PMID: 16978136.
      View in: PubMed
    16. Karoor V, Walchak SJ, Miller YE, Dempsey EC. Role of rho in the increased migration of pulmonary artery smooth muscle cells observed in the neprilysin knockout mouse. Chest. 2005 Dec; 128(6 Suppl):582S-583S. PMID: 16373846.
      View in: PubMed
    17. Littler CM, Wehling CA, Fagan KA, Messing RO, Dempsey EC. Divergent contractile and structural responses of the murine protein kinase C-epsilon null pulmonary circulation to chronic hypoxia. Chest. 2005 Dec; 128(6 Suppl):620S-621S. PMID: 16373877.
      View in: PubMed
    18. Littler CM, Wehling CA, Wick MJ, Fagan KA, Cool CD, Messing RO, Dempsey EC. Divergent contractile and structural responses of the murine PKC-epsilon null pulmonary circulation to chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2005 Dec; 289(6):L1083-93. PMID: 16085670.
      View in: PubMed
    19. Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA, Miller YE. High prevalence of occult endobronchial malignancy in high risk patients with moderate sputum atypia. Lung Cancer. 2005 Aug; 49(2):187-91. PMID: 16022912.
      View in: PubMed
    20. Kennedy TC, Franklin WA, Prindiville SA, Cook R, Dempsey EC, Keith RL, Hirsch FR, Merrick TA, Shroyer KR, Petty TL, Byers T, Bunn PA, Miller YE. High prevalence of endobronchial malignancy in high-risk patients with moderate dysplasia in sputum. Chest. 2004 May; 125(5 Suppl):109S. PMID: 15136448.
      View in: PubMed
    21. Littler CM, Morris KG, Fagan KA, McMurtry IF, Messing RO, Dempsey EC. Protein kinase C-epsilon-null mice have decreased hypoxic pulmonary vasoconstriction. Am J Physiol Heart Circ Physiol. 2003 Apr; 284(4):H1321-31. PMID: 12505875.
      View in: PubMed
    22. Das M, Dempsey EC, Reeves JT, Stenmark KR. Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 2002 May; 282(5):L976-86. PMID: 11943662.
      View in: PubMed
    23. Hirsch FR, Prindiville SA, Miller YE, Franklin WA, Dempsey EC, Murphy JR, Bunn PA, Kennedy TC. Fluorescence versus white-light bronchoscopy for detection of preneoplastic lesions: a randomized study. J Natl Cancer Inst. 2001 Sep 19; 93(18):1385-91. PMID: 11562389.
      View in: PubMed
    24. Klemm DJ, Watson PA, Frid MG, Dempsey EC, Schaack J, Colton LA, Nesterova A, Stenmark KR, Reusch JE. cAMP response element-binding protein content is a molecular determinant of smooth muscle cell proliferation and migration. J Biol Chem. 2001 Dec 07; 276(49):46132-41. PMID: 11560924.
      View in: PubMed
    25. Dempsey EC, Newton AC, Mochly-Rosen D, Fields AP, Reyland ME, Insel PA, Messing RO. Protein kinase C isozymes and the regulation of diverse cell responses. Am J Physiol Lung Cell Mol Physiol. 2000 Sep; 279(3):L429-38. PMID: 10956616.
      View in: PubMed
    26. Keith RL, Miller YE, Gemmill RM, Drabkin HA, Dempsey EC, Kennedy TC, Prindiville S, Franklin WA. Angiogenic squamous dysplasia in bronchi of individuals at high risk for lung cancer. Clin Cancer Res. 2000 May; 6(5):1616-25. PMID: 10815878.
      View in: PubMed
    27. Das M, Dempsey EC, Bouchey D, Reyland ME, Stenmark KR. Chronic hypoxia induces exaggerated growth responses in pulmonary artery adventitial fibroblasts: potential contribution of specific protein kinase c isozymes. Am J Respir Cell Mol Biol. 2000 Jan; 22(1):15-25. PMID: 10615061.
      View in: PubMed
    28. Stenmark KR, Bouchey D, Nemenoff R, Dempsey EC, Das M. Hypoxia-induced pulmonary vascular remodeling: contribution of the adventitial fibroblasts. Physiol Res. 2000; 49(5):503-17. PMID: 11191356.
      View in: PubMed
    29. Stenmark KR, Frid M, Nemenoff R, Dempsey EC, Das M. Hypoxia induces cell-specific changes in gene expression in vascular wall cells: implications for pulmonary hypertension. Adv Exp Med Biol. 1999; 474:231-58. PMID: 10635005.
      View in: PubMed
    30. Dempsey EC, Das M, Frid MG, Xu Y, Stenmark KR. Hypoxic growth of bovine pulmonary artery smooth muscle cells: dependence on synergy, heterogeneity, and injury-induced phenotypic change. Chest. 1998 Jul; 114(1 Suppl):29S-30S. PMID: 9676612.
      View in: PubMed
    31. Frid MG, Aldashev AA, Cabirac GF, Dempsey EC, Stenmark KR. Hypoxia stimulates proliferation of a unique cell population isolated from the bovine vascular media. Chest. 1998 Jul; 114(1 Suppl):28S-29S. PMID: 9676611.
      View in: PubMed
    32. Das M, Stenmark KR, Ruff LJ, Dempsey EC. The Ca2+-dependent isozymes of protein kinase C are uniquely important in the enhanced growth of immature adventitial fibroblasts isolated from the bovine pulmonary arterial wall at a time of heightened susceptibility to vascular injury. Chest. 1998 Jul; 114(1 Suppl):68S-69S. PMID: 9676640.
      View in: PubMed
    33. Das M, Stenmark KR, Ruff LJ, Dempsey EC. Selected isozymes of PKC contribute to augmented growth of fetal and neonatal bovine PA adventitial fibroblasts. Am J Physiol. 1997 Dec; 273(6 Pt 1):L1276-84. PMID: 9435584.
      View in: PubMed
    34. Frid MG, Aldashev AA, Dempsey EC, Stenmark KR. Smooth muscle cells isolated from discrete compartments of the mature vascular media exhibit unique phenotypes and distinct growth capabilities. Circ Res. 1997 Dec; 81(6):940-52. PMID: 9400374.
      View in: PubMed
    35. Frid MG, Dempsey EC, Durmowicz AG, Stenmark KR. Smooth muscle cell heterogeneity in pulmonary and systemic vessels. Importance in vascular disease. Arterioscler Thromb Vasc Biol. 1997 Jul; 17(7):1203-9. PMID: 9261247.
      View in: PubMed
    36. Xu Y, Stenmark KR, Das M, Walchak SJ, Ruff LJ, Dempsey EC. Pulmonary artery smooth muscle cells from chronically hypoxic neonatal calves retain fetal-like and acquire new growth properties. Am J Physiol. 1997 Jul; 273(1 Pt 1):L234-45. PMID: 9252561.
      View in: PubMed
    37. Dempsey EC, Frid MG, Aldashev AA, Das M, Stenmark KR. Heterogeneity in the proliferative response of bovine pulmonary artery smooth muscle cells to mitogens and hypoxia: importance of protein kinase C. Can J Physiol Pharmacol. 1997 Jul; 75(7):936-44. PMID: 9315363.
      View in: PubMed
    38. Keyes LE, Majack R, Dempsey EC, Moore LG. Pregnancy stimulation of DNA synthesis and uterine blood flow in the guinea pig. Pediatr Res. 1997 May; 41(5):708-15. PMID: 9128295.
      View in: PubMed
    39. Scott FM, Modali R, Lehman TA, Seddon M, Kelly K, Dempsey EC, Wilson V, Tockman MS, Mulshine JL. High frequency of K-ras codon 12 mutations in bronchoalveolar lavage fluid of patients at high risk for second primary lung cancer. Clin Cancer Res. 1997 Mar; 3(3):479-82. PMID: 9815708.
      View in: PubMed
    40. Franklin WA, Folkvord JM, Varella-Garcia M, Kennedy T, Proudfoot S, Cook R, Dempsey EC, Helm K, Bunn PA, Miller YE. Expansion of bronchial epithelial cell populations by in vitro culture of explants from dysplastic and histologically normal sites. Am J Respir Cell Mol Biol. 1996 Sep; 15(3):297-304. PMID: 8810633.
      View in: PubMed
    41. Lehman TA, Scott F, Seddon M, Kelly K, Dempsey EC, Wilson VL, Mulshine JL, Modali R. Detection of K-ras oncogene mutations by polymerase chain reaction-based ligase chain reaction. Anal Biochem. 1996 Aug 01; 239(2):153-9. PMID: 8811898.
      View in: PubMed
    42. Scott FM, Treston AM, Shaw GL, Avis I, Sorenson J, Kelly K, Dempsey EC, Cantor AB, Tockman M, Mulshine JL. Peptide amidating activity in human bronchoalveolar lavage fluid. Lung Cancer. 1996 Jun; 14(2-3):239-51. PMID: 8794407.
      View in: PubMed
    43. Dempsey EC, Das M, Frid MG, Stenmark KR. Unique growth properties of neonatal pulmonary vascular cells: importance of time- and site-specific responses, cell-cell interaction, and synergy. J Perinatol. 1996 Mar-Apr; 16(2 Pt 2 Su):S2-11. PMID: 8732542.
      View in: PubMed
    44. Keyes LE, Moore LG, Walchak SJ, Dempsey EC. Pregnancy-stimulated growth of vascular smooth muscle cells: importance of protein kinase C-dependent synergy between estrogen and platelet-derived growth factor. J Cell Physiol. 1996 Jan; 166(1):22-32. PMID: 8557771.
      View in: PubMed
    45. Zamora MR, Stelzner TJ, Webb S, Panos RJ, Ruff LJ, Dempsey EC. Overexpression of endothelin-1 and enhanced growth of pulmonary artery smooth muscle cells from fawn-hooded rats. Am J Physiol. 1996 Jan; 270(1 Pt 1):L101-9. PMID: 8772532.
      View in: PubMed
    46. Das M, Stenmark KR, Dempsey EC. Enhanced growth of fetal and neonatal pulmonary artery adventitial fibroblasts is dependent on protein kinase C. Am J Physiol. 1995 Nov; 269(5 Pt 1):L660-7. PMID: 7491986.
      View in: PubMed
    47. Crowley ST, Dempsey EC, Horwitz KB, Horwitz LD. Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate. Circulation. 1994 Oct; 90(4):1908-18. PMID: 7923679.
      View in: PubMed
    48. Dempsey EC, Badesch DB, Dobyns EL, Stenmark KR. Enhanced growth capacity of neonatal pulmonary artery smooth muscle cells in vitro: dependence on cell size, time from birth, insulin-like growth factor I, and auto-activation of protein kinase C. J Cell Physiol. 1994 Sep; 160(3):469-81. PMID: 8077285.
      View in: PubMed
    49. Lake FR, Dempsey EC, Spahn JD, Riches DW. Involvement of protein kinase C in macrophage activation by poly(I.C). Am J Physiol. 1994 Jan; 266(1 Pt 1):C134-42. PMID: 8304411.
      View in: PubMed
    50. Zamora MA, Dempsey EC, Walchak SJ, Stelzner TJ. BQ123, an ETA receptor antagonist, inhibits endothelin-1-mediated proliferation of human pulmonary artery smooth muscle cells. Am J Respir Cell Mol Biol. 1993 Oct; 9(4):429-33. PMID: 8398181.
      View in: PubMed
    51. Dempsey EC, McMurtry IF, O'Brien RF. Protein kinase C activation allows pulmonary artery smooth muscle cells to proliferate to hypoxia. Am J Physiol. 1991 Feb; 260(2 Pt 1):L136-45. PMID: 1996657.
      View in: PubMed
    52. Dempsey EC, Stenmark KR, McMurtry IF, O'Brien RF, Voelkel NF, Badesch DB. Insulin-like growth factor I and protein kinase C activation stimulate pulmonary artery smooth muscle cell proliferation through separate but synergistic pathways. J Cell Physiol. 1990 Jul; 144(1):159-65. PMID: 2365741.
      View in: PubMed
    53. Leiter EH, Dempsey EC, Eppig JJ. Exocrine pancreatic insufficiency syndrome in CBA/J mice. II. Biochemical studies. Am J Pathol. 1977 Jan; 86(1):31-46. PMID: 64119; PMCID: PMC2032051.
      View in: PubMed, PubMed Central
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